Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Satoshi Wada, Christopher M Jackson, Kiyoshi Yoshimura, Hung-Rong Yen, Derese Getnet, Timothy J Harris, Monica V Goldberg, Tullia C Bruno, Joseph F Grosso, Nicholas Durham, George J Netto, Drew M Pardoll, Charles G Drake

ABSTRACT

BACKGROUND: The FDA recently approved an anti-CTLA-4 antibody (Iplimumab) for the treatment of metastatic melanoma. This decision was based on Phase III results, which demonstrate that blocking this immune checkpoint provides a survival advantage in patients with advanced disease. As a single agent, ipilimumab is also being clinically evaluated in advanced (metastatic, castrate-resistant) prostate cancer and two randomized, placebo-controlled Phase III studies have recently completed accrual. METHODS: We used a well-described genetically engineered mouse (GEM), autochronous prostate cancer model (Pro-TRAMP) to explore the relative sequencing and dosing of anti-CTLA-4 antibody when combined with a cell-based, GM-CSF-secreting vaccine (GVAX). RESULTS: Our results show that combined treatment results in a dramatic increase in effector CD8 T cells in the prostate gland, and enhanced tumor-antigen directed lytic function. These effects are maximized when CTLA-4 blockade is applied after, but not before, vaccination. Additional experiments, using models of metastatic disease, show that incorporation of low-dose cyclophosphamide into this combined treatment regimen results in an additional pre-clinical benefit. CONCLUSIONS: Together these studies define a combination regimen using anti-CTLA-4/GVAX immunotherapy and low-dose chemotherapy for potential translation to a clinical trial setting. More... »

