Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Joanna D Holbrook, Joel S Parker, Kathleen T Gallagher, Wendy S Halsey, Ashley M Hughes, Victor J Weigman, Peter F Lebowitz, Rakesh Kumar

ABSTRACT

BACKGROUND: Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries. METHODS: Here, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to various pathways known to be altered in other cancers. RESULTS: Genetic alterations were observed in the WNT, Hedgehog, cell cycle, DNA damage and epithelial-to-mesenchymal-transition pathways. CONCLUSIONS: The data suggests targeted therapies approved or in clinical development for gastric carcinoma would be of benefit to ~22% of the patients studied. In addition, the novel mutations detected here, are likely to influence clinical response and suggest new targets for drug discovery. More... »

PAGES

119

References to SciGraph publications

  • 2008-12. Expression of the RON receptor tyrosine kinase and its association with gastric carcinoma versus normal gastric tissues in BMC CANCER
  • 2009. Epidemiology of Gastric Cancer and Helicobacter pylori in THE BIOLOGY OF GASTRIC CANCERS
  • 2008-12. ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel in BMC CANCER
  • 2010-04. Activating ROCK1 somatic mutations in human cancer in ONCOGENE
  • 2007-08. Orchestration of chromatin-based processes: mind the TRRAP in ONCOGENE
  • 2009-09. High resolution analysis of DNA copy-number aberrations of chromosomes 8, 13, and 20 in gastric cancers in VIRCHOWS ARCHIV
  • 2009-12. A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth in BMC CANCER
  • 2009-05. Does the Expression of Cyclin E, pRb, and p21 Correlate with Prognosis in Gastric Adenocarcinoma? in DIGESTIVE DISEASES AND SCIENCES
  • 2009-10. Allelic Imbalance at p53 and Microsatellite Instability Are Predictive Markers for Resistance to Chemotherapy in Gastric Carcinoma in ANNALS OF SURGICAL ONCOLOGY
  • 2009-07. Gastric cancer in the era of molecularly targeted agents: current drug development strategies in JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
  • 2009-10. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling in NATURE
  • 2010-12. Genome-wide gene copy number and expression analysis of primary gastric tumors and gastric cancer cell lines in BMC CANCER
  • 2005-12. Mutations of PIK3CAin gastric adenocarcinoma in BMC CANCER
  • 2007-07. Management of gastric adenocarcinoma in CLINICAL AND TRANSLATIONAL ONCOLOGY
  • 2009-10-08. Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution in NATURE
  • 2007-12. Characterizing the cancer genome in lung adenocarcinoma in NATURE
  • 2011-02. Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2009-10-07. GDC-0449 - Targeting the Hedgehog Signaling Pathway in SMALL MOLECULES IN ONCOLOGY
  • 2010-09. Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy in ACTA PHARMACOLOGICA SINICA
  • 2006-01. Oncogenic pathway signatures in human cancers as a guide to targeted therapies in NATURE
  • 2004-07. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website in BRITISH JOURNAL OF CANCER
  • 2008-10-23. Comprehensive genomic characterization defines human glioblastoma genes and core pathways in NATURE
  • 2010-03. Targeted therapy for gastrointestinal stromal tumors: current status and future perspectives in CANCER AND METASTASIS REVIEWS
  • 2005-02. PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas in ONCOGENE
  • 2002-12. A transcriptional response to Wnt protein in human embryonic carcinoma cells in BMC DEVELOPMENTAL BIOLOGY
  • 2010-01. A small-cell lung cancer genome with complex signatures of tobacco exposure in NATURE
  • 2009. The Role of Helicobacter pylori Virulence Factors in Rodent and Primate Models of Disease in THE BIOLOGY OF GASTRIC CANCERS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1479-5876-9-119

    DOI

    http://dx.doi.org/10.1186/1479-5876-9-119

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003297095

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21781349


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Copy Number Variations", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Epithelium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Profiling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "High-Throughput Nucleotide Sequencing", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phenotype", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Precision Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Neoplasm", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproducibility of Results", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Analysis, DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Stomach Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Wnt Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "National University of Singapore", 
              "id": "https://www.grid.ac/institutes/grid.4280.e", 
              "name": [
                "Cancer Research, Oncology R&D, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA", 
                "Growth, Development and Metabolism Programme, Singapore Institute of Clinical Sciences (SICS), Agency for Science Technology and Research (A*STAR), Brenner Centre for Molecular Medicine, National University of Singapore, 30 Medical Drive, 117609, Singapore"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Holbrook", 
            "givenName": "Joanna D", 
            "id": "sg:person.0763664474.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763664474.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Expression Analysis Inc., 4324 South Alston Avenue, NC27713, Durham, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Parker", 
            "givenName": "Joel S", 
            "id": "sg:person.0645004267.58", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645004267.58"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GlaxoSmithKline (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418019.5", 
              "name": [
                "MDR, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gallagher", 
            "givenName": "Kathleen T", 
            "id": "sg:person.01271757772.88", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271757772.88"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GlaxoSmithKline (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418019.5", 
              "name": [
                "MDR, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Halsey", 
            "givenName": "Wendy S", 
            "id": "sg:person.01352221547.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352221547.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GlaxoSmithKline (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418019.5", 
              "name": [
                "MDR, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hughes", 
            "givenName": "Ashley M", 
            "id": "sg:person.01307747447.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307747447.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Expression Analysis Inc., 4324 South Alston Avenue, NC27713, Durham, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Weigman", 
            "givenName": "Victor J", 
            "id": "sg:person.0750457233.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750457233.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GlaxoSmithKline (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418019.5", 
              "name": [
                "Cancer Research, Oncology R&D, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lebowitz", 
            "givenName": "Peter F", 
            "id": "sg:person.01320226301.81", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320226301.81"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "GlaxoSmithKline (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418019.5", 
