Dynamics of symbiont-mediated antibiotic production reveal efficient long-term protection for beewolf offspring View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Sabrina Koehler, Jan Doubský, Martin Kaltenpoth

ABSTRACT

BACKGROUND: Insects have evolved a wide range of mechanisms to defend themselves and their offspring against antagonists. One of these strategies involves the utilization of antimicrobial compounds provided by symbiotic bacteria to protect the host or its nutritional resources from pathogens and parasites. In the symbiosis of the solitary digger wasp, Philanthus triangulum (Hymenoptera, Crabronidae), the bacterial symbiont 'Candidatus Streptomyces philanthi' defends the developing larvae against pathogens by producing a mixture of at least nine antimicrobial substances on the cocoon surface. This antibiotic cocktail inhibits the growth of a broad range of detrimental fungi and bacteria, thereby significantly enhancing the offspring's survival probability. RESULTS: Here we show that the production of antimicrobial compounds by the beewolf symbionts is confined to the first two weeks after cocoon spinning, leading to a high concentration of piericidins and streptochlorin on the cocoon surface. Expression profiling of housekeeping, sporulation, and antibiotic biosynthesis genes indicates that antibiotic production coincides with morphological differentiation that enables the symbionts to survive the nutrient-limited conditions on the beewolf cocoon. The antibiotic substances remain stable on the cocoon surface for the entire duration of the beewolf's hibernation period, demonstrating that the compounds are resistant against environmental influences. CONCLUSIONS: The antibiotic production by the beewolf symbionts serves as a reliable protection for the wasp offspring against pathogenic microorganisms during the long and unpredictable developmental phase in the subterranean brood cells. Thus, the beewolf-Streptomyces symbiosis provides one of the rare examples of antibiotics serving as an efficient defense in the natural environment and may aid in devising new strategies for the utilization of antibiotic combination therapies in human medicine against increasingly resistant bacterial and fungal pathogens. More... »

PAGES

3

References to SciGraph publications

  • 2012-03. Constitutive expression of ftsZ overrides the whi developmental genes to initiate sporulation of Streptomyces coelicolor in ANTONIE VAN LEEUWENHOEK
  • 2008-05. The Chemistry of the Postpharyngeal Gland of Female European Beewolves in JOURNAL OF CHEMICAL ECOLOGY
  • 2010-04. Symbiotic streptomycetes provide antibiotic combination prophylaxis for wasp offspring in NATURE CHEMICAL BIOLOGY
  • 2001-11. How many antibiotics are produced by the genus Streptomyces? in ARCHIVES OF MICROBIOLOGY
  • 2002-11. Variable sensitivity of fungi and bacteria to compounds produced by the metapleural glands of leaf-cutting ants in INSECTES SOCIAUX
  • 2007-02. Disease prevention and resistance in social insects: modeling the survival consequences of immunity, hygienic behavior, and colony organization in BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
  • 2008-02. Real-time PCR determination of rRNA gene copy number: absolute and relative quantification assays with Escherichia coli in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2004-04. Pre-social benefits of extended parental care in NATURE
  • 1999-04. Fungus-growing ants use antibiotic-producing bacteria to control garden parasites in NATURE
  • 2001-11. Phaedon cochleariae and Gastrophysa viridula (Coleoptera: Chrysomelidae) produce defensive iridoid monoterpenes de novo and are able to sequester glycosidically bound terpenoid precursors in CHEMOECOLOGY
  • 2004-01. Individual variation in immune function in the ant Formica exsecta; effects of the nest, body size and sex in EVOLUTIONARY ECOLOGY
  • 1963. The Polyene Antifungal Antibiotics in PROGRESS IN THE CHEMISTRY OF ORGANIC NATURAL PRODUCTS/PROGRÈS DANS LA CHIMIE DES SUBSTANCES ORGANIQUES NATURELLES
  • 2009-12. Blochmannia endosymbionts improve colony growth and immune defence in the ant Camponotus fellah in BMC MICROBIOLOGY
  • 2007-04. Food Wrapping with the Postpharyngeal Gland Secretion by Females of the European beewolf Philanthus triangulum in JOURNAL OF CHEMICAL ECOLOGY
  • 1999-03. Combination therapy as a tool to prevent emergence of bacterial resistance in INFECTION
  • 2011-07. Secondary Metabolites Released by The Burying Beetle Nicrophorus vespilloides: Chemical Analyses and Possible Ecological Functions in JOURNAL OF CHEMICAL ECOLOGY
  • 2012-06. Biologically active secondary metabolites from Actinomycetes in CENTRAL EUROPEAN JOURNAL OF BIOLOGY
  • 2010-12. Marine Streptomyces as a novel source of bioactive substances in WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
  • 2010-01. Novel lactic acid bacteria inhibiting Paenibacillus larvae in honey bee larvae in APIDOLOGIE
  • 2010-03. Life cycle and population dynamics of a protective insect symbiont reveal severe bottlenecks during vertical transmission in EVOLUTIONARY ECOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1742-9994-10-3

    DOI

    http://dx.doi.org/10.1186/1742-9994-10-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037281454

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23369509


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0605", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Microbiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Chemical Ecology", 
              "id": "https://www.grid.ac/institutes/grid.418160.a", 
              "name": [
                "Max Planck Institute for Chemical Ecology, Insect Symbiosis Research Group, Hans-Knoell-Str. 8, 07745, Jena, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koehler", 
            "givenName": "Sabrina", 
            "id": "sg:person.0607673054.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607673054.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sanofi (Czechia)", 