PAGES

89

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1479-5876-11-89

DOI

http://dx.doi.org/10.1186/1479-5876-11-89

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030594536

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23557194


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD8-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CTLA-4 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cancer Vaccines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Granulocyte-Macrophage Colony-Stimulating Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ipilimumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Liver Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lung Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prostatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Saitama Red Cross Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416704.0", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA", 
            "Saitama Red Cross Hospital, 338-8553, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wada", 
        "givenName": "Satoshi", 
        "id": "sg:person.01226257466.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226257466.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jackson", 
        "givenName": "Christopher M", 
        "id": "sg:person.01105515177.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105515177.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Yamaguchi University", 
          "id": "https://www.grid.ac/institutes/grid.268397.1", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA", 
            "Department of Digestive Surgery & Surgical Oncology, Yamaguchi University, Yamaguchi University Graduate School of Medicine, 755-8505, Yamaguchi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshimura", 
        "givenName": "Kiyoshi", 
        "id": "sg:person.01014540270.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014540270.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yen", 
        "givenName": "Hung-Rong", 
        "id": "sg:person.0621453323.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621453323.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Getnet", 
        "givenName": "Derese", 
        "id": "sg:person.01067451467.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067451467.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harris", 
        "givenName": "Timothy J", 
        "id": "sg:person.014221220557.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014221220557.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goldberg", 
        "givenName": "Monica V", 
        "id": "sg:person.01244370611.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244370611.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruno", 
        "givenName": "Tullia C", 
        "id": "sg:person.0705107667.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705107667.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bristol-Myers Squibb (United States)", 
          "id": "https://www.grid.ac/institutes/grid.419971.3", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA", 
            "Bristol-Myers Squibb, 08543, Princeton, NJ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grosso", 
        "givenName": "Joseph F", 
        "id": "sg:person.01345057423.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345057423.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Durham", 
        "givenName": "Nicholas", 
        "id": "sg:person.01113332605.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113332605.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA", 
            "Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA", 
            "Department of Pathology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Netto", 
        "givenName": "George J", 
        "id": "sg:person.0712550525.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712550525.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins University", 
          "id": "https://www.grid.ac/institutes/grid.21107.35", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pardoll", 
        "givenName": "Drew M", 
        "id": "sg:person.012740423777.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740423777.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Johns Hopkins Medicine", 
          "id": "https://www.grid.ac/institutes/grid.469474.c", 
          "name": [
            "Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA", 
            "Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA", 
            "Departments of Oncology, Immunology, and Urology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB 410, 21231, Baltimore, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Drake", 
        "givenName": "Charles G", 
        "id": "sg:person.014571064077.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014571064077.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci27745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001407871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002675699", 
          "https://doi.org/10.1038/nri2742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2742", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002675699", 
          "https://doi.org/10.1038/nri2742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2011.35.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002866902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00137-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004088701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-0407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006484617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-011-0245-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006731314", 
          "https://doi.org/10.1007/s00281-011-0245-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-1759(00)00329-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010089262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-3402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012318522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci31202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013653524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/scbi.2001.0373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014170849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.3.1178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014211724"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-010-0927-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014498084", 
          "https://doi.org/10.1007/s00262-010-0927-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017331759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0573", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017791574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1001294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017807249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1014618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018044872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.34.3996", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018423185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018879892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci31184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018967538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-7-35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020630921", 
          "https://doi.org/10.1186/1479-5876-7-35"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70006-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022625227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nri2817", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023167441", 
          "https://doi.org/10.1038/nri2817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023754056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.25429", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023754056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-009-0782-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028734929", 
          "https://doi.org/10.1007/s00262-009-0782-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-009-0782-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028734929", 
          "https://doi.org/10.1007/s00262-009-0782-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-009-0782-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028734929", 
          "https://doi.org/10.1007/s00262-009-0782-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa040720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029249997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.180.1.25", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030822225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2007-11-125435", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031638407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2002-07-2233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039563454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042069193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2005.01.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042837436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.10215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043736500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1207506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044642614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-3243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044664845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0910341107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045039443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(12)70007-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045422353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2006-12-062422", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045631068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.190.3.355", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046049906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/11594010-000000000-00000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048688011", 
          "https://doi.org/10.2165/11594010-000000000-00000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1074-7613(95)90125-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049355847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/pros.20549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050705680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1003466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052212829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-4102", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052789534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.26.15074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053180856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0803400", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053652672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/10430349950017347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059202880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074640242", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082940603", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-12", 
    "datePublishedReg": "2013-12-01", 
    "description": "BACKGROUND: The FDA recently approved an anti-CTLA-4 antibody (Iplimumab) for the treatment of metastatic melanoma. This decision was based on Phase III results, which demonstrate that blocking this immune checkpoint provides a survival advantage in patients with advanced disease. As a single agent, ipilimumab is also being clinically evaluated in advanced (metastatic, castrate-resistant) prostate cancer and two randomized, placebo-controlled Phase III studies have recently completed accrual.\nMETHODS: We used a well-described genetically engineered mouse (GEM), autochronous prostate cancer model (Pro-TRAMP) to explore the relative sequencing and dosing of anti-CTLA-4 antibody when combined with a cell-based, GM-CSF-secreting vaccine (GVAX).\nRESULTS: Our results show that combined treatment results in a dramatic increase in effector CD8 T cells in the prostate gland, and enhanced tumor-antigen directed lytic function. These effects are maximized when CTLA-4 blockade is applied after, but not before, vaccination. Additional experiments, using models of metastatic disease, show that incorporation of low-dose cyclophosphamide into this combined treatment regimen results in an additional pre-clinical benefit.\nCONCLUSIONS: Together these studies define a combination regimen using anti-CTLA-4/GVAX immunotherapy and low-dose chemotherapy for potential translation to a clinical trial setting.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1479-5876-11-89", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2681801", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "name": "Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer", 
    "pagination": "89", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "91bfa0bcd486f9df8259bb5b13ed4db013937806f0141bc95d68b3e997bb805b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23557194"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1479-5876-11-89"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030594536"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1479-5876-11-89", 
      "https://app.dimensions.ai/details/publication/pub.1030594536"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:37", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1479-5876-11-89"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-11-89'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-11-89'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-11-89'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-11-89'


 

This table displays all metadata directly associated to this object as RDF triples.

