Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03-23

AUTHORS

Rakhi Malhotra, Liangyuan Hu, Wei Song, Ilene Brill, Joseph Mulenga, Susan Allen, Eric Hunter, Sadeep Shrestha, Jianming Tang, Richard A Kaslow

ABSTRACT

BACKGROUND: Polymorphisms in chemokine (C-C motif) receptors 2 and 5 genes (CCR2 and CCR5) have been associated with HIV-1 infection and disease progression. We investigated the impact of CCR2-CCR5 haplotypes on HIV-1 viral load (VL) and heterosexual transmission in an African cohort. Between 1995 and 2006, cohabiting Zambian couples discordant for HIV-1 (index seropositive and HIV-1 exposed seronegative {HESN}) were monitored prospectively to determine the role of host genetic factors in HIV-1 control and heterosexual transmission. Genotyping for eight CCR2 and CCR5 variants resolved nine previously recognized haplotypes. By regression and survival analytic techniques, controlling for non-genetic factors, we estimated the effects of these haplotypic variants on a) index partner VL, b) seroconverter VL, c) HIV-1 transmission by index partners, d) HIV-1 acquisition by HESN partners. RESULTS: Among 567 couples, 240 virologically linked transmission events had occurred through 2006. HHF*2 homozygosity was associated with significantly lower VL in seroconverters (mean beta = -0.58, log10 P = 0.027) and the HHD/HHE diplotype was associated with significantly higher VL in the seroconverters (mean beta = 0.54, log10 P = 0.014) adjusted for age and gender in multivariable model. HHD/HHE was associated with more rapid acquisition of infection by the HESNs (HR = 2.0, 95% CI = 1.20-3.43, P = 0.008), after adjustments for index partner VL and the presence of genital ulcer or inflammation in either partner in Cox multivariable models. The HHD/HHE effect was stronger in exposed females (HR = 2.1, 95% CI = 1.14-3.95, P = 0.018). CONCLUSIONS: Among Zambian discordant couples, HIV-1 coreceptor gene haplotypes and diplotypes appear to modulate HIV-1 VL in seroconverters and alter the rate of HIV-1 acquisition by HESNs. These associations replicate or resemble findings reported in other African and European populations. More... »

PAGES

22-22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1742-4690-8-22

DOI

http://dx.doi.org/10.1186/1742-4690-8-22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025635388

