Paclitaxel-incorporated nanoparticles using block copolymers composed of poly(ethylene glycol)/poly(3-hydroxyoctanoate) View Full Text


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Article Info

DATE

2014-09-24

AUTHORS

Hyun Yul Kim, Je Ho Ryu, Chong Woo Chu, Gyung Mo Son, Young-IL Jeong, Tae-Won Kwak, Do Hyung Kim, Chung-Wook Chung, Young Ha Rhee, Dae Hwan Kang, Hyung Wook Kim

ABSTRACT

Block copolymers composed of poly(3-hydroxyoctanoate) (PHO) and methoxy poly(ethylene glycol) (PEG) were synthesized to prepare paclitaxel-incorporated nanoparticle for antitumor drug delivery. In a 1H-NMR study, chemical structures of PHO/PEG block copolymers were confirmed and their molecular weight (M.W.) was analyzed with gel permeation chromatography (GPC). Paclitaxel as a model anticancer drug was incorporated into the nanoparticles of PHO/PEG block copolymer. They have spherical shapes and their particle sizes were less than 100 nm. In a 1H-NMR study in D2O, specific peaks of PEG solely appeared while peaks of PHO disappeared, indicating that nanoparticles have core-shell structures. The higher M.W. of PEG decreased loading efficiency and particle size. The higher drug feeding increased drug contents and average size of nanoparticles. In the drug release study, the higher M.W. of PEG block induced the acceleration of drug release rate. The increase in drug contents induced the slow release rate of drug. In an antitumor activity study in vitro, paclitaxel nanoparticles have practically similar anti-proliferation activity against HCT116 human colon carcinoma cells. In an in vivo animal study using HCT116 colon carcinoma cell-bearing mice, paclitaxel nanoparticles have enhanced antitumor activity compared to paclitaxel itself. Therefore, paclitaxel-incorporated nanoparticles of PHO/PEG block copolymer are a promising vehicle for antitumor drug delivery. More... »

PAGES

525

References to SciGraph publications

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  • 2011-11-14. Nanoparticle mediated targeting of VEGFR and cancer stem cells for cancer therapy in VASCULAR CELL
  • 2012-02-17. Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research in CLINICAL AND TRANSLATIONAL ONCOLOGY
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    http://scigraph.springernature.com/pub.10.1186/1556-276x-9-525

    DOI

    http://dx.doi.org/10.1186/1556-276x-9-525

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25288916


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