              "id": "https://www.grid.ac/institutes/grid.486745.c", 
              "name": [
                "Max Planck Institute for Chemical Ecology, Mass Spectrometry/Proteomics Research Group, Jena, Germany", 
                "API Synthesis Department, Zentiva, Prague, Czech Republic"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Doubsk\u00fd", 
            "givenName": "Jan", 
            "id": "sg:person.0656006254.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656006254.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Max Planck Institute for Chemical Ecology", 
              "id": "https://www.grid.ac/institutes/grid.418160.a", 
              "name": [
                "Max Planck Institute for Chemical Ecology, Insect Symbiosis Research Group, Hans-Knoell-Str. 8, 07745, Jena, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kaltenpoth", 
            "givenName": "Martin", 
            "id": "sg:person.01354467105.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354467105.69"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1098/rspb.2002.2265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000175242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2007.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000468957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2958.2000.02177.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000719109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0965-1748(01)00115-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001157891"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10886-007-9263-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001275288", 
              "https://doi.org/10.1007/s10886-007-9263-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rsbl.2010.0466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003096489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10886-008-9447-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004090373", 
              "https://doi.org/10.1007/s10886-008-9447-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.phytochem.2009.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004981721"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.asd.2006.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006060673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chembiol.2011.12.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006621712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0335320100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006783919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1051/apido/2009065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007304847", 
              "https://doi.org/10.1051/apido/2009065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1051/apido/2009065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007304847", 
              "https://doi.org/10.1051/apido/2009065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6976.2009.00206.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007544742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009149164", 
              "https://doi.org/10.1038/nchembio.331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.331", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009149164", 
              "https://doi.org/10.1038/nchembio.331"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/beheco/ari054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010757843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3032.2010.00729.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011505543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-3032.2010.00729.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011505543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1432-1033.1976.tb10183.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011844296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.ento.49.061802.123416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012263194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2656.2009.01593.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014373173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2656.2009.01593.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014373173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1439-0442.2000.00300.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014937296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rsbl.2011.0963", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015898008"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rstb.2007.2044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016154902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2311.2001.00300.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016324373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1934677100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016520701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3209/saj.7_100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017022647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rspb.2002.2217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017057729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1997.7694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018581763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1001300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018987474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tim.2009.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019463196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rspb.2002.2113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020872117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s002030100345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021056638", 
              "https://doi.org/10.1007/s002030100345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00265-006-0285-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021529716", 