407 TRIPLES      21 PREDICATES      98 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1479-5876-11-89 schema:about N074ae7c10d1641b7ab1ff7d4bcb54432
2 N07b9c6f3b080407cb00f29e58a86fe1d
3 N174cdbd285614036bf3fcc31afeb964c
4 N23af9faafe0647bfa66b981edb716082
5 N23bc35ef01f54544b62d9b0f589da85b
6 N50e82ca8a13e45778cf5c65e48387876
7 N5b7a6cd1d81b4e0e979aeb5180c17f6b
8 N680d7de039094d60a4469de2f1315ece
9 N74bafdfd1f2449a28725b9402e00435e
10 N831d2654d3b84be0b491017468234cde
11 N839c396939ae435cb9ec36bce505902e
12 N8dc01d0a9bfd4cc480e192a833f1a0b4
13 N8eeb6f69a0e64f5484a552a00940f56b
14 N91d79e1a569f4a178e6321de4272c897
15 Na34730847f18451398271e8763e24740
16 Nb0d0488ee3304862b92daf21785d6318
17 Ncbdaf1c003b74b41ab16d797cba05fa6
18 Nd987bf4614f94863b71997a96876b37c
19 Ne1e6fdb3ad034da09babdbbbc026f3da
20 Ne744d2004f0f4638b251871ffd3fe932
21 Nede441549bf9447286facb3e9eb15810
22 Nf611a2adaea2432dbe82253d0596de9c
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N646ca9d20a7e4bb0bb5fc99ef4f0d546
26 schema:citation sg:pub.10.1007/s00262-009-0782-8
27 sg:pub.10.1007/s00262-010-0927-9
28 sg:pub.10.1007/s00281-011-0245-0
29 sg:pub.10.1038/nri2742
30 sg:pub.10.1038/nri2817
31 sg:pub.10.1186/1479-5876-7-35
32 sg:pub.10.2165/11594010-000000000-00000
33 https://app.dimensions.ai/details/publication/pub.1074640242
34 https://app.dimensions.ai/details/publication/pub.1082940603
35 https://doi.org/10.1002/cncr.23669
36 https://doi.org/10.1002/ijc.25429
37 https://doi.org/10.1002/pros.10215
38 https://doi.org/10.1002/pros.20549
39 https://doi.org/10.1006/scbi.2001.0373
40 https://doi.org/10.1016/1074-7613(95)90125-6
41 https://doi.org/10.1016/j.ccr.2005.01.027
42 https://doi.org/10.1016/s0022-1759(00)00329-x
43 https://doi.org/10.1016/s1470-2045(12)70006-2
44 https://doi.org/10.1016/s1470-2045(12)70007-4
45 https://doi.org/10.1056/nejmoa040720
46 https://doi.org/10.1056/nejmoa1001294
47 https://doi.org/10.1056/nejmoa1003466
48 https://doi.org/10.1056/nejmoa1014618
49 https://doi.org/10.1056/nejmoa1207506
50 https://doi.org/10.1073/pnas.0910341107
51 https://doi.org/10.1073/pnas.95.3.1178
52 https://doi.org/10.1073/pnas.96.26.15074
53 https://doi.org/10.1084/jem.180.1.25
54 https://doi.org/10.1084/jem.190.3.355
55 https://doi.org/10.1089/10430349950017347
56 https://doi.org/10.1128/jvi.00137-07
57 https://doi.org/10.1158/0008-5472.can-04-0757
58 https://doi.org/10.1158/0008-5472.can-07-0573
59 https://doi.org/10.1158/0008-5472.can-08-4102
60 https://doi.org/10.1158/1078-0432.ccr-09-3243
61 https://doi.org/10.1158/1078-0432.ccr-10-3402
62 https://doi.org/10.1158/1078-0432.ccr-11-0407
63 https://doi.org/10.1172/jci27745
64 https://doi.org/10.1172/jci31184
65 https://doi.org/10.1172/jci31202
66 https://doi.org/10.1182/blood-2002-07-2233
67 https://doi.org/10.1182/blood-2006-12-062422
68 https://doi.org/10.1182/blood-2007-11-125435
69 https://doi.org/10.1200/jco.2010.34.3996
70 https://doi.org/10.1200/jco.2011.35.2005
71 https://doi.org/10.3322/caac.20073
72 https://doi.org/10.4049/jimmunol.0803400
73 schema:datePublished 2013-12
74 schema:datePublishedReg 2013-12-01
75 schema:description BACKGROUND: The FDA recently approved an anti-CTLA-4 antibody (Iplimumab) for the treatment of metastatic melanoma. This decision was based on Phase III results, which demonstrate that blocking this immune checkpoint provides a survival advantage in patients with advanced disease. As a single agent, ipilimumab is also being clinically evaluated in advanced (metastatic, castrate-resistant) prostate cancer and two randomized, placebo-controlled Phase III studies have recently completed accrual. METHODS: We used a well-described genetically engineered mouse (GEM), autochronous prostate cancer model (Pro-TRAMP) to explore the relative sequencing and dosing of anti-CTLA-4 antibody when combined with a cell-based, GM-CSF-secreting vaccine (GVAX). RESULTS: Our results show that combined treatment results in a dramatic increase in effector CD8 T cells in the prostate gland, and enhanced tumor-antigen directed lytic function. These effects are maximized when CTLA-4 blockade is applied after, but not before, vaccination. Additional experiments, using models of metastatic disease, show that incorporation of low-dose cyclophosphamide into this combined treatment regimen results in an additional pre-clinical benefit. CONCLUSIONS: Together these studies define a combination regimen using anti-CTLA-4/GVAX immunotherapy and low-dose chemotherapy for potential translation to a clinical trial setting.
