Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Kelly L Brown, Reza Falsafi, Winnie Kum, Pamela Hamill, Jennifer L Gardy, Donald J Davidson, Stuart Turvey, Brett B Finlay, David P Speert, Robert EW Hancock

ABSTRACT

BACKGROUND: Activation of Toll-like receptors (TLRs) is widely accepted as an essential event for defence against infection. Many TLRs utilize a common signalling pathway that relies on activation of the kinase IRAK4 and the transcription factor NFkappaB for the rapid expression of immunity genes. METHODS: 21 K DNA microarray technology was used to evaluate LPS-induced (TLR4) gene responses in blood monocytes from a child with an IRAK4-deficiency. In vitro responsiveness to LPS was confirmed by real-time PCR and ELISA and compared to the clinical predisposition of the child and IRAK4-deficient mice to Gram negative infection. RESULTS: We demonstrated that the vast majority of LPS-responsive genes in IRAK4-deficient monocytes were greatly suppressed, an observation that is consistent with the described role for IRAK4 as an essential component of TLR4 signalling. The severely impaired response to LPS, however, is inconsistent with a remarkably low incidence of Gram negative infections observed in this child and other children with IRAK4-deficiency. This unpredicted clinical phenotype was validated by demonstrating that IRAK4-deficient mice had a similar resistance to infection with Gram negative S. typhimurium as wildtype mice. A number of immunity genes, such as chemokines, were expressed at normal levels in human IRAK4-deficient monocytes, indicating that particular IRAK4-independent elements within the repertoire of TLR4-induced responses are expressed. CONCLUSIONS: Sufficient defence to Gram negative immunity does not require IRAK4 or a robust, 'classic' inflammatory and immune response. More... »

PAGES

6

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1479-5876-8-6

DOI

http://dx.doi.org/10.1186/1479-5876-8-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004232048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20105294


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Child", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-1 Receptor-Associated Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipopolysaccharides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Monocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-kappa B", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Salmonella typhimurium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Toll-Like Receptor 4", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Gothenburg", 
          "id": "https://www.grid.ac/institutes/grid.8761.8", 
          "name": [
            "Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada", 
            "Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, V5Z 4H4, Vancouver, British Columbia, Canada", 
            "Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10, S-413 46, Gothenburg, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brown", 
        "givenName": "Kelly L", 
        "id": "sg:person.0733531603.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733531603.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Falsafi", 
        "givenName": "Reza", 
        "id": "sg:person.0663327337.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663327337.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kum", 
        "givenName": "Winnie", 
        "id": "sg:person.01212362334.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212362334.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hamill", 
        "givenName": "Pamela", 
        "id": "sg:person.01137260042.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137260042.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gardy", 
        "givenName": "Jennifer L", 
        "id": "sg:person.0744777402.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744777402.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Edinburgh", 
          "id": "https://www.grid.ac/institutes/grid.4305.2", 
          "name": [
            "Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, V5Z 4H4, Vancouver, British Columbia, Canada", 
            "MRC/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute W2 03, 47 Little France Crescent, EH16 4T, Edinburgh, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davidson", 
        "givenName": "Donald J", 
        "id": "sg:person.014220213672.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014220213672.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, V5Z 4H4, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turvey", 
        "givenName": "Stuart", 
        "id": "sg:person.0765661111.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765661111.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Finlay", 
        "givenName": "Brett B", 
        "id": "sg:person.015564661542.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015564661542.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, V5Z 4H4, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Speert", 
        "givenName": "David P", 
        "id": "sg:person.01132600451.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132600451.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hancock", 
        "givenName": "Robert EW", 
        "id": "sg:person.01125176622.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125176622.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.cell.2006.02.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002827362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003145143", 
          "https://doi.org/10.1038/nature736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003145143", 
          "https://doi.org/10.1038/nature736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0280551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003289349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0280551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003289349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004682502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200838161", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011438033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200737886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012135195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015379793", 
          "https://doi.org/10.1038/nature04267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015379793", 
          "https://doi.org/10.1038/nature04267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015379793", 
          "https://doi.org/10.1038/nature04267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0510874103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015771737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2007.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019014221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.0022-202x.2005.23841.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021020153", 
          "https://doi.org/10.1111/j.0022-202x.2005.23841.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0022-202x.2005.23841.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021020153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023753307", 
          "https://doi.org/10.1038/nri1391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri1391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023753307", 