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21429204


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "African Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Family Characteristics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "HIV-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Haplotypes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CCR2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, CCR5", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Load", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Zambia", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malhotra", 
        "givenName": "Rakhi", 
        "id": "sg:person.01264763427.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264763427.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Liangyuan", 
        "id": "sg:person.0655605727.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655605727.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Wei", 
        "id": "sg:person.01056165213.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056165213.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brill", 
        "givenName": "Ilene", 
        "id": "sg:person.01053513473.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053513473.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rwanda-Zambia HIV-1 Research Group, Lusaka, Zambia", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Rwanda-Zambia HIV-1 Research Group, Lusaka, Zambia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mulenga", 
        "givenName": "Joseph", 
        "id": "sg:person.01076221507.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076221507.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University, Atlanta, GA, USA", 
          "id": "http://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Rwanda-Zambia HIV-1 Research Group, Lusaka, Zambia", 
            "Emory University, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Allen", 
        "givenName": "Susan", 
        "id": "sg:person.015233407417.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015233407417.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Emory University, Atlanta, GA, USA", 
          "id": "http://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Emory University, Atlanta, GA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunter", 
        "givenName": "Eric", 
        "id": "sg:person.0731773046.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731773046.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shrestha", 
        "givenName": "Sadeep", 
        "id": "sg:person.0750724423.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750724423.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Jianming", 
        "id": "sg:person.010303503657.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010303503657.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA", 
            "Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kaslow", 
        "givenName": "Richard A", 
        "id": "sg:person.0645544507.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645544507.23"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/382722a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050488632", 
          "https://doi.org/10.1038/382722a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/417140a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014746135", 
          "https://doi.org/10.1038/417140a"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03401665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083082328", 
          "https://doi.org/10.1007/bf03401665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-7-84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049858485", 
          "https://doi.org/10.1186/1742-4690-7-84"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0798-786", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009077802", 
          "https://doi.org/10.1038/nm0798-786"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-03-23", 
    "datePublishedReg": "2011-03-23", 
    "description": "BACKGROUND: Polymorphisms in chemokine (C-C motif) receptors 2 and 5 genes (CCR2 and CCR5) have been associated with HIV-1 infection and disease progression. We investigated the impact of CCR2-CCR5 haplotypes on HIV-1 viral load (VL) and heterosexual transmission in an African cohort. Between 1995 and 2006, cohabiting Zambian couples discordant for HIV-1 (index seropositive and HIV-1 exposed seronegative {HESN}) were monitored prospectively to determine the role of host genetic factors in HIV-1 control and heterosexual transmission. Genotyping for eight CCR2 and CCR5 variants resolved nine previously recognized haplotypes. By regression and survival analytic techniques, controlling for non-genetic factors, we estimated the effects of these haplotypic variants on a) index partner VL, b) seroconverter VL, c) HIV-1 transmission by index partners, d) HIV-1 acquisition by HESN partners.\nRESULTS: Among 567 couples, 240 virologically linked transmission events had occurred through 2006. HHF*2 homozygosity was associated with significantly lower VL in seroconverters (mean beta = -0.58, log10 P = 0.027) and the HHD/HHE diplotype was associated with significantly higher VL in the seroconverters (mean beta = 0.54, log10 P = 0.014) adjusted for age and gender in multivariable model. HHD/HHE was associated with more rapid acquisition of infection by the HESNs (HR = 2.0, 95% CI = 1.20-3.43, P = 0.008), after adjustments for index partner VL and the presence of genital ulcer or inflammation in either partner in Cox multivariable models. The HHD/HHE effect was stronger in exposed females (HR = 2.1, 95% CI = 1.14-3.95, P = 0.018).\nCONCLUSIONS: Among Zambian discordant couples, HIV-1 coreceptor gene haplotypes and diplotypes appear to modulate HIV-1 VL in seroconverters and alter the rate of HIV-1 acquisition by HESNs. These associations replicate or resemble findings reported in other African and European populations.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1742-4690-8-22", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2457757", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2457055", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1033800", 
        "issn": [
          "1742-4690"
        ], 
        "name": "Retrovirology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "HIV-1 viral load", 
      "partner's viral load", 
      "HIV-1 acquisition", 
      "HIV-1 infection", 
      "viral load", 
      "heterosexual transmission", 
      "multivariable model", 
      "Cox multivariable model", 
      "HIV-1 transmission", 
      "HIV-1 control", 
      "chemokine receptor 2", 
      "low viral load", 
      "high viral load", 
      "host genetic factors", 
      "chemokine receptor genes", 
      "CCR2-CCR5 haplotypes", 
      "survival analytic techniques", 
      "index partner", 
      "genital ulcers", 
      "discordant couples", 
      "Zambian couples", 
      "disease progression", 
      "HIV-1", 
      "African cohort", 
      "CCR5 variants", 
      "receptor 2", 
      "seroconverters", 
      "non-genetic factors", 
      "more rapid acquisition", 
      "infection", 
      "genetic factors", 
      "receptor gene", 
      "transmission events", 
      "gene haplotypes", 
      "association", 
      "diplotypes", 
      "European populations", 
      "haplotypic variants", 
      "HESNs", 
      "HESN", 
      "ulcers", 
      "CCR2", 
      "inflammation", 
      "cohort", 
      "progression", 
      "haplotypes", 
      "age", 
      "factors", 
      "rapid acquisition", 
      "control", 
      "variants", 
      "HHE", 
      "genes", 
      "transmission", 
      "females", 
      "effect", 
      "gender", 
      "homozygosity", 
      "polymorphism", 
      "regression", 
      "partners", 
      "population", 
      "findings", 
      "Zambians", 
      "adjustment", 
      "couples", 
      "role", 
      "acquisition", 
      "rate", 
      "events", 
      "presence", 
      "analytic techniques", 
      "impact", 
      "model", 
      "technique", 
      "load", 
      "index partner VL", 
      "seroconverter VL", 
      "HESN partners", 
      "HHD/HHE diplotype", 
      "HHE diplotype", 
      "HHD/HHE", 
      "HHD/HHE effect", 
      "HHE effect", 
      "Zambian discordant couples", 
      "HIV-1 coreceptor gene haplotypes", 
      "coreceptor gene haplotypes", 
      "resemble findings"
    ], 
    "name": "Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians", 
    "pagination": "22-22", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025635388"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1742-4690-8-22"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21429204"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1742-4690-8-22", 
      "https://app.dimensions.ai/details/publication/pub.1025635388"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_533.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1742-4690-8-22"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1742-4690-8-22'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1742-4690-8-22'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1742-4690-8-22'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1742-4690-8-22'


