Cast adhesive polyelectrolyte complex particle films of unmodified or maltose-modified poly(ethyleneimine) and cellulose sulphate: fabrication, film stability and retarded release ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Bernhard Torger, David Vehlow, Birgit Urban, Samaa Salem, Dietmar Appelhans, Martin Müller

ABSTRACT

The bone therapeutic drug zoledronate (ZOL) was loaded at and released by polyelectrolyte complex (PEC) particle films composed of either pure poly(ethyleneimine) (PEI) or maltose-modified poly(ethyleneimine) (PEI-M) and oppositely charged cellulose sulfate attached to model germanium (Ge) substrates by solution casting. Dispersions of colloidally stable polyelectrolyte complex (PEC) particles in the size range 11-141 nm were obtained by mixing PEI or PEI-M, CS and ZOL in defined stoichiometric ratios. TRANS-FTIR spectroscopy was used to determine the stability of the PEC films against detachment, in-situ-ATR-FTIR spectroscopy for the ZOL loss in the PEC film and UV-VIS spectroscopy for the ZOL enrichment of the release medium. Films of casted ZOL/CS/PEI-M or ZOL/CS/PEI particles were stable in contact to water, while films of the pure drug (ZOL) and of the binary systems ZOL/PEI-M or ZOL/PEI were not stable against detachment. Retarded releases of ZOL from various PEC films compared to the pure drug film were observed. The molecular weight of PEI showed a considerable effect on the initial burst (IB) of ZOL. No significant effect of the maltose modification of PEI-25 K on IB could be found. Generally, after one day the ZOL release process was finished for all measured ZOL/PEC samples and residual amounts of 0-30% were obtained. Surface adhesive drug loaded PEC particles are promising drug delivery systems to supply and release a defined amount of bone therapeutics and to functionalize bone substitution materials. More... »

PAGES

25

References to SciGraph publications

  • 1988-07. On particle coalescence in latex films (II) in COLLOID AND POLYMER SCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1559-4106-8-25