          "https://doi.org/10.1038/nri1391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.0105-2896.2005.00235.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024481081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00128.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027184516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2004.06.065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027233918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2005.04.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029156800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029788541", 
          "https://doi.org/10.1038/nbt1288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1473-3099(09)70255-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030286323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2006.10.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031034142"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20061523", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033041964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-5-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033139728", 
          "https://doi.org/10.1186/1471-2105-5-16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-5-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033139728", 
          "https://doi.org/10.1186/1471-2105-5-16"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1112304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035171949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20070628", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037437104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199906103402312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037663367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2005.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038598649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkh446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041187811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/428733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042788899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-7613(00)80086-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044146057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clim.2008.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044517166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/291238a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044840752", 
          "https://doi.org/10.1038/291238a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.176.4.2455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045733464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1465-9921-5-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045735703", 
          "https://doi.org/10.1186/1465-9921-5-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00335-002-2261-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050447380", 
          "https://doi.org/10.1007/s00335-002-2261-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpeds.2003.10.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052095486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052167491", 
          "https://doi.org/10.1038/nature02738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature02738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052167491", 
          "https://doi.org/10.1038/nature02738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20061825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052626956"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.1239303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052744398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5483/bmbrep.2005.38.2.121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053665896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1081902", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062447874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.281.5379.1001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062562056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci21027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.165.10.5392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074724722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.167.9.5367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074944335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.169.7.3863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075128353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.171.9.4758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076583951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.171.11.6065", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076602203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.172.6.3377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076805983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.177.11.8202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077326032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083056592", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-12", 
    "datePublishedReg": "2010-12-01", 
    "description": "BACKGROUND: Activation of Toll-like receptors (TLRs) is widely accepted as an essential event for defence against infection. Many TLRs utilize a common signalling pathway that relies on activation of the kinase IRAK4 and the transcription factor NFkappaB for the rapid expression of immunity genes.\nMETHODS: 21 K DNA microarray technology was used to evaluate LPS-induced (TLR4) gene responses in blood monocytes from a child with an IRAK4-deficiency. In vitro responsiveness to LPS was confirmed by real-time PCR and ELISA and compared to the clinical predisposition of the child and IRAK4-deficient mice to Gram negative infection.\nRESULTS: We demonstrated that the vast majority of LPS-responsive genes in IRAK4-deficient monocytes were greatly suppressed, an observation that is consistent with the described role for IRAK4 as an essential component of TLR4 signalling. The severely impaired response to LPS, however, is inconsistent with a remarkably low incidence of Gram negative infections observed in this child and other children with IRAK4-deficiency. This unpredicted clinical phenotype was validated by demonstrating that IRAK4-deficient mice had a similar resistance to infection with Gram negative S. typhimurium as wildtype mice. A number of immunity genes, such as chemokines, were expressed at normal levels in human IRAK4-deficient monocytes, indicating that particular IRAK4-independent elements within the repertoire of TLR4-induced responses are expressed.\nCONCLUSIONS: Sufficient defence to Gram negative immunity does not require IRAK4 or a robust, 'classic' inflammatory and immune response.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1479-5876-8-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3628651", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3772849", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "name": "Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity", 
    "pagination": "6", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "142aa3bc80f10a033ceabfd70ae97dc792301483f64db4d9c10b83cb5cd21d29"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20105294"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1479-5876-8-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004232048"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1479-5876-8-6", 
      "https://app.dimensions.ai/details/publication/pub.1004232048"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1479-5876-8-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-8-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-8-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-8-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-8-6'


 

This table displays all metadata directly associated to this object as RDF triples.

