Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

David H Cribbs, Nicole C Berchtold, Victoria Perreau, Paul D Coleman, Joseph Rogers, Andrea J Tenner, Carl W Cotman

ABSTRACT

BACKGROUND: This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer's disease (AD). METHODS: In a well-powered microarray study of young (20 to 59 years), aged (60 to 99 years), and AD (74 to 95 years) cases, gene responses were assessed in the hippocampus, entorhinal cortex, superior frontal gyrus, and post-central gyrus. RESULTS: Several novel concepts emerge. First, immune/inflammation-related genes showed major changes in gene expression over the course of cognitively normal aging, with the extent of gene response far greater in aging than in AD. Of the 759 immune-related probesets interrogated on the microarray, approximately 40% were significantly altered in the SFG, PCG and HC with increasing age, with the majority upregulated (64 to 86%). In contrast, far fewer immune/inflammation genes were significantly changed in the transition to AD (approximately 6% of immune-related probesets), with gene responses primarily restricted to the SFG and HC. Second, relatively few significant changes in immune/inflammation genes were detected in the EC either in aging or AD, although many genes in the EC showed similar trends in responses as in the other brain regions. Third, immune/inflammation genes undergo gender-specific patterns of response in aging and AD, with the most pronounced differences emerging in aging. Finally, there was widespread upregulation of genes reflecting activation of microglia and perivascular macrophages in the aging brain, coupled with a downregulation of select factors (TOLLIP, fractalkine) that when present curtail microglial/macrophage activation. Notably, essentially all pathways of the innate immune system were upregulated in aging, including numerous complement components, genes involved in toll-like receptor signaling and inflammasome signaling, as well as genes coding for immunoglobulin (Fc) receptors and human leukocyte antigens I and II. CONCLUSIONS: Unexpectedly, the extent of innate immune gene upregulation in AD was modest relative to the robust response apparent in the aged brain, consistent with the emerging idea of a critical involvement of inflammation in the earliest stages, perhaps even in the preclinical stage, of AD. Ultimately, our data suggest that an important strategy to maintain cognitive health and resilience involves reducing chronic innate immune activation that should be initiated in late midlife. More... »

PAGES

179

References to SciGraph publications

  • 2005-12. Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease in JOURNAL OF NEUROINFLAMMATION
  • 2000-08. Innate immunity—beginning to fulfill its promise? in NATURE IMMUNOLOGY
  • 2006-07. Control of microglial neurotoxicity by the fractalkine receptor in NATURE NEUROSCIENCE
  • 2004-10. Toll-like receptor control of the adaptive immune responses in NATURE IMMUNOLOGY
  • 2010-06. Involvement of Fc Receptors in Disorders of the Central Nervous System in NEUROMOLECULAR MEDICINE
  • 2008-08. The NALP3 inflammasome is involved in the innate immune response to amyloid-β in NATURE IMMUNOLOGY
  • 2010-03. NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production? in NATURE REVIEWS IMMUNOLOGY
  • 2003-02. The impact of systemic infection on the progression of neurodegenerative disease in NATURE REVIEWS NEUROSCIENCE
  • 2006-12. Effects of filtering by Present call on analysis of microarray experiments in BMC BIOINFORMATICS
  • 2010-03. Prion-like mechanisms in neurodegenerative diseases in NATURE REVIEWS NEUROSCIENCE
  • 2011-02. NLR functions beyond pathogen recognition in NATURE IMMUNOLOGY
  • 2011-10. Inflammation-associated S100 proteins: new mechanisms that regulate function in AMINO ACIDS
  • 2008-12. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease in JOURNAL OF NEUROINFLAMMATION
  • 2007-09-02. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock in NATURE MEDICINE
  • 2007-02. Systemic infections and inflammation affect chronic neurodegeneration in NATURE REVIEWS IMMUNOLOGY
  • 2008-01. Fcγ receptors as regulators of immune responses in NATURE REVIEWS IMMUNOLOGY
  • 2009-06. Regulation of innate immune responses in the brain in NATURE REVIEWS IMMUNOLOGY
  • 2006-12. Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD in JOURNAL OF NEUROINFLAMMATION
  • 2002-11. Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases in JOURNAL OF NEUROVIROLOGY
  • 1982-06. Immunoglobulins and complement factors in senile plaques in ACTA NEUROPATHOLOGICA
  • 2010-02. NLRP3 has a sweet tooth in NATURE IMMUNOLOGY
  • 2002-03. Innate immunity: the missing link in neuroprotection and neurodegeneration? in NATURE REVIEWS NEUROSCIENCE
  • 2009. Toll-Like Receptors in Alzheimer's Disease in TOLL-LIKE RECEPTORS: ROLES IN INFECTION AND NEUROPATHOLOGY
  • 2001-11. Toll-like receptors and innate immunity in NATURE REVIEWS IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1742-2094-9-179