76 schema:genre research_article
77 schema:inLanguage en
78 schema:isAccessibleForFree true
79 schema:isPartOf N024e2c329c014e1fbb32164c04a45870
80 Nb6d0a6afba7b49e9b323b4c76d4a2e99
81 sg:journal.1032886
82 schema:name Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer
83 schema:pagination 89
84 schema:productId N157b6a0e7ea64324a96dd7c85fd7bbd7
85 Nad4a6bc223ab4403b6152e332de8c8db
86 Nb38929ee25e64b0f98d7bb1dc327a046
87 Nb72d0bfce2f9465ab1ded392f5b350a7
88 Nf41736d357b34cabb65ecdb74f33be4d
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030594536
90 https://doi.org/10.1186/1479-5876-11-89
91 schema:sdDatePublished 2019-04-10T21:37
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Nae9708e6ca2c4617bba719a5f4eddceb
94 schema:url http://link.springer.com/10.1186%2F1479-5876-11-89
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N024e2c329c014e1fbb32164c04a45870 schema:issueNumber 1
99 rdf:type schema:PublicationIssue
100 N074ae7c10d1641b7ab1ff7d4bcb54432 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Humans
102 rdf:type schema:DefinedTerm
103 N07b9c6f3b080407cb00f29e58a86fe1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Antineoplastic Agents
105 rdf:type schema:DefinedTerm
106 N157b6a0e7ea64324a96dd7c85fd7bbd7 schema:name readcube_id
107 schema:value 91bfa0bcd486f9df8259bb5b13ed4db013937806f0141bc95d68b3e997bb805b
108 rdf:type schema:PropertyValue
109 N174cdbd285614036bf3fcc31afeb964c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Mice, Inbred C57BL
111 rdf:type schema:DefinedTerm
112 N1d8ff42456a14fa687722d167dc206d3 rdf:first sg:person.014571064077.28
113 rdf:rest rdf:nil
114 N23af9faafe0647bfa66b981edb716082 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Animals
116 rdf:type schema:DefinedTerm
117 N23bc35ef01f54544b62d9b0f589da85b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Time Factors
119 rdf:type schema:DefinedTerm
120 N31009249e6de4ef284ca4046f83758e4 rdf:first sg:person.0705107667.78
121 rdf:rest N85686880297441b28515c761206dbcc4
122 N3230aca311904fa083522a6f088489d2 rdf:first sg:person.0712550525.22
123 rdf:rest Nf8172530f9484c1c996a746c1fa63aa1
124 N50e82ca8a13e45778cf5c65e48387876 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Male
126 rdf:type schema:DefinedTerm
127 N5b7a6cd1d81b4e0e979aeb5180c17f6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cell Proliferation
129 rdf:type schema:DefinedTerm
130 N63c194fa7d1d43cd97406e82bc59f7db rdf:first sg:person.01113332605.90
131 rdf:rest N3230aca311904fa083522a6f088489d2
132 N6452e843cb7944e1a2f9634b8797c4ef rdf:first sg:person.01067451467.32
133 rdf:rest N6e2059dbb78b429da245b75c1d819a61
134 N646ca9d20a7e4bb0bb5fc99ef4f0d546 rdf:first sg:person.01226257466.09
135 rdf:rest Nbc45f515fa104390a34a195e935b87d8
136 N680d7de039094d60a4469de2f1315ece schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Granulocyte-Macrophage Colony-Stimulating Factor
138 rdf:type schema:DefinedTerm
139 N6e2059dbb78b429da245b75c1d819a61 rdf:first sg:person.014221220557.46
140 rdf:rest Nda93a433a3864a4fa9db9500249bcd49
141 N74bafdfd1f2449a28725b9402e00435e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Cell Line, Tumor
143 rdf:type schema:DefinedTerm
144 N831d2654d3b84be0b491017468234cde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Ipilimumab
146 rdf:type schema:DefinedTerm
147 N839c396939ae435cb9ec36bce505902e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Lung Neoplasms
149 rdf:type schema:DefinedTerm
