Effects of 8 weeks of Xpand® 2X pre workout supplementation on skeletal muscle hypertrophy, lean body mass, and strength in ... View Full Text


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Article Info

DATE

2013-10-09

AUTHORS

Ryan P Lowery, Jordan M Joy, Joshua E Dudeck, Eduardo Oliveira de Souza, Sean A McCleary, Shawn Wells, Robert Wildman, Jacob M Wilson

ABSTRACT

BACKGROUND: Xpand® 2X is a proprietary blend comprised of branched chain amino acids, creatine monohydrate, beta-alanine (CarnoSyn®), quercetin, coenzymated B-vitamins, alanyl-glutamine (Sustamine®), and natural nitrate sources from pomegranate and beet root extracts purported to enhance the neuromuscular adaptations of resistance training. However to date, no long-term studies have been conducted with this supplement. The purpose of this study was to investigate the effects of a multi-ingredient performance supplement (MIPS) on skeletal muscle hypertrophy, lean body mass and lower body strength in resistance-trained males. METHODS: Twenty resistance-trained males (21.3 ± 1.9 years) were randomly assigned to consume a MIPS or a placebo of equal weight and volume (food-grade orange flavors and sweeteners) in a double-blind manner, 30 minutes prior to exercise. All subjects participated in an 8-week, 3-day per week, periodized, resistance-training program that was split-focused on multi-joint movements such as leg press, bench press, and bent-over rows. Ultrasonography measured muscle thickness of the quadriceps, dual-energy X-ray absorptiometry (DEXA) determined lean body mass, and strength of the bench press and leg press were determined at weeks 0, 4, and 8 of the study. Data were analyzed with a 2 × 3 repeated measures ANOVA with LSD post hoc tests utilized to locate differences. RESULTS: There was a significant group-by-time interaction in which the MIPS supplementation resulted in a significant (p < 0.01) increase in strength of the bench press (18.4% vs. 9.6%) compared with placebo after 4 and 8 weeks of training. There were no significant group by time interactions between MIPS supplementation nor the placebo in leg press strength (p = .08). MIPS supplementation also resulted in a significant increase in lean body mass (7.8% vs. 3.6%) and quadriceps muscle thickness (11.8% vs. 4.5%) compared with placebo (group*time, p <0.01). CONCLUSIONS: These results suggest that this MIPS can positively augment adaptations in strength, and skeletal muscle hypertrophy in resistance-trained men. More... »

PAGES

44-44

References to SciGraph publications

  • 2009-10-16. β-Alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise in EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
  • 2012-11-15. The effects of six weeks of supplementation with multi-ingredient performance supplements and resistance training on anabolic hormones, body composition, strength, and power in resistance-trained men in JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
  • 2009-08-05. Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, NO-Shotgun®, on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers in males in JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
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  • 2006-03-24. The absorption of orally supplied β-alanine and its effect on muscle carnosine synthesis in human vastus lateralis in AMINO ACIDS
  • 2007-08-30. International Society of Sports Nutrition position stand: creatine supplementation and exercise in JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
  • 2011-11-03. Effects of 28 days of resistance exercise while consuming commercially available pre- and post-workout supplements, NO-Shotgun® and NO-Synthesize® on body composition, muscle strength and mass, markers of protein synthesis, and clinical safety markers in males in NUTRITION & METABOLISM
  • 2006-07-28. Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity in AMINO ACIDS
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    http://scigraph.springernature.com/pub.10.1186/1550-2783-10-44

    DOI

    http://dx.doi.org/10.1186/1550-2783-10-44

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024517610

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24107586


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