377 TRIPLES      21 PREDICATES      97 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1479-5876-8-6 schema:about N283b3aff375f40cd99d4438f0077fb2e
2 N39cb8245a8d54f81a6fe228f1addc7f2
3 N612d9b7d4d9c4d3d817c1c217ca2bf0a
4 N66538fc700054a19b7cf70933ee1064c
5 N679aaa2059d34b3592b88190a0f6eb94
6 N6e0217f2a2bd461e89d9df09492f9839
7 N80a695b9ad6e4edaaec9e6a8b90add83
8 N84f110e86e224d37aec19673f54c49da
9 N8bcebca9dc53446b8cae734a416c18cb
10 N8e66ce3b5c4443329af2c63ec53a273a
11 N9bc0cd4b2f30483db4bb9f1c240874cf
12 N9ebaddba263f43c79a499d0190ade98b
13 Na6e7886c0104469597100aa2495b3da1
14 Nacda98ca35924fdcb7c6d860d33b0207
15 Nad75f5ca22ff4a3d8fd0119e30cc5775
16 Nbc40fb7b9f424dbfbb3ba40afb1239e8
17 Nce61bae05a684430bd782a966f7bf654
18 Ne30613d2f4164c689f3d8a1ced60e82e
19 Ne8272707a1f54ea688c49fcab0e320e7
20 anzsrc-for:11
21 anzsrc-for:1107
22 schema:author Nd40fa88ae5d04657bbf1d90b2d99aa0f
23 schema:citation sg:pub.10.1007/s00335-002-2261-9
24 sg:pub.10.1038/291238a0
25 sg:pub.10.1038/nature02738
26 sg:pub.10.1038/nature04267
27 sg:pub.10.1038/nature736
28 sg:pub.10.1038/nbt1288
29 sg:pub.10.1038/nri1391
30 sg:pub.10.1111/j.0022-202x.2005.23841.x
31 sg:pub.10.1186/1465-9921-5-1
32 sg:pub.10.1186/1471-2105-5-16
33 https://app.dimensions.ai/details/publication/pub.1083056592
34 https://doi.org/10.1002/eji.200737886
35 https://doi.org/10.1002/eji.200838161
36 https://doi.org/10.1016/j.cell.2006.02.015
37 https://doi.org/10.1016/j.clim.2006.10.012
38 https://doi.org/10.1016/j.clim.2008.06.005
39 https://doi.org/10.1016/j.febslet.2005.04.024
40 https://doi.org/10.1016/j.it.2005.06.004
41 https://doi.org/10.1016/j.it.2007.04.005
42 https://doi.org/10.1016/j.jpeds.2003.10.034
43 https://doi.org/10.1016/j.jpeds.2004.06.065
44 https://doi.org/10.1016/s1074-7613(00)80086-2
45 https://doi.org/10.1016/s1473-3099(09)70255-5
46 https://doi.org/10.1042/bst0280551
47 https://doi.org/10.1056/nejm199906103402312
48 https://doi.org/10.1073/pnas.0510874103
49 https://doi.org/10.1084/jem.20030701
50 https://doi.org/10.1084/jem.20061523
51 https://doi.org/10.1084/jem.20061825
52 https://doi.org/10.1084/jem.20070628
53 https://doi.org/10.1086/428733
54 https://doi.org/10.1093/nar/gkh446
55 https://doi.org/10.1101/gr.1239303
56 https://doi.org/10.1111/j.0022-202x.2005.23841.x
57 https://doi.org/10.1111/j.0105-2896.2005.00235.x
58 https://doi.org/10.1126/science.1081902
59 https://doi.org/10.1126/science.1112304
60 https://doi.org/10.1126/science.281.5379.1001
61 https://doi.org/10.1152/physiolgenomics.00128.2004
62 https://doi.org/10.1172/jci21027
63 https://doi.org/10.4049/jimmunol.165.10.5392
64 https://doi.org/10.4049/jimmunol.167.9.5367
65 https://doi.org/10.4049/jimmunol.169.7.3863
66 https://doi.org/10.4049/jimmunol.171.11.6065
67 https://doi.org/10.4049/jimmunol.171.9.4758
68 https://doi.org/10.4049/jimmunol.172.6.3377
69 https://doi.org/10.4049/jimmunol.176.4.2455
70 https://doi.org/10.4049/jimmunol.177.11.8202
71 https://doi.org/10.5483/bmbrep.2005.38.2.121
72 schema:datePublished 2010-12
73 schema:datePublishedReg 2010-12-01
74 schema:description BACKGROUND: Activation of Toll-like receptors (TLRs) is widely accepted as an essential event for defence against infection. Many TLRs utilize a common signalling pathway that relies on activation of the kinase IRAK4 and the transcription factor NFkappaB for the rapid expression of immunity genes. METHODS: 21 K DNA microarray technology was used to evaluate LPS-induced (TLR4) gene responses in blood monocytes from a child with an IRAK4-deficiency. In vitro responsiveness to LPS was confirmed by real-time PCR and ELISA and compared to the clinical predisposition of the child and IRAK4-deficient mice to Gram negative infection. RESULTS: We demonstrated that the vast majority of LPS-responsive genes in IRAK4-deficient monocytes were greatly suppressed, an observation that is consistent with the described role for IRAK4 as an essential component of TLR4 signalling. The severely impaired response to LPS, however, is inconsistent with a remarkably low incidence of Gram negative infections observed in this child and other children with IRAK4-deficiency. This unpredicted clinical phenotype was validated by demonstrating that IRAK4-deficient mice had a similar resistance to infection with Gram negative S. typhimurium as wildtype mice. A number of immunity genes, such as chemokines, were expressed at normal levels in human IRAK4-deficient monocytes, indicating that particular IRAK4-independent elements within the repertoire of TLR4-induced responses are expressed. CONCLUSIONS: Sufficient defence to Gram negative immunity does not require IRAK4 or a robust, 'classic' inflammatory and immune response.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N3b8fcc79ceb8493e886b15f07934682b