 

This table displays all metadata directly associated to this object as RDF triples.

317 TRIPLES      22 PREDICATES      137 URIs      124 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1742-4690-8-22 schema:about N081d2c719721477c869ff300d1e4d9e1
2 N28b61a2b285f46cfb00ed7f4af9ec5b9
3 N2d0b42fc0e464a7087d2202a118d7a0b
4 N381b7f170f2f4b3aa083e4ffce256fb1
5 N4226a40f05a44d45a955aa6ff7393305
6 N433cc8b193384199ae30155675b675c5
7 N592c9b4c2793404aa581e60f3c6094af
8 N6b6e588e840e493b83e47f94a8eee41e
9 N86080c1e837442879c2628bc6143ad10
10 N86294c3803c14c818bcf9dafde9a43c4
11 N8a0c7ee309e74b87ac71c6e93db1e672
12 N8e2968daf96947d785abadb8ab0e888b
13 Na1944ca481a4433e841389df6861d286
14 Na48f312e0e4346388c8b14b2bcbe0401
15 Nb3c256359d714f3aaa51497a845b6db1
16 Ncf350309676341bb920e64685036b7a7
17 Ndd988b001e774ae88e615f99f5529464
18 Ne7e0a67475194083b3176e6f9ec20a88
19 anzsrc-for:11
20 anzsrc-for:1108
21 schema:author Nd01cfb56daf54d0a978dfb47fe6c2dee
22 schema:citation sg:pub.10.1007/bf03401665
23 sg:pub.10.1038/382722a0
24 sg:pub.10.1038/417140a
25 sg:pub.10.1038/nm0798-786
26 sg:pub.10.1186/1742-4690-7-84
27 schema:datePublished 2011-03-23
28 schema:datePublishedReg 2011-03-23
29 schema:description BACKGROUND: Polymorphisms in chemokine (C-C motif) receptors 2 and 5 genes (CCR2 and CCR5) have been associated with HIV-1 infection and disease progression. We investigated the impact of CCR2-CCR5 haplotypes on HIV-1 viral load (VL) and heterosexual transmission in an African cohort. Between 1995 and 2006, cohabiting Zambian couples discordant for HIV-1 (index seropositive and HIV-1 exposed seronegative {HESN}) were monitored prospectively to determine the role of host genetic factors in HIV-1 control and heterosexual transmission. Genotyping for eight CCR2 and CCR5 variants resolved nine previously recognized haplotypes. By regression and survival analytic techniques, controlling for non-genetic factors, we estimated the effects of these haplotypic variants on a) index partner VL, b) seroconverter VL, c) HIV-1 transmission by index partners, d) HIV-1 acquisition by HESN partners. RESULTS: Among 567 couples, 240 virologically linked transmission events had occurred through 2006. HHF*2 homozygosity was associated with significantly lower VL in seroconverters (mean beta = -0.58, log10 P = 0.027) and the HHD/HHE diplotype was associated with significantly higher VL in the seroconverters (mean beta = 0.54, log10 P = 0.014) adjusted for age and gender in multivariable model. HHD/HHE was associated with more rapid acquisition of infection by the HESNs (HR = 2.0, 95% CI = 1.20-3.43, P = 0.008), after adjustments for index partner VL and the presence of genital ulcer or inflammation in either partner in Cox multivariable models. The HHD/HHE effect was stronger in exposed females (HR = 2.1, 95% CI = 1.14-3.95, P = 0.018). CONCLUSIONS: Among Zambian discordant couples, HIV-1 coreceptor gene haplotypes and diplotypes appear to modulate HIV-1 VL in seroconverters and alter the rate of HIV-1 acquisition by HESNs. These associations replicate or resemble findings reported in other African and European populations.
30 schema:genre article
31 schema:inLanguage en
32 schema:isAccessibleForFree true
33 schema:isPartOf Nb013d3f2749942bb9ca8864a3835b823
34 Nb8c3e55421654051b2040f10abff4d51
35 sg:journal.1033800
36 schema:keywords African cohort
37 CCR2
38 CCR2-CCR5 haplotypes
39 CCR5 variants
40 Cox multivariable model
41 European populations
42 HESN
43 HESN partners
44 HESNs
45 HHD/HHE
46 HHD/HHE diplotype
47 HHD/HHE effect
48 HHE
49 HHE diplotype
50 HHE effect
51 HIV-1
52 HIV-1 acquisition