              "https://doi.org/10.1007/s00265-006-0285-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00265-006-0285-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021529716", 
              "https://doi.org/10.1007/s00265-006-0285-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0608949103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021712764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10482-011-9678-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022140690", 
              "https://doi.org/10.1007/s10482-011-9678-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2007.10.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023233359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00001851", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024039308", 
              "https://doi.org/10.1007/pl00001851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0812082106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025223194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00012660", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025869813", 
              "https://doi.org/10.1007/pl00012660"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jee/97.3.752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026857023"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.14.7998", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027450945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jbiotec.2005.11.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028054267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02561666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028679003", 
              "https://doi.org/10.1007/bf02561666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02561666", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028679003", 
              "https://doi.org/10.1007/bf02561666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1110474108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028692537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2004.12.084", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028827161"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tim.2009.05.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029341333"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2180-9-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030193202", 
              "https://doi.org/10.1186/1471-2180-9-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-007-1300-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030443497", 
              "https://doi.org/10.1007/s00253-007-1300-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00253-007-1300-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030443497", 
              "https://doi.org/10.1007/s00253-007-1300-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1098/rspb.2010.2118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030829232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2478/s11535-012-0036-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032152991", 
              "https://doi.org/10.2478/s11535-012-0036-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1420-9101.2011.02230.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032744560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/19519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034280644", 
              "https://doi.org/10.1038/19519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/19519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034280644", 
              "https://doi.org/10.1038/19519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cbic.200900226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034659036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cbic.200900226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034659036"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1758-2229.2009.00098.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034899560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1758-2229.2009.00098.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034899560"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2435.2005.00979.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034902422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2435.2005.00979.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034902422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ol802709x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035207416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ol802709x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035207416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/b:evec.0000017726.73906.b2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035307628", 
              "https://doi.org/10.1023/b:evec.0000017726.73906.b2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1113908108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035751189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1603/0022-0493(2004)097[0752:bpiair]2.0.co;2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037242507"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-7091-7149-3_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039142874", 
              "https://doi.org/10.1007/978-3-7091-7149-3_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0008748", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041715013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11274-010-0415-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041855314", 
              "https://doi.org/10.1007/s11274-010-0415-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10682-009-9319-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043350109", 
              "https://doi.org/10.1007/s10682-009-9319-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10682-009-9319-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043350109", 
