Antitumor activity of sorafenib-incorporated nanoparticles of dextran/poly(dl-lactide-co-glycolide) block copolymer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-27

AUTHORS

Do Hyung Kim, Min-Dae Kim, Cheol-Woong Choi, Chung-Wook Chung, Seung Hee Ha, Cy Hyun Kim, Yong-Ho Shim, Young-Il Jeong, Dae Hwan Kang

ABSTRACT

Sorafenib-incoporated nanoparticles were prepared using a block copolymer that is composed of dextran and poly(DL-lactide-co-glycolide) [Dexb LG] for antitumor drug delivery. Sorafenib-incorporated nanoparticles were prepared by a nanoprecipitation-dialysis method. Sorafenib-incorporated Dexb LG nanoparticles were uniformly distributed in an aqueous solution regardless of the content of sorafenib. Transmission electron microscopy of the sorafenib-incorporated Dexb LG nanoparticles revealed a spherical shape with a diameter < 300 nm. Sorafenib-incorporated Dexb LG nanoparticles at a polymer/drug weight ratio of 40:5 showed a relatively uniform size and morphology. Higher initial drug feeding was associated with increased drug content in nanoparticles and in nanoparticle size. A drug release study revealed a decreased drug release rate with increasing drug content. In an in vitro anti-proliferation assay using human cholangiocarcinoma cells, sorafenib-incorporated Dexb LG nanoparticles showed a similar antitumor activity as sorafenib. Sorafenib-incorporated Dexb LG nanoparticles are promising candidates as vehicles for antitumor drug targeting. More... »

PAGES

91

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1556-276x-7-91

DOI

http://dx.doi.org/10.1186/1556-276x-7-91

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006730892

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22283905


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