    DOI

    http://dx.doi.org/10.1186/1742-2094-9-179

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013789475

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22824372


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Alzheimer Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cognition Disorders", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunity, Innate", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurodegenerative Diseases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Array Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transcriptome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA", 
                "Department of Neurology, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cribbs", 
            "givenName": "David H", 
            "id": "sg:person.0771133375.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771133375.20"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Berchtold", 
            "givenName": "Nicole C", 
            "id": "sg:person.01257057417.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257057417.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Melbourne", 
              "id": "https://www.grid.ac/institutes/grid.1008.9", 
              "name": [
                "Centre for Neuroscience, University of Melbourne, 3010, Parkville, VIC, Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perreau", 
            "givenName": "Victoria", 
            "id": "sg:person.01111556607.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111556607.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Rochester Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412750.5", 
              "name": [
                "Center on Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, 14642, Rochester, NY, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Coleman", 
            "givenName": "Paul D", 
            "id": "sg:person.0625535354.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625535354.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Banner Sun Health Research Institute", 
              "id": "https://www.grid.ac/institutes/grid.414208.b", 
              "name": [
                "Sun Health Research Institute, L. J. Roberts Center for Alzheimer\u2019s Research, 10515 West Santa Fe Drive, 85372, Sun City, AZ, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rogers", 
            "givenName": "Joseph", 
            "id": "sg:person.015724574447.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015724574447.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA", 
                "Departments of Molecular Biology and Biochemistry, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA", 
                "Deparment of Neurobiology and Behavior, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA", 
                "Institute for Immunology, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tenner", 
            "givenName": "Andrea J", 
            "id": "sg:person.0643544333.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643544333.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of California, Irvine", 
              "id": "https://www.grid.ac/institutes/grid.266093.8", 
              "name": [
                "Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA", 
                "Department of Neurology, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cotman", 
            "givenName": "Carl W", 
            "id": "sg:person.0716606642.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716606642.72"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.jneuroim.2006.11.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000105668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.18.10896", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000343474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2614-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000672780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.0953-816x.2001.01666.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001551236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001618656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000110455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002543825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(01)00292-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002933787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(09)70299-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003108805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.440070114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004091132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2005.09.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004703704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1080/13550280290100941", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004817366", 
              "https://doi.org/10.1080/13550280290100941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005072972", 
              "https://doi.org/10.1038/nri2206"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.201005144", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005118825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2007.12.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005227133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2008.05.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005274770"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00685397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005289164", 
              "https://doi.org/10.1007/bf00685397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00685397", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005289164", 
              "https://doi.org/10.1007/bf00685397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0011102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007141568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1750-3639.1998.tb00136.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007670544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(98)00103-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007716176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007943902", 
              "https://doi.org/10.1038/ni.1985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35100529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008398067", 
              "https://doi.org/10.1038/35100529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35100529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008398067", 
              "https://doi.org/10.1038/35100529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-00549-7_8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009302567", 
              "https://doi.org/10.1007/978-3-642-00549-7_8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2006.04076.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010519476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1636", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010961553", 
              "https://doi.org/10.1038/ni.1636"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2868-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011687907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011925781", 
              "https://doi.org/10.1038/77773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/77773", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011925781", 
              "https://doi.org/10.1038/77773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-9961(03)00069-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011945419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-9961(03)00069-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011945419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-5728(93)90060-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012755330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0165-5728(93)90060-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012755330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3158-09.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014436108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2009.01.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015358941"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awh609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016120728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awh609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016120728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wnr.0000132203.76836.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017448078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wnr.0000132203.76836.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017448078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.wnr.0000132203.76836.16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017448078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/00207459809003341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017588374"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181b6bb95", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017671254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181b6bb95", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017671254"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2006.03.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018081516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcc.0b013e3280106806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018183614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mcc.0b013e3280106806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018183614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018331635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/glia.20928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018331635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0528-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018337141", 
              "https://doi.org/10.1007/s00726-010-0528-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0528-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018337141", 
              "https://doi.org/10.1007/s00726-010-0528-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gng015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018638362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(97)00042-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020190752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-2-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020216706", 
              "https://doi.org/10.1186/1742-2094-2-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000285514", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020300725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2008.09.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020323270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/nbm.1479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020527951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/nbm.1479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020527951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.imbio.2011.07.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020890470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.0901005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020966625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021332650", 
              "https://doi.org/10.1038/nn1715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021332650", 
              "https://doi.org/10.1038/nn1715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2007.05001.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021768659"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12017-009-8099-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022307844", 
              "https://doi.org/10.1007/s12017-009-8099-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12017-009-8099-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022307844", 
              "https://doi.org/10.1007/s12017-009-8099-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(00)00094-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022405644"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0306164", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024353994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0806883105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025210750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurol.2010.258", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025541375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1026133541", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-3-27", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026338055", 
              "https://doi.org/10.1186/1742-2094-3-27"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.167.11.6374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027766375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2004.03.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028202208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.imbio.2005.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028483143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.imbio.2005.05.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028483143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1742-2094-5-23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028531601", 
              "https://doi.org/10.1186/1742-2094-5-23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci31450", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028559047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029495068", 
