Patients with posttraumatic stress disorder exhibit an altered phenotype of regulatory T cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Mladen Jergović, Krešo Bendelja, Anđelko Vidović, Ana Savić, Valerija Vojvoda, Neda Aberle, Sabina Rabatić, Tanja Jovanovic, Ante Sabioncello

ABSTRACT

BACKGROUND: Regulatory T cells (Tregs) play a key role in immune homeostasis in vivo. Tregs have a critical role in preventing the development of autoimmune diseases and defects in Treg function are implicated in various autoimmune disorders. Individuals with posttraumatic stress disorder (PTSD) have higher prevalence of autoimmune disorders than the general population. We hypothesized that war veterans with PTSD would exhibit a decreased number and/or altered phenotype of Tregs. METHODS: We analyzed peripheral blood mononuclear cells (PBMCs) of patients with PTSD (N = 21) (mean age = 45.9) and age-matched healthy controls (N = 23) (mean age = 45.7) to determine the proportion of Tregs and their phenotype according to the expression of CD127 and HLA-DR markers which describe the differentiation stages of Tregs. In addition, we analyzed the expression of membrane ectoenzyme CD39 on Tregs of the study groups, an important component of the suppressive machinery of Tregs. RESULTS: We found no differences in the proportion of Tregs between PTSD patients and controls, but PTSD patients had a higher percentage of CD127(-)HLA-DR(-) Tregs and a lower percentage of CD127(lo)HLA-DR(+) Tregs compared to controls. There was no difference in expression of CD39 on Tregs of the study groups. CONCLUSIONS: Although the proportions of Tregs in PTSD patients were unchanged, we found that they exhibit a different phenotype of Tregs that might be less suppressive. Impaired differentiation and function of Tregs is likely involved in disruption of immune homeostasis in PTSD. More... »

PAGES

43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1710-1492-10-43

DOI

http://dx.doi.org/10.1186/1710-1492-10-43

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039100612

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25670936


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282 Department for Cellular Immunology, Institute of Immunology, Rockfellerova ulica 10, Zagreb, Croatia
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.4808.4 schema:alternateName University of Zagreb
285 schema:name Centre for research and knowledge transfer in biotechnology, University of Zagreb, Zagreb, Croatia
286 rdf:type schema:Organization
 




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