Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Åsa Ehlén, Donal J Brennan, Björn Nodin, Darran P O'Connor, Jakob Eberhard, Maria Alvarado-Kristensson, Ian B Jeffrey, Jonas Manjer, Jenny Brändstedt, Mathias Uhlén, Fredrik Pontén, Karin Jirström

ABSTRACT

BACKGROUND: We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line. METHODS: RBM3 mRNA expression was analysed in tumors from a cohort of 267 EOC cases (Cohort I) and RBM3 protein expression was analysed using immunohistochemistry (IHC) in an independent cohort of 154 prospectively collected EOC cases (Cohort II). Kaplan Meier analysis and Cox proportional hazards modelling were applied to assess the relationship between RBM3 and recurrence free survival (RFS) and overall survival (OS). Immunoblotting and IHC were used to examine the expression of RBM3 in a cisplatin-resistant ovarian cancer cell line A2780-Cp70 and its cisplatin-responsive parental cell line A2780. The impact of RBM3 on cisplatin response in EOC was assessed using siRNA-mediated silencing of RBM3 in A2780 cells followed by cell viability assay and cell cycle analysis. RESULTS: Increased RBM3 mRNA expression was associated with a prolonged RFS (HR = 0.64, 95% CI = 0.47-0.86, p = 0.003) and OS (HR = 0.64, 95% CI = 0.44-0.95, p = 0.024) in Cohort I. Multivariate analysis confirmed that RBM3 mRNA expression was an independent predictor of a prolonged RFS, (HR = 0.61, 95% CI = 0.44-0.84, p = 0.003) and OS (HR = 0.62, 95% CI = 0.41-0.95; p = 0.028) in Cohort I. In Cohort II, RBM3 protein expression was associated with a prolonged OS (HR = 0.53, 95% CI = 0.35-0.79, p = 0.002) confirmed by multivariate analysis (HR = 0.61, 95% CI = 0.40-0.92, p = 0.017). RBM3 mRNA and protein expression levels were significantly higher in the cisplatin sensitive A2780 cell line compared to the cisplatin resistant A2780-Cp70 derivative. siRNA-mediated silencing of RBM3 expression in the A2780 cells resulted in a decreased sensitivity to cisplatin as demonstrated by increased cell viability and reduced proportion of cells arrested in the G2/M-phase. CONCLUSIONS: These data demonstrate that RBM3 expression is associated with cisplatin sensitivity in vitro and with a good prognosis in EOC. Taken together these findings suggest that RBM3 may be a useful prognostic and treatment predictive marker in EOC. More... »