79 N734e319b5efa4d2d99dbaf661255005b
80 sg:journal.1032886
81 schema:name Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity
82 schema:pagination 6
83 schema:productId N543cba5f23e44c8d9269ec050be8fcb1
84 N57ec8485efca4990b2ccd1f096d261a1
85 Naf2d40497584475d80f3b3e94d5a752b
86 Nbc5def6ee3224c52a9c6966818537530
87 Nd0e89c2d96db4db1b9a0504c03935283
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004232048
89 https://doi.org/10.1186/1479-5876-8-6
90 schema:sdDatePublished 2019-04-11T00:15
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher N9b45abff448a4246a338b03fab126f72
93 schema:url http://link.springer.com/10.1186%2F1479-5876-8-6
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N108fee5fb2e24ec3a626d568569b6667 rdf:first sg:person.0663327337.59
98 rdf:rest N4ba6aaac8e8246f09e8032613b621504
99 N16d4df252d3b4c75ae22545b57931bf7 rdf:first sg:person.01125176622.90
100 rdf:rest rdf:nil
101 N266d7f0103954c1a9444e60d40d0160b rdf:first sg:person.0744777402.71
102 rdf:rest N979f3dfade6c4baab33cc3c3e08a5d9d
103 N283b3aff375f40cd99d4438f0077fb2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Child
105 rdf:type schema:DefinedTerm
106 N31c83efa216b46fd94dcc0ee7bb25c0b rdf:first sg:person.015564661542.34
107 rdf:rest Nb0246e23c2c44fb3a8aa100399dfbadf
108 N39cb8245a8d54f81a6fe228f1addc7f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Salmonella typhimurium
110 rdf:type schema:DefinedTerm
111 N3b8fcc79ceb8493e886b15f07934682b schema:volumeNumber 8
112 rdf:type schema:PublicationVolume
113 N4ba6aaac8e8246f09e8032613b621504 rdf:first sg:person.01212362334.61
114 rdf:rest Nf6d001e0f7864f369c48315dd382456c
115 N543cba5f23e44c8d9269ec050be8fcb1 schema:name dimensions_id
116 schema:value pub.1004232048
117 rdf:type schema:PropertyValue
118 N57ec8485efca4990b2ccd1f096d261a1 schema:name readcube_id
119 schema:value 142aa3bc80f10a033ceabfd70ae97dc792301483f64db4d9c10b83cb5cd21d29
120 rdf:type schema:PropertyValue
121 N612d9b7d4d9c4d3d817c1c217ca2bf0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Polymerase Chain Reaction
123 rdf:type schema:DefinedTerm
124 N66538fc700054a19b7cf70933ee1064c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Toll-Like Receptor 4
126 rdf:type schema:DefinedTerm
127 N679aaa2059d34b3592b88190a0f6eb94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Humans
129 rdf:type schema:DefinedTerm
130 N6e0217f2a2bd461e89d9df09492f9839 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Interleukin-1 Receptor-Associated Kinases
132 rdf:type schema:DefinedTerm
133 N734e319b5efa4d2d99dbaf661255005b schema:issueNumber 1
134 rdf:type schema:PublicationIssue
135 N80a695b9ad6e4edaaec9e6a8b90add83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Gene Expression Profiling
137 rdf:type schema:DefinedTerm
138 N84f110e86e224d37aec19673f54c49da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Signal Transduction
140 rdf:type schema:DefinedTerm
141 N8bcebca9dc53446b8cae734a416c18cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Animals
143 rdf:type schema:DefinedTerm
144 N8e66ce3b5c4443329af2c63ec53a273a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Monocytes
146 rdf:type schema:DefinedTerm
147 N979f3dfade6c4baab33cc3c3e08a5d9d rdf:first sg:person.014220213672.66
148 rdf:rest Nf23f2985034a40449962104417ff80ef
149 N9b45abff448a4246a338b03fab126f72 schema:name Springer Nature - SN SciGraph project
150 rdf:type schema:Organization
151 N9bc0cd4b2f30483db4bb9f1c240874cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Lipopolysaccharides
153 rdf:type schema:DefinedTerm
154 N9ebaddba263f43c79a499d0190ade98b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Mice
156 rdf:type schema:DefinedTerm
157 Na6e7886c0104469597100aa2495b3da1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Immunity