150 N85686880297441b28515c761206dbcc4 rdf:first sg:person.01345057423.11
151 rdf:rest N63c194fa7d1d43cd97406e82bc59f7db
152 N8dc01d0a9bfd4cc480e192a833f1a0b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Cancer Vaccines
154 rdf:type schema:DefinedTerm
155 N8eeb6f69a0e64f5484a552a00940f56b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Cyclophosphamide
157 rdf:type schema:DefinedTerm
158 N91d79e1a569f4a178e6321de4272c897 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Antibodies, Monoclonal
160 rdf:type schema:DefinedTerm
161 N9afe90e8c78c4d6a860763976d30ecac rdf:first sg:person.0621453323.38
162 rdf:rest N6452e843cb7944e1a2f9634b8797c4ef
163 Na34730847f18451398271e8763e24740 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name CTLA-4 Antigen
165 rdf:type schema:DefinedTerm
166 Nad4a6bc223ab4403b6152e332de8c8db schema:name nlm_unique_id
167 schema:value 101190741
168 rdf:type schema:PropertyValue
169 Nae9708e6ca2c4617bba719a5f4eddceb schema:name Springer Nature - SN SciGraph project
170 rdf:type schema:Organization
171 Nb0d0488ee3304862b92daf21785d6318 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Mice, Transgenic
173 rdf:type schema:DefinedTerm
174 Nb38929ee25e64b0f98d7bb1dc327a046 schema:name pubmed_id
175 schema:value 23557194
176 rdf:type schema:PropertyValue
177 Nb6d0a6afba7b49e9b323b4c76d4a2e99 schema:volumeNumber 11
178 rdf:type schema:PublicationVolume
179 Nb72d0bfce2f9465ab1ded392f5b350a7 schema:name doi
180 schema:value 10.1186/1479-5876-11-89
181 rdf:type schema:PropertyValue
182 Nbc45f515fa104390a34a195e935b87d8 rdf:first sg:person.01105515177.64
183 rdf:rest Nd88bc85e464c4a68bbc610a69b73eb41
184 Ncbdaf1c003b74b41ab16d797cba05fa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Immunotherapy
186 rdf:type schema:DefinedTerm
187 Nd88bc85e464c4a68bbc610a69b73eb41 rdf:first sg:person.01014540270.17
188 rdf:rest N9afe90e8c78c4d6a860763976d30ecac
189 Nd987bf4614f94863b71997a96876b37c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Prostatic Neoplasms
191 rdf:type schema:DefinedTerm
192 Nda93a433a3864a4fa9db9500249bcd49 rdf:first sg:person.01244370611.53
193 rdf:rest N31009249e6de4ef284ca4046f83758e4
194 Ne1e6fdb3ad034da09babdbbbc026f3da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Neoplasm Metastasis
196 rdf:type schema:DefinedTerm
197 Ne744d2004f0f4638b251871ffd3fe932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Liver Neoplasms
199 rdf:type schema:DefinedTerm
200 Nede441549bf9447286facb3e9eb15810 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name CD8-Positive T-Lymphocytes
202 rdf:type schema:DefinedTerm
203 Nf41736d357b34cabb65ecdb74f33be4d schema:name dimensions_id
204 schema:value pub.1030594536
205 rdf:type schema:PropertyValue
206 Nf611a2adaea2432dbe82253d0596de9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Mice
208 rdf:type schema:DefinedTerm
209 Nf8172530f9484c1c996a746c1fa63aa1 rdf:first sg:person.012740423777.12
210 rdf:rest N1d8ff42456a14fa687722d167dc206d3
211 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
212 schema:name Medical and Health Sciences
213 rdf:type schema:DefinedTerm
214 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
215 schema:name Oncology and Carcinogenesis
216 rdf:type schema:DefinedTerm
217 sg:grant.2681801 http://pending.schema.org/fundedItem sg:pub.10.1186/1479-5876-11-89
218 rdf:type schema:MonetaryGrant
219 sg:journal.1032886 schema:issn 1479-5876
220 schema:name Journal of Translational Medicine
221 rdf:type schema:Periodical
222 sg:person.01014540270.17 schema:affiliation https://www.grid.ac/institutes/grid.268397.1
223 schema:familyName Yoshimura
224 schema:givenName Kiyoshi
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014540270.17
226 rdf:type schema:Person
227 sg:person.01067451467.32 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
228 schema:familyName Getnet
229 schema:givenName Derese
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067451467.32
231 rdf:type schema:Person
