Uremia causes premature ageing of the T cell compartment in end-stage renal disease patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Ruud WJ Meijers, Nicolle HR Litjens, Elly A de Wit, Anton W Langerak, Ashley van der Spek, Carla C Baan, Willem Weimar, Michiel GH Betjes

ABSTRACT

BACKGROUND: End-stage renal disease (ESRD) patients treated with renal replacement therapy (RRT) have premature immunologically aged T cells which may underlie uremia-associated immune dysfunction. The aim of this study was to investigate whether uremia was able to induce premature ageing of the T cell compartment. For this purpose, we examined the degree of premature immunological T cell ageing by examining the T cell differentiation status, thymic output via T cell receptor excision circle (TREC) content and proliferative history via relative telomere length in ESRD patients not on RRT. RESULTS: Compared to healthy controls, these patients already had a lower TREC content and an increased T cell differentiation accompanied by shorter telomeres. RRT was able to enhance CD8+ T cell differentiation and to reduce CD8+ T cell telomere length in young dialysis patients. An increased differentiation status of memory CD4+ T cells was also noted in young dialysis patients. CONCLUSION: Based on these results we can conclude that uremia already causes premature immunological ageing of the T cell system and RRT further increases immunological ageing of the CD8+ T cell compartment in particular in young ESRD patients. More... »

PAGES

19

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1742-4933-9-19

DOI

http://dx.doi.org/10.1186/1742-4933-9-19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034987589

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22971545


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