              "name": [
                "Cancer Research, Oncology R&D, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kumar", 
            "givenName": "Rakesh", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1002/ijc.24763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000290902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000290902"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbamcr.2010.06.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000367895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pme.09.49", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000708484"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-9-198", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001192234", 
              "https://doi.org/10.1186/1471-2407-9-198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2010.03.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001597182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkg509", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002198958"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/lary.21145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002992176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/lary.21145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002992176"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1563", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004733468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.2923", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005288572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005686924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-2541", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005791134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-3293", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006293846"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.26.5983", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006572289"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-009-0590-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006632690", 
              "https://doi.org/10.1245/s10434-009-0590-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-009-0590-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006632690", 
              "https://doi.org/10.1245/s10434-009-0590-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-69182-4_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006688878", 
              "https://doi.org/10.1007/978-0-387-69182-4_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-69182-4_2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006688878", 
              "https://doi.org/10.1007/978-0-387-69182-4_2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1164368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006710792"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006711248", 
              "https://doi.org/10.1038/nature08489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006711248", 
              "https://doi.org/10.1038/nature08489"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007395103", 
              "https://doi.org/10.1038/sj.bjc.6601894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6601894", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007395103", 
              "https://doi.org/10.1038/sj.bjc.6601894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/13543770802653622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007568085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-1749", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007756336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgi130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007891704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgi130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007891704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-10-1028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008347445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32833a6b8e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008394486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32833a6b8e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008394486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32833a6b8e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008394486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.canlet.2010.04.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008504925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/aps.2010.106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010645689", 
              "https://doi.org/10.1038/aps.2010.106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/aps.2010.106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010645689", 
              "https://doi.org/10.1038/aps.2010.106"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2005.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011213819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2005.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011213819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1515/bc.2008.087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012977118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1586/era.10.128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013700950"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.drup.2008.07.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014564926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-010-1318-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015138321", 
              "https://doi.org/10.1007/s00280-010-1318-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32833d5954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017579354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32833d5954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017579354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08356", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018211800", 
              "https://doi.org/10.1038/nature08356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0903840", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019484764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019512248", 
              "https://doi.org/10.1186/1471-2407-10-73"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature06358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019681472", 
              "https://doi.org/10.1038/nature06358"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020908732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020908732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-3788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021328466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.110.114769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022574760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.110.114769", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022574760"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp352", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023014918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1210605", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023246195", 
              "https://doi.org/10.1038/sj.onc.1210605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-2138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025022529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-0943", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025194635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-09-0300", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025235674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2010.3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025790258", 
