Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-04-20

AUTHORS

Bruno Salaun, Takuya Yamamoto, Bassam Badran, Yasuko Tsunetsugu-Yokota, Antoine Roux, Lukas Baitsch, Redouane Rouas, Hussein Fayyad-Kazan, Petra Baumgaertner, Estelle Devevre, Anirudh Ramesh, Marion Braun, Daniel Speiser, Brigitte Autran, Philippe Martiat, Victor Appay, Pedro Romero

ABSTRACT

BackgroundThe differentiation of CD8+ T lymphocytes following priming of naïve cells is central in the establishment of the adaptive immune response. Yet, the molecular events underlying this process are not fully understood. MicroRNAs have been recently shown to play a key role in the regulation of haematopoiesis in mouse, but their implication in peripheral lymphocyte differentiation in humans remains largely unknown.MethodsIn order to explore the potential implication of microRNAs in CD8+ T cell differentiation in humans, microRNA expression profiles were analysed using microarrays and quantitative PCR in several human CD8+ T cell subsets defining the major steps of the T cell differentiation pathway.ResultsWe found expression of a limited set of microRNAs, including the miR-17~92 cluster. Moreover, we reveal the existence of differentiation-associated regulation of specific microRNAs. When compared to naive cells, miR-21 and miR-155 were indeed found upregulated upon differentiation to effector cells, while expression of the miR-17~92 cluster tended to concomitantly decrease.ConclusionsThis study establishes for the first time in a large panel of individuals the existence of differentiation associated regulation of microRNA expression in human CD8+ T lymphocytes in vivo, which is likely to impact on specific cellular functions. More... »

PAGES

44

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1479-5876-9-44

DOI

http://dx.doi.org/10.1186/1479-5876-9-44

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044340276

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21507256


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32 T lymphocytes
33 adaptive immune responses
34 cell differentiation
35 cell differentiation pathway
36 cell subsets
37 cells
38 cellular functions
39 clusters
40 differentiation
41 differentiation of CD8
42 differentiation pathway
43 effector cells
44 establishment
45 events
46 existence
47 existence of differentiation
48 expression
49 expression profiles
50 first time
51 function
52 haematopoiesis
53 human CD8
54 humans
55 immune response
56 implications
57 individuals
58 key role
59 large panel
60 limited set
61 lymphocyte differentiation
62 lymphocytes
63 major step
64 miR
65 miR-155
66 miR-21
67 mice
68 microRNA expression
69 microRNAs
70 microarray
71 molecular events
72 naive cells
73 naïve cells
74 order
75 panel
76 pathway
77 potential implications
78 priming
79 process
80 profile
81 quantitative PCR
82 regulation
83 regulation of haematopoiesis
84 response
85 role
86 set
87 specific cellular functions
88 specific microRNAs
89 step
90 study
91 subset
92 time
93 vivo
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