    DOI

    http://dx.doi.org/10.1186/1559-4106-8-25

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052952354

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24706138


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0306", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Physical Chemistry (incl. Structural)", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Chemical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cellulose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diphosphonates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Imidazoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Maltose", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polyethyleneimine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymers", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Leibniz Institute of Polymer Research", 
              "id": "https://www.grid.ac/institutes/grid.419239.4", 
              "name": [
                "Leibniz Institute of Polymer Research (IPF) Dresden, Hohe Stra\u00dfe 6, D-01069, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Torger", 
            "givenName": "Bernhard", 
            "id": "sg:person.01107573510.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107573510.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leibniz Institute of Polymer Research", 
              "id": "https://www.grid.ac/institutes/grid.419239.4", 
              "name": [
                "Leibniz Institute of Polymer Research (IPF) Dresden, Hohe Stra\u00dfe 6, D-01069, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Vehlow", 
            "givenName": "David", 
            "id": "sg:person.01155706710.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155706710.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leibniz Institute of Polymer Research", 
              "id": "https://www.grid.ac/institutes/grid.419239.4", 
              "name": [
                "Leibniz Institute of Polymer Research (IPF) Dresden, Hohe Stra\u00dfe 6, D-01069, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Urban", 
            "givenName": "Birgit", 
            "id": "sg:person.01224022110.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224022110.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leibniz Institute of Polymer Research", 
              "id": "https://www.grid.ac/institutes/grid.419239.4", 
              "name": [
                "Leibniz Institute of Polymer Research (IPF) Dresden, Hohe Stra\u00dfe 6, D-01069, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Salem", 
            "givenName": "Samaa", 
            "id": "sg:person.01272135310.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272135310.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leibniz Institute of Polymer Research", 
              "id": "https://www.grid.ac/institutes/grid.419239.4", 
              "name": [
                "Leibniz Institute of Polymer Research (IPF) Dresden, Hohe Stra\u00dfe 6, D-01069, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Appelhans", 
            "givenName": "Dietmar", 
            "id": "sg:person.01221464357.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221464357.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leibniz Institute of Polymer Research", 
              "id": "https://www.grid.ac/institutes/grid.419239.4", 
              "name": [
                "Leibniz Institute of Polymer Research (IPF) Dresden, Hohe Stra\u00dfe 6, D-01069, Dresden, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00fcller", 
            "givenName": "Martin", 
            "id": "sg:person.01255143630.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255143630.06"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0079-6700(89)90018-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011323354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0079-6700(89)90018-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011323354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/ijn.s61198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011543176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/17425247.2011.541438", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012330062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-3659(87)90034-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014894217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-3659(87)90034-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014894217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.saa.2012.11.080", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015765785"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jpba.2012.03.047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016608095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/masy.200850509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018722176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinthera.2007.08.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020561212"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mabi.200600143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023750833"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bone.2004.10.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023773629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.a.32708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027968325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.a.32708", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027968325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c000190b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030491518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c000190b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030491518"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1039/c1nj20455f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033882442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jconrel.2010.10.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039838940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa067312", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039913130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bone.2010.12.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045281726"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0601643103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045347933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jbm.b.31130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046044073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01411504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049059533", 
              "https://doi.org/10.1007/bf01411504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01411504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049059533", 
              "https://doi.org/10.1007/bf01411504"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/17453670810016768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051830260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bm050631r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055220709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bm050631r", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055220709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bm801310d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055224179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bm801310d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055224179"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/j100113a008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055653454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp800581y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056106851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jp800581y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056106851"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la050716d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056148699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la050716d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056148699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la202908b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056154916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la202908b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056154916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/la204230a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056155424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074950178", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-12", 
        "datePublishedReg": "2013-12-01", 
        "description": "The bone therapeutic drug zoledronate (ZOL) was loaded at and released by polyelectrolyte complex (PEC) particle films composed of either pure poly(ethyleneimine) (PEI) or maltose-modified poly(ethyleneimine) (PEI-M) and oppositely charged cellulose sulfate attached to model germanium (Ge) substrates by solution casting. Dispersions of colloidally stable polyelectrolyte complex (PEC) particles in the size range 11-141 nm were obtained by mixing PEI or PEI-M, CS and ZOL in defined stoichiometric ratios. TRANS-FTIR spectroscopy was used to determine the stability of the PEC films against detachment, in-situ-ATR-FTIR spectroscopy for the ZOL loss in the PEC film and UV-VIS spectroscopy for the ZOL enrichment of the release medium. Films of casted ZOL/CS/PEI-M or ZOL/CS/PEI particles were stable in contact to water, while films of the pure drug (ZOL) and of the binary systems ZOL/PEI-M or ZOL/PEI were not stable against detachment. Retarded releases of ZOL from various PEC films compared to the pure drug film were observed. The molecular weight of PEI showed a considerable effect on the initial burst (IB) of ZOL. No significant effect of the maltose modification of PEI-25 K on IB could be found. Generally, after one day the ZOL release process was finished for all measured ZOL/PEC samples and residual amounts of 0-30% were obtained. Surface adhesive drug loaded PEC particles are promising drug delivery systems to supply and release a defined amount of bone therapeutics and to functionalize bone substitution materials.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1559-4106-8-25", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1036922", 
            "issn": [
              "1934-8630", 
              "1559-4106"
            ], 
            "name": "Biointerphases", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "8"
          }
        ], 
        "name": "Cast adhesive polyelectrolyte complex particle films of unmodified or maltose-modified poly(ethyleneimine) and cellulose sulphate: fabrication, film stability and retarded release of zoledronate", 
        "pagination": "25", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "fc39f11d844d53198df6a3fd2410277f841b395c8f116c6964c422006697a897"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24706138"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101275679"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1559-4106-8-25"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1052952354"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1559-4106-8-25", 
          "https://app.dimensions.ai/details/publication/pub.1052952354"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:53", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000516.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1559-4106-8-25"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1559-4106-8-25'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1559-4106-8-25'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1559-4106-8-25'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1559-4106-8-25'


     

    This table displays all metadata directly associated to this object as RDF triples.