              "https://doi.org/10.1038/onc.2010.3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000096289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025844831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-69182-4_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026188417", 
              "https://doi.org/10.1007/978-0-387-69182-4_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-69182-4_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026188417", 
              "https://doi.org/10.1007/978-0-387-69182-4_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-0106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026911925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-8-97", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027793974", 
              "https://doi.org/10.1186/1471-2407-8-97"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24290", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028032072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028145633", 
              "https://doi.org/10.1038/nature04296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028145633", 
              "https://doi.org/10.1038/nature04296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature04296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028145633", 
              "https://doi.org/10.1038/nature04296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2009.09.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028533572"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-5-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029975692", 
              "https://doi.org/10.1186/1471-2407-5-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.23371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030430137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.21170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031930529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.21170", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031930529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-8-353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032788410", 
              "https://doi.org/10.1186/1471-2407-8-353"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/028418601750444204", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033114810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1073096", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034063178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1742-4658.2010.07735.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034320894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/clo-2009-0497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034695709"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s0004-27302007000500003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035643404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036710331", 
              "https://doi.org/10.1038/sj.onc.1208304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1208304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036710331", 
              "https://doi.org/10.1038/sj.onc.1208304"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-4889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036742267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038266369"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10620-008-0464-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038514680", 
              "https://doi.org/10.1007/s10620-008-0464-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-09-1173", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038961173"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07385", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039570773", 
              "https://doi.org/10.1038/nature07385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-213x-2-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039713853", 
              "https://doi.org/10.1186/1471-213x-2-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpgi.00005.2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040358255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbcan.2010.01.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040853951"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041012667", 
              "https://doi.org/10.1038/nature08629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08629", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041012667", 
              "https://doi.org/10.1038/nature08629"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000676", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041390395"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2009.02.081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042043646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2005.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042185129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2005.04.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042185129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-09-0477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042691795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-01222-8_17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043455657", 
              "https://doi.org/10.1007/978-3-642-01222-8_17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-642-01222-8_17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043455657", 
              "https://doi.org/10.1007/978-3-642-01222-8_17"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12094-007-0082-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043580656", 
              "https://doi.org/10.1007/s12094-007-0082-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-291x(92)91548-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043687980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci37539", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043989506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(10)61121-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044182432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-10-0359", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044374790"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.110.209395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044651642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.110.209395", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044651642"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-009-0814-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045193395", 
              "https://doi.org/10.1007/s00428-009-0814-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-009-0814-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045193395", 
              "https://doi.org/10.1007/s00428-009-0814-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.01082-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045947446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-009-0583-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046766075", 
              "https://doi.org/10.1007/s00432-009-0583-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-009-0583-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046766075", 
              "https://doi.org/10.1007/s00432-009-0583-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00432-009-0583-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046766075", 
              "https://doi.org/10.1007/s00432-009-0583-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2008.07.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047606865"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2009.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048269639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-010-9206-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048622995", 
