HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Amin S Hassan, Helen M Nabwera, Shalton M Mwaringa, Clare A Obonyo, Eduard J Sanders, Tobias F Rinke de Wit, Patricia A Cane, James A Berkley

ABSTRACT

BACKGROUND: An increasing number of people on antiretroviral therapy (ART) in sub-Saharan Africa has led to declines in HIV related morbidity and mortality. However, virologic failure (VF) and acquired drug resistance (ADR) may negatively affect these gains. This study describes the prevalence and correlates of HIV-1 VF and ADR among first-line ART experienced adults at a rural HIV clinic in Coastal Kenya. METHODS: HIV-infected adults on first-line ART for ≥6 months were cross-sectionally recruited between November 2008 and March 2011. The primary outcome was VF, defined as a one-off plasma viral load of ≥400 copies/ml. The secondary outcome was ADR, defined as the presence of resistance associated mutations. Logistic regression and Fishers exact test were used to describe correlates of VF and ADR respectively. RESULTS: Of the 232 eligible participants on ART over a median duration of 13.9 months, 57 (24.6% [95% CI: 19.2 - 30.6]) had VF. Fifty-five viraemic samples were successfully amplified and sequenced. Of these, 29 (52.7% [95% CI: 38.8 - 66.3]) had at least one ADR, with 25 samples having dual-class resistance mutations. The most prevalent ADR mutations were the M184V (n = 24), K103N/S (n = 14) and Y181C/Y/I/V (n = 8). Twenty-six of the 55 successfully amplified viraemic samples (47.3%) did not have any detectable resistance mutation. Younger age (15-34 vs. ≥35 years: adjusted odd ratios [95% CI], p-value: 0.3 [0.1-0.6], p = 0.002) and unsatisfactory adherence (<95% vs. ≥95%: 3.0 [1.5-6.5], p = 0.003) were strong correlates of VF. Younger age, unsatisfactory adherence and high viral load were also strong correlates of ADR. CONCLUSIONS: High levels of VF and ADR were observed in younger patients and those with unsatisfactory adherence. Youth-friendly ART initiatives and strengthened adherence support should be prioritized in this Coastal Kenyan setting. To prevent unnecessary/premature switches, targeted HIV drug resistance testing for patients with confirmed VF should be considered. More... »

PAGES

9

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1742-6405-11-9

DOI

http://dx.doi.org/10.1186/1742-6405-11-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044670703