    212 TRIPLES      21 PREDICATES      63 URIs      27 LITERALS      15 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1559-4106-8-25 schema:about N3443d549d15f40ef98c2bbcd519c62a5
    2 N63f2347b7cb84102b6797c4df5bfb445
    3 N6ef5fa871dd541239974545aec4c0c4a
    4 N752c8f2c3a1c4934ab3461ade242cb55
    5 Nb5b2fb563bb74f5d8261ebe54a0a9643
    6 Ned5dc7f6191c4a04a747e6e3f6e84c25
    7 anzsrc-for:03
    8 anzsrc-for:0306
    9 schema:author Nfad3e0e72f1544dc97b2bba7a09245cf
    10 schema:citation sg:pub.10.1007/bf01411504
    11 https://app.dimensions.ai/details/publication/pub.1074950178
    12 https://doi.org/10.1002/jbm.a.32708
    13 https://doi.org/10.1002/jbm.b.31130
    14 https://doi.org/10.1002/mabi.200600143
    15 https://doi.org/10.1002/masy.200850509
    16 https://doi.org/10.1016/0079-6700(89)90018-x
    17 https://doi.org/10.1016/0168-3659(87)90034-4
    18 https://doi.org/10.1016/j.bone.2004.10.004
    19 https://doi.org/10.1016/j.bone.2010.12.024
    20 https://doi.org/10.1016/j.clinthera.2007.08.008
    21 https://doi.org/10.1016/j.jconrel.2010.10.008
    22 https://doi.org/10.1016/j.jpba.2012.03.047
    23 https://doi.org/10.1016/j.saa.2012.11.080
    24 https://doi.org/10.1021/bm050631r
    25 https://doi.org/10.1021/bm801310d
    26 https://doi.org/10.1021/j100113a008
    27 https://doi.org/10.1021/jp800581y
    28 https://doi.org/10.1021/la050716d
    29 https://doi.org/10.1021/la202908b
    30 https://doi.org/10.1021/la204230a
    31 https://doi.org/10.1039/c000190b
    32 https://doi.org/10.1039/c1nj20455f
    33 https://doi.org/10.1056/nejmoa067312
    34 https://doi.org/10.1073/pnas.0601643103
    35 https://doi.org/10.1080/17453670810016768
    36 https://doi.org/10.1517/17425247.2011.541438
    37 https://doi.org/10.2147/ijn.s61198
    38 schema:datePublished 2013-12
    39 schema:datePublishedReg 2013-12-01
    40 schema:description The bone therapeutic drug zoledronate (ZOL) was loaded at and released by polyelectrolyte complex (PEC) particle films composed of either pure poly(ethyleneimine) (PEI) or maltose-modified poly(ethyleneimine) (PEI-M) and oppositely charged cellulose sulfate attached to model germanium (Ge) substrates by solution casting. Dispersions of colloidally stable polyelectrolyte complex (PEC) particles in the size range 11-141 nm were obtained by mixing PEI or PEI-M, CS and ZOL in defined stoichiometric ratios. TRANS-FTIR spectroscopy was used to determine the stability of the PEC films against detachment, in-situ-ATR-FTIR spectroscopy for the ZOL loss in the PEC film and UV-VIS spectroscopy for the ZOL enrichment of the release medium. Films of casted ZOL/CS/PEI-M or ZOL/CS/PEI particles were stable in contact to water, while films of the pure drug (ZOL) and of the binary systems ZOL/PEI-M or ZOL/PEI were not stable against detachment. Retarded releases of ZOL from various PEC films compared to the pure drug film were observed. The molecular weight of PEI showed a considerable effect on the initial burst (IB) of ZOL. No significant effect of the maltose modification of PEI-25 K on IB could be found. Generally, after one day the ZOL release process was finished for all measured ZOL/PEC samples and residual amounts of 0-30% were obtained. Surface adhesive drug loaded PEC particles are promising drug delivery systems to supply and release a defined amount of bone therapeutics and to functionalize bone substitution materials.
    41 schema:genre research_article
    42 schema:inLanguage en
    43 schema:isAccessibleForFree true
    44 schema:isPartOf N84dba6e5bb724261b3952a550b9df0e5
    45 Necb32df6f1764009b977eb42af13e222
    46 sg:journal.1036922
    47 schema:name Cast adhesive polyelectrolyte complex particle films of unmodified or maltose-modified poly(ethyleneimine) and cellulose sulphate: fabrication, film stability and retarded release of zoledronate
    48 schema:pagination 25
    49 schema:productId N7bb4dcbcf3b84b6fa354c3cd111e4e90
    50 N8534278381df46c8a668603e36d6ebaf
    51 N86a7ae91c057471eab8586702786e7d7
    52 N8b03bd5396634d8e806396f0527ebb49
    53 Ne795035c934e44f5973052e7df569221
    54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052952354
    55 https://doi.org/10.1186/1559-4106-8-25
    56 schema:sdDatePublished 2019-04-10T15:53
    57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    58 schema:sdPublisher Ndaf7efb0cd8d4293bbc4ee021d099b34
    59 schema:url http://link.springer.com/10.1186%2F1559-4106-8-25
    60 sgo:license sg:explorer/license/
    61 sgo:sdDataset articles