              "https://doi.org/10.1007/s10555-010-9206-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10555-010-9206-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048622995", 
              "https://doi.org/10.1007/s10555-010-9206-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ctrv.2009.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049783583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0508776103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050433384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-10-0002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050560606"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-3573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050706361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2010.01514.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050747602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1349-7006.2010.01514.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050747602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci119497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051614127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejca.2010.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052132896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-3746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052989529"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1145720", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053548183"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1358/dot.2009.45.11.1437052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1065063841"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2146/ajhp090247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069099379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2146/ajhp090247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069099379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2146/ajhp090247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069099379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156652407779940431", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069185827"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/156652409789105570", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069186048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or.12.3.593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071529322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/or_00000465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071537270"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/auto.6.2.11042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072290643"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cbt.7.9.6416", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072295067"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.8.16.9278", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072300194"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077137564", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077844790", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078165988", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078196733", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080065151", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5694/j.1326-5377.1985.tb113444.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080065151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083025057", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083347816", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083390009", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-12", 
        "datePublishedReg": "2011-12-01", 
        "description": "BACKGROUND: Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries.\nMETHODS: Here, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to various pathways known to be altered in other cancers.\nRESULTS: Genetic alterations were observed in the WNT, Hedgehog, cell cycle, DNA damage and epithelial-to-mesenchymal-transition pathways.\nCONCLUSIONS: The data suggests targeted therapies approved or in clinical development for gastric carcinoma would be of benefit to ~22% of the patients studied. In addition, the novel mutations detected here, are likely to influence clinical response and suggest new targets for drug discovery.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1479-5876-9-119", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1032886", 
            "issn": [
              "1479-5876"
            ], 
            "name": "Journal of Translational Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine", 
        "pagination": "119", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "0fb4663f472761dd327c51f5cde01ea5c0105d3ed7739bb61ab235280867ff1c"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21781349"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101190741"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1479-5876-9-119"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1003297095"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1479-5876-9-119", 
          "https://app.dimensions.ai/details/publication/pub.1003297095"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T01:06", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000510.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1479-5876-9-119"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-9-119'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-9-119'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-9-119'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-9-119'


     

    This table displays all metadata directly associated to this object as RDF triples.

    566 TRIPLES      21 PREDICATES      163 URIs      41 LITERALS      29 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1479-5876-9-119 schema:about N1436e239b44b405abe7e1203f3d726f8
    2 N214b19fd8ace4bc9bd311624adb5025a
    3 N26c60001029440bf922cc52d6dc278b6
    4 N285bfb5f2ac54970a79d5de928d88246
    5 N326be8a986fc4c3b988d51f2ace22e98
    6 N35a8b9ce264e4a138b7bbcae94a97129
    7 N36ad6820553b4939ad052ebe2428a1f4
    8 N413a3b53ffcf4ddb9a25b3cbb0149c79
    9 N4d5b9143bc0a48488d7926fee6a94351
    10 N53a6519ea8d044b08d5c3d3b30ffc681
    11 N5b1d82af63ad4e2682b50a545412cf57
    12 N675985805e68414e9ed606ab37f24570
    13 N67aac26bd17a4b3bb4bbf1c73c2281e0
    14 N9a44b1e570de433bb098445d8a380120
    15 Na2b9ec65755548eea598a475058b9d79
    16 Naa4f96c5af334f3993d3193460c3a746
    17 Nbfa4d028c19f4176b73fc5097722d167
    18 Nd401088ee7434662950c0577f5fa307e
    19 Nd770bf0c648e4ca0bd93929ef57f915f
    20 Nf6f7f555d27c45bb948619c2de6cfa8f
    21 anzsrc-for:11
    22 anzsrc-for:1112
    23 schema:author N288313173693428f81037bce98516d86
    24 schema:citation sg:pub.10.1007/978-0-387-69182-4_16
    25 sg:pub.10.1007/978-0-387-69182-4_2
    26 sg:pub.10.1007/978-3-642-01222-8_17
    27 sg:pub.10.1007/s00280-010-1318-9
    28 sg:pub.10.1007/s00428-009-0814-y
    29 sg:pub.10.1007/s00432-009-0583-7
    30 sg:pub.10.1007/s10555-010-9206-7
    31 sg:pub.10.1007/s10620-008-0464-y
    32 sg:pub.10.1007/s12094-007-0082-8
    33 sg:pub.10.1038/aps.2010.106
    34 sg:pub.10.1038/nature04296
    35 sg:pub.10.1038/nature06358
    36 sg:pub.10.1038/nature07385
    37 sg:pub.10.1038/nature08356
    38 sg:pub.10.1038/nature08489
    39 sg:pub.10.1038/nature08629
    40 sg:pub.10.1038/onc.2010.3
    41 sg:pub.10.1038/sj.bjc.6601894
    42 sg:pub.10.1038/sj.onc.1208304
    43 sg:pub.10.1038/sj.onc.1210605
    44 sg:pub.10.1186/1471-213x-2-8
    45 sg:pub.10.1186/1471-2407-10-73
    46 sg:pub.10.1186/1471-2407-5-29
    47 sg:pub.10.1186/1471-2407-8-353
    48 sg:pub.10.1186/1471-2407-8-97
    49 sg:pub.10.1186/1471-2407-9-198
    50 sg:pub.10.1245/s10434-009-0590-6
    51 https://app.dimensions.ai/details/publication/pub.1077137564
    52 https://app.dimensions.ai/details/publication/pub.1077844790