              "https://doi.org/10.1007/s10682-009-9319-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2006.11.060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043757724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/aem.06809-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046566671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047846120", 
              "https://doi.org/10.1038/nature02427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047846120", 
              "https://doi.org/10.1038/nature02427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1897/03-582r.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048289899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1897/03-582r.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048289899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1897/03-582r.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048289899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10886-011-9978-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048941766", 
              "https://doi.org/10.1007/s10886-011-9978-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c1np00003a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050883866"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6976.2011.00313.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050943132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6968.2010.02154.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051473526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1574-6968.2010.02154.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051473526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0805403105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052678611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac025762m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054994159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/ac025762m", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054994159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/03601230701734824", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058324765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/283200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058593323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/00221287-127-1-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060364193"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/00221287-7-3-4-295", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060374489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/00221287-72-1-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060374647"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1160423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062458424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2533/000942903777679064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1070913171"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7164/antibiotics.28.132", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073629825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074513038", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076390024", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076397485", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081001659", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2175/193864701790860236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1102008225"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-12", 
        "datePublishedReg": "2013-12-01", 
        "description": "BACKGROUND: Insects have evolved a wide range of mechanisms to defend themselves and their offspring against antagonists. One of these strategies involves the utilization of antimicrobial compounds provided by symbiotic bacteria to protect the host or its nutritional resources from pathogens and parasites. In the symbiosis of the solitary digger wasp, Philanthus triangulum (Hymenoptera, Crabronidae), the bacterial symbiont 'Candidatus Streptomyces philanthi' defends the developing larvae against pathogens by producing a mixture of at least nine antimicrobial substances on the cocoon surface. This antibiotic cocktail inhibits the growth of a broad range of detrimental fungi and bacteria, thereby significantly enhancing the offspring's survival probability.\nRESULTS: Here we show that the production of antimicrobial compounds by the beewolf symbionts is confined to the first two weeks after cocoon spinning, leading to a high concentration of piericidins and streptochlorin on the cocoon surface. Expression profiling of housekeeping, sporulation, and antibiotic biosynthesis genes indicates that antibiotic production coincides with morphological differentiation that enables the symbionts to survive the nutrient-limited conditions on the beewolf cocoon. The antibiotic substances remain stable on the cocoon surface for the entire duration of the beewolf's hibernation period, demonstrating that the compounds are resistant against environmental influences.\nCONCLUSIONS: The antibiotic production by the beewolf symbionts serves as a reliable protection for the wasp offspring against pathogenic microorganisms during the long and unpredictable developmental phase in the subterranean brood cells. Thus, the beewolf-Streptomyces symbiosis provides one of the rare examples of antibiotics serving as an efficient defense in the natural environment and may aid in devising new strategies for the utilization of antibiotic combination therapies in human medicine against increasingly resistant bacterial and fungal pathogens.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1742-9994-10-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1034452", 
            "issn": [
              "1742-9994"
            ], 
            "name": "Frontiers in Zoology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "name": "Dynamics of symbiont-mediated antibiotic production reveal efficient long-term protection for beewolf offspring", 
