A real-time view of the TAR:Tat:P-TEFb complex at HIV-1 transcription sites View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

Dorothée Molle, Paolo Maiuri, Stéphanie Boireau, Edouard Bertrand, Anna Knezevich, Alessandro Marcello, Eugenia Basyuk

ABSTRACT

HIV-1 transcription is tightly regulated: silent in long-term latency and highly active in acutely-infected cells. Transcription is activated by the viral protein Tat, which recruits the elongation factor P-TEFb by binding the TAR sequence present in nascent HIV-1 RNAs. In this study, we analyzed the dynamic of the TAR:Tat:P-TEFb complex in living cells, by performing FRAP experiments at HIV-1 transcription sites. Our results indicate that a large fraction of Tat present at these sites is recruited by Cyclin T1. We found that in the presence of Tat, Cdk9 remained bound to nascent HIV-1 RNAs for 71s. In contrast, when transcription was activated by PMA/ionomycin, in the absence of Tat, Cdk9 turned-over rapidly and resided on the HIV-1 promoter for only 11s. Thus, the mechanism of trans-activation determines the residency time of P-TEFb at the HIV-1 gene, possibly explaining why Tat is such a potent transcriptional activator. In addition, we observed that Tat occupied HIV-1 transcription sites for 55s, suggesting that the TAR:Tat:P-TEFb complex dissociates from the polymerase following transcription initiation, and undergoes subsequent cycles of association/dissociation. More... »

PAGES

36

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1742-4690-4-36

DOI

http://dx.doi.org/10.1186/1742-4690-4-36

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044044191

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17537237


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