              "https://doi.org/10.1038/nri2015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-4580(96)00108-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029652531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2009.08.039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029754049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awh452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031166924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wad.0b013e318166ca4c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031247724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/wad.0b013e318166ca4c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031247724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2010.01.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031371585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200111223452110", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031476277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0074-7742(07)82012-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031483551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032783840", 
              "https://doi.org/10.1038/nrn1032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032783840", 
              "https://doi.org/10.1038/nrn1032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1032", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032783840", 
              "https://doi.org/10.1038/nrn1032"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/exnr.1996.0043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033144325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1432609100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034227933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(00)00124-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034618968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.03-0364fje", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034690573"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awl249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034748067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci33585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034936322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.1206755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035248953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awh531", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036198726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jalz.2010.12.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036506189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2007.02.027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037001753"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/biostatistics/4.2.249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037543114"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(98)00096-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037907409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037916934", 
              "https://doi.org/10.1038/nrn2786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2786", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037916934", 
              "https://doi.org/10.1038/nrn2786"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038342228", 
              "https://doi.org/10.1038/nri2725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2725", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038342228", 
              "https://doi.org/10.1038/nri2725"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.162350199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038603204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.188.3.431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039395693"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-5728(98)00145-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039849960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2105-7-49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039973931", 
              "https://doi.org/10.1186/1471-2105-7-49"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0805453106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040119704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.0304127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040547668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0531-5565(00)00110-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041447481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000109414.78907.f9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042075483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000109414.78907.f9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042075483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.1008647", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042370487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0210-105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042901638", 
              "https://doi.org/10.1038/ni0210-105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni0210-105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042901638", 
              "https://doi.org/10.1038/ni0210-105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2308-09.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043744239"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m808759200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043864473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043885234", 
              "https://doi.org/10.1038/nri2565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2565", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043885234", 
              "https://doi.org/10.1038/nri2565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2010.05786.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044853694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.2010.05786.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044853694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/07853890410033171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045003775"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.intimp.2011.05.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045021283"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.21.10016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045059771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0065-2776(06)91004-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045297027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1638", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046044565", 
              "https://doi.org/10.1038/nm1638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3667-11.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046074558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/14737175.1.1.53", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046158613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.27654", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046745608"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0197-4580(96)00115-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047343069"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048249003", 
              "https://doi.org/10.1038/nrn752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048249003", 
              "https://doi.org/10.1038/nrn752"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(01)00301-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050035414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(02)00090-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050563555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2009.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050622776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-6147(03)00176-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050671401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0165-6147(03)00176-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050671401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m508125200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051192358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4521-10.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051698125"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052724075", 
              "https://doi.org/10.1038/ni1112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni1112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052724075", 
              "https://doi.org/10.1038/ni1112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000313813.48505.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064350279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000313813.48505.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064350279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/01.wnl.0000313813.48505.86", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064350279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181a18691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181a18691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181a18691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182343314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182343314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3182343314", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064356558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156720511795256080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069189029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/187152710791012071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069221542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/187152710791012080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069221543"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/187152711794488665", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069221624"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.20-15-05709.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074672682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1189/jlb.72.2.233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075096083"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.23-20-07504.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075335912"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076803247", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-2006-9s330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077285283"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-12", 
        "datePublishedReg": "2012-12-01", 
        "description": "BACKGROUND: This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer's disease (AD).\nMETHODS: In a well-powered microarray study of young (20 to 59 years), aged (60 to 99 years), and AD (74 to 95 years) cases, gene responses were assessed in the hippocampus, entorhinal cortex, superior frontal gyrus, and post-central gyrus.\nRESULTS: Several novel concepts emerge. First, immune/inflammation-related genes showed major changes in gene expression over the course of cognitively normal aging, with the extent of gene response far greater in aging than in AD. Of the 759 immune-related probesets interrogated on the microarray, approximately 40% were significantly altered in the SFG, PCG and HC with increasing age, with the majority upregulated (64 to 86%). In contrast, far fewer immune/inflammation genes were significantly changed in the transition to AD (approximately 6% of immune-related probesets), with gene responses primarily restricted to the SFG and HC. Second, relatively few significant changes in immune/inflammation genes were detected in the EC either in aging or AD, although many genes in the EC showed similar trends in responses as in the other brain regions. Third, immune/inflammation genes undergo gender-specific patterns of response in aging and AD, with the most pronounced differences emerging in aging. Finally, there was widespread upregulation of genes reflecting activation of microglia and perivascular macrophages in the aging brain, coupled with a downregulation of select factors (TOLLIP, fractalkine) that when present curtail microglial/macrophage activation. Notably, essentially all pathways of the innate immune system were upregulated in aging, including numerous complement components, genes involved in toll-like receptor signaling and inflammasome signaling, as well as genes coding for immunoglobulin (Fc) receptors and human leukocyte antigens I and II.\nCONCLUSIONS: Unexpectedly, the extent of innate immune gene upregulation in AD was modest relative to the robust response apparent in the aged brain, consistent with the emerging idea of a critical involvement of inflammation in the earliest stages, perhaps even in the preclinical stage, of AD. Ultimately, our data suggest that an important strategy to maintain cognitive health and resilience involves reducing chronic innate immune activation that should be initiated in late midlife.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1742-2094-9-179", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2434579", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2447617", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2440027", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2448640", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438625", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1034001", 
            "issn": [
              "1742-2094"
            ], 
            "name": "Journal of Neuroinflammation", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study", 
        "pagination": "179", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "41b120a6757379e4f9a9d70540380f4a5780cc6cfe79e0f1357c08afddfe6bc7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22824372"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101222974"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1742-2094-9-179"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1013789475"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1742-2094-9-179", 
          "https://app.dimensions.ai/details/publication/pub.1013789475"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:15", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000511.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1742-2094-9-179"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1742-2094-9-179'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1742-2094-9-179'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1742-2094-9-179'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1742-2094-9-179'