    53 https://app.dimensions.ai/details/publication/pub.1078165988
    54 https://app.dimensions.ai/details/publication/pub.1078196733
    55 https://app.dimensions.ai/details/publication/pub.1080065151
    56 https://app.dimensions.ai/details/publication/pub.1083025057
    57 https://app.dimensions.ai/details/publication/pub.1083347816
    58 https://app.dimensions.ai/details/publication/pub.1083390009
    59 https://doi.org/10.1002/cncr.23371
    60 https://doi.org/10.1002/ijc.21170
    61 https://doi.org/10.1002/ijc.24290
    62 https://doi.org/10.1002/ijc.24699
    63 https://doi.org/10.1002/ijc.24763
    64 https://doi.org/10.1002/lary.21145
    65 https://doi.org/10.1016/0006-291x(92)91548-5
    66 https://doi.org/10.1016/j.bbamcr.2010.06.009
    67 https://doi.org/10.1016/j.bbcan.2010.01.007
    68 https://doi.org/10.1016/j.bbrc.2009.02.081
    69 https://doi.org/10.1016/j.canlet.2010.04.015
    70 https://doi.org/10.1016/j.ccr.2005.04.023
    71 https://doi.org/10.1016/j.cmet.2009.09.010
    72 https://doi.org/10.1016/j.ctrv.2009.12.009
    73 https://doi.org/10.1016/j.drup.2008.07.001
    74 https://doi.org/10.1016/j.ejca.2005.04.022
    75 https://doi.org/10.1016/j.ejca.2010.05.003
    76 https://doi.org/10.1016/j.gde.2008.07.014
    77 https://doi.org/10.1016/j.gde.2010.03.007
    78 https://doi.org/10.1016/j.molcel.2009.06.001
    79 https://doi.org/10.1016/s0140-6736(10)61121-x
    80 https://doi.org/10.1056/nejmoa0903840
    81 https://doi.org/10.1073/pnas.0508776103
    82 https://doi.org/10.1080/028418601750444204
    83 https://doi.org/10.1093/bioinformatics/btp324
    84 https://doi.org/10.1093/bioinformatics/btp352
    85 https://doi.org/10.1093/carcin/bgi130
    86 https://doi.org/10.1093/nar/gkg509
    87 https://doi.org/10.1097/cco.0b013e32833a6b8e
    88 https://doi.org/10.1097/cco.0b013e32833d5954
    89 https://doi.org/10.1111/j.1349-7006.2010.01514.x
    90 https://doi.org/10.1111/j.1742-4658.2010.07735.x
    91 https://doi.org/10.1126/science.1073096
    92 https://doi.org/10.1126/science.1145720
    93 https://doi.org/10.1126/science.1164368
    94 https://doi.org/10.1128/mcb.01082-08
    95 https://doi.org/10.1152/ajpgi.00005.2010
    96 https://doi.org/10.1158/0008-5472.can-07-3293
    97 https://doi.org/10.1158/0008-5472.can-08-4889
    98 https://doi.org/10.1158/0008-5472.can-09-2541
    99 https://doi.org/10.1158/0008-5472.can-09-3573
    100 https://doi.org/10.1158/0008-5472.can-09-3746
    101 https://doi.org/10.1158/0008-5472.can-09-3788
    102 https://doi.org/10.1158/0008-5472.can-10-1028
    103 https://doi.org/10.1158/0008-5472.can-10-1749
    104 https://doi.org/10.1158/1078-0432.ccr-05-0943
    105 https://doi.org/10.1158/1078-0432.ccr-08-2138
    106 https://doi.org/10.1158/1078-0432.ccr-09-1112
    107 https://doi.org/10.1158/1078-0432.ccr-09-1563
    108 https://doi.org/10.1158/1078-0432.ccr-10-0106
    109 https://doi.org/10.1158/1535-7163.mct-09-0300
    110 https://doi.org/10.1158/1535-7163.mct-09-0477
    111 https://doi.org/10.1158/1535-7163.mct-09-1173
    112 https://doi.org/10.1158/1535-7163.mct-10-0002
    113 https://doi.org/10.1158/1535-7163.mct-10-0359
    114 https://doi.org/10.1159/000096289
    115 https://doi.org/10.1161/atvbaha.110.209395
    116 https://doi.org/10.1172/jci119497
    117 https://doi.org/10.1172/jci37539
    118 https://doi.org/10.1200/jco.2009.26.2923
    119 https://doi.org/10.1200/jco.2009.26.5983
    120 https://doi.org/10.1358/dot.2009.45.11.1437052
    121 https://doi.org/10.1371/journal.pgen.1000676
    122 https://doi.org/10.1515/bc.2008.087
    123 https://doi.org/10.1517/13543770802653622
    124 https://doi.org/10.1534/genetics.110.114769
    125 https://doi.org/10.1586/era.10.128
    126 https://doi.org/10.1590/s0004-27302007000500003
    127 https://doi.org/10.2146/ajhp090247
    128 https://doi.org/10.2174/156652407779940431
    129 https://doi.org/10.2174/156652409789105570
    130 https://doi.org/10.2217/pme.09.49
    131 https://doi.org/10.3233/clo-2009-0497
    132 https://doi.org/10.3892/or.12.3.593
    133 https://doi.org/10.3892/or_00000465
    134 https://doi.org/10.4161/auto.6.2.11042
    135 https://doi.org/10.4161/cbt.7.9.6416
    136 https://doi.org/10.4161/cc.8.16.9278
    137 https://doi.org/10.5694/j.1326-5377.1985.tb113444.x
    138 schema:datePublished 2011-12
    139 schema:datePublishedReg 2011-12-01
    140 schema:description BACKGROUND: Globally, gastric cancer is the second most common cause of cancer-related death, with the majority of the health burden borne by economically less-developed countries. METHODS: Here, we report a genetic characterization of 50 gastric adenocarcinoma samples, using affymetrix SNP arrays and Illumina mRNA expression arrays as well as Illumina sequencing of the coding regions of 384 genes belonging to various pathways known to be altered in other cancers. RESULTS: Genetic alterations were observed in the WNT, Hedgehog, cell cycle, DNA damage and epithelial-to-mesenchymal-transition pathways. CONCLUSIONS: The data suggests targeted therapies approved or in clinical development for gastric carcinoma would be of benefit to ~22% of the patients studied. In addition, the novel mutations detected here, are likely to influence clinical response and suggest new targets for drug discovery.
    141 schema:genre research_article
    142 schema:inLanguage en
    143 schema:isAccessibleForFree true
    144 schema:isPartOf N67d92bc843a542479c0dc19984c27fc3
    145 Nfd8c45ff8306410f97189c27a7069ed6
    146 sg:journal.1032886
    147 schema:name Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine
    148 schema:pagination 119
    149 schema:productId N2c1b545f81914f9696ac3d915ab7fe60
    150 N2f8cdab041e44b44b965f6c180e8f460
    151 N4d7de77795524b14b4fbeb7e07a87a19
    152 Nc61a8e01a6f94b9381b54f682ecb455f
    153 Nf88b4ecdbdf345f0925223c25b31acd1
    154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003297095
    155 https://doi.org/10.1186/1479-5876-9-119
    156 schema:sdDatePublished 2019-04-11T01:06
    157 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    158 schema:sdPublisher N0a3799c759da4f09959af15f774d6b69
    159 schema:url http://link.springer.com/10.1186%2F1479-5876-9-119
    160 sgo:license sg:explorer/license/
    161 sgo:sdDataset articles
    162 rdf:type schema:ScholarlyArticle
    163 N02ff75f6166042dd9e8b92da1402f501 schema:name Expression Analysis Inc., 4324 South Alston Avenue, NC27713, Durham, USA
    164 rdf:type schema:Organization
    165 N077ae3a92db44cdebcdf27f29ef6ab9b schema:name Expression Analysis Inc., 4324 South Alston Avenue, NC27713, Durham, USA
    166 rdf:type schema:Organization
    167 N0a3799c759da4f09959af15f774d6b69 schema:name Springer Nature - SN SciGraph project
    168 rdf:type schema:Organization
    169 N1436e239b44b405abe7e1203f3d726f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Stomach Neoplasms
    171 rdf:type schema:DefinedTerm
    172 N154a194e732c4679939f21d5b4dca7d0 rdf:first sg:person.01352221547.29
    173 rdf:rest Nd476cbe74d82469684cf229e43b98f64
    174 N214b19fd8ace4bc9bd311624adb5025a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Mutation
    176 rdf:type schema:DefinedTerm
    177 N26c60001029440bf922cc52d6dc278b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name DNA, Neoplasm
    179 rdf:type schema:DefinedTerm
    180 N285bfb5f2ac54970a79d5de928d88246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Gene Expression Regulation, Neoplastic
    182 rdf:type schema:DefinedTerm
    183 N288313173693428f81037bce98516d86 rdf:first sg:person.0763664474.93
    184 rdf:rest N8006ac3db19348098b5046ad683a4244
    185 N2c1b545f81914f9696ac3d915ab7fe60 schema:name doi
    186 schema:value 10.1186/1479-5876-9-119
    187 rdf:type schema:PropertyValue
    188 N2f8cdab041e44b44b965f6c180e8f460 schema:name nlm_unique_id