PAGES

78

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1479-5876-8-78

DOI

http://dx.doi.org/10.1186/1479-5876-8-78

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024363411

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20727170


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibody Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cisplatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms, Glandular and Epithelial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ehl\u00e9n", 
        "givenName": "\u00c5sa", 
        "id": "sg:person.01361322431.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361322431.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Dublin", 
          "id": "https://www.grid.ac/institutes/grid.7886.1", 
          "name": [
            "UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brennan", 
        "givenName": "Donal J", 
        "id": "sg:person.01143415300.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143415300.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nodin", 
        "givenName": "Bj\u00f6rn", 
        "id": "sg:person.0652655660.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652655660.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Dublin", 
          "id": "https://www.grid.ac/institutes/grid.7886.1", 
          "name": [
            "UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Connor", 
        "givenName": "Darran P", 
        "id": "sg:person.0737210461.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737210461.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Oncology, Department of Clinical Sciences, Lund University, Sk\u00e5ne University Hospital, Lund, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eberhard", 
        "givenName": "Jakob", 
        "id": "sg:person.0767340254.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767340254.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alvarado-Kristensson", 
        "givenName": "Maria", 
        "id": "sg:person.01037643515.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037643515.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University College Dublin", 
          "id": "https://www.grid.ac/institutes/grid.7886.1", 
          "name": [
            "School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jeffrey", 
        "givenName": "Ian B", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sk\u00e5ne University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411843.b", 
          "name": [
            "Division of Surgery, Department of Clinical Sciences, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden", 
            "The Malm\u00f6 Diet and Cancer Study, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Manjer", 
        "givenName": "Jonas", 
        "id": "sg:person.01001561122.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001561122.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Br\u00e4ndstedt", 
        "givenName": "Jenny", 
        "id": "sg:person.01277015413.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277015413.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Royal Institute of Technology", 
          "id": "https://www.grid.ac/institutes/grid.5037.1", 
          "name": [
            "Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Uhl\u00e9n", 
        "givenName": "Mathias", 
        "id": "sg:person.01023367713.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023367713.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Uppsala University", 
          "id": "https://www.grid.ac/institutes/grid.8993.b", 
          "name": [
            "Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pont\u00e9n", 
        "givenName": "Fredrik", 
        "id": "sg:person.0624124156.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624124156.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jirstr\u00f6m", 
        "givenName": "Karin", 
        "id": "sg:person.0773201354.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773201354.68"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1021/cr980421n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003460388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr980421n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003460388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.22114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004201935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.22114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004201935"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200500072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009612430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200500072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009612430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181c13326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010208528", 
          "https://doi.org/10.1203/pdr.0b013e3181c13326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181c13326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010208528", 
          "https://doi.org/10.1203/pdr.0b013e3181c13326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/pdr.0b013e3181c13326", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010208528", 
          "https://doi.org/10.1203/pdr.0b013e3181c13326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pmic.200800203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010974419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011224910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/19.2.185", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011853799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012184342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.20725", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012184342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m102399200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015579054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2009.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017485839", 
          "https://doi.org/10.1038/modpathol.2009.124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/modpathol.2009.124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017485839", 
          "https://doi.org/10.1038/modpathol.2009.124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018900397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018900397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019127499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m700411-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020687899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-0625.2003.00026.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022698170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022825825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024090124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024090124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030663176", 
          "https://doi.org/10.1038/nrc2167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1993.tb00647.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032578394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.1993.tb00647.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032578394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11864-009-0100-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033089256", 
          "https://doi.org/10.1007/s11864-009-0100-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11864-009-0100-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033089256", 
          "https://doi.org/10.1007/s11864-009-0100-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2796.1996.483819000.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034118802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.7059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034761890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035533524", 
          "https://doi.org/10.1038/sj.onc.1206933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206933", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035533524", 
          "https://doi.org/10.1038/sj.onc.1206933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/11.19.2279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035711191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)65039-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036823974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/mcp.m500279-mcp200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039760212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m402904200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042324711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.22547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043385388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcb.22547", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043385388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044896419", 
          "https://doi.org/10.1038/nrd1691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd1691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044896419", 
          "https://doi.org/10.1038/nrd1691"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/gyno.2001.6537", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045847444"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00301.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049121999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00301.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049121999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049534215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2008.97", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050040643", 
          "https://doi.org/10.1038/onc.2008.97"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0798-844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051373741", 
          "https://doi.org/10.1038/nm0798-844"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/4.12.2307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059645273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8036511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062652041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077127237", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "BACKGROUND: We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line.\nMETHODS: RBM3 mRNA expression was analysed in tumors from a cohort of 267 EOC cases (Cohort I) and RBM3 protein expression was analysed using immunohistochemistry (IHC) in an independent cohort of 154 prospectively collected EOC cases (Cohort II). Kaplan Meier analysis and Cox proportional hazards modelling were applied to assess the relationship between RBM3 and recurrence free survival (RFS) and overall survival (OS). Immunoblotting and IHC were used to examine the expression of RBM3 in a cisplatin-resistant ovarian cancer cell line A2780-Cp70 and its cisplatin-responsive parental cell line A2780. The impact of RBM3 on cisplatin response in EOC was assessed using siRNA-mediated silencing of RBM3 in A2780 cells followed by cell viability assay and cell cycle analysis.\nRESULTS: Increased RBM3 mRNA expression was associated with a prolonged RFS (HR = 0.64, 95% CI = 0.47-0.86, p = 0.003) and OS (HR = 0.64, 95% CI = 0.44-0.95, p = 0.024) in Cohort I. Multivariate analysis confirmed that RBM3 mRNA expression was an independent predictor of a prolonged RFS, (HR = 0.61, 95% CI = 0.44-0.84, p = 0.003) and OS (HR = 0.62, 95% CI = 0.41-0.95; p = 0.028) in Cohort I. In Cohort II, RBM3 protein expression was associated with a prolonged OS (HR = 0.53, 95% CI = 0.35-0.79, p = 0.002) confirmed by multivariate analysis (HR = 0.61, 95% CI = 0.40-0.92, p = 0.017). RBM3 mRNA and protein expression levels were significantly higher in the cisplatin sensitive A2780 cell line compared to the cisplatin resistant A2780-Cp70 derivative. siRNA-mediated silencing of RBM3 expression in the A2780 cells resulted in a decreased sensitivity to cisplatin as demonstrated by increased cell viability and reduced proportion of cells arrested in the G2/M-phase.\nCONCLUSIONS: These data demonstrate that RBM3 expression is associated with cisplatin sensitivity in vitro and with a good prognosis in EOC. Taken together these findings suggest that RBM3 may be a useful prognostic and treatment predictive marker in EOC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1479-5876-8-78", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer", 
    "pagination": "78", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7411c573e309ebaecaacec07b4e6d744b05579f3608e6dd3c6a3c795429f3bed"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20727170"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1479-5876-8-78"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024363411"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1479-5876-8-78", 
      "https://app.dimensions.ai/details/publication/pub.1024363411"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1479-5876-8-78"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-8-78'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-8-78'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-8-78'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-8-78'