     

    This table displays all metadata directly associated to this object as RDF triples.

    597 TRIPLES      21 PREDICATES      171 URIs      37 LITERALS      25 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1742-2094-9-179 schema:about N2785573876af4ee18d41bfdeb068f674
    2 N3ba4aa8adb20415b8112268430898caf
    3 N4f7b5225c46b4b16afd3d5496a5d8376
    4 N53c25e25764c42f688be6d76f297829b
    5 N6e8a0834e3b54bcaadff59588b1e1e8a
    6 N73e6f92508c94ac095ceaa0ecced2e15
    7 Na49890e1faae4ae7a5148ed97516692b
    8 Nbb7d8c916105407c99cbb8a2922cf913
    9 Nc0c78e2ac85c4da4a284c2b2cba6ec22
    10 Nc6230fa677cd40c38776e4c6758d9147
    11 Ndee9567f88b4498db53824f8f193d010
    12 Ne344686334da462280f636510675fc86
    13 Ne58383f14fe34668a1ebd29ad8a21d3c
    14 Neca6ae13bb5c4ee79faee7e346911b2c
    15 Nef2b3b10e7ff480486c596a6257eb12b
    16 Nf0e50ba6c0bb4d47a5a82f5c2d17d64e
    17 anzsrc-for:11
    18 anzsrc-for:1109
    19 schema:author N1aa4d86816534b0fa306dbaa700b6c96
    20 schema:citation sg:pub.10.1007/978-3-642-00549-7_8
    21 sg:pub.10.1007/bf00685397
    22 sg:pub.10.1007/s00726-010-0528-0
    23 sg:pub.10.1007/s12017-009-8099-5
    24 sg:pub.10.1038/35100529
    25 sg:pub.10.1038/77773
    26 sg:pub.10.1038/ni.1636
    27 sg:pub.10.1038/ni.1985
    28 sg:pub.10.1038/ni0210-105
    29 sg:pub.10.1038/ni1112
    30 sg:pub.10.1038/nm1638
    31 sg:pub.10.1038/nn1715
    32 sg:pub.10.1038/nri2015
    33 sg:pub.10.1038/nri2206
    34 sg:pub.10.1038/nri2565
    35 sg:pub.10.1038/nri2725
    36 sg:pub.10.1038/nrn1032
    37 sg:pub.10.1038/nrn2786
    38 sg:pub.10.1038/nrn752
    39 sg:pub.10.1080/13550280290100941
    40 sg:pub.10.1186/1471-2105-7-49
    41 sg:pub.10.1186/1742-2094-2-27
    42 sg:pub.10.1186/1742-2094-3-27
    43 sg:pub.10.1186/1742-2094-5-23
    44 https://app.dimensions.ai/details/publication/pub.1026133541
    45 https://app.dimensions.ai/details/publication/pub.1076803247
    46 https://doi.org/10.1001/archneurol.2010.258
    47 https://doi.org/10.1002/art.27654
    48 https://doi.org/10.1002/glia.20763
    49 https://doi.org/10.1002/glia.20928
    50 https://doi.org/10.1002/glia.440070114
    51 https://doi.org/10.1002/nbm.1479
    52 https://doi.org/10.1006/exnr.1996.0043
    53 https://doi.org/10.1016/0165-5728(93)90060-c
    54 https://doi.org/10.1016/0197-4580(96)00108-x
    55 https://doi.org/10.1016/0197-4580(96)00115-7
    56 https://doi.org/10.1016/j.cell.2007.12.040
    57 https://doi.org/10.1016/j.cell.2010.01.040
    58 https://doi.org/10.1016/j.expneurol.2008.05.014
    59 https://doi.org/10.1016/j.imbio.2005.05.010
    60 https://doi.org/10.1016/j.imbio.2011.07.023
    61 https://doi.org/10.1016/j.intimp.2011.05.006
    62 https://doi.org/10.1016/j.jalz.2008.09.004
    63 https://doi.org/10.1016/j.jalz.2010.12.014
    64 https://doi.org/10.1016/j.jneuroim.2006.11.017
    65 https://doi.org/10.1016/j.nbd.2004.03.010
    66 https://doi.org/10.1016/j.nbd.2009.01.006
    67 https://doi.org/10.1016/j.neurobiolaging.2005.09.043
    68 https://doi.org/10.1016/j.neurobiolaging.2006.03.013
    69 https://doi.org/10.1016/j.neurobiolaging.2007.02.027
    70 https://doi.org/10.1016/j.neurobiolaging.2009.05.003
    71 https://doi.org/10.1016/j.neuron.2009.08.039
    72 https://doi.org/10.1016/s0065-2776(06)91004-9
    73 https://doi.org/10.1016/s0074-7742(07)82012-5
    74 https://doi.org/10.1016/s0165-5728(98)00145-3
    75 https://doi.org/10.1016/s0165-6147(03)00176-7
    76 https://doi.org/10.1016/s0197-4580(00)00094-4
    77 https://doi.org/10.1016/s0197-4580(00)00124-x
    78 https://doi.org/10.1016/s0197-4580(01)00292-5
    79 https://doi.org/10.1016/s0197-4580(01)00301-3
    80 https://doi.org/10.1016/s0197-4580(02)00090-8
    81 https://doi.org/10.1016/s0197-4580(97)00042-0
    82 https://doi.org/10.1016/s0197-4580(98)00096-7
    83 https://doi.org/10.1016/s0197-4580(98)00103-1
    84 https://doi.org/10.1016/s0531-5565(00)00110-8
    85 https://doi.org/10.1016/s0969-9961(03)00069-x
    86 https://doi.org/10.1016/s1474-4422(09)70299-6
    87 https://doi.org/10.1046/j.0953-816x.2001.01666.x
    88 https://doi.org/10.1056/nejm200111223452110
    89 https://doi.org/10.1073/pnas.0805453106
    90 https://doi.org/10.1073/pnas.0806883105
    91 https://doi.org/10.1073/pnas.1432609100
    92 https://doi.org/10.1073/pnas.162350199
    93 https://doi.org/10.1073/pnas.89.21.10016
    94 https://doi.org/10.1073/pnas.95.18.10896
    95 https://doi.org/10.1074/jbc.m508125200
    96 https://doi.org/10.1074/jbc.m808759200
    97 https://doi.org/10.1080/07853890410033171
    98 https://doi.org/10.1083/jcb.201005144
    99 https://doi.org/10.1084/jem.188.3.431
    100 https://doi.org/10.1093/biostatistics/4.2.249
    101 https://doi.org/10.1093/brain/awh452
    102 https://doi.org/10.1093/brain/awh531
    103 https://doi.org/10.1093/brain/awh609
    104 https://doi.org/10.1093/brain/awl249
    105 https://doi.org/10.1093/nar/gng015
    106 https://doi.org/10.1096/fj.03-0364fje
    107 https://doi.org/10.1097/01.wnr.0000132203.76836.16
    108 https://doi.org/10.1097/mcc.0b013e3280106806
    109 https://doi.org/10.1097/wad.0b013e318166ca4c
    110 https://doi.org/10.1111/j.1471-4159.2006.04076.x
    111 https://doi.org/10.1111/j.1471-4159.2007.05001.x
    112 https://doi.org/10.1111/j.1749-6632.2010.05786.x
    113 https://doi.org/10.1111/j.1750-3639.1998.tb00136.x
    114 https://doi.org/10.1159/000110455
    115 https://doi.org/10.1159/000285514
    116 https://doi.org/10.1161/01.res.0000109414.78907.f9
    117 https://doi.org/10.1172/jci31450
    118 https://doi.org/10.1172/jci33585
    119 https://doi.org/10.1189/jlb.0304127
    120 https://doi.org/10.1189/jlb.0306164
    121 https://doi.org/10.1189/jlb.1008647
    122 https://doi.org/10.1189/jlb.1206755
    123 https://doi.org/10.1189/jlb.72.2.233
    124 https://doi.org/10.1212/01.wnl.0000313813.48505.86
    125 https://doi.org/10.1212/wnl.0b013e3181a18691
    126 https://doi.org/10.1212/wnl.0b013e3181b6bb95
    127 https://doi.org/10.1212/wnl.0b013e3182343314
    128 https://doi.org/10.1371/journal.pone.0011102
    129 https://doi.org/10.1523/jneurosci.20-15-05709.2000
    130 https://doi.org/10.1523/jneurosci.23-20-07504.2003
    131 https://doi.org/10.1523/jneurosci.2308-09.2009
    132 https://doi.org/10.1523/jneurosci.2614-05.2005
    133 https://doi.org/10.1523/jneurosci.2868-05.2005
    134 https://doi.org/10.1523/jneurosci.3158-09.2009
    135 https://doi.org/10.1523/jneurosci.3667-11.2011
    136 https://doi.org/10.1523/jneurosci.4521-10.2010
    137 https://doi.org/10.1586/14737175.1.1.53
    138 https://doi.org/10.2174/156720511795256080
    139 https://doi.org/10.2174/187152710791012071
    140 https://doi.org/10.2174/187152710791012080
    141 https://doi.org/10.2174/187152711794488665
    142 https://doi.org/10.3109/00207459809003341
    143 https://doi.org/10.3233/jad-2006-9s330
    144 https://doi.org/10.4049/jimmunol.0901005
    145 https://doi.org/10.4049/jimmunol.167.11.6374
    146 schema:datePublished 2012-12
    147 schema:datePublishedReg 2012-12-01