    62 rdf:type schema:ScholarlyArticle
    63 N3443d549d15f40ef98c2bbcd519c62a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    64 schema:name Maltose
    65 rdf:type schema:DefinedTerm
    66 N455f7187132c4446952e17374e58267a rdf:first sg:person.01255143630.06
    67 rdf:rest rdf:nil
    68 N4cc9974047904ec7a2c1f8b9fea55f69 rdf:first sg:person.01155706710.32
    69 rdf:rest Ncf75cd749ab54359a45736a614f49557
    70 N63f2347b7cb84102b6797c4df5bfb445 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    71 schema:name Imidazoles
    72 rdf:type schema:DefinedTerm
    73 N674d913d33b143cfb35690bed044d62a rdf:first sg:person.01221464357.18
    74 rdf:rest N455f7187132c4446952e17374e58267a
    75 N6ef5fa871dd541239974545aec4c0c4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    76 schema:name Diphosphonates
    77 rdf:type schema:DefinedTerm
    78 N752c8f2c3a1c4934ab3461ade242cb55 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    79 schema:name Polyethyleneimine
    80 rdf:type schema:DefinedTerm
    81 N7bb4dcbcf3b84b6fa354c3cd111e4e90 schema:name doi
    82 schema:value 10.1186/1559-4106-8-25
    83 rdf:type schema:PropertyValue
    84 N84dba6e5bb724261b3952a550b9df0e5 schema:issueNumber 1
    85 rdf:type schema:PublicationIssue
    86 N8534278381df46c8a668603e36d6ebaf schema:name pubmed_id
    87 schema:value 24706138
    88 rdf:type schema:PropertyValue
    89 N86a7ae91c057471eab8586702786e7d7 schema:name nlm_unique_id
    90 schema:value 101275679
    91 rdf:type schema:PropertyValue
    92 N8b03bd5396634d8e806396f0527ebb49 schema:name dimensions_id
    93 schema:value pub.1052952354
    94 rdf:type schema:PropertyValue
    95 Nb5b2fb563bb74f5d8261ebe54a0a9643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Cellulose
    97 rdf:type schema:DefinedTerm
    98 Ncf75cd749ab54359a45736a614f49557 rdf:first sg:person.01224022110.16
    99 rdf:rest Nf303c29717354182a2a0bfb8da110297
    100 Ndaf7efb0cd8d4293bbc4ee021d099b34 schema:name Springer Nature - SN SciGraph project
    101 rdf:type schema:Organization
    102 Ne795035c934e44f5973052e7df569221 schema:name readcube_id
    103 schema:value fc39f11d844d53198df6a3fd2410277f841b395c8f116c6964c422006697a897
    104 rdf:type schema:PropertyValue
    105 Necb32df6f1764009b977eb42af13e222 schema:volumeNumber 8
    106 rdf:type schema:PublicationVolume
    107 Ned5dc7f6191c4a04a747e6e3f6e84c25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Polymers
    109 rdf:type schema:DefinedTerm
    110 Nf303c29717354182a2a0bfb8da110297 rdf:first sg:person.01272135310.89
    111 rdf:rest N674d913d33b143cfb35690bed044d62a
    112 Nfad3e0e72f1544dc97b2bba7a09245cf rdf:first sg:person.01107573510.96
    113 rdf:rest N4cc9974047904ec7a2c1f8b9fea55f69
    114 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
    115 schema:name Chemical Sciences
    116 rdf:type schema:DefinedTerm
    117 anzsrc-for:0306 schema:inDefinedTermSet anzsrc-for:
    118 schema:name Physical Chemistry (incl. Structural)
    119 rdf:type schema:DefinedTerm
    120 sg:journal.1036922 schema:issn 1559-4106
    121 1934-8630
    122 schema:name Biointerphases
    123 rdf:type schema:Periodical
    124 sg:person.01107573510.96 schema:affiliation https://www.grid.ac/institutes/grid.419239.4
    125 schema:familyName Torger
    126 schema:givenName Bernhard
    127 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107573510.96
    128 rdf:type schema:Person
    129 sg:person.01155706710.32 schema:affiliation https://www.grid.ac/institutes/grid.419239.4
    130 schema:familyName Vehlow
    131 schema:givenName David
    132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155706710.32
    133 rdf:type schema:Person
    134 sg:person.01221464357.18 schema:affiliation https://www.grid.ac/institutes/grid.419239.4
    135 schema:familyName Appelhans
    136 schema:givenName Dietmar
    137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221464357.18
    138 rdf:type schema:Person
    139 sg:person.01224022110.16 schema:affiliation https://www.grid.ac/institutes/grid.419239.4
    140 schema:familyName Urban
    141 schema:givenName Birgit
    142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224022110.16
    143 rdf:type schema:Person
    144 sg:person.01255143630.06 schema:affiliation https://www.grid.ac/institutes/grid.419239.4
    145 schema:familyName Müller
    146 schema:givenName Martin
    147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255143630.06
    148 rdf:type schema:Person
    149 sg:person.01272135310.89 schema:affiliation https://www.grid.ac/institutes/grid.419239.4