 

This table displays all metadata directly associated to this object as RDF triples.

362 TRIPLES      21 PREDICATES      85 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1479-5876-8-78 schema:about N0435c19867344c4f9d9c9ec427a854af
2 N15d3d5477cb840238355012f38c3d1e4
3 N1c9a468c535149349ebf684642426cec
4 N2dab77e9b6154e0f904c32dfb6e47e44
5 N3c613e33b61448eea96537e8479cc2b1
6 N47086aeeedca477681ae9f766d2115d7
7 N5906c39110184aa9a799e7c8f0c874a5
8 N5de00c71cb7a45b5baeb9ca3cf4d1714
9 N71e708ea6d664b10be5258628aeb2e4a
10 N862e90749bee44f5b769314c7f06ef25
11 N8f279af7b71f4be3b0118091a300f9df
12 N98d11a22b5b041c898a938eccd554365
13 Na9ab00a728f84cd1abfcc76955d667ab
14 Nb8b59494b485493dacd4517cec26ddfd
15 Nbfc7242352064fd0b47dc877008894fe
16 Ncc96b9f724b7474384c2e292e9826b43
17 Ne71403811cc14e708d118ff7674f232d
18 Nebb4d342ea634a99a7e06dfc7400f35f
19 Ned0a033ac2ca4379819d70419ca46dae
20 Nf9dfb3d5f29c4065bf9ff94c2694823b
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author N4563368eddf64d4c9f3c9217f3ba4b0e
24 schema:citation sg:pub.10.1007/s11864-009-0100-x
25 sg:pub.10.1038/modpathol.2009.124
26 sg:pub.10.1038/nm0798-844
27 sg:pub.10.1038/nrc2167
28 sg:pub.10.1038/nrd1691
29 sg:pub.10.1038/onc.2008.97
30 sg:pub.10.1038/sj.onc.1206933
31 sg:pub.10.1203/pdr.0b013e3181c13326
32 https://app.dimensions.ai/details/publication/pub.1077127237
33 https://doi.org/10.1002/jcb.20204
34 https://doi.org/10.1002/jcb.20725
35 https://doi.org/10.1002/jcb.22114
36 https://doi.org/10.1002/jcb.22547
37 https://doi.org/10.1002/path.2440
38 https://doi.org/10.1002/pmic.200500072
39 https://doi.org/10.1002/pmic.200800203
40 https://doi.org/10.1006/bbrc.1997.7059
41 https://doi.org/10.1006/gyno.2001.6537
42 https://doi.org/10.1016/j.ccr.2005.07.009
43 https://doi.org/10.1016/s0002-9440(10)65039-0
44 https://doi.org/10.1021/cr980421n
45 https://doi.org/10.1034/j.1600-0625.2003.00026.x
46 https://doi.org/10.1046/j.1365-2796.1996.483819000.x
47 https://doi.org/10.1074/jbc.m102399200
48 https://doi.org/10.1074/jbc.m402904200
49 https://doi.org/10.1074/mcp.m500279-mcp200
50 https://doi.org/10.1074/mcp.m700411-mcp200
51 https://doi.org/10.1093/bioinformatics/19.2.185
52 https://doi.org/10.1093/hmg/11.19.2279
53 https://doi.org/10.1093/hmg/4.12.2307
54 https://doi.org/10.1111/j.1365-2796.1993.tb00647.x
55 https://doi.org/10.1126/science.8036511
56 https://doi.org/10.1152/physiolgenomics.00301.2004
57 https://doi.org/10.1158/1078-0432.ccr-08-0196
58 https://doi.org/10.1242/jcs.01026
59 https://doi.org/10.3322/caac.20006
60 schema:datePublished 2010-12
61 schema:datePublishedReg 2010-12-01
62 schema:description BACKGROUND: We recently demonstrated that increased expression of the RNA-binding protein RBM3 is associated with a favourable prognosis in breast cancer. The aim of this study was to examine the prognostic value of RBM3 mRNA and protein expression in epithelial ovarian cancer (EOC) and the cisplatin response upon RBM3 depletion in a cisplatin-sensitive ovarian cancer cell line. METHODS: RBM3 mRNA expression was analysed in tumors from a cohort of 267 EOC cases (Cohort I) and RBM3 protein expression was analysed using immunohistochemistry (IHC) in an independent cohort of 154 prospectively collected EOC cases (Cohort II). Kaplan Meier analysis and Cox proportional hazards modelling were applied to assess the relationship between RBM3 and recurrence free survival (RFS) and overall survival (OS). Immunoblotting and IHC were used to examine the expression of RBM3 in a cisplatin-resistant ovarian cancer cell line A2780-Cp70 and its cisplatin-responsive parental cell line A2780. The impact of RBM3 on cisplatin response in EOC was assessed using siRNA-mediated silencing of RBM3 in A2780 cells followed by cell viability assay and cell cycle analysis. RESULTS: Increased RBM3 mRNA expression was associated with a prolonged RFS (HR = 0.64, 95% CI = 0.47-0.86, p = 0.003) and OS (HR = 0.64, 95% CI = 0.44-0.95, p = 0.024) in Cohort I. Multivariate analysis confirmed that RBM3 mRNA expression was an independent predictor of a prolonged RFS, (HR = 0.61, 95% CI = 0.44-0.84, p = 0.003) and OS (HR = 0.62, 95% CI = 0.41-0.95; p = 0.028) in Cohort I. In Cohort II, RBM3 