Relationship between coronary flow reserve evaluated by phase-contrast cine cardiovascular magnetic resonance and serum eicosapentaenoic acid View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12-20

AUTHORS

Shingo Kato, Kazuki Fukui, Junko Kawaguchi, Nao Ishii, Masashi Koga, Yuka Kusakawa, Ikuyoshi Kusama, Tatsuya Nakachi, Takeshi Nakagawa, Yasuo Terauchi, Kazuaki Uchino, Kazuo Kimura, Satoshi Umemura

ABSTRACT

BackgroundLong-term intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs), especially eicosapentaenoic acid (EPA) is associated with a low risk for cardiovascular disease. Phase-contrast cine cardiovascular magnetic resonance (PC cine CMR) can assess coronary flow reserve (CFR). The present study investigates the relationship between CFR evaluated by PC cine CMR and the serum EPA.MethodsWe studied 127 patients (male, 116 (91%); mean age, 72.2 ± 7.4 years) with known or suspected coronary artery disease (CAD). X-ray coronary angiography revealed no significant coronary arterial stenoses (defined as luminal diameter reduction ≥50% on quantitative coronary angiogram (QCA) analysis) in all study participants. Breath-hold PC cine CMR images of the coronary sinus (CS) were acquired to assess blood flow of the CS both at rest and during adenosine triphosphate (ATP) infusion. We calculated CFR as CS blood flow during ATP infusion divided by that at rest. Patients were allocated to groups according to whether they had high (n = 64, EPA ≥ 75.8 μg/mL) or low (n = 63, EPA < 75.8 μg/mL) median serum EPA.ResultsCFR was significantly lower in the low, than in the high EPA group (2.54 ± 1.00 vs. 2.91 ± 0.98, p = 0.038). Serum EPA positively correlated with CFR (R = 0.35, p < 0.001). We defined preserved CFR as > 2.5, which is the previously reported lower limit of normal flow reserve without obstructive CAD. Multivariate analysis revealed that EPA is an independent predictor of CFR > 2.5 (odds ratio, 1.01; 95% confidence interval, 1.00 – 1.02, p = 0.008).ConclusionsThe serum EPA is significantly correlated with CFR in CAD patients without significant coronary artery stenosis. More... »

PAGES

106

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http://scigraph.springernature.com/pub.10.1186/1532-429x-15-106

DOI

http://dx.doi.org/10.1186/1532-429x-15-106

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https://app.dimensions.ai/details/publication/pub.1027922586

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24359564


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26 schema:description BackgroundLong-term intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs), especially eicosapentaenoic acid (EPA) is associated with a low risk for cardiovascular disease. Phase-contrast cine cardiovascular magnetic resonance (PC cine CMR) can assess coronary flow reserve (CFR). The present study investigates the relationship between CFR evaluated by PC cine CMR and the serum EPA.MethodsWe studied 127 patients (male, 116 (91%); mean age, 72.2 ± 7.4 years) with known or suspected coronary artery disease (CAD). X-ray coronary angiography revealed no significant coronary arterial stenoses (defined as luminal diameter reduction ≥50% on quantitative coronary angiogram (QCA) analysis) in all study participants. Breath-hold PC cine CMR images of the coronary sinus (CS) were acquired to assess blood flow of the CS both at rest and during adenosine triphosphate (ATP) infusion. We calculated CFR as CS blood flow during ATP infusion divided by that at rest. Patients were allocated to groups according to whether they had high (n = 64, EPA ≥ 75.8 μg/mL) or low (n = 63, EPA < 75.8 μg/mL) median serum EPA.ResultsCFR was significantly lower in the low, than in the high EPA group (2.54 ± 1.00 vs. 2.91 ± 0.98, p = 0.038). Serum EPA positively correlated with CFR (R = 0.35, p < 0.001). We defined preserved CFR as > 2.5, which is the previously reported lower limit of normal flow reserve without obstructive CAD. Multivariate analysis revealed that EPA is an independent predictor of CFR > 2.5 (odds ratio, 1.01; 95% confidence interval, 1.00 – 1.02, p = 0.008).ConclusionsThe serum EPA is significantly correlated with CFR in CAD patients without significant coronary artery stenosis.
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32 schema:keywords ATP infusion
33 CAD patients
34 CMR
35 CMR images
36 CS blood flow
37 EPA group
38 MethodsWe
39 X-ray coronary angiography
40 acid
41 adenosine
42 analysis
43 angiography
44 arterial stenosis
45 artery disease
46 artery stenosis
47 blood flow
48 cardiovascular disease
49 cardiovascular magnetic resonance
50 cine CMR
51 cine CMR images
52 cine cardiovascular magnetic resonance
53 coronary angiography
54 coronary arterial stenosis
55 coronary artery disease
56 coronary artery stenosis
57 coronary flow reserve
58 coronary sinus
59 disease
60 eicosapentaenoic acid
61 fatty acids
62 flow
63 flow reserve
64 group
65 images
66 independent predictors
67 infusion
68 intake
69 limit
70 low
71 lower limit
72 lower risk
73 magnetic resonance
74 multivariate analysis
75 normal flow reserve
76 obstructive coronary artery disease
77 participants
78 patients
79 predictors
80 present study
81 relationship
82 reserves
83 resonance
84 rest
85 risk
86 serum eicosapentaenoic acid
87 significant coronary arterial stenosis
88 significant coronary artery stenosis
89 sinus
90 stenosis
91 study
92 study participants
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