Inter-study reproducibility of cardiovascular magnetic resonance myocardial feature tracking View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06-21

AUTHORS

Geraint Morton, Andreas Schuster, Roy Jogiya, Shelby Kutty, Philipp Beerbaum, Eike Nagel

ABSTRACT

BackgroundCardiovascular magnetic resonance myocardial feature tracking (CMR-FT) is a recently described method of post processing routine cine acquisitions which aims to provide quantitative measurements of circumferentially and radially directed ventricular wall strain. Inter-study reproducibility is important for serial assessments however has not been defined for CMR-FT.Methods16 healthy volunteers were imaged 3 times within a single day. The first examination was performed at 0900 after fasting and was immediately followed by the second. The third, non-fasting scan, was performed at 1400.CMR-FT measures of segmental and global strain parameters were calculated. Left ventricular (LV) circumferential and radial strain were determined in the short axis orientation (EccSAX and ErrSAX respectively). LV and right ventricular longitudinal strain and LV radial strain were determined from the 4-chamber orientation (EllLV, EllRV, and ErrLAX respectively). LV volumes and function were also analysed.Inter-study reproducibility and study sample sizes required to demonstrate 5% changes in absolute strain were determined by comparison of the first and second exams. The third exam was used to determine whether diurnal variation affected reproducibility.ResultsCMR-FT strain analysis inter-study reproducibility was variable. Global strain assessment was more reproducible than segmental analysis. Overall EccSAX was the most reproducible measure of strain: coefficient of variation (CV) 38% and 20.3% and intraclass correlation coefficient (ICC) 0.68 (0.55-0.78) and 0.7 (0.32-0.89) for segmental and global analysis respectively. The least reproducible segmental measure was EllRV: CV 60% and ICC 0.56 (0.41-0.69) whilst the least reproducible global measure was ErrLAX: CV 33.3% and ICC 0.44 (0–0.77). Variable reproducibility was also reflected in the calculated sample sizes, which ranged from 11 (global EccSAX) to 156 subjects (segmental EllRV). The reproducibility of LV volumes and function was excellent. There was no diurnal variation in global strain or LV volumetric measurements.ConclusionsInter-study reproducibility of CMR-FT varied between different parameters, as summarized above and was better for global rather than segmental analysis. It was not measurably affected by diurnal variation. CMR-FT may have potential for quantitative wall motion analysis with applications in patient management and clinical trials. However, inter-study reproducibility was relatively poor for segmental and long axis analyses of strain, which have yet to be validated, and may benefit from further development. More... »

PAGES

43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1532-429x-14-43

DOI

http://dx.doi.org/10.1186/1532-429x-14-43

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038334561

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22721175


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78 radial strain
79 reproducibility
80 reproducible measure
81 right ventricular longitudinal strain
82 sample size
83 scans
84 second exam
85 segmental analysis
86 segmental measures
87 serial assessment
88 short-axis orientation
89 single day
90 size
91 strain assessment
92 strain parameters
93 strains
94 study sample size
95 subjects
96 third exam
97 time
98 tracking
99 trials
100 variable reproducibility
101 variation
102 ventricular
103 ventricular longitudinal strain
104 ventricular wall
105 volume
106 volumetric measurements
107 volunteers
108 wall
109 wall motion analysis
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