        "pagination": "3", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b198b015640d44e4213f07a831ea99c798616f2e8b6ac9b06bded984e51be230"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23369509"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101231669"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1742-9994-10-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037281454"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1742-9994-10-3", 
          "https://app.dimensions.ai/details/publication/pub.1037281454"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000550.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1742-9994-10-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1742-9994-10-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1742-9994-10-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1742-9994-10-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1742-9994-10-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    357 TRIPLES      21 PREDICATES      114 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1742-9994-10-3 schema:about anzsrc-for:06
    2 anzsrc-for:0605
    3 schema:author N2760c9f0cc4a43ffac008268b03b1396
    4 schema:citation sg:pub.10.1007/978-3-7091-7149-3_2
    5 sg:pub.10.1007/bf02561666
    6 sg:pub.10.1007/pl00001851
    7 sg:pub.10.1007/pl00012660
    8 sg:pub.10.1007/s002030100345
    9 sg:pub.10.1007/s00253-007-1300-6
    10 sg:pub.10.1007/s00265-006-0285-y
    11 sg:pub.10.1007/s10482-011-9678-7
    12 sg:pub.10.1007/s10682-009-9319-z
    13 sg:pub.10.1007/s10886-007-9263-8
    14 sg:pub.10.1007/s10886-008-9447-x
    15 sg:pub.10.1007/s10886-011-9978-4
    16 sg:pub.10.1007/s11274-010-0415-6
    17 sg:pub.10.1023/b:evec.0000017726.73906.b2
    18 sg:pub.10.1038/19519
    19 sg:pub.10.1038/nature02427
    20 sg:pub.10.1038/nchembio.331
    21 sg:pub.10.1051/apido/2009065
    22 sg:pub.10.1186/1471-2180-9-29
    23 sg:pub.10.2478/s11535-012-0036-1
    24 https://app.dimensions.ai/details/publication/pub.1074513038
    25 https://app.dimensions.ai/details/publication/pub.1076390024
    26 https://app.dimensions.ai/details/publication/pub.1076397485
    27 https://app.dimensions.ai/details/publication/pub.1081001659
    28 https://doi.org/10.1002/cbic.200900226
    29 https://doi.org/10.1006/bbrc.1997.7694
    30 https://doi.org/10.1016/j.asd.2006.08.003
    31 https://doi.org/10.1016/j.chembiol.2011.12.018
    32 https://doi.org/10.1016/j.cub.2004.12.084
    33 https://doi.org/10.1016/j.cub.2006.11.060
    34 https://doi.org/10.1016/j.cub.2007.06.008
    35 https://doi.org/10.1016/j.cub.2007.10.029
    36 https://doi.org/10.1016/j.jbiotec.2005.11.014
    37 https://doi.org/10.1016/j.phytochem.2009.08.002
    38 https://doi.org/10.1016/j.tim.2009.05.005
    39 https://doi.org/10.1016/j.tim.2009.09.006
    40 https://doi.org/10.1016/s0965-1748(01)00115-1
    41 https://doi.org/10.1021/ac025762m
    42 https://doi.org/10.1021/ol802709x
    43 https://doi.org/10.1039/c1np00003a
    44 https://doi.org/10.1046/j.1365-2311.2001.00300.x
    45 https://doi.org/10.1046/j.1365-2958.2000.02177.x
    46 https://doi.org/10.1046/j.1439-0442.2000.00300.x
    47 https://doi.org/10.1073/pnas.0335320100
    48 https://doi.org/10.1073/pnas.0608949103
    49 https://doi.org/10.1073/pnas.0805403105
    50 https://doi.org/10.1073/pnas.0812082106
    51 https://doi.org/10.1073/pnas.1110474108
    52 https://doi.org/10.1073/pnas.1113908108
    53 https://doi.org/10.1073/pnas.1934677100
    54 https://doi.org/10.1073/pnas.96.14.7998
    55 https://doi.org/10.1080/03601230701734824
    56 https://doi.org/10.1086/283200
    57 https://doi.org/10.1093/beheco/ari054
    58 https://doi.org/10.1093/jee/97.3.752
    59 https://doi.org/10.1098/rsbl.2010.0466
    60 https://doi.org/10.1098/rsbl.2011.0963
    61 https://doi.org/10.1098/rspb.2002.2113
    62 https://doi.org/10.1098/rspb.2002.2217
    63 https://doi.org/10.1098/rspb.2002.2265
    64 https://doi.org/10.1098/rspb.2010.2118
    65 https://doi.org/10.1098/rstb.2007.2044
    66 https://doi.org/10.1099/00221287-127-1-11
    67 https://doi.org/10.1099/00221287-7-3-4-295
    68 https://doi.org/10.1099/00221287-72-1-9
    69 https://doi.org/10.1111/j.1365-2435.2005.00979.x
    70 https://doi.org/10.1111/j.1365-2656.2009.01593.x
    71 https://doi.org/10.1111/j.1365-3032.2010.00729.x
    72 https://doi.org/10.1111/j.1420-9101.2011.02230.x
    73 https://doi.org/10.1111/j.1432-1033.1976.tb10183.x
    74 https://doi.org/10.1111/j.1574-6968.2010.02154.x
    75 https://doi.org/10.1111/j.1574-6976.2009.00206.x
    76 https://doi.org/10.1111/j.1574-6976.2011.00313.x
    77 https://doi.org/10.1111/j.1758-2229.2009.00098.x
    78 https://doi.org/10.1126/science.1160423
    79 https://doi.org/10.1128/aem.06809-11
    80 https://doi.org/10.1146/annurev.ento.49.061802.123416
    81 https://doi.org/10.1371/journal.pbio.1001300
    82 https://doi.org/10.1371/journal.pone.0008748
    83 https://doi.org/10.1603/0022-0493(2004)097[0752:bpiair]2.0.co;2
    84 https://doi.org/10.1897/03-582r.1
    85 https://doi.org/10.2175/193864701790860236
    86 https://doi.org/10.2533/000942903777679064
    87 https://doi.org/10.3209/saj.7_100
    88 https://doi.org/10.7164/antibiotics.28.132
    89 schema:datePublished 2013-12
    90 schema:datePublishedReg 2013-12-01
