JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capsid Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epitopes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Transfer Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Engineering", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vaccines", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matthews", 
        "givenName": "Qiana L", 
        "id": "sg:person.01125203445.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125203445.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yang", 
        "givenName": "PingAr", 
        "id": "sg:person.016612437322.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612437322.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Qi", 
        "id": "sg:person.0660620434.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660620434.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Experimental Diagnostic Imaging, MD Anderson Cancer Center, University of Texas, Houston, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Experimental Diagnostic Imaging, MD Anderson Cancer Center, University of Texas, Houston, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Belousova", 
        "givenName": "Natalya", 
        "id": "sg:person.0700172155.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700172155.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rivera", 
        "givenName": "Angel A", 
        "id": "sg:person.015064013177.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015064013177.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Obstetrics and Gynecology, University of Duesseldorf, Medical Center, Duesseldorf, Germany", 
          "id": "http://www.grid.ac/institutes/grid.411327.2", 
          "name": [
            "Department of Obstetrics and Gynecology, University of Duesseldorf, Medical Center, Duesseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stoff-Khalili", 
        "givenName": "Mariam A", 
        "id": "sg:person.01003507456.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003507456.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Waehler", 
        "givenName": "Reinhard", 
        "id": "sg:person.01140652131.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01140652131.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "Hui-Chen", 
        "id": "sg:person.01263522210.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263522210.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Alabama School of Fine Arts, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.487484.3", 
          "name": [
            "Alabama School of Fine Arts, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Jing", 
        "id": "sg:person.014305542547.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014305542547.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Birmingham VA Medical Center, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.280808.a", 
          "name": [
            "Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, USA", 
            "Birmingham VA Medical Center, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mountz", 
        "givenName": "John D", 
        "id": "sg:person.016504134024.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016504134024.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Hongju", 
        "id": "sg:person.013652302444.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013652302444.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Human Gene Therapy, Departments of Medicine, Pathology, Surgery, Obstetrics and Gynecology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Curiel", 
        "givenName": "David T", 
        "id": "sg:person.014245610777.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014245610777.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/35073500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050535971", 
          "https://doi.org/10.1038/35073500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051485127", 
          "https://doi.org/10.1038/ni1254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/334255a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043121411", 
          "https://doi.org/10.1038/334255a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038063655", 
          "https://doi.org/10.1038/sj.gt.3302037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043278106", 
          "https://doi.org/10.1038/nature04754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35046108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037258664", 
          "https://doi.org/10.1038/35046108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/83324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047292282", 
          "https://doi.org/10.1038/83324"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-08-21", 
    "datePublishedReg": "2008-08-21", 
    "description": "Despite the many potential advantages of Ad vectors for vaccine application, the full utility of current Ad vaccines may be limited by the host anti-vector immune response. Direct incorporation of antigens into the adenovirus capsid offers a new and exciting approach for vaccination strategies; this strategy exploits the inherent antigenicity of the Ad vector. Critical to exploiting Ad in this new context is the placement of antigenic epitopes within the major Ad capsid protein, hexon. In our current study we illustrate that we have the capability to place a range of antigenic epitopes within Ad5 capsid protein hexon hypervariable regions (HVRs) 2 or 5, thus producing viable Ad virions. Our data define the maximal incorporation size at HVR2 or HVR5 as it relates to identical antigenic epitopes. In addition, this data suggests that Ad5 HVR5 is more permissive to a range of insertions. Most importantly, repeated administration of our hexon-modified viruses resulted in a secondary anti-antigen response, whereas minimal secondary effect was present after administration of Ad5 control. Our study describes antigen placement and optimization within the context of the capsid incorporation approach of Ad vaccine employment, thereby broadening this new methodology.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1743-422x-5-98", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2681906", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2599476", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438761", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2454082", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1034449", 
        "issn": [
          "1743-422X"
        ], 
        "name": "Virology Journal", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "keywords": [
      "antigenic epitopes", 
      "anti-vector immune responses", 
      "Ad vectors", 
      "identical antigenic epitopes", 
      "AD vaccine", 
      "vaccine approaches", 
      "vaccination strategies", 
      "immune response", 
      "minimal secondary effects", 
      "Ad capsid proteins", 
      "inherent antigenicity", 
      "vaccine applications", 
      "epitopes", 
      "antigen", 
      "administration", 
      "current study", 
      "HVR5", 
      "secondary effects", 
      "capsid protein", 
      "hypervariable region 2", 
      "vaccine", 
      "exciting approach", 
      "placement", 
      "response", 
      "potential advantages", 
      "virus", 
      "HVR2", 
      "antigenicity", 
      "full utility", 
      "study", 
      "adenovirus capsid", 
      "Ad virion", 
      "virions", 
      "hexon", 
      "data", 
      "control", 
      "strategies", 
      "protein", 
      "region 2", 
      "insertion", 
      "utility", 
      "effect", 
      "capsid", 
      "addition", 
      "approach", 
      "AD", 
      "vector", 
      "incorporation", 
      "range", 
      "size", 
      "context", 
      "employment", 
      "direct incorporation", 
      "advantages", 
      "incorporation approach", 
      "applications", 
      "methodology", 
      "capability", 
      "new context", 
      "new methodology", 
      "optimization"
    ], 
    "name": "Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach", 
    "pagination": "98", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052291741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1743-422x-5-98"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18718011"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1743-422x-5-98", 
      "https://app.dimensions.ai/details/publication/pub.1052291741"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_458.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1743-422x-5-98"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      22 PREDICATES      107 URIs      92 LITERALS      20 BLANK NODES