    148 schema:description BACKGROUND: This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer's disease (AD). METHODS: In a well-powered microarray study of young (20 to 59 years), aged (60 to 99 years), and AD (74 to 95 years) cases, gene responses were assessed in the hippocampus, entorhinal cortex, superior frontal gyrus, and post-central gyrus. RESULTS: Several novel concepts emerge. First, immune/inflammation-related genes showed major changes in gene expression over the course of cognitively normal aging, with the extent of gene response far greater in aging than in AD. Of the 759 immune-related probesets interrogated on the microarray, approximately 40% were significantly altered in the SFG, PCG and HC with increasing age, with the majority upregulated (64 to 86%). In contrast, far fewer immune/inflammation genes were significantly changed in the transition to AD (approximately 6% of immune-related probesets), with gene responses primarily restricted to the SFG and HC. Second, relatively few significant changes in immune/inflammation genes were detected in the EC either in aging or AD, although many genes in the EC showed similar trends in responses as in the other brain regions. Third, immune/inflammation genes undergo gender-specific patterns of response in aging and AD, with the most pronounced differences emerging in aging. Finally, there was widespread upregulation of genes reflecting activation of microglia and perivascular macrophages in the aging brain, coupled with a downregulation of select factors (TOLLIP, fractalkine) that when present curtail microglial/macrophage activation. Notably, essentially all pathways of the innate immune system were upregulated in aging, including numerous complement components, genes involved in toll-like receptor signaling and inflammasome signaling, as well as genes coding for immunoglobulin (Fc) receptors and human leukocyte antigens I and II. CONCLUSIONS: Unexpectedly, the extent of innate immune gene upregulation in AD was modest relative to the robust response apparent in the aged brain, consistent with the emerging idea of a critical involvement of inflammation in the earliest stages, perhaps even in the preclinical stage, of AD. Ultimately, our data suggest that an important strategy to maintain cognitive health and resilience involves reducing chronic innate immune activation that should be initiated in late midlife.
    149 schema:genre research_article
    150 schema:inLanguage en
    151 schema:isAccessibleForFree true
    152 schema:isPartOf N3a7b93eb78d2421fb1711cc2f2774461
    153 N537af0a8ebc34b90ba8028fbdaff4f71
    154 sg:journal.1034001
    155 schema:name Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
    156 schema:pagination 179
    157 schema:productId N048c835dc23a4bb883b9b8d77aba7757
    158 N2537f7b7b4b74cef8be15d38e5bf30fe
    159 N7f18c46011ae4b3f98095fbd69b4dc71
    160 N9564d8bab34640f2a1cb370795bec9ee
    161 Nee1bb6f30cb04b7eaff5fd9f7654099c
    162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013789475
    163 https://doi.org/10.1186/1742-2094-9-179
    164 schema:sdDatePublished 2019-04-11T00:15
    165 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    166 schema:sdPublisher Nb0f1dfc335b247ed8e313bcccc334a73
    167 schema:url http://link.springer.com/10.1186%2F1742-2094-9-179
    168 sgo:license sg:explorer/license/
    169 sgo:sdDataset articles
    170 rdf:type schema:ScholarlyArticle
    171 N0080209b71234a578b009d40f925f793 rdf:first sg:person.015724574447.98
    172 rdf:rest Ne000f07648b74529b7c9f589dfb92277
    173 N048c835dc23a4bb883b9b8d77aba7757 schema:name doi
    174 schema:value 10.1186/1742-2094-9-179
    175 rdf:type schema:PropertyValue
    176 N1aa4d86816534b0fa306dbaa700b6c96 rdf:first sg:person.0771133375.20
    177 rdf:rest N308bb1f923b4457296d6f98fd1ba1e61
    178 N2537f7b7b4b74cef8be15d38e5bf30fe schema:name pubmed_id
    179 schema:value 22824372
    180 rdf:type schema:PropertyValue
    181 N2785573876af4ee18d41bfdeb068f674 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Immunity, Innate
    183 rdf:type schema:DefinedTerm
    184 N308bb1f923b4457296d6f98fd1ba1e61 rdf:first sg:person.01257057417.32
    185 rdf:rest Nae176f1f3bbe49b9bbfd5e9030514658
    186 N3a7b93eb78d2421fb1711cc2f2774461 schema:volumeNumber 9
    187 rdf:type schema:PublicationVolume
    188 N3ba4aa8adb20415b8112268430898caf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Transcriptome
    190 rdf:type schema:DefinedTerm
    191 N4f7b5225c46b4b16afd3d5496a5d8376 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Brain
    193 rdf:type schema:DefinedTerm
    194 N537af0a8ebc34b90ba8028fbdaff4f71 schema:issueNumber 1
    195 rdf:type schema:PublicationIssue
    196 N53c25e25764c42f688be6d76f297829b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    197 schema:name Adult
    198 rdf:type schema:DefinedTerm
    199 N6e8a0834e3b54bcaadff59588b1e1e8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Female
    201 rdf:type schema:DefinedTerm
    202 N73e6f92508c94ac095ceaa0ecced2e15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Neurodegenerative Diseases
    204 rdf:type schema:DefinedTerm
    205 N7f18c46011ae4b3f98095fbd69b4dc71 schema:name readcube_id
    206 schema:value 41b120a6757379e4f9a9d70540380f4a5780cc6cfe79e0f1357c08afddfe6bc7
    207 rdf:type schema:PropertyValue
    208 N9564d8bab34640f2a1cb370795bec9ee schema:name nlm_unique_id
    209 schema:value 101222974
    210 rdf:type schema:PropertyValue
    211 Na25ecec2eb3c4b2b8308aacbd52cddaf rdf:first sg:person.0716606642.72
    212 rdf:rest rdf:nil
    213 Na49890e1faae4ae7a5148ed97516692b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name Aged
    215 rdf:type schema:DefinedTerm
    216 Nae176f1f3bbe49b9bbfd5e9030514658 rdf:first sg:person.01111556607.15
    217 rdf:rest Nb2c51ee2a7494f4d8a463631e18135f9
    218 Nb0f1dfc335b247ed8e313bcccc334a73 schema:name Springer Nature - SN SciGraph project
    219 rdf:type schema:Organization
    220 Nb2c51ee2a7494f4d8a463631e18135f9 rdf:first sg:person.0625535354.72
    221 rdf:rest N0080209b71234a578b009d40f925f793
    222 Nbb7d8c916105407c99cbb8a2922cf913 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Cognition Disorders
    224 rdf:type schema:DefinedTerm
    225 Nc0c78e2ac85c4da4a284c2b2cba6ec22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name Young Adult
    227 rdf:type schema:DefinedTerm
    228 Nc6230fa677cd40c38776e4c6758d9147 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Alzheimer Disease
    230 rdf:type schema:DefinedTerm
    231 Ndee9567f88b4498db53824f8f193d010 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Humans
    233 rdf:type schema:DefinedTerm
    234 Ne000f07648b74529b7c9f589dfb92277 rdf:first sg:person.0643544333.34
    235 rdf:rest Na25ecec2eb3c4b2b8308aacbd52cddaf
    236 Ne344686334da462280f636510675fc86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Middle Aged
    238 rdf:type schema:DefinedTerm
    239 Ne58383f14fe34668a1ebd29ad8a21d3c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Protein Array Analysis
    241 rdf:type schema:DefinedTerm
    242 Neca6ae13bb5c4ee79faee7e346911b2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Aged, 80 and over
    244 rdf:type schema:DefinedTerm
    245 Nee1bb6f30cb04b7eaff5fd9f7654099c schema:name dimensions_id
    246 schema:value pub.1013789475
    247 rdf:type schema:PropertyValue
    248 Nef2b3b10e7ff480486c596a6257eb12b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    249 schema:name Aging
    250 rdf:type schema:DefinedTerm
    251 Nf0e50ba6c0bb4d47a5a82f5c2d17d64e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name Male
    253 rdf:type schema:DefinedTerm
    254 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    255 schema:name Medical and Health Sciences
    256 rdf:type schema:DefinedTerm