    189 schema:value 101190741
    190 rdf:type schema:PropertyValue
    191 N326be8a986fc4c3b988d51f2ace22e98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Phenotype
    193 rdf:type schema:DefinedTerm
    194 N35a8b9ce264e4a138b7bbcae94a97129 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Sequence Analysis, DNA
    196 rdf:type schema:DefinedTerm
    197 N36ad6820553b4939ad052ebe2428a1f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Reproducibility of Results
    199 rdf:type schema:DefinedTerm
    200 N37d5eb488c1d400390fd9eb47b771b55 rdf:first N6b33717b383941888386a49ad517b7a1
    201 rdf:rest rdf:nil
    202 N413a3b53ffcf4ddb9a25b3cbb0149c79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    203 schema:name Neoplasm Proteins
    204 rdf:type schema:DefinedTerm
    205 N4d5b9143bc0a48488d7926fee6a94351 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    206 schema:name RNA, Neoplasm
    207 rdf:type schema:DefinedTerm
    208 N4d7de77795524b14b4fbeb7e07a87a19 schema:name readcube_id
    209 schema:value 0fb4663f472761dd327c51f5cde01ea5c0105d3ed7739bb61ab235280867ff1c
    210 rdf:type schema:PropertyValue
    211 N53a6519ea8d044b08d5c3d3b30ffc681 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    212 schema:name High-Throughput Nucleotide Sequencing
    213 rdf:type schema:DefinedTerm
    214 N5b1d82af63ad4e2682b50a545412cf57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Genotype
    216 rdf:type schema:DefinedTerm
    217 N675985805e68414e9ed606ab37f24570 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Molecular Targeted Therapy
    219 rdf:type schema:DefinedTerm
    220 N67aac26bd17a4b3bb4bbf1c73c2281e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Cell Cycle Proteins
    222 rdf:type schema:DefinedTerm
    223 N67d92bc843a542479c0dc19984c27fc3 schema:issueNumber 1
    224 rdf:type schema:PublicationIssue
    225 N6b33717b383941888386a49ad517b7a1 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
    226 schema:familyName Kumar
    227 schema:givenName Rakesh
    228 rdf:type schema:Person
    229 N6dc14e594c59401aa1264f2e07aece30 rdf:first sg:person.01271757772.88
    230 rdf:rest N154a194e732c4679939f21d5b4dca7d0
    231 N8006ac3db19348098b5046ad683a4244 rdf:first sg:person.0645004267.58
    232 rdf:rest N6dc14e594c59401aa1264f2e07aece30
    233 N9a44b1e570de433bb098445d8a380120 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Wnt Proteins
    235 rdf:type schema:DefinedTerm
    236 Na2b9ec65755548eea598a475058b9d79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Signal Transduction
    238 rdf:type schema:DefinedTerm
    239 Naa4f96c5af334f3993d3193460c3a746 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name DNA Copy Number Variations
    241 rdf:type schema:DefinedTerm
    242 Nae626cb439884aaaae5f271a4dcfdaf8 rdf:first sg:person.01320226301.81
    243 rdf:rest N37d5eb488c1d400390fd9eb47b771b55
    244 Nbfa4d028c19f4176b73fc5097722d167 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    245 schema:name Epithelium
    246 rdf:type schema:DefinedTerm
    247 Nc61a8e01a6f94b9381b54f682ecb455f schema:name pubmed_id
    248 schema:value 21781349
    249 rdf:type schema:PropertyValue
    250 Ncafa03b1702e4c059ef8907c25e90a7c rdf:first sg:person.0750457233.14
    251 rdf:rest Nae626cb439884aaaae5f271a4dcfdaf8
    252 Nd401088ee7434662950c0577f5fa307e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    253 schema:name Gene Expression Profiling
    254 rdf:type schema:DefinedTerm
    255 Nd476cbe74d82469684cf229e43b98f64 rdf:first sg:person.01307747447.57
    256 rdf:rest Ncafa03b1702e4c059ef8907c25e90a7c
    257 Nd770bf0c648e4ca0bd93929ef57f915f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    258 schema:name Precision Medicine
    259 rdf:type schema:DefinedTerm
    260 Nf6f7f555d27c45bb948619c2de6cfa8f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    261 schema:name Humans
    262 rdf:type schema:DefinedTerm
    263 Nf88b4ecdbdf345f0925223c25b31acd1 schema:name dimensions_id
    264 schema:value pub.1003297095
    265 rdf:type schema:PropertyValue
    266 Nfd8c45ff8306410f97189c27a7069ed6 schema:volumeNumber 9
    267 rdf:type schema:PublicationVolume
    268 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    269 schema:name Medical and Health Sciences
    270 rdf:type schema:DefinedTerm
    271 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    272 schema:name Oncology and Carcinogenesis
    273 rdf:type schema:DefinedTerm
    274 sg:journal.1032886 schema:issn 1479-5876
    275 schema:name Journal of Translational Medicine
    276 rdf:type schema:Periodical
    277 sg:person.01271757772.88 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
    278 schema:familyName Gallagher
    279 schema:givenName Kathleen T
    280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271757772.88
    281 rdf:type schema:Person
    282 sg:person.01307747447.57 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
    283 schema:familyName Hughes
    284 schema:givenName Ashley M
    285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307747447.57
    286 rdf:type schema:Person
    287 sg:person.01320226301.81 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
    288 schema:familyName Lebowitz
    289 schema:givenName Peter F
    290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320226301.81
    291 rdf:type schema:Person
    292 sg:person.01352221547.29 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
    293 schema:familyName Halsey
    294 schema:givenName Wendy S
    295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352221547.29
    296 rdf:type schema:Person
    297 sg:person.0645004267.58 schema:affiliation N077ae3a92db44cdebcdf27f29ef6ab9b
    298 schema:familyName Parker
    299 schema:givenName Joel S
    300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645004267.58
    301 rdf:type schema:Person
    302 sg:person.0750457233.14 schema:affiliation N02ff75f6166042dd9e8b92da1402f501
    303 schema:familyName Weigman
    304 schema:givenName Victor J
    305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750457233.14
    306 rdf:type schema:Person
    307 sg:person.0763664474.93 schema:affiliation https://www.grid.ac/institutes/grid.4280.e
    308 schema:familyName Holbrook
    309 schema:givenName Joanna D
    310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0763664474.93
    311 rdf:type schema:Person
    312 sg:pub.10.1007/978-0-387-69182-4_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026188417
    313 https://doi.org/10.1007/978-0-387-69182-4_16
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1007/978-0-387-69182-4_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006688878
    316 https://doi.org/10.1007/978-0-387-69182-4_2
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1007/978-3-642-01222-8_17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043455657
    319 https://doi.org/10.1007/978-3-642-01222-8_17
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1007/s00280-010-1318-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015138321
    322 https://doi.org/10.1007/s00280-010-1318-9
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1007/s00428-009-0814-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1045193395
    325 https://doi.org/10.1007/s00428-009-0814-y
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1007/s00432-009-0583-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046766075
    328 https://doi.org/10.1007/s00432-009-0583-7
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1007/s10555-010-9206-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048622995
    331 https://doi.org/10.1007/s10555-010-9206-7
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1007/s10620-008-0464-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1038514680