    91 schema:description BACKGROUND: Insects have evolved a wide range of mechanisms to defend themselves and their offspring against antagonists. One of these strategies involves the utilization of antimicrobial compounds provided by symbiotic bacteria to protect the host or its nutritional resources from pathogens and parasites. In the symbiosis of the solitary digger wasp, Philanthus triangulum (Hymenoptera, Crabronidae), the bacterial symbiont 'Candidatus Streptomyces philanthi' defends the developing larvae against pathogens by producing a mixture of at least nine antimicrobial substances on the cocoon surface. This antibiotic cocktail inhibits the growth of a broad range of detrimental fungi and bacteria, thereby significantly enhancing the offspring's survival probability. RESULTS: Here we show that the production of antimicrobial compounds by the beewolf symbionts is confined to the first two weeks after cocoon spinning, leading to a high concentration of piericidins and streptochlorin on the cocoon surface. Expression profiling of housekeeping, sporulation, and antibiotic biosynthesis genes indicates that antibiotic production coincides with morphological differentiation that enables the symbionts to survive the nutrient-limited conditions on the beewolf cocoon. The antibiotic substances remain stable on the cocoon surface for the entire duration of the beewolf's hibernation period, demonstrating that the compounds are resistant against environmental influences. CONCLUSIONS: The antibiotic production by the beewolf symbionts serves as a reliable protection for the wasp offspring against pathogenic microorganisms during the long and unpredictable developmental phase in the subterranean brood cells. Thus, the beewolf-Streptomyces symbiosis provides one of the rare examples of antibiotics serving as an efficient defense in the natural environment and may aid in devising new strategies for the utilization of antibiotic combination therapies in human medicine against increasingly resistant bacterial and fungal pathogens.
    92 schema:genre research_article
    93 schema:inLanguage en
    94 schema:isAccessibleForFree true
    95 schema:isPartOf N687dcf2d75784f19994f146ce181269d
    96 N8c4c779a476d4e65bdbdb7f1101f8b09
    97 sg:journal.1034452
    98 schema:name Dynamics of symbiont-mediated antibiotic production reveal efficient long-term protection for beewolf offspring
    99 schema:pagination 3
    100 schema:productId N4ccb391d78e242fa95c637dcce65279e
    101 N80a775101ad542fe863fbf31756802d6
    102 Nb48964ff0c454409ace328cf50decba0
    103 Nc75e0cae725645128dc2784963ec3b67
    104 Nf7d280e3b24643bfb3af27a53dcd4af5
    105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037281454
    106 https://doi.org/10.1186/1742-9994-10-3
    107 schema:sdDatePublished 2019-04-10T17:38
    108 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    109 schema:sdPublisher N8bc85ca1e57d408c882bfbb22646d4bb
    110 schema:url http://link.springer.com/10.1186%2F1742-9994-10-3
    111 sgo:license sg:explorer/license/
    112 sgo:sdDataset articles
    113 rdf:type schema:ScholarlyArticle
    114 N2760c9f0cc4a43ffac008268b03b1396 rdf:first sg:person.0607673054.31
    115 rdf:rest N623034b2092947e6b658b41015766a9c
    116 N2bc2d75b917f4104b6bda60b2a4b6b27 rdf:first sg:person.01354467105.69
    117 rdf:rest rdf:nil
    118 N4ccb391d78e242fa95c637dcce65279e schema:name dimensions_id
    119 schema:value pub.1037281454
    120 rdf:type schema:PropertyValue
    121 N623034b2092947e6b658b41015766a9c rdf:first sg:person.0656006254.38
    122 rdf:rest N2bc2d75b917f4104b6bda60b2a4b6b27
    123 N687dcf2d75784f19994f146ce181269d schema:volumeNumber 10
    124 rdf:type schema:PublicationVolume
    125 N80a775101ad542fe863fbf31756802d6 schema:name nlm_unique_id
    126 schema:value 101231669
    127 rdf:type schema:PropertyValue
    128 N8bc85ca1e57d408c882bfbb22646d4bb schema:name Springer Nature - SN SciGraph project
    129 rdf:type schema:Organization
    130 N8c4c779a476d4e65bdbdb7f1101f8b09 schema:issueNumber 1
    131 rdf:type schema:PublicationIssue
    132 Nb48964ff0c454409ace328cf50decba0 schema:name doi
    133 schema:value 10.1186/1742-9994-10-3
    134 rdf:type schema:PropertyValue
    135 Nc75e0cae725645128dc2784963ec3b67 schema:name readcube_id
    136 schema:value b198b015640d44e4213f07a831ea99c798616f2e8b6ac9b06bded984e51be230
    137 rdf:type schema:PropertyValue
    138 Nf7d280e3b24643bfb3af27a53dcd4af5 schema:name pubmed_id
    139 schema:value 23369509
    140 rdf:type schema:PropertyValue
    141 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    142 schema:name Biological Sciences
    143 rdf:type schema:DefinedTerm
    144 anzsrc-for:0605 schema:inDefinedTermSet anzsrc-for:
    145 schema:name Microbiology
    146 rdf:type schema:DefinedTerm
    147 sg:journal.1034452 schema:issn 1742-9994
    148 schema:name Frontiers in Zoology
    149 rdf:type schema:Periodical
    150 sg:person.01354467105.69 schema:affiliation https://www.grid.ac/institutes/grid.418160.a
    151 schema:familyName Kaltenpoth
    152 schema:givenName Martin
    153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354467105.69
    154 rdf:type schema:Person
    155 sg:person.0607673054.31 schema:affiliation https://www.grid.ac/institutes/grid.418160.a
    156 schema:familyName Koehler
    157 schema:givenName Sabrina
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607673054.31
    159 rdf:type schema:Person
    160 sg:person.0656006254.38 schema:affiliation https://www.grid.ac/institutes/grid.486745.c
    161 schema:familyName Doubský
    162 schema:givenName Jan
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0656006254.38
    164 rdf:type schema:Person
    165 sg:pub.10.1007/978-3-7091-7149-3_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039142874
    166 https://doi.org/10.1007/978-3-7091-7149-3_2
    167 rdf:type schema:CreativeWork
    168 sg:pub.10.1007/bf02561666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028679003
    169 https://doi.org/10.1007/bf02561666
    170 rdf:type schema:CreativeWork
    171 sg:pub.10.1007/pl00001851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024039308
    172 https://doi.org/10.1007/pl00001851
    173 rdf:type schema:CreativeWork
    174 sg:pub.10.1007/pl00012660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025869813
    175 https://doi.org/10.1007/pl00012660
    176 rdf:type schema:CreativeWork
    177 sg:pub.10.1007/s002030100345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021056638
    178 https://doi.org/10.1007/s002030100345
    179 rdf:type schema:CreativeWork
    180 sg:pub.10.1007/s00253-007-1300-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030443497