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24456757


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kenya Medical Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.33058.3d", 
          "name": [
            "KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hassan", 
        "givenName": "Amin S", 
        "id": "sg:person.0720137653.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720137653.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kenya Medical Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.33058.3d", 
          "name": [
            "KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nabwera", 
        "givenName": "Helen M", 
        "id": "sg:person.01157755733.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157755733.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kenya Medical Research Institute", 
          "id": "https://www.grid.ac/institutes/grid.33058.3d", 
          "name": [
            "KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mwaringa", 
        "givenName": "Shalton M", 
        "id": "sg:person.01334753042.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334753042.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Kilifi District Hospital, Kilifi, Kenya"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Obonyo", 
        "givenName": "Clare A", 
        "id": "sg:person.0611346742.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611346742.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya", 
            "Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sanders", 
        "givenName": "Eduard J", 
        "id": "sg:person.01202104156.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202104156.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Academic Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.5650.6", 
          "name": [
            "PharmAccess Foundation, Amsterdam, Netherlands", 
            "Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rinke de Wit", 
        "givenName": "Tobias F", 
        "id": "sg:person.01304150161.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304150161.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Health Protection Agency", 
          "id": "https://www.grid.ac/institutes/grid.9004.d", 
          "name": [
            "Health Protection Agency, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cane", 
        "givenName": "Patricia A", 
        "id": "sg:person.01247677303.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247677303.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Oxford", 
          "id": "https://www.grid.ac/institutes/grid.4991.5", 
          "name": [
            "KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya", 
            "Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berkley", 
        "givenName": "James A", 
        "id": "sg:person.0616622774.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616622774.31"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.pone.0017518", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001683674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2011/434375", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004465385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkl092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004512573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/cir1015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005274373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pcbi.1000581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005613156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)61038-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006992672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(11)70255-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009736815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3182084b5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009877145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e3182084b5a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009877145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-817-1_8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015871844", 
          "https://doi.org/10.1007/978-1-60761-817-1_8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-60761-817-1_8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015871844", 
          "https://doi.org/10.1007/978-1-60761-817-1_8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-8-89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016573611", 
          "https://doi.org/10.1186/1471-2334-8-89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(11)70149-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017099859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(06)69118-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019458658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2011.02889.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021480269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(11)70032-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021690766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60693-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024114938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32830e4cd8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030279394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32830e4cd8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030279394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2009.02309.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033563487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3156.2009.02309.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033563487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832e05b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033732402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832e05b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033732402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qad.0b013e32832e05b2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033732402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000225015.43266.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035757642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.qai.0000225015.43266.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035757642"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(09)70328-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038241499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(09)70136-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038357016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2012.0167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041185590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkt033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041530962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/503914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043175344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/528802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043745381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/600396", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045677754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.293.7.817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050089341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e31816a1d4f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051215543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/qai.0b013e31816a1d4f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051215543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052306251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/aid.2008.0035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059225648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1542/peds.2011-0068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067829213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3851/imp2437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071479663"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-150-10-200905190-00117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073710459"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: An increasing number of people on antiretroviral therapy (ART) in sub-Saharan Africa has led to declines in HIV related morbidity and mortality. However, virologic failure (VF) and acquired drug resistance (ADR) may negatively affect these gains. This study describes the prevalence and correlates of HIV-1 VF and ADR among first-line ART experienced adults at a rural HIV clinic in Coastal Kenya.\nMETHODS: HIV-infected adults on first-line ART for \u22656\u00a0months were cross-sectionally recruited between November 2008 and March 2011. The primary outcome was VF, defined as a one-off plasma viral load of \u2265400 copies/ml. The secondary outcome was ADR, defined as the presence of resistance associated mutations. Logistic regression and Fishers exact test were used to describe correlates of VF and ADR respectively.\nRESULTS: Of the 232 eligible participants on ART over a median duration of 13.9\u00a0months, 57 (24.6% [95% CI: 19.2 - 30.6]) had VF. Fifty-five viraemic samples were successfully amplified and sequenced. Of these, 29 (52.7% [95% CI: 38.8 - 66.3]) had at least one ADR, with 25 samples having dual-class resistance mutations. The most prevalent ADR mutations were the M184V (n\u2009=\u200924), K103N/S (n\u2009=\u200914) and Y181C/Y/I/V (n\u2009=\u20098). Twenty-six of the 55 successfully amplified viraemic samples (47.3%) did not have any detectable resistance mutation. Younger age (15-34 vs. \u226535\u00a0years: adjusted odd ratios [95% CI], p-value: 0.3 [0.1-0.6], p\u2009=\u20090.002) and unsatisfactory adherence (<95% vs. \u226595%: 3.0 [1.5-6.5], p\u2009=\u20090.003) were strong correlates of VF. Younger age, unsatisfactory adherence and high viral load were also strong correlates of ADR.\nCONCLUSIONS: High levels of VF and ADR were observed in younger patients and those with unsatisfactory adherence. Youth-friendly ART initiatives and strengthened adherence support should be prioritized in this Coastal Kenyan setting. To prevent unnecessary/premature switches, targeted HIV drug resistance testing for patients with confirmed VF should be considered.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1742-6405-11-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3635759", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1034921", 
        "issn": [
          "1742-6405"
        ], 
        "name": "AIDS Research and Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study", 
    "pagination": "9", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "d4c89acc77df846241146a9b021fa14386f9592fc3d62bbdc4d421b54a3dada9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24456757"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101237921"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1742-6405-11-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1044670703"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1742-6405-11-9", 
      "https://app.dimensions.ai/details/publication/pub.1044670703"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000515.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1742-6405-11-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1742-6405-11-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1742-6405-11-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1742-6405-11-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1742-6405-11-9'


 

This table displays all metadata directly associated to this object as RDF triples.

