Ontology type: schema:ScholarlyArticle Open Access: True
2008-12
AUTHORSTanja Kosutic-Gulija, Dubravko Forcic, Maja Šantak, Ana Ramljak, Sanja Mateljak-Lukacevic, Renata Mazuran
ABSTRACTBACKGROUND: The most often used mumps vaccine strains Jeryl Lynn (JL), RIT4385, Urabe-AM9, L-Zagreb and L-3 differ in immunogenicity and reactogenicity. Previous analyses showed that JL, Urabe-AM9 and L-3 are genetically heterogeneous. RESULTS: We identified the heterogeneity of L-Zagreb throughout the entire genome. Two major variants were defined: variant A being identical to the consensus sequence of viral seeds and vaccine(s) and variant B which differs from variant A in three nucleotide positions. The difference between viral variants in L-Zagreb strain is insufficient for distinct viral strains to be defined. We demonstrated that proportion of variants in L-Zagreb viral population depends on cell substrate used for viral replication in vitro and in vivo. CONCLUSION: L-Zagreb strain should be considered as a single strain composed of at least two variant viral genomes. More... »
PAGES79
http://scigraph.springernature.com/pub.10.1186/1743-422x-5-79
DOIhttp://dx.doi.org/10.1186/1743-422x-5-79
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