Vaccination with autologous dendritic cells loaded with autologous tumor lysate or homogenate combined with immunomodulating radiotherapy and/or preleukapheresis IFN-α in ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Francesco de Rosa, Laura Ridolfi, Ruggero Ridolfi, Giorgia Gentili, Linda Valmorri, Oriana Nanni, Massimiliano Petrini, Laura Fiammenghi, Anna Maria Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati, Serena Cassan, Angela Riccobon, Elisabetta Parisi, Antonino Romeo, Livia Turci, Massimo Guidoboni

ABSTRACT

BACKGROUND: Vaccination with dendritic cells (DC) loaded with tumor antigens elicits tumor-specific immune responses capable of killing cancer cells without inducing meaningful side-effects. Patients with advanced melanoma enrolled onto our phase II clinical studies have been treated with autologous DC loaded with autologous tumor lysate/homogenate matured with a cytokine cocktail, showing a clinical benefit (PR + SD) in 55.5% of evaluable cases to date. The beneficial effects of the vaccine were mainly restricted to patients who developed vaccine-specific immune response after treatment. However, immunological responses were only induced in about two-thirds of patients, and treatments aimed at improving immunological responsiveness to the vaccine are needed. METHODS/DESIGN: This is a phase II, "proof-of-principle", randomized, open-label trial of vaccination with autologous DC loaded with tumor lysate or homogenate in metastatic melanoma patients combined with immunomodulating RT and/or preleukapheresis IFN-α. All patients will receive four bi-weekly doses of the vaccine during the induction phase and monthly doses thereafter for up to a maximum of 14 vaccinations or until confirmed progression. Patients will be randomized to receive:(1.) three daily doses of 8 Gy up to 12 Gy radiotherapy delivered to one non-index metastatic field between vaccine doses 1 and 2 and, optionally, between doses 7 and 8, using IMRT-IMAT techniques;(2.) daily 3 MU subcutaneous IFN-α for 7 days before leukapheresis;(3.) both 1 and 2;(4.) neither 1 nor 2.At least six patients eligible for treatment will be enrolled per arm. Daily 3 MU IL-2 will be administered subcutaneously for 5 days starting from the second day after each vaccine dose. Serial DTH testing and blood sampling to evaluate treatment-induced immune response will be performed. Objective response will be evaluated according to immune-related response criteria (irRC). DISCUSSION: Based upon the emerging role of radiotherapy as an immunologic modifier, we designed a randomized phase II trial adding radiotherapy and/or preleukapheresis IFN-α to our DC vaccine in metastatic melanoma patients. Our aim was to find the best combination of complementary interventions to enhance anti-tumor response induced by DC vaccination, which could ultimately lead to better survival and milder toxicity. More... »

PAGES

209

References to SciGraph publications

  • 2005. Clinical Trial Designs for Therapeutic Cancer Vaccines in TUMOR IMMUNOLOGY AND CANCER VACCINES
  • 2010-12. Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2010-11. Leukemic cell products down-regulate human dendritic cell differentiation in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2010-12. FRET microscopy autologous tumor lysate processing in mature dendritic cell vaccine therapy in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2004-12. Evaluation of in vivo labelled dendritic cell migration in cancer patients in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-12. Low-dose temozolomide before dendritic-cell vaccination reduces (specifically) CD4+CD25++Foxp3+ regulatory T-cells in advanced melanoma patients in JOURNAL OF TRANSLATIONAL MEDICINE
  • 1998-03. Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells in NATURE MEDICINE
  • 2009-01. Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2011-12. Concomitant detection of IFNα signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNα-treated subjects at early times after repeated local cytokine treatments in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2002-11. Cancer immunoediting: from immunosurveillance to tumor escape in NATURE IMMUNOLOGY
  • 2010-01. Tumor endothelial marker 8 expression levels in dendritic cell-based cancer vaccines are related to clinical outcome in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2007-07. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo in NATURE REVIEWS IMMUNOLOGY
  • 2006-06. Improved overall survival in dendritic cell vaccination-induced immunoreactive subgroup of advanced melanoma patients in JOURNAL OF TRANSLATIONAL MEDICINE
  • 1999-06. Molecular mechanisms of ionizing radiation-induced apoptosis in IMMUNOLOGY AND CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1479-5876-12-209

    DOI

    http://dx.doi.org/10.1186/1479-5876-12-209

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047578565

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25053129


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