CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12-02

AUTHORS

William Raoul, Constance Auvynet, Serge Camelo, Xavier Guillonneau, Charles Feumi, Christophe Combadière, Florian Sennlaub

ABSTRACT

The causes of age-related macular degeneration (AMD) are not well understood. Due to demographic shifts in the industrialized world a growing number of people will develop AMD in the coming decades. To develop treatments it is essential to characterize the disease's pathogenic process. Over the past few years, numerous studies have focused on the role of chemotactic cytokines, also known as chemokines. Certain chemokines, such as CCL2 and CX3CL1, appear to be crucial in subretinal microglia and macrophage accumulation observed in AMD, and participate in the development of retinal degeneration as well as in choroidal neovascularization. This paper reviews the possible implications of CCL2 and CX3CL1 signaling in AMD. Expression patterns, single nucleotide polymorphisms (SNPs) association studies, chemokine and chemokine receptor knockout models are discussed. Future AMD treatments could target chemokines and/or their receptors. More... »

PAGES

87

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1742-2094-7-87

DOI

http://dx.doi.org/10.1186/1742-2094-7-87

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015695346

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21126357


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