53 HIV-1 control
54 HIV-1 coreceptor gene haplotypes
55 HIV-1 infection
56 HIV-1 transmission
57 HIV-1 viral load
58 Zambian couples
59 Zambian discordant couples
60 Zambians
61 acquisition
62 adjustment
63 age
64 analytic techniques
65 association
66 chemokine receptor 2
67 chemokine receptor genes
68 cohort
69 control
70 coreceptor gene haplotypes
71 couples
72 diplotypes
73 discordant couples
74 disease progression
75 effect
76 events
77 factors
78 females
79 findings
80 gender
81 gene haplotypes
82 genes
83 genetic factors
84 genital ulcers
85 haplotypes
86 haplotypic variants
87 heterosexual transmission
88 high viral load
89 homozygosity
90 host genetic factors
91 impact
92 index partner
93 index partner VL
94 infection
95 inflammation
96 load
97 low viral load
98 model
99 more rapid acquisition
100 multivariable model
101 non-genetic factors
102 partner's viral load
103 partners
104 polymorphism
105 population
106 presence
107 progression
108 rapid acquisition
109 rate
110 receptor 2
111 receptor gene
112 regression
113 resemble findings
114 role
115 seroconverter VL
116 seroconverters
117 survival analytic techniques
118 technique
119 transmission
120 transmission events
121 ulcers
122 variants
123 viral load
124 schema:name Association of chemokine receptor gene (CCR2-CCR5) haplotypes with acquisition and control of HIV-1 infection in Zambians
125 schema:pagination 22-22
126 schema:productId N22b2219c72ae45549f39915c32a06d67
127 N7f00a6ccb30c40d7b42bd242f17718c0
128 Nbbb627b4881444788367ad3f23fb7bc2
129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025635388
130 https://doi.org/10.1186/1742-4690-8-22
131 schema:sdDatePublished 2021-12-01T19:25
132 schema:sdLicense https://scigraph.springernature.com/explorer/license/
133 schema:sdPublisher N565958e986a84f7380d69328758080ee
134 schema:url https://doi.org/10.1186/1742-4690-8-22
135 sgo:license sg:explorer/license/
136 sgo:sdDataset articles
137 rdf:type schema:ScholarlyArticle
138 N081d2c719721477c869ff300d1e4d9e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Receptors, CCR5
140 rdf:type schema:DefinedTerm
141 N2122b982f0944559925de864cbb389ce rdf:first sg:person.01056165213.41
142 rdf:rest Nc739e49aa32243d6a76e3fdf6ae7c598
143 N22b2219c72ae45549f39915c32a06d67 schema:name dimensions_id
144 schema:value pub.1025635388
145 rdf:type schema:PropertyValue
146 N28b61a2b285f46cfb00ed7f4af9ec5b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Gene Frequency
148 rdf:type schema:DefinedTerm
149 N2d0b42fc0e464a7087d2202a118d7a0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name HIV Infections
151 rdf:type schema:DefinedTerm
152 N381b7f170f2f4b3aa083e4ffce256fb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name African Continental Ancestry Group
154 rdf:type schema:DefinedTerm
155 N4226a40f05a44d45a955aa6ff7393305 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Polymorphism, Genetic
157 rdf:type schema:DefinedTerm
158 N433cc8b193384199ae30155675b675c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Family Characteristics
160 rdf:type schema:DefinedTerm
161 N4f9d7a737cd64021ae539ba18e7be555 rdf:first sg:person.01076221507.67
162 rdf:rest N64c2d35fdb954a6eafd90c33198784ae
163 N565958e986a84f7380d69328758080ee schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 N592c9b4c2793404aa581e60f3c6094af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Viral Load
167 rdf:type schema:DefinedTerm
168 N64c2d35fdb954a6eafd90c33198784ae rdf:first sg:person.015233407417.28
169 rdf:rest N7c7c06dcffaf41c9b6f98e8383ae2751
170 N6b6e588e840e493b83e47f94a8eee41e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Female