protein expression was associated with a prolonged OS (HR = 0.53, 95% CI = 0.35-0.79, p = 0.002) confirmed by multivariate analysis (HR = 0.61, 95% CI = 0.40-0.92, p = 0.017). RBM3 mRNA and protein expression levels were significantly higher in the cisplatin sensitive A2780 cell line compared to the cisplatin resistant A2780-Cp70 derivative. siRNA-mediated silencing of RBM3 expression in the A2780 cells resulted in a decreased sensitivity to cisplatin as demonstrated by increased cell viability and reduced proportion of cells arrested in the G2/M-phase. CONCLUSIONS: These data demonstrate that RBM3 expression is associated with cisplatin sensitivity in vitro and with a good prognosis in EOC. Taken together these findings suggest that RBM3 may be a useful prognostic and treatment predictive marker in EOC.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf N2cba13c571ea4935b5eda25eb3fa23d3
67 Nd4546a10818f47978aa35be0fb8452cd
68 sg:journal.1032886
69 schema:name Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
70 schema:pagination 78
71 schema:productId N172f69970fab41e8b03447b61661d39a
72 Na34eecec203842e99e8859a808e600f8
73 Ncee72659ea3e4d46ac52a0b0f41d6ce4
74 Nd3539356a6444e288dae91f0ba7f1e34
75 Nf6b31bd337c54c41bfff33b7570a19a5
76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024363411
77 https://doi.org/10.1186/1479-5876-8-78
78 schema:sdDatePublished 2019-04-10T13:16
79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
80 schema:sdPublisher N7802a7818ea946d3869dce9821d6ece9
81 schema:url http://link.springer.com/10.1186%2F1479-5876-8-78
82 sgo:license sg:explorer/license/
83 sgo:sdDataset articles
84 rdf:type schema:ScholarlyArticle
85 N0435c19867344c4f9d9c9ec427a854af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name RNA-Binding Proteins
87 rdf:type schema:DefinedTerm
88 N07d8432fb64d4c268a287f8d7034803f schema:name Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden
89 rdf:type schema:Organization
90 N07e979618ec244b3b1826a89ce1fbda6 rdf:first sg:person.01037643515.36
91 rdf:rest N83d317670c884c23a20e90b33b9a0b12
92 N15d3d5477cb840238355012f38c3d1e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Prognosis
94 rdf:type schema:DefinedTerm
95 N172f69970fab41e8b03447b61661d39a schema:name dimensions_id
96 schema:value pub.1024363411
97 rdf:type schema:PropertyValue
98 N1c9a468c535149349ebf684642426cec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 N2cba13c571ea4935b5eda25eb3fa23d3 schema:issueNumber 1
102 rdf:type schema:PublicationIssue
103 N2dab77e9b6154e0f904c32dfb6e47e44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Apoptosis
105 rdf:type schema:DefinedTerm
106 N3b6e4c83d65041c4acea7c331cac8822 rdf:first sg:person.01277015413.32
107 rdf:rest N8f62d04959714f158a4d4a006e8c743e
108 N3c613e33b61448eea96537e8479cc2b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cell Line, Tumor
110 rdf:type schema:DefinedTerm
111 N43d9a422d6664ae0b131d22ac50e194f rdf:first sg:person.01143415300.42
112 rdf:rest Nac7cb075f6954a3f91ed91b88033932f
113 N4563368eddf64d4c9f3c9217f3ba4b0e rdf:first sg:person.01361322431.33
114 rdf:rest N43d9a422d6664ae0b131d22ac50e194f
115 N47086aeeedca477681ae9f766d2115d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Antibody Specificity
117 rdf:type schema:DefinedTerm
118 N5906c39110184aa9a799e7c8f0c874a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Ovarian Neoplasms
120 rdf:type schema:DefinedTerm
121 N5de00c71cb7a45b5baeb9ca3cf4d1714 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Down-Regulation
123 rdf:type schema:DefinedTerm
124 N609390fd007a42389284f9677f5727e8 schema:name Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden
125 rdf:type schema:Organization
126 N6307feaffa154169843bdb47f97bf4ae schema:name Division of Oncology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden
127 rdf:type schema:Organization
128 N71e708ea6d664b10be5258628aeb2e4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cell Cycle
130 rdf:type schema:DefinedTerm
131 N7802a7818ea946d3869dce9821d6ece9 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 N7b3c5782be9d4143ade9905092dc7005 rdf:first sg:person.01001561122.12
134 rdf:rest N3b6e4c83d65041c4acea7c331cac8822