    150 schema:familyName Salem
    151 schema:givenName Samaa
    152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01272135310.89
    153 rdf:type schema:Person
    154 sg:pub.10.1007/bf01411504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049059533
    155 https://doi.org/10.1007/bf01411504
    156 rdf:type schema:CreativeWork
    157 https://app.dimensions.ai/details/publication/pub.1074950178 schema:CreativeWork
    158 https://doi.org/10.1002/jbm.a.32708 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027968325
    159 rdf:type schema:CreativeWork
    160 https://doi.org/10.1002/jbm.b.31130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046044073
    161 rdf:type schema:CreativeWork
    162 https://doi.org/10.1002/mabi.200600143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023750833
    163 rdf:type schema:CreativeWork
    164 https://doi.org/10.1002/masy.200850509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018722176
    165 rdf:type schema:CreativeWork
    166 https://doi.org/10.1016/0079-6700(89)90018-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011323354
    167 rdf:type schema:CreativeWork
    168 https://doi.org/10.1016/0168-3659(87)90034-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014894217
    169 rdf:type schema:CreativeWork
    170 https://doi.org/10.1016/j.bone.2004.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023773629
    171 rdf:type schema:CreativeWork
    172 https://doi.org/10.1016/j.bone.2010.12.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045281726
    173 rdf:type schema:CreativeWork
    174 https://doi.org/10.1016/j.clinthera.2007.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020561212
    175 rdf:type schema:CreativeWork
    176 https://doi.org/10.1016/j.jconrel.2010.10.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039838940
    177 rdf:type schema:CreativeWork
    178 https://doi.org/10.1016/j.jpba.2012.03.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016608095
    179 rdf:type schema:CreativeWork
    180 https://doi.org/10.1016/j.saa.2012.11.080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015765785
    181 rdf:type schema:CreativeWork
    182 https://doi.org/10.1021/bm050631r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055220709
    183 rdf:type schema:CreativeWork
    184 https://doi.org/10.1021/bm801310d schema:sameAs https://app.dimensions.ai/details/publication/pub.1055224179
    185 rdf:type schema:CreativeWork
    186 https://doi.org/10.1021/j100113a008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055653454
    187 rdf:type schema:CreativeWork
    188 https://doi.org/10.1021/jp800581y schema:sameAs https://app.dimensions.ai/details/publication/pub.1056106851
    189 rdf:type schema:CreativeWork
    190 https://doi.org/10.1021/la050716d schema:sameAs https://app.dimensions.ai/details/publication/pub.1056148699
    191 rdf:type schema:CreativeWork
    192 https://doi.org/10.1021/la202908b schema:sameAs https://app.dimensions.ai/details/publication/pub.1056154916
    193 rdf:type schema:CreativeWork
    194 https://doi.org/10.1021/la204230a schema:sameAs https://app.dimensions.ai/details/publication/pub.1056155424
    195 rdf:type schema:CreativeWork
    196 https://doi.org/10.1039/c000190b schema:sameAs https://app.dimensions.ai/details/publication/pub.1030491518
    197 rdf:type schema:CreativeWork
    198 https://doi.org/10.1039/c1nj20455f schema:sameAs https://app.dimensions.ai/details/publication/pub.1033882442
    199 rdf:type schema:CreativeWork
    200 https://doi.org/10.1056/nejmoa067312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039913130
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1073/pnas.0601643103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045347933
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1080/17453670810016768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051830260
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1517/17425247.2011.541438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012330062
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.2147/ijn.s61198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011543176
    209 rdf:type schema:CreativeWork
    210 https://www.grid.ac/institutes/grid.419239.4 schema:alternateName Leibniz Institute of Polymer Research
    211 schema:name Leibniz Institute of Polymer Research (IPF) Dresden, Hohe Straße 6, D-01069, Dresden, Germany
    212 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...