172 rdf:type schema:DefinedTerm
173 N6ddf533db547446c8d7e2d12c38ad20a rdf:first sg:person.0655605727.08
174 rdf:rest N2122b982f0944559925de864cbb389ce
175 N6f74c30f6e8345f4a07b3d7d4b9c4bcf rdf:first sg:person.010303503657.05
176 rdf:rest Nc0cc64927b4e496787d59b8a674b94ac
177 N7c7c06dcffaf41c9b6f98e8383ae2751 rdf:first sg:person.0731773046.09
178 rdf:rest Nfa24b4b621d345cc9244510e9b6330b2
179 N7f00a6ccb30c40d7b42bd242f17718c0 schema:name pubmed_id
180 schema:value 21429204
181 rdf:type schema:PropertyValue
182 N86080c1e837442879c2628bc6143ad10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Young Adult
184 rdf:type schema:DefinedTerm
185 N86294c3803c14c818bcf9dafde9a43c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Male
187 rdf:type schema:DefinedTerm
188 N8a0c7ee309e74b87ac71c6e93db1e672 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name HIV-1
190 rdf:type schema:DefinedTerm
191 N8e2968daf96947d785abadb8ab0e888b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Adult
193 rdf:type schema:DefinedTerm
194 Na1944ca481a4433e841389df6861d286 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Haplotypes
196 rdf:type schema:DefinedTerm
197 Na48f312e0e4346388c8b14b2bcbe0401 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Receptors, CCR2
199 rdf:type schema:DefinedTerm
200 Nb013d3f2749942bb9ca8864a3835b823 schema:issueNumber 1
201 rdf:type schema:PublicationIssue
202 Nb3c256359d714f3aaa51497a845b6db1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Disease Progression
204 rdf:type schema:DefinedTerm
205 Nb8c3e55421654051b2040f10abff4d51 schema:volumeNumber 8
206 rdf:type schema:PublicationVolume
207 Nbbb627b4881444788367ad3f23fb7bc2 schema:name doi
208 schema:value 10.1186/1742-4690-8-22
209 rdf:type schema:PropertyValue
210 Nc0cc64927b4e496787d59b8a674b94ac rdf:first sg:person.0645544507.23
211 rdf:rest rdf:nil
212 Nc739e49aa32243d6a76e3fdf6ae7c598 rdf:first sg:person.01053513473.65
213 rdf:rest N4f9d7a737cd64021ae539ba18e7be555
214 Ncf350309676341bb920e64685036b7a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
215 schema:name Zambia
216 rdf:type schema:DefinedTerm
217 Nd01cfb56daf54d0a978dfb47fe6c2dee rdf:first sg:person.01264763427.01
218 rdf:rest N6ddf533db547446c8d7e2d12c38ad20a
219 Ndd988b001e774ae88e615f99f5529464 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
220 schema:name Genotype
221 rdf:type schema:DefinedTerm
222 Ne7e0a67475194083b3176e6f9ec20a88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
223 schema:name Humans
224 rdf:type schema:DefinedTerm
225 Nfa24b4b621d345cc9244510e9b6330b2 rdf:first sg:person.0750724423.43
226 rdf:rest N6f74c30f6e8345f4a07b3d7d4b9c4bcf
227 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
228 schema:name Medical and Health Sciences
229 rdf:type schema:DefinedTerm
230 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
231 schema:name Medical Microbiology
232 rdf:type schema:DefinedTerm
233 sg:grant.2457055 http://pending.schema.org/fundedItem sg:pub.10.1186/1742-4690-8-22
234 rdf:type schema:MonetaryGrant
235 sg:grant.2457757 http://pending.schema.org/fundedItem sg:pub.10.1186/1742-4690-8-22
236 rdf:type schema:MonetaryGrant
237 sg:journal.1033800 schema:issn 1742-4690
238 schema:name Retrovirology
239 schema:publisher Springer Nature
240 rdf:type schema:Periodical
241 sg:person.010303503657.05 schema:affiliation grid-institutes:grid.265892.2
242 schema:familyName Tang
243 schema:givenName Jianming
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010303503657.05
245 rdf:type schema:Person
246 sg:person.01053513473.65 schema:affiliation grid-institutes:grid.265892.2