135 N83d317670c884c23a20e90b33b9a0b12 rdf:first Na274eb78dd7f4f7396a3bda8088621f5
136 rdf:rest N7b3c5782be9d4143ade9905092dc7005
137 N862e90749bee44f5b769314c7f06ef25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Antibodies, Neoplasm
139 rdf:type schema:DefinedTerm
140 N893bcc031d3b4382a747251f950a193c schema:name Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden
141 rdf:type schema:Organization
142 N8f279af7b71f4be3b0118091a300f9df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Drug Resistance, Neoplasm
144 rdf:type schema:DefinedTerm
145 N8f62d04959714f158a4d4a006e8c743e rdf:first sg:person.01023367713.91
146 rdf:rest Na3d35734fb514811b039d1d3a5e45826
147 N98d11a22b5b041c898a938eccd554365 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Gene Expression Regulation, Neoplastic
149 rdf:type schema:DefinedTerm
150 N9afb87a5018c41158fc63b4b91f04fa7 rdf:first sg:person.0773201354.68
151 rdf:rest rdf:nil
152 Na274eb78dd7f4f7396a3bda8088621f5 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
153 schema:familyName Jeffrey
154 schema:givenName Ian B
155 rdf:type schema:Person
156 Na34eecec203842e99e8859a808e600f8 schema:name nlm_unique_id
157 schema:value 101190741
158 rdf:type schema:PropertyValue
159 Na3d35734fb514811b039d1d3a5e45826 rdf:first sg:person.0624124156.53
160 rdf:rest N9afb87a5018c41158fc63b4b91f04fa7
161 Na948e0ac4c3f4f1c8a5427675b484208 rdf:first sg:person.0737210461.31
162 rdf:rest Ne7d9f6dc2e534825a94b70b253268809
163 Na9ab00a728f84cd1abfcc76955d667ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Neoplasms, Glandular and Epithelial
165 rdf:type schema:DefinedTerm
166 Nac7cb075f6954a3f91ed91b88033932f rdf:first sg:person.0652655660.10
167 rdf:rest Na948e0ac4c3f4f1c8a5427675b484208
168 Nb0b36d38114d45d19c697b20eafc2ad3 schema:name Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden
169 rdf:type schema:Organization
170 Nb8b59494b485493dacd4517cec26ddfd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Cisplatin
172 rdf:type schema:DefinedTerm
173 Nbfc7242352064fd0b47dc877008894fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Antineoplastic Agents
175 rdf:type schema:DefinedTerm
176 Ncc96b9f724b7474384c2e292e9826b43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Female
178 rdf:type schema:DefinedTerm
179 Ncee72659ea3e4d46ac52a0b0f41d6ce4 schema:name readcube_id
180 schema:value 7411c573e309ebaecaacec07b4e6d744b05579f3608e6dd3c6a3c795429f3bed
181 rdf:type schema:PropertyValue
182 Nd3539356a6444e288dae91f0ba7f1e34 schema:name pubmed_id
183 schema:value 20727170
184 rdf:type schema:PropertyValue
185 Nd4546a10818f47978aa35be0fb8452cd schema:volumeNumber 8
186 rdf:type schema:PublicationVolume
187 Ne6545c4c12d944eb8efb96f8a0d308aa schema:name Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden
188 rdf:type schema:Organization
189 Ne71403811cc14e708d118ff7674f232d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Cell Survival
191 rdf:type schema:DefinedTerm
192 Ne7d9f6dc2e534825a94b70b253268809 rdf:first sg:person.0767340254.86
193 rdf:rest N07e979618ec244b3b1826a89ce1fbda6
194 Nebb4d342ea634a99a7e06dfc7400f35f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name RNA, Messenger
196 rdf:type schema:DefinedTerm
197 Ned0a033ac2ca4379819d70419ca46dae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Survival Analysis
199 rdf:type schema:DefinedTerm
200 Nf6b31bd337c54c41bfff33b7570a19a5 schema:name doi
201 schema:value 10.1186/1479-5876-8-78
202 rdf:type schema:PropertyValue
203 Nf9dfb3d5f29c4065bf9ff94c2694823b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Reproducibility of Results
205 rdf:type schema:DefinedTerm
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
210 schema:name Oncology and Carcinogenesis
211 rdf:type schema:DefinedTerm
212 sg:journal.1032886 schema:issn 1479-5876
213 schema:name Journal of Translational Medicine
214 rdf:type schema:Periodical
215 sg:person.01001561122.12 schema:affiliation https://www.grid.ac/institutes/grid.411843.b
216 schema:familyName Manjer
217 schema:givenName Jonas
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001561122.12
219 rdf:type schema:Person
220 sg:person.01023367713.91 schema:affiliation https://www.grid.ac/institutes/grid.5037.1