159 rdf:type schema:DefinedTerm
160 Nacda98ca35924fdcb7c6d860d33b0207 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Gene Expression Regulation
162 rdf:type schema:DefinedTerm
163 Nad75f5ca22ff4a3d8fd0119e30cc5775 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name NF-kappa B
165 rdf:type schema:DefinedTerm
166 Naf2d40497584475d80f3b3e94d5a752b schema:name pubmed_id
167 schema:value 20105294
168 rdf:type schema:PropertyValue
169 Nb0246e23c2c44fb3a8aa100399dfbadf rdf:first sg:person.01132600451.96
170 rdf:rest N16d4df252d3b4c75ae22545b57931bf7
171 Nbc40fb7b9f424dbfbb3ba40afb1239e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Oligonucleotide Array Sequence Analysis
173 rdf:type schema:DefinedTerm
174 Nbc5def6ee3224c52a9c6966818537530 schema:name nlm_unique_id
175 schema:value 101190741
176 rdf:type schema:PropertyValue
177 Nce61bae05a684430bd782a966f7bf654 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Mice, Inbred C57BL
179 rdf:type schema:DefinedTerm
180 Nd0e89c2d96db4db1b9a0504c03935283 schema:name doi
181 schema:value 10.1186/1479-5876-8-6
182 rdf:type schema:PropertyValue
183 Nd40fa88ae5d04657bbf1d90b2d99aa0f rdf:first sg:person.0733531603.43
184 rdf:rest N108fee5fb2e24ec3a626d568569b6667
185 Ne30613d2f4164c689f3d8a1ced60e82e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Cytokines
187 rdf:type schema:DefinedTerm
188 Ne8272707a1f54ea688c49fcab0e320e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Chemokines
190 rdf:type schema:DefinedTerm
191 Nf23f2985034a40449962104417ff80ef rdf:first sg:person.0765661111.14
192 rdf:rest N31c83efa216b46fd94dcc0ee7bb25c0b
193 Nf6d001e0f7864f369c48315dd382456c rdf:first sg:person.01137260042.75
194 rdf:rest N266d7f0103954c1a9444e60d40d0160b
195 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
196 schema:name Medical and Health Sciences
197 rdf:type schema:DefinedTerm
198 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
199 schema:name Immunology
200 rdf:type schema:DefinedTerm
201 sg:grant.3628651 http://pending.schema.org/fundedItem sg:pub.10.1186/1479-5876-8-6
202 rdf:type schema:MonetaryGrant
203 sg:grant.3772849 http://pending.schema.org/fundedItem sg:pub.10.1186/1479-5876-8-6
204 rdf:type schema:MonetaryGrant
205 sg:journal.1032886 schema:issn 1479-5876
206 schema:name Journal of Translational Medicine
207 rdf:type schema:Periodical
208 sg:person.01125176622.90 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
209 schema:familyName Hancock
210 schema:givenName Robert EW
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125176622.90
212 rdf:type schema:Person
213 sg:person.01132600451.96 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
214 schema:familyName Speert
215 schema:givenName David P
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132600451.96
217 rdf:type schema:Person
218 sg:person.01137260042.75 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
219 schema:familyName Hamill
220 schema:givenName Pamela
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01137260042.75
222 rdf:type schema:Person
223 sg:person.01212362334.61 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
224 schema:familyName Kum
225 schema:givenName Winnie
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212362334.61
227 rdf:type schema:Person
228 sg:person.014220213672.66 schema:affiliation https://www.grid.ac/institutes/grid.4305.2
229 schema:familyName Davidson
230 schema:givenName Donald J
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014220213672.66
232 rdf:type schema:Person
233 sg:person.015564661542.34 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
234 schema:familyName Finlay
235 schema:givenName Brett B
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015564661542.34
237 rdf:type schema:Person
238 sg:person.0663327337.59 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
239 schema:familyName Falsafi
240 schema:givenName Reza
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663327337.59
242 rdf:type schema:Person
243 sg:person.0733531603.43 schema:affiliation https://www.grid.ac/institutes/grid.8761.8
244 schema:familyName Brown
245 schema:givenName Kelly L
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733531603.43
247 rdf:type schema:Person
