Denitrification in human dental plaque View Full Text


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Article Info

DATE

2010-03-22

AUTHORS

Frank Schreiber, Peter Stief, Armin Gieseke, Ines M Heisterkamp, Willy Verstraete, Dirk de Beer, Paul Stoodley

ABSTRACT

BACKGROUND: Microbial denitrification is not considered important in human-associated microbial communities. Accordingly, metabolic investigations of the microbial biofilm communities of human dental plaque have focused on aerobic respiration and acid fermentation of carbohydrates, even though it is known that the oral habitat is constantly exposed to nitrate (NO3-) concentrations in the millimolar range and that dental plaque houses bacteria that can reduce this NO3- to nitrite (NO2-). RESULTS: We show that dental plaque mediates denitrification of NO3- to nitric oxide (NO), nitrous oxide (N2O), and dinitrogen (N2) using microsensor measurements, 15N isotopic labelling and molecular detection of denitrification genes. In vivo N2O accumulation rates in the mouth depended on the presence of dental plaque and on salivary NO3- concentrations. NO and N2O production by denitrification occurred under aerobic conditions and was regulated by plaque pH. CONCLUSIONS: Increases of NO concentrations were in the range of effective concentrations for NO signalling to human host cells and, thus, may locally affect blood flow, signalling between nerves and inflammatory processes in the gum. This is specifically significant for the understanding of periodontal diseases, where NO has been shown to play a key role, but where gingival cells are believed to be the only source of NO. More generally, this study establishes denitrification by human-associated microbial communities as a significant metabolic pathway which, due to concurrent NO formation, provides a basis for symbiotic interactions. More... »

PAGES

24-24

References to SciGraph publications

  • 1984-11. Aerobic denitrification: a controversy revived in ARCHIVES OF MICROBIOLOGY
  • 2001-10. Nitric oxide and the immune response in NATURE IMMUNOLOGY
  • 2004-07. Nitrate, bacteria and human health in NATURE REVIEWS MICROBIOLOGY
  • 2009-12-10. Aerobic denitrification in permeable Wadden Sea sediments in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2007-10-17. The Human Microbiome Project in NATURE
  • 2007-10-17. An ecological and evolutionary perspective on human–microbe mutualism and disease in NATURE
  • 2008-02. The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics in NATURE REVIEWS DRUG DISCOVERY
  • 2009-06-11. Mechanisms of transient nitric oxide and nitrous oxide production in a complex biofilm in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 1995-06-01. Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate in NATURE MEDICINE
  • 2004-02. Bacterial biofilms: from the Natural environment to infectious diseases in NATURE REVIEWS MICROBIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1741-7007-8-24

    DOI

    http://dx.doi.org/10.1186/1741-7007-8-24

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020463270

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20307293


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