    257 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    258 schema:name Neurosciences
    259 rdf:type schema:DefinedTerm
    260 sg:grant.2434579 http://pending.schema.org/fundedItem sg:pub.10.1186/1742-2094-9-179
    261 rdf:type schema:MonetaryGrant
    262 sg:grant.2438625 http://pending.schema.org/fundedItem sg:pub.10.1186/1742-2094-9-179
    263 rdf:type schema:MonetaryGrant
    264 sg:grant.2440027 http://pending.schema.org/fundedItem sg:pub.10.1186/1742-2094-9-179
    265 rdf:type schema:MonetaryGrant
    266 sg:grant.2447617 http://pending.schema.org/fundedItem sg:pub.10.1186/1742-2094-9-179
    267 rdf:type schema:MonetaryGrant
    268 sg:grant.2448640 http://pending.schema.org/fundedItem sg:pub.10.1186/1742-2094-9-179
    269 rdf:type schema:MonetaryGrant
    270 sg:journal.1034001 schema:issn 1742-2094
    271 schema:name Journal of Neuroinflammation
    272 rdf:type schema:Periodical
    273 sg:person.01111556607.15 schema:affiliation https://www.grid.ac/institutes/grid.1008.9
    274 schema:familyName Perreau
    275 schema:givenName Victoria
    276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111556607.15
    277 rdf:type schema:Person
    278 sg:person.01257057417.32 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    279 schema:familyName Berchtold
    280 schema:givenName Nicole C
    281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257057417.32
    282 rdf:type schema:Person
    283 sg:person.015724574447.98 schema:affiliation https://www.grid.ac/institutes/grid.414208.b
    284 schema:familyName Rogers
    285 schema:givenName Joseph
    286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015724574447.98
    287 rdf:type schema:Person
    288 sg:person.0625535354.72 schema:affiliation https://www.grid.ac/institutes/grid.412750.5
    289 schema:familyName Coleman
    290 schema:givenName Paul D
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625535354.72
    292 rdf:type schema:Person
    293 sg:person.0643544333.34 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    294 schema:familyName Tenner
    295 schema:givenName Andrea J
    296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643544333.34
    297 rdf:type schema:Person
    298 sg:person.0716606642.72 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    299 schema:familyName Cotman
    300 schema:givenName Carl W
    301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716606642.72
    302 rdf:type schema:Person
    303 sg:person.0771133375.20 schema:affiliation https://www.grid.ac/institutes/grid.266093.8
    304 schema:familyName Cribbs
    305 schema:givenName David H
    306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771133375.20
    307 rdf:type schema:Person
    308 sg:pub.10.1007/978-3-642-00549-7_8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009302567
    309 https://doi.org/10.1007/978-3-642-00549-7_8
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1007/bf00685397 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005289164
    312 https://doi.org/10.1007/bf00685397
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1007/s00726-010-0528-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018337141
    315 https://doi.org/10.1007/s00726-010-0528-0
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1007/s12017-009-8099-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022307844
    318 https://doi.org/10.1007/s12017-009-8099-5
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/35100529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008398067
    321 https://doi.org/10.1038/35100529
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/77773 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011925781
    324 https://doi.org/10.1038/77773
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/ni.1636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010961553
    327 https://doi.org/10.1038/ni.1636
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/ni.1985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007943902
    330 https://doi.org/10.1038/ni.1985
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/ni0210-105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042901638
    333 https://doi.org/10.1038/ni0210-105
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/ni1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052724075
    336 https://doi.org/10.1038/ni1112
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/nm1638 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046044565
    339 https://doi.org/10.1038/nm1638
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/nn1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021332650
    342 https://doi.org/10.1038/nn1715
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/nri2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029495068
    345 https://doi.org/10.1038/nri2015
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/nri2206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005072972
    348 https://doi.org/10.1038/nri2206
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/nri2565 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043885234
    351 https://doi.org/10.1038/nri2565
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nri2725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038342228
    354 https://doi.org/10.1038/nri2725
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nrn1032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032783840
    357 https://doi.org/10.1038/nrn1032
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nrn2786 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037916934
    360 https://doi.org/10.1038/nrn2786
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1038/nrn752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048249003
    363 https://doi.org/10.1038/nrn752
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1080/13550280290100941 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004817366
    366 https://doi.org/10.1080/13550280290100941
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1186/1471-2105-7-49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039973931
    369 https://doi.org/10.1186/1471-2105-7-49
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1186/1742-2094-2-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020216706
    372 https://doi.org/10.1186/1742-2094-2-27
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.1186/1742-2094-3-27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026338055
    375 https://doi.org/10.1186/1742-2094-3-27
    376 rdf:type schema:CreativeWork
    377 sg:pub.10.1186/1742-2094-5-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028531601
    378 https://doi.org/10.1186/1742-2094-5-23
    379 rdf:type schema:CreativeWork
    380 https://app.dimensions.ai/details/publication/pub.1026133541 schema:CreativeWork
    381 https://app.dimensions.ai/details/publication/pub.1076803247 schema:CreativeWork
    382 https://doi.org/10.1001/archneurol.2010.258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025541375
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1002/art.27654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046745608
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1002/glia.20763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001618656
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1002/glia.20928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018331635
