Timing and source of subtype-C HIV-1 superinfection in the newly infected partner of Zambian couples with disparate viruses View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-03-20

AUTHORS

Colleen S Kraft, Debby Basu, Paulina A Hawkins, Peter T Hraber, Elwyn Chomba, Joseph Mulenga, William Kilembe, Naw H Khu, Cynthia A Derdeyn, Susan A Allen, Olivier Manigart, Eric Hunter

ABSTRACT

BACKGROUND: HIV-1 superinfection occurs at varying frequencies in different at risk populations. Though seroincidence is decreased, in the negative partner of HIV-discordant couples after joint testing and counseling in the Zambia Emory HIV Research Project (ZEHRP) cohort, the annual infection rate remains relatively high at 7-8%. Based on sequencing within the gp41 region of each partner's virus, 24% of new infections between 2004 and 2008 were the result of transmission from a non-spousal partner. Since these seroconvertors and their spouses have disparate epidemiologically-unlinked viruses, there is a risk of superinfection within the marriage. We have, therefore, investigated the incidence and viral origin of superinfection in these couples. RESULTS: Superinfection was detected by heteroduplex mobility assay (HMA), degenerate base counting of the gp41 sequence, or by phylogenetic analysis of the longitudinal sequences. It was confirmed by full-length env single genome amplification and phylogenetic analysis. In 22 couples (44 individuals), followed for up to five years, three of the newly infected (initially HIV uninfected) partners became superinfected. In each case superinfection occurred during the first 12 months following initial infection of the negative partner, and in each case the superinfecting virus was derived from a non-spousal partner. In addition, one probable case of intra-couple HIV-1 superinfection was observed in a chronically infected partner at the time of his seroconverting spouse's initial viremia. Extensive recombination within the env gene was observed following superinfection. CONCLUSIONS: In this subtype-C discordant couple cohort, superinfection, during the first year after HIV-1 infection of the previously negative partner, occurred at a rate similar to primary infection (13.6% [95% CI 5.2-34.8] vs 7.8% [7.1-8.6]). While limited intra-couple superinfection may in part reflect continued condom usage within couples, this and our lack of detecting newly superinfected individuals after one year of primary infection raise the possibility that immunological resistance to intra-subtype superinfection may develop over time in subtype C infected individuals. More... »

PAGES

22-22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1742-4690-9-22

DOI

http://dx.doi.org/10.1186/1742-4690-9-22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042893617

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22433432


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25 schema:description BACKGROUND: HIV-1 superinfection occurs at varying frequencies in different at risk populations. Though seroincidence is decreased, in the negative partner of HIV-discordant couples after joint testing and counseling in the Zambia Emory HIV Research Project (ZEHRP) cohort, the annual infection rate remains relatively high at 7-8%. Based on sequencing within the gp41 region of each partner's virus, 24% of new infections between 2004 and 2008 were the result of transmission from a non-spousal partner. Since these seroconvertors and their spouses have disparate epidemiologically-unlinked viruses, there is a risk of superinfection within the marriage. We have, therefore, investigated the incidence and viral origin of superinfection in these couples. RESULTS: Superinfection was detected by heteroduplex mobility assay (HMA), degenerate base counting of the gp41 sequence, or by phylogenetic analysis of the longitudinal sequences. It was confirmed by full-length env single genome amplification and phylogenetic analysis. In 22 couples (44 individuals), followed for up to five years, three of the newly infected (initially HIV uninfected) partners became superinfected. In each case superinfection occurred during the first 12 months following initial infection of the negative partner, and in each case the superinfecting virus was derived from a non-spousal partner. In addition, one probable case of intra-couple HIV-1 superinfection was observed in a chronically infected partner at the time of his seroconverting spouse's initial viremia. Extensive recombination within the env gene was observed following superinfection. CONCLUSIONS: In this subtype-C discordant couple cohort, superinfection, during the first year after HIV-1 infection of the previously negative partner, occurred at a rate similar to primary infection (13.6% [95% CI 5.2-34.8] vs 7.8% [7.1-8.6]). While limited intra-couple superinfection may in part reflect continued condom usage within couples, this and our lack of detecting newly superinfected individuals after one year of primary infection raise the possibility that immunological resistance to intra-subtype superinfection may develop over time in subtype C infected individuals.
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32 schema:keywords C infected individuals
33 Emory HIV Research Project (ZEHRP) cohort
34 HIV Research Project (ZEHRP) cohort
35 HIV-1 infection
36 HIV-1 superinfection
37 HIV-discordant couples
38 Project cohort
39 Research Project (ZEHRP) cohort
40 Zambia Emory HIV Research Project (ZEHRP) cohort
41 Zambian couples
42 addition
43 amplification
44 analysis
45 annual infection rate
46 base counting
47 case superinfection
48 cases
49 cohort
50 condom usage
51 counseling
52 counting
53 couple cohort
54 couples
55 degenerate base counting
56 discordant couple cohort
57 disparate viruses
58 env gene
59 env single genome amplification
60 extensive recombination
61 first year
62 frequency
63 full-length env single genome amplification
64 genes
65 genome amplification
66 gp41 region
67 gp41 sequences
68 heteroduplex mobility
69 immunological resistance
70 incidence
71 individuals
72 infected individuals
73 infected partner
74 infection
75 infection rate
76 initial infection
77 initial viremia
78 intra-couple HIV-1 superinfection
79 intra-couple superinfection
80 intra-subtype superinfection
81 joint testing
82 lack
83 limited intra-couple superinfection
84 longitudinal sequences
85 marriage
86 mobility
87 months
88 negative partner
89 new infections
90 non-spousal partners
91 origin
92 part
93 partner's virus
94 partners
95 phylogenetic analysis
96 population
97 possibility
98 primary infection
99 probable cases
100 rate
101 recombination
102 region
103 resistance
104 result of transmission
105 results
106 risk
107 risk of superinfection
108 risk populations
109 sequence
110 sequencing
111 seroconvertors
112 seroincidence
113 single genome amplification
114 source
115 source of subtype
116 spouse's initial viremia
117 spouses
118 subtype C infected individuals
119 subtypes
120 superinfecting virus
121 superinfection
122 testing
123 time
124 timing
125 transmission
126 unlinked viruses
127 usage
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129 viremia
130 virus
131 years
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