    181 https://doi.org/10.1007/s00253-007-1300-6
    182 rdf:type schema:CreativeWork
    183 sg:pub.10.1007/s00265-006-0285-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1021529716
    184 https://doi.org/10.1007/s00265-006-0285-y
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/s10482-011-9678-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022140690
    187 https://doi.org/10.1007/s10482-011-9678-7
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s10682-009-9319-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1043350109
    190 https://doi.org/10.1007/s10682-009-9319-z
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1007/s10886-007-9263-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001275288
    193 https://doi.org/10.1007/s10886-007-9263-8
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1007/s10886-008-9447-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004090373
    196 https://doi.org/10.1007/s10886-008-9447-x
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1007/s10886-011-9978-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048941766
    199 https://doi.org/10.1007/s10886-011-9978-4
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1007/s11274-010-0415-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041855314
    202 https://doi.org/10.1007/s11274-010-0415-6
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1023/b:evec.0000017726.73906.b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035307628
    205 https://doi.org/10.1023/b:evec.0000017726.73906.b2
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/19519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034280644
    208 https://doi.org/10.1038/19519
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nature02427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047846120
    211 https://doi.org/10.1038/nature02427
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nchembio.331 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009149164
    214 https://doi.org/10.1038/nchembio.331
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1051/apido/2009065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007304847
    217 https://doi.org/10.1051/apido/2009065
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1186/1471-2180-9-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030193202
    220 https://doi.org/10.1186/1471-2180-9-29
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.2478/s11535-012-0036-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032152991
    223 https://doi.org/10.2478/s11535-012-0036-1
    224 rdf:type schema:CreativeWork
    225 https://app.dimensions.ai/details/publication/pub.1074513038 schema:CreativeWork
    226 https://app.dimensions.ai/details/publication/pub.1076390024 schema:CreativeWork
    227 https://app.dimensions.ai/details/publication/pub.1076397485 schema:CreativeWork
    228 https://app.dimensions.ai/details/publication/pub.1081001659 schema:CreativeWork
    229 https://doi.org/10.1002/cbic.200900226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034659036
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1006/bbrc.1997.7694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018581763
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.asd.2006.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006060673
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.chembiol.2011.12.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006621712
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.cub.2004.12.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028827161
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.cub.2006.11.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043757724
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/j.cub.2007.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000468957
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/j.cub.2007.10.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023233359
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/j.jbiotec.2005.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028054267
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1016/j.phytochem.2009.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004981721
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1016/j.tim.2009.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029341333
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1016/j.tim.2009.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019463196
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1016/s0965-1748(01)00115-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001157891
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1021/ac025762m schema:sameAs https://app.dimensions.ai/details/publication/pub.1054994159
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1021/ol802709x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035207416
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1039/c1np00003a schema:sameAs https://app.dimensions.ai/details/publication/pub.1050883866
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1046/j.1365-2311.2001.00300.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1016324373
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1046/j.1365-2958.2000.02177.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000719109
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1046/j.1439-0442.2000.00300.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014937296
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1073/pnas.0335320100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006783919
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1073/pnas.0608949103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021712764
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1073/pnas.0805403105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052678611