    334 https://doi.org/10.1007/s10620-008-0464-y
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1007/s12094-007-0082-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043580656
    337 https://doi.org/10.1007/s12094-007-0082-8
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/aps.2010.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010645689
    340 https://doi.org/10.1038/aps.2010.106
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nature04296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028145633
    343 https://doi.org/10.1038/nature04296
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nature06358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019681472
    346 https://doi.org/10.1038/nature06358
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nature07385 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039570773
    349 https://doi.org/10.1038/nature07385
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nature08356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018211800
    352 https://doi.org/10.1038/nature08356
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nature08489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006711248
    355 https://doi.org/10.1038/nature08489
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nature08629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041012667
    358 https://doi.org/10.1038/nature08629
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/onc.2010.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025790258
    361 https://doi.org/10.1038/onc.2010.3
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/sj.bjc.6601894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007395103
    364 https://doi.org/10.1038/sj.bjc.6601894
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/sj.onc.1208304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036710331
    367 https://doi.org/10.1038/sj.onc.1208304
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/sj.onc.1210605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023246195
    370 https://doi.org/10.1038/sj.onc.1210605
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1186/1471-213x-2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039713853
    373 https://doi.org/10.1186/1471-213x-2-8
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1186/1471-2407-10-73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019512248
    376 https://doi.org/10.1186/1471-2407-10-73
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1186/1471-2407-5-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029975692
    379 https://doi.org/10.1186/1471-2407-5-29
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1186/1471-2407-8-353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032788410
    382 https://doi.org/10.1186/1471-2407-8-353
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1186/1471-2407-8-97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027793974
    385 https://doi.org/10.1186/1471-2407-8-97
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1186/1471-2407-9-198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001192234
    388 https://doi.org/10.1186/1471-2407-9-198
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1245/s10434-009-0590-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006632690
    391 https://doi.org/10.1245/s10434-009-0590-6
    392 rdf:type schema:CreativeWork
    393 https://app.dimensions.ai/details/publication/pub.1077137564 schema:CreativeWork
    394 https://app.dimensions.ai/details/publication/pub.1077844790 schema:CreativeWork
    395 https://app.dimensions.ai/details/publication/pub.1078165988 schema:CreativeWork
    396 https://app.dimensions.ai/details/publication/pub.1078196733 schema:CreativeWork
    397 https://app.dimensions.ai/details/publication/pub.1080065151 schema:CreativeWork
    398 https://app.dimensions.ai/details/publication/pub.1083025057 schema:CreativeWork
    399 https://app.dimensions.ai/details/publication/pub.1083347816 schema:CreativeWork
    400 https://app.dimensions.ai/details/publication/pub.1083390009 schema:CreativeWork
    401 https://doi.org/10.1002/cncr.23371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030430137
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1002/ijc.21170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031930529
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1002/ijc.24290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028032072
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1002/ijc.24699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020908732
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1002/ijc.24763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000290902
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1002/lary.21145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002992176
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1016/0006-291x(92)91548-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043687980
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/j.bbamcr.2010.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000367895
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/j.bbcan.2010.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040853951
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/j.bbrc.2009.02.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042043646
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/j.canlet.2010.04.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008504925
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/j.ccr.2005.04.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042185129
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/j.cmet.2009.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028533572
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/j.ctrv.2009.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049783583
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/j.drup.2008.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014564926
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/j.ejca.2005.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011213819
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/j.ejca.2010.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052132896
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/j.gde.2008.07.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047606865
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/j.gde.2010.03.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001597182
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.molcel.2009.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048269639
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/s0140-6736(10)61121-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044182432
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1056/nejmoa0903840 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019484764
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1073/pnas.0508776103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050433384
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1080/028418601750444204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033114810
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1093/bioinformatics/btp324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038266369
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1093/bioinformatics/btp352 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023014918
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1093/carcin/bgi130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007891704
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1093/nar/gkg509 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002198958
