Comparison of taurine, GABA, Glu, and Asp as scavengers of malondialdehyde in vitro and in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Yan Deng, Wei Wang, Pingfeng Yu, Zhijiang Xi, Lijian Xu, Xiaolong Li, Nongyue He

ABSTRACT

The purpose of this study is to determine if amino acid neurotransmitters such as gamma-aminobutyric acid (GABA), taurine, glutamate (Glu), and aspartate (Asp) can scavenge activated carbonyl toxicants. In vitro, direct reaction between malondialdehyde (MDA) and amino acids was researched using different analytical methods. The results indicated that scavenging activated carbonyl function of taurine and GABA is very strong and that of Glu and Asp is very weak in pathophysiological situations. The results provided perspective into the reaction mechanism of taurine and GABA as targets of activated carbonyl such as MDA in protecting nerve terminals. In vivo, we studied the effect of taurine and GABA as antioxidants by detecting MDA concentration and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. It was shown that MDA concentration was decreased significantly, and the activities of SOD and GSH-Px were increased significantly in the cerebral cortex and hippocampus of acute epileptic state rats, after the administration of taurine and GABA. The results indicated that the peripherally administered taurine and GABA can scavenge free radicals and protect the tissue against activated carbonyl in vivo and in vitro. More... »

PAGES

190

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1556-276x-8-190

DOI

http://dx.doi.org/10.1186/1556-276x-8-190

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042196713

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23618076


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Download the RDF metadata as:  json-ld nt turtle xml License info

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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