221 schema:familyName Uhlén
222 schema:givenName Mathias
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023367713.91
224 rdf:type schema:Person
225 sg:person.01037643515.36 schema:affiliation Ne6545c4c12d944eb8efb96f8a0d308aa
226 schema:familyName Alvarado-Kristensson
227 schema:givenName Maria
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037643515.36
229 rdf:type schema:Person
230 sg:person.01143415300.42 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
231 schema:familyName Brennan
232 schema:givenName Donal J
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143415300.42
234 rdf:type schema:Person
235 sg:person.01277015413.32 schema:affiliation N609390fd007a42389284f9677f5727e8
236 schema:familyName Brändstedt
237 schema:givenName Jenny
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277015413.32
239 rdf:type schema:Person
240 sg:person.01361322431.33 schema:affiliation N07d8432fb64d4c268a287f8d7034803f
241 schema:familyName Ehlén
242 schema:givenName Åsa
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361322431.33
244 rdf:type schema:Person
245 sg:person.0624124156.53 schema:affiliation https://www.grid.ac/institutes/grid.8993.b
246 schema:familyName Pontén
247 schema:givenName Fredrik
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624124156.53
249 rdf:type schema:Person
250 sg:person.0652655660.10 schema:affiliation N893bcc031d3b4382a747251f950a193c
251 schema:familyName Nodin
252 schema:givenName Björn
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652655660.10
254 rdf:type schema:Person
255 sg:person.0737210461.31 schema:affiliation https://www.grid.ac/institutes/grid.7886.1
256 schema:familyName O'Connor
257 schema:givenName Darran P
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737210461.31
259 rdf:type schema:Person
260 sg:person.0767340254.86 schema:affiliation N6307feaffa154169843bdb47f97bf4ae
261 schema:familyName Eberhard
262 schema:givenName Jakob
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767340254.86
264 rdf:type schema:Person
265 sg:person.0773201354.68 schema:affiliation Nb0b36d38114d45d19c697b20eafc2ad3
266 schema:familyName Jirström
267 schema:givenName Karin
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0773201354.68
269 rdf:type schema:Person
270 sg:pub.10.1007/s11864-009-0100-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033089256
271 https://doi.org/10.1007/s11864-009-0100-x
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/modpathol.2009.124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017485839
274 https://doi.org/10.1038/modpathol.2009.124
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nm0798-844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051373741
277 https://doi.org/10.1038/nm0798-844
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nrc2167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030663176
280 https://doi.org/10.1038/nrc2167
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nrd1691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044896419
283 https://doi.org/10.1038/nrd1691
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/onc.2008.97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050040643
286 https://doi.org/10.1038/onc.2008.97
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/sj.onc.1206933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035533524
289 https://doi.org/10.1038/sj.onc.1206933
290 rdf:type schema:CreativeWork
291 sg:pub.10.1203/pdr.0b013e3181c13326 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010208528
292 https://doi.org/10.1203/pdr.0b013e3181c13326
293 rdf:type schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1077127237 schema:CreativeWork
295 https://doi.org/10.1002/jcb.20204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011224910
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1002/jcb.20725 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012184342
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1002/jcb.22114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004201935
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/jcb.22547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043385388