233 TRIPLES      21 PREDICATES      62 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1742-6405-11-9 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author Nb909079f19d64c4ea10437212890f3ea
4 schema:citation sg:pub.10.1007/978-1-60761-817-1_8
5 sg:pub.10.1186/1471-2334-8-89
6 https://doi.org/10.1001/jama.293.7.817
7 https://doi.org/10.1016/s0140-6736(06)69118-6
8 https://doi.org/10.1016/s0140-6736(08)60693-5
9 https://doi.org/10.1016/s0140-6736(12)61038-1
10 https://doi.org/10.1016/s1473-3099(09)70136-7
11 https://doi.org/10.1016/s1473-3099(09)70328-7
12 https://doi.org/10.1016/s1473-3099(11)70032-9
13 https://doi.org/10.1016/s1473-3099(11)70149-9
14 https://doi.org/10.1016/s1473-3099(11)70255-9
15 https://doi.org/10.1086/503914
16 https://doi.org/10.1086/528802
17 https://doi.org/10.1086/600396
18 https://doi.org/10.1089/aid.2008.0035
19 https://doi.org/10.1089/aid.2012.0167
20 https://doi.org/10.1093/cid/cir1015
21 https://doi.org/10.1093/jac/dkl092
22 https://doi.org/10.1093/jac/dkt033
23 https://doi.org/10.1093/nar/gkg100
24 https://doi.org/10.1097/01.qai.0000225015.43266.46
25 https://doi.org/10.1097/qad.0b013e32830e4cd8
26 https://doi.org/10.1097/qad.0b013e32832e05b2
27 https://doi.org/10.1097/qai.0b013e31816a1d4f
28 https://doi.org/10.1097/qai.0b013e3182084b5a
29 https://doi.org/10.1111/j.1365-3156.2009.02309.x
30 https://doi.org/10.1111/j.1365-3156.2011.02889.x
31 https://doi.org/10.1155/2011/434375
32 https://doi.org/10.1371/journal.pcbi.1000581
33 https://doi.org/10.1371/journal.pone.0017518
34 https://doi.org/10.1542/peds.2011-0068
35 https://doi.org/10.3851/imp2437
36 https://doi.org/10.7326/0003-4819-150-10-200905190-00117
37 schema:datePublished 2014-12
38 schema:datePublishedReg 2014-12-01
39 schema:description BACKGROUND: An increasing number of people on antiretroviral therapy (ART) in sub-Saharan Africa has led to declines in HIV related morbidity and mortality. However, virologic failure (VF) and acquired drug resistance (ADR) may negatively affect these gains. This study describes the prevalence and correlates of HIV-1 VF and ADR among first-line ART experienced adults at a rural HIV clinic in Coastal Kenya. METHODS: HIV-infected adults on first-line ART for ≥6 months were cross-sectionally recruited between November 2008 and March 2011. The primary outcome was VF, defined as a one-off plasma viral load of ≥400 copies/ml. The secondary outcome was ADR, defined as the presence of resistance associated mutations. Logistic regression and Fishers exact test were used to describe correlates of VF and ADR respectively. RESULTS: Of the 232 eligible participants on ART over a median duration of 13.9 months, 57 (24.6% [95% CI: 19.2 - 30.6]) had VF. Fifty-five viraemic samples were successfully amplified and sequenced. Of these, 29 (52.7% [95% CI: 38.8 - 66.3]) had at least one ADR, with 25 samples having dual-class resistance mutations. The most prevalent ADR mutations were the M184V (n = 24), K103N/S (n = 14) and Y181C/Y/I/V (n = 8). Twenty-six of the 55 successfully amplified viraemic samples (47.3%) did not have any detectable resistance mutation. Younger age (15-34 vs. ≥35 years: adjusted odd ratios [95% CI], p-value: 0.3 [0.1-0.6], p = 0.002) and unsatisfactory adherence (<95% vs. ≥95%: 3.0 [1.5-6.5], p = 0.003) were strong correlates of VF. Younger age, unsatisfactory adherence and high viral load were also strong correlates of ADR. CONCLUSIONS: High levels of VF and ADR were observed in younger patients and those with unsatisfactory adherence. Youth-friendly ART initiatives and strengthened adherence support should be prioritized in this Coastal Kenyan setting. To prevent unnecessary/premature switches, targeted HIV drug resistance testing for patients with confirmed VF should be considered.
40 schema:genre research_article
41 schema:inLanguage en
42 schema:isAccessibleForFree true
43 schema:isPartOf N06cf33426b0042e8ae2c6e5657ce8508
44 Nf44ccbb9b1fe4386bb1b37f99e32478c
45 sg:journal.1034921
46 schema:name HIV-1 virologic failure and acquired drug resistance among first-line antiretroviral experienced adults at a rural HIV clinic in coastal Kenya: a cross-sectional study
47 schema:pagination 9
48 schema:productId N04543cc39e1b4a96bd9219df77ebc183
49 N6567f28743604380ae55d59c0ce726ec
50 Na03956aea4fc4c8bad71357d6227fb3b
51 Nb83fed2e99b14eafb694f400be2e4263
52 Nc9b56fde2fa84e268b2fcf3bc0fd8480
53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044670703
54 https://doi.org/10.1186/1742-6405-11-9
55 schema:sdDatePublished 2019-04-10T19:09
56 schema:sdLicense https://scigraph.springernature.com/explorer/license/
57 schema:sdPublisher N8db6f1100004438c8f2246da07ce020d
58 schema:url http://link.springer.com/10.1186%2F1742-6405-11-9
59 sgo:license sg:explorer/license/
60 sgo:sdDataset articles
61 rdf:type schema:ScholarlyArticle
62 N01b3bd5df37e424aab14f11dbd629fc8 rdf:first sg:person.01157755733.54