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1073/pnas.0812082106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025223194
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1073/pnas.1110474108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028692537
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1073/pnas.1113908108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035751189
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1073/pnas.1934677100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016520701
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1073/pnas.96.14.7998 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027450945
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1080/03601230701734824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058324765
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1086/283200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058593323
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1093/beheco/ari054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010757843
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1093/jee/97.3.752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026857023
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1098/rsbl.2010.0466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003096489
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1098/rsbl.2011.0963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015898008
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1098/rspb.2002.2113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020872117
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1098/rspb.2002.2217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017057729
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1098/rspb.2002.2265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000175242
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1098/rspb.2010.2118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030829232
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1098/rstb.2007.2044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016154902
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1099/00221287-127-1-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060364193
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1099/00221287-7-3-4-295 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060374489
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1099/00221287-72-1-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060374647
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1111/j.1365-2435.2005.00979.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034902422
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1111/j.1365-2656.2009.01593.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014373173
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1111/j.1365-3032.2010.00729.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011505543
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1111/j.1420-9101.2011.02230.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032744560
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1111/j.1432-1033.1976.tb10183.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011844296
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1111/j.1574-6968.2010.02154.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051473526
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1111/j.1574-6976.2009.00206.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007544742
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1111/j.1574-6976.2011.00313.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050943132
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1111/j.1758-2229.2009.00098.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034899560
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1126/science.1160423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062458424
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1128/aem.06809-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046566671
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1146/annurev.ento.49.061802.123416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012263194
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1371/journal.pbio.1001300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018987474
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1371/journal.pone.0008748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041715013
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1603/0022-0493(2004)097[0752:bpiair]2.0.co;2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037242507
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1897/03-582r.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048289899
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.2175/193864701790860236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1102008225
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.2533/000942903777679064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070913171
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.3209/saj.7_100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017022647
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.7164/antibiotics.28.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073629825
    350 rdf:type schema:CreativeWork
    351 https://www.grid.ac/institutes/grid.418160.a schema:alternateName Max Planck Institute for Chemical Ecology
    352 schema:name Max Planck Institute for Chemical Ecology, Insect Symbiosis Research Group, Hans-Knoell-Str. 8, 07745, Jena, Germany
    353 rdf:type schema:Organization
    354 https://www.grid.ac/institutes/grid.486745.c schema:alternateName Sanofi (Czechia)
    355 schema:name API Synthesis Department, Zentiva, Prague, Czech Republic
    356 Max Planck Institute for Chemical Ecology, Mass Spectrometry/Proteomics Research Group, Jena, Germany
    357 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...