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1002/glia.440070114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004091132
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1002/nbm.1479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020527951
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1006/exnr.1996.0043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033144325
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/0165-5728(93)90060-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1012755330
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1016/0197-4580(96)00108-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029652531
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1016/0197-4580(96)00115-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047343069
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1016/j.cell.2007.12.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005227133
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1016/j.cell.2010.01.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031371585
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1016/j.expneurol.2008.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005274770
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1016/j.imbio.2005.05.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028483143
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1016/j.imbio.2011.07.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020890470
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1016/j.intimp.2011.05.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045021283
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1016/j.jalz.2008.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020323270
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1016/j.jalz.2010.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036506189
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1016/j.jneuroim.2006.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000105668
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1016/j.nbd.2004.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028202208
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1016/j.nbd.2009.01.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015358941
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1016/j.neurobiolaging.2005.09.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004703704
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1016/j.neurobiolaging.2006.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018081516
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1016/j.neurobiolaging.2007.02.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037001753
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1016/j.neurobiolaging.2009.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050622776
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1016/j.neuron.2009.08.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029754049
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1016/s0065-2776(06)91004-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045297027
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1016/s0074-7742(07)82012-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031483551
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1016/s0165-5728(98)00145-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039849960
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1016/s0165-6147(03)00176-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050671401
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1016/s0197-4580(00)00094-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022405644
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1016/s0197-4580(00)00124-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034618968
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1016/s0197-4580(01)00292-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002933787
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1016/s0197-4580(01)00301-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050035414
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1016/s0197-4580(02)00090-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050563555
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1016/s0197-4580(97)00042-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020190752
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1016/s0197-4580(98)00096-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037907409
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1016/s0197-4580(98)00103-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007716176
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1016/s0531-5565(00)00110-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041447481
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1016/s0969-9961(03)00069-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011945419
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1016/s1474-4422(09)70299-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003108805
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1046/j.0953-816x.2001.01666.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001551236
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1056/nejm200111223452110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031476277
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1073/pnas.0805453106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040119704
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1073/pnas.0806883105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025210750
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1073/pnas.1432609100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034227933
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1073/pnas.162350199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038603204
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1073/pnas.89.21.10016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045059771
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1073/pnas.95.18.10896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000343474
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1074/jbc.m508125200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051192358
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1074/jbc.m808759200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043864473
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1080/07853890410033171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045003775
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1083/jcb.201005144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005118825
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1084/jem.188.3.431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039395693
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1093/biostatistics/4.2.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037543114
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1093/brain/awh452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031166924
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1093/brain/awh531 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036198726
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1093/brain/awh609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016120728