63 rdf:rest Na3c9918c821c4a898a58d16ca957c84c
64 N04543cc39e1b4a96bd9219df77ebc183 schema:name doi
65 schema:value 10.1186/1742-6405-11-9
66 rdf:type schema:PropertyValue
67 N06cf33426b0042e8ae2c6e5657ce8508 schema:issueNumber 1
68 rdf:type schema:PublicationIssue
69 N0a2f5b5c8386469990520e1bca51546f schema:name Kilifi District Hospital, Kilifi, Kenya
70 rdf:type schema:Organization
71 N19dc7f6953bf4370a2aeb14c9d7bf054 rdf:first sg:person.01247677303.20
72 rdf:rest Ne72f12c74b7947c1b38049d004703791
73 N235f0bd0c2dd4cd9b4758ffe790f1b24 rdf:first sg:person.0611346742.88
74 rdf:rest Nd1aec78030d84647945f7dd12e8168e5
75 N6567f28743604380ae55d59c0ce726ec schema:name dimensions_id
76 schema:value pub.1044670703
77 rdf:type schema:PropertyValue
78 N84cbe94fadcf4cd7b5aa68eb7ffe231c rdf:first sg:person.01304150161.09
79 rdf:rest N19dc7f6953bf4370a2aeb14c9d7bf054
80 N8db6f1100004438c8f2246da07ce020d schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 Na03956aea4fc4c8bad71357d6227fb3b schema:name readcube_id
83 schema:value d4c89acc77df846241146a9b021fa14386f9592fc3d62bbdc4d421b54a3dada9
84 rdf:type schema:PropertyValue
85 Na3c9918c821c4a898a58d16ca957c84c rdf:first sg:person.01334753042.35
86 rdf:rest N235f0bd0c2dd4cd9b4758ffe790f1b24
87 Nb83fed2e99b14eafb694f400be2e4263 schema:name nlm_unique_id
88 schema:value 101237921
89 rdf:type schema:PropertyValue
90 Nb909079f19d64c4ea10437212890f3ea rdf:first sg:person.0720137653.92
91 rdf:rest N01b3bd5df37e424aab14f11dbd629fc8
92 Nc9b56fde2fa84e268b2fcf3bc0fd8480 schema:name pubmed_id
93 schema:value 24456757
94 rdf:type schema:PropertyValue
95 Nd1aec78030d84647945f7dd12e8168e5 rdf:first sg:person.01202104156.16
96 rdf:rest N84cbe94fadcf4cd7b5aa68eb7ffe231c
97 Ne72f12c74b7947c1b38049d004703791 rdf:first sg:person.0616622774.31
98 rdf:rest rdf:nil
99 Nf44ccbb9b1fe4386bb1b37f99e32478c schema:volumeNumber 11
100 rdf:type schema:PublicationVolume
101 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
102 schema:name Medical and Health Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
105 schema:name Clinical Sciences
106 rdf:type schema:DefinedTerm
107 sg:grant.3635759 http://pending.schema.org/fundedItem sg:pub.10.1186/1742-6405-11-9
108 rdf:type schema:MonetaryGrant
109 sg:journal.1034921 schema:issn 1742-6405
110 schema:name AIDS Research and Therapy
111 rdf:type schema:Periodical
112 sg:person.01157755733.54 schema:affiliation https://www.grid.ac/institutes/grid.33058.3d
113 schema:familyName Nabwera
114 schema:givenName Helen M
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157755733.54
116 rdf:type schema:Person
117 sg:person.01202104156.16 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
118 schema:familyName Sanders
119 schema:givenName Eduard J
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202104156.16
121 rdf:type schema:Person
122 sg:person.01247677303.20 schema:affiliation https://www.grid.ac/institutes/grid.9004.d
123 schema:familyName Cane
124 schema:givenName Patricia A
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247677303.20
126 rdf:type schema:Person
127 sg:person.01304150161.09 schema:affiliation https://www.grid.ac/institutes/grid.5650.6
128 schema:familyName Rinke de Wit
129 schema:givenName Tobias F
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304150161.09
131 rdf:type schema:Person
132 sg:person.01334753042.35 schema:affiliation https://www.grid.ac/institutes/grid.33058.3d
133 schema:familyName Mwaringa
134 schema:givenName Shalton M
135 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334753042.35
136 rdf:type schema:Person
137 sg:person.0611346742.88 schema:affiliation N0a2f5b5c8386469990520e1bca51546f
138 schema:familyName Obonyo
139 schema:givenName Clare A
140 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611346742.88
141 rdf:type schema:Person
142 sg:person.0616622774.31 schema:affiliation https://www.grid.ac/institutes/grid.4991.5
143 schema:familyName Berkley
144 schema:givenName James A
145 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0616622774.31
146 rdf:type schema:Person
147 sg:person.0720137653.92 schema:affiliation https://www.grid.ac/institutes/grid.33058.3d
148 schema:familyName Hassan
149 schema:givenName Amin S
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720137653.92
151 rdf:type schema:Person
152 sg:pub.10.1007/978-1-60761-817-1_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015871844
153 https://doi.org/10.1007/978-1-60761-817-1_8
154 rdf:type schema:CreativeWork
155 sg:pub.10.1186/1471-2334-8-89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016573611
156 https://doi.org/10.1186/1471-2334-8-89
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1001/jama.293.7.817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050089341
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/s0140-6736(06)69118-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019458658