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1097/cco.0b013e32833a6b8e schema:sameAs https://app.dimensions.ai/details/publication/pub.1008394486
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1097/cco.0b013e32833d5954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017579354
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1111/j.1349-7006.2010.01514.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050747602
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1111/j.1742-4658.2010.07735.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034320894
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1126/science.1073096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034063178
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1126/science.1145720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053548183
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1126/science.1164368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006710792
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1128/mcb.01082-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045947446
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1152/ajpgi.00005.2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040358255
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1158/0008-5472.can-07-3293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006293846
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1158/0008-5472.can-08-4889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036742267
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1158/0008-5472.can-09-2541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005791134
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1158/0008-5472.can-09-3573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050706361
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1158/0008-5472.can-09-3746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052989529
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1158/0008-5472.can-09-3788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021328466
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1158/0008-5472.can-10-1028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008347445
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1158/0008-5472.can-10-1749 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007756336
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1158/1078-0432.ccr-05-0943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025194635
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1158/1078-0432.ccr-08-2138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025022529
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1158/1078-0432.ccr-09-1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005686924
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1158/1078-0432.ccr-09-1563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004733468
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1158/1078-0432.ccr-10-0106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026911925
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1158/1535-7163.mct-09-0300 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025235674
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1158/1535-7163.mct-09-0477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042691795
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1158/1535-7163.mct-09-1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038961173
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1158/1535-7163.mct-10-0002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050560606
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1158/1535-7163.mct-10-0359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044374790
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1159/000096289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025844831
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1161/atvbaha.110.209395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044651642
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1172/jci119497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051614127
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1172/jci37539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043989506
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1200/jco.2009.26.2923 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005288572
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1200/jco.2009.26.5983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006572289
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1358/dot.2009.45.11.1437052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065063841
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1371/journal.pgen.1000676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041390395
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1515/bc.2008.087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012977118
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1517/13543770802653622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007568085
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1534/genetics.110.114769 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022574760
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1586/era.10.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013700950
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1590/s0004-27302007000500003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035643404
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.2146/ajhp090247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069099379
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.2174/156652407779940431 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069185827
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.2174/156652409789105570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069186048
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.2217/pme.09.49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000708484
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.3233/clo-2009-0497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034695709
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.3892/or.12.3.593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071529322
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.3892/or_00000465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071537270
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.4161/auto.6.2.11042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072290643
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.4161/cbt.7.9.6416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072295067
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.4161/cc.8.16.9278 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300194
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.5694/j.1326-5377.1985.tb113444.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1080065151
    558 rdf:type schema:CreativeWork
    559 https://www.grid.ac/institutes/grid.418019.5 schema:alternateName GlaxoSmithKline (United States)
    560 schema:name Cancer Research, Oncology R&D, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA
    561 MDR, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA
    562 rdf:type schema:Organization
    563 https://www.grid.ac/institutes/grid.4280.e schema:alternateName National University of Singapore
    564 schema:name Cancer Research, Oncology R&D, Glaxosmithkline R&D, 1250 Collegeville Road, Collegeville, USA
    565 Growth, Development and Metabolism Programme, Singapore Institute of Clinical Sciences (SICS), Agency for Science Technology and Research (A*STAR), Brenner Centre for Molecular Medicine, National University of Singapore, 30 Medical Drive, 117609, Singapore
    566 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...