247 schema:familyName Brill
248 schema:givenName Ilene
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053513473.65
250 rdf:type schema:Person
251 sg:person.01056165213.41 schema:affiliation grid-institutes:grid.265892.2
252 schema:familyName Song
253 schema:givenName Wei
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01056165213.41
255 rdf:type schema:Person
256 sg:person.01076221507.67 schema:affiliation grid-institutes:None
257 schema:familyName Mulenga
258 schema:givenName Joseph
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01076221507.67
260 rdf:type schema:Person
261 sg:person.01264763427.01 schema:affiliation grid-institutes:grid.265892.2
262 schema:familyName Malhotra
263 schema:givenName Rakhi
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264763427.01
265 rdf:type schema:Person
266 sg:person.015233407417.28 schema:affiliation grid-institutes:grid.189967.8
267 schema:familyName Allen
268 schema:givenName Susan
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015233407417.28
270 rdf:type schema:Person
271 sg:person.0645544507.23 schema:affiliation grid-institutes:grid.265892.2
272 schema:familyName Kaslow
273 schema:givenName Richard A
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645544507.23
275 rdf:type schema:Person
276 sg:person.0655605727.08 schema:affiliation grid-institutes:grid.265892.2
277 schema:familyName Hu
278 schema:givenName Liangyuan
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655605727.08
280 rdf:type schema:Person
281 sg:person.0731773046.09 schema:affiliation grid-institutes:grid.189967.8
282 schema:familyName Hunter
283 schema:givenName Eric
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731773046.09
285 rdf:type schema:Person
286 sg:person.0750724423.43 schema:affiliation grid-institutes:grid.265892.2
287 schema:familyName Shrestha
288 schema:givenName Sadeep
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750724423.43
290 rdf:type schema:Person
291 sg:pub.10.1007/bf03401665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083082328
292 https://doi.org/10.1007/bf03401665
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/382722a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050488632
295 https://doi.org/10.1038/382722a0
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/417140a schema:sameAs https://app.dimensions.ai/details/publication/pub.1014746135
298 https://doi.org/10.1038/417140a
299 rdf:type schema:CreativeWork
300 sg:pub.10.1038/nm0798-786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009077802
301 https://doi.org/10.1038/nm0798-786
302 rdf:type schema:CreativeWork
303 sg:pub.10.1186/1742-4690-7-84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049858485
304 https://doi.org/10.1186/1742-4690-7-84
305 rdf:type schema:CreativeWork
306 grid-institutes:None schema:alternateName Rwanda-Zambia HIV-1 Research Group, Lusaka, Zambia
307 schema:name Rwanda-Zambia HIV-1 Research Group, Lusaka, Zambia
308 rdf:type schema:Organization
309 grid-institutes:grid.189967.8 schema:alternateName Emory University, Atlanta, GA, USA
310 schema:name Emory University, Atlanta, GA, USA
311 Rwanda-Zambia HIV-1 Research Group, Lusaka, Zambia
312 rdf:type schema:Organization
313 grid-institutes:grid.265892.2 schema:alternateName Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA
314 Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA
315 schema:name Department of Epidemiology University of Alabama at Birmingham (UAB), Birmingham, AL, USA
316 Department of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA
317 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...