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/s0140-6736(08)60693-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024114938
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/s0140-6736(12)61038-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006992672
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/s1473-3099(09)70136-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038357016
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/s1473-3099(09)70328-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038241499
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/s1473-3099(11)70032-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021690766
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/s1473-3099(11)70149-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017099859
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/s1473-3099(11)70255-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009736815
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1086/503914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043175344
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1086/528802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043745381
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1086/600396 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045677754
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1089/aid.2008.0035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059225648
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1089/aid.2012.0167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041185590
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1093/cid/cir1015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005274373
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1093/jac/dkl092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004512573
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1093/jac/dkt033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041530962
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1093/nar/gkg100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052306251
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1097/01.qai.0000225015.43266.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035757642
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1097/qad.0b013e32830e4cd8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030279394
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1097/qad.0b013e32832e05b2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033732402
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1097/qai.0b013e31816a1d4f schema:sameAs https://app.dimensions.ai/details/publication/pub.1051215543
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/qai.0b013e3182084b5a schema:sameAs https://app.dimensions.ai/details/publication/pub.1009877145
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1111/j.1365-3156.2009.02309.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033563487
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1365-3156.2011.02889.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021480269
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1155/2011/434375 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004465385
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1371/journal.pcbi.1000581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005613156
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1371/journal.pone.0017518 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001683674
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1542/peds.2011-0068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067829213
215 rdf:type schema:CreativeWork
216 https://doi.org/10.3851/imp2437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071479663
217 rdf:type schema:CreativeWork
218 https://doi.org/10.7326/0003-4819-150-10-200905190-00117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073710459
219 rdf:type schema:CreativeWork
220 https://www.grid.ac/institutes/grid.33058.3d schema:alternateName Kenya Medical Research Institute
221 schema:name KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya
222 rdf:type schema:Organization
223 https://www.grid.ac/institutes/grid.4991.5 schema:alternateName University of Oxford
224 schema:name Centre for Clinical Vaccinology & Tropical Medicine, University of Oxford, Oxford, UK
225 KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya
226 rdf:type schema:Organization
227 https://www.grid.ac/institutes/grid.5650.6 schema:alternateName Academic Medical Center
228 schema:name Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
229 PharmAccess Foundation, Amsterdam, Netherlands
230 rdf:type schema:Organization
231 https://www.grid.ac/institutes/grid.9004.d schema:alternateName Health Protection Agency
232 schema:name Health Protection Agency, London, UK
233 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...