248 sg:person.0744777402.71 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
249 schema:familyName Gardy
250 schema:givenName Jennifer L
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744777402.71
252 rdf:type schema:Person
253 sg:person.0765661111.14 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
254 schema:familyName Turvey
255 schema:givenName Stuart
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765661111.14
257 rdf:type schema:Person
258 sg:pub.10.1007/s00335-002-2261-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050447380
259 https://doi.org/10.1007/s00335-002-2261-9
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/291238a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044840752
262 https://doi.org/10.1038/291238a0
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/nature02738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052167491
265 https://doi.org/10.1038/nature02738
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/nature04267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015379793
268 https://doi.org/10.1038/nature04267
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nature736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003145143
271 https://doi.org/10.1038/nature736
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nbt1288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029788541
274 https://doi.org/10.1038/nbt1288
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/nri1391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023753307
277 https://doi.org/10.1038/nri1391
278 rdf:type schema:CreativeWork
279 sg:pub.10.1111/j.0022-202x.2005.23841.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021020153
280 https://doi.org/10.1111/j.0022-202x.2005.23841.x
281 rdf:type schema:CreativeWork
282 sg:pub.10.1186/1465-9921-5-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045735703
283 https://doi.org/10.1186/1465-9921-5-1
284 rdf:type schema:CreativeWork
285 sg:pub.10.1186/1471-2105-5-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033139728
286 https://doi.org/10.1186/1471-2105-5-16
287 rdf:type schema:CreativeWork
288 https://app.dimensions.ai/details/publication/pub.1083056592 schema:CreativeWork
289 https://doi.org/10.1002/eji.200737886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012135195
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1002/eji.200838161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011438033
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1016/j.cell.2006.02.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002827362
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1016/j.clim.2006.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031034142
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1016/j.clim.2008.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044517166
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1016/j.febslet.2005.04.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029156800
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1016/j.it.2005.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038598649
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1016/j.it.2007.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019014221
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.jpeds.2003.10.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052095486
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.jpeds.2004.06.065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027233918
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/s1074-7613(00)80086-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044146057
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/s1473-3099(09)70255-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030286323
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1042/bst0280551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003289349
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1056/nejm199906103402312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037663367
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1073/pnas.0510874103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015771737