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/path.2440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018900397
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1002/pmic.200500072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009612430
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1002/pmic.200800203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010974419
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1006/bbrc.1997.7059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034761890
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1006/gyno.2001.6537 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045847444
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.ccr.2005.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024090124
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/s0002-9440(10)65039-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036823974
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1021/cr980421n schema:sameAs https://app.dimensions.ai/details/publication/pub.1003460388
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1034/j.1600-0625.2003.00026.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1022698170
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1046/j.1365-2796.1996.483819000.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034118802
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1074/jbc.m102399200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015579054
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1074/jbc.m402904200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042324711
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1074/mcp.m500279-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039760212
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1074/mcp.m700411-mcp200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020687899
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1093/bioinformatics/19.2.185 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011853799
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1093/hmg/11.19.2279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035711191
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1093/hmg/4.12.2307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059645273
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1111/j.1365-2796.1993.tb00647.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032578394
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1126/science.8036511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652041
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1152/physiolgenomics.00301.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049121999
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1158/1078-0432.ccr-08-0196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049534215
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1242/jcs.01026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019127499
346 rdf:type schema:CreativeWork
347 https://doi.org/10.3322/caac.20006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022825825
348 rdf:type schema:CreativeWork
349 https://www.grid.ac/institutes/grid.411843.b schema:alternateName Skåne University Hospital
350 schema:name Division of Surgery, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden
351 The Malmö Diet and Cancer Study, Skåne University Hospital, Malmö, Sweden
352 rdf:type schema:Organization
353 https://www.grid.ac/institutes/grid.5037.1 schema:alternateName Royal Institute of Technology
354 schema:name Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology, Stockholm, Sweden
355 rdf:type schema:Organization
356 https://www.grid.ac/institutes/grid.7886.1 schema:alternateName University College Dublin
357 schema:name School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
358 UCD School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
359 rdf:type schema:Organization
360 https://www.grid.ac/institutes/grid.8993.b schema:alternateName Uppsala University
361 schema:name Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
362 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...