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1093/brain/awl249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034748067
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1093/nar/gng015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018638362
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1096/fj.03-0364fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1034690573
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1097/01.wnr.0000132203.76836.16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017448078
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1097/mcc.0b013e3280106806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018183614
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1097/wad.0b013e318166ca4c schema:sameAs https://app.dimensions.ai/details/publication/pub.1031247724
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1111/j.1471-4159.2006.04076.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010519476
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1111/j.1471-4159.2007.05001.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021768659
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1111/j.1749-6632.2010.05786.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044853694
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1111/j.1750-3639.1998.tb00136.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007670544
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1159/000110455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002543825
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1159/000285514 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020300725
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1161/01.res.0000109414.78907.f9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042075483
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1172/jci31450 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028559047
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1172/jci33585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034936322
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.1189/jlb.0304127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040547668
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.1189/jlb.0306164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024353994
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.1189/jlb.1008647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042370487
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.1189/jlb.1206755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035248953
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.1189/jlb.72.2.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075096083
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.1212/01.wnl.0000313813.48505.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064350279
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.1212/wnl.0b013e3181a18691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354287
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.1212/wnl.0b013e3181b6bb95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017671254
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.1212/wnl.0b013e3182343314 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064356558
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.1371/journal.pone.0011102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007141568
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.1523/jneurosci.20-15-05709.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074672682
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.1523/jneurosci.23-20-07504.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075335912
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.1523/jneurosci.2308-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043744239
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.1523/jneurosci.2614-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000672780
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.1523/jneurosci.2868-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011687907
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.1523/jneurosci.3158-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014436108
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.1523/jneurosci.3667-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046074558
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.1523/jneurosci.4521-10.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051698125
    563 rdf:type schema:CreativeWork
    564 https://doi.org/10.1586/14737175.1.1.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046158613
    565 rdf:type schema:CreativeWork
    566 https://doi.org/10.2174/156720511795256080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069189029
    567 rdf:type schema:CreativeWork
    568 https://doi.org/10.2174/187152710791012071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069221542
    569 rdf:type schema:CreativeWork
    570 https://doi.org/10.2174/187152710791012080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069221543
    571 rdf:type schema:CreativeWork
    572 https://doi.org/10.2174/187152711794488665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069221624
    573 rdf:type schema:CreativeWork
    574 https://doi.org/10.3109/00207459809003341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017588374
    575 rdf:type schema:CreativeWork
    576 https://doi.org/10.3233/jad-2006-9s330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077285283
    577 rdf:type schema:CreativeWork
    578 https://doi.org/10.4049/jimmunol.0901005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020966625
    579 rdf:type schema:CreativeWork
    580 https://doi.org/10.4049/jimmunol.167.11.6374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027766375
    581 rdf:type schema:CreativeWork
    582 https://www.grid.ac/institutes/grid.1008.9 schema:alternateName University of Melbourne
    583 schema:name Centre for Neuroscience, University of Melbourne, 3010, Parkville, VIC, Australia
    584 rdf:type schema:Organization
    585 https://www.grid.ac/institutes/grid.266093.8 schema:alternateName University of California, Irvine
    586 schema:name Deparment of Neurobiology and Behavior, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA
    587 Department of Neurology, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA
    588 Departments of Molecular Biology and Biochemistry, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA
    589 Institute for Immunology, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA
    590 Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, 1226 Gillespie NRF, 92697, Irvine, CA, USA
    591 rdf:type schema:Organization
    592 https://www.grid.ac/institutes/grid.412750.5 schema:alternateName University of Rochester Medical Center
    593 schema:name Center on Aging and Developmental Biology, University of Rochester Medical Center, 601 Elmwood Ave, 14642, Rochester, NY, USA
    594 rdf:type schema:Organization
    595 https://www.grid.ac/institutes/grid.414208.b schema:alternateName Banner Sun Health Research Institute
    596 schema:name Sun Health Research Institute, L. J. Roberts Center for Alzheimer’s Research, 10515 West Santa Fe Drive, 85372, Sun City, AZ, USA
    597 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...