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1084/jem.20030701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004682502
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1084/jem.20061523 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033041964
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1084/jem.20061825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052626956
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1084/jem.20070628 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037437104
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1086/428733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042788899
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1093/nar/gkh446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041187811
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1101/gr.1239303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052744398
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1111/j.0022-202x.2005.23841.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021020153
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1111/j.0105-2896.2005.00235.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024481081
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1126/science.1081902 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062447874
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1126/science.1112304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035171949
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1126/science.281.5379.1001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562056
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1152/physiolgenomics.00128.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027184516
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1172/jci21027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416582
346 rdf:type schema:CreativeWork
347 https://doi.org/10.4049/jimmunol.165.10.5392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074724722
348 rdf:type schema:CreativeWork
349 https://doi.org/10.4049/jimmunol.167.9.5367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074944335
350 rdf:type schema:CreativeWork
351 https://doi.org/10.4049/jimmunol.169.7.3863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075128353
352 rdf:type schema:CreativeWork
353 https://doi.org/10.4049/jimmunol.171.11.6065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076602203
354 rdf:type schema:CreativeWork
355 https://doi.org/10.4049/jimmunol.171.9.4758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076583951
356 rdf:type schema:CreativeWork
357 https://doi.org/10.4049/jimmunol.172.6.3377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076805983
358 rdf:type schema:CreativeWork
359 https://doi.org/10.4049/jimmunol.176.4.2455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045733464
360 rdf:type schema:CreativeWork
361 https://doi.org/10.4049/jimmunol.177.11.8202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077326032
362 rdf:type schema:CreativeWork
363 https://doi.org/10.5483/bmbrep.2005.38.2.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053665896
364 rdf:type schema:CreativeWork
365 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
366 schema:name Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada
367 Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, V5Z 4H4, Vancouver, British Columbia, Canada
368 rdf:type schema:Organization
369 https://www.grid.ac/institutes/grid.4305.2 schema:alternateName University of Edinburgh
370 schema:name Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, V5Z 4H4, Vancouver, British Columbia, Canada
371 MRC/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute W2 03, 47 Little France Crescent, EH16 4T, Edinburgh, UK
372 rdf:type schema:Organization
373 https://www.grid.ac/institutes/grid.8761.8 schema:alternateName University of Gothenburg
374 schema:name Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, V6T 1Z3, Vancouver, British Columbia, Canada
375 Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, V5Z 4H4, Vancouver, British Columbia, Canada
376 Department of Rheumatology and Inflammation Research, University of Gothenburg, Guldhedsgatan 10, S-413 46, Gothenburg, Sweden
377 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...