232 sg:person.01105515177.64 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
233 schema:familyName Jackson
234 schema:givenName Christopher M
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105515177.64
236 rdf:type schema:Person
237 sg:person.01113332605.90 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
238 schema:familyName Durham
239 schema:givenName Nicholas
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113332605.90
241 rdf:type schema:Person
242 sg:person.01226257466.09 schema:affiliation https://www.grid.ac/institutes/grid.416704.0
243 schema:familyName Wada
244 schema:givenName Satoshi
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226257466.09
246 rdf:type schema:Person
247 sg:person.01244370611.53 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
248 schema:familyName Goldberg
249 schema:givenName Monica V
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244370611.53
251 rdf:type schema:Person
252 sg:person.012740423777.12 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
253 schema:familyName Pardoll
254 schema:givenName Drew M
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740423777.12
256 rdf:type schema:Person
257 sg:person.01345057423.11 schema:affiliation https://www.grid.ac/institutes/grid.419971.3
258 schema:familyName Grosso
259 schema:givenName Joseph F
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345057423.11
261 rdf:type schema:Person
262 sg:person.014221220557.46 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
263 schema:familyName Harris
264 schema:givenName Timothy J
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014221220557.46
266 rdf:type schema:Person
267 sg:person.014571064077.28 schema:affiliation https://www.grid.ac/institutes/grid.469474.c
268 schema:familyName Drake
269 schema:givenName Charles G
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014571064077.28
271 rdf:type schema:Person
272 sg:person.0621453323.38 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
273 schema:familyName Yen
274 schema:givenName Hung-Rong
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621453323.38
276 rdf:type schema:Person
277 sg:person.0705107667.78 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
278 schema:familyName Bruno
279 schema:givenName Tullia C
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705107667.78
281 rdf:type schema:Person
282 sg:person.0712550525.22 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
283 schema:familyName Netto
284 schema:givenName George J
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712550525.22
286 rdf:type schema:Person
287 sg:pub.10.1007/s00262-009-0782-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028734929
288 https://doi.org/10.1007/s00262-009-0782-8
289 rdf:type schema:CreativeWork
290 sg:pub.10.1007/s00262-010-0927-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014498084
291 https://doi.org/10.1007/s00262-010-0927-9
292 rdf:type schema:CreativeWork
293 sg:pub.10.1007/s00281-011-0245-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006731314
294 https://doi.org/10.1007/s00281-011-0245-0
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/nri2742 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002675699
297 https://doi.org/10.1038/nri2742
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/nri2817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023167441
300 https://doi.org/10.1038/nri2817
301 rdf:type schema:CreativeWork
302 sg:pub.10.1186/1479-5876-7-35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020630921
303 https://doi.org/10.1186/1479-5876-7-35
304 rdf:type schema:CreativeWork
305 sg:pub.10.2165/11594010-000000000-00000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048688011
306 https://doi.org/10.2165/11594010-000000000-00000
307 rdf:type schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1074640242 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1082940603 schema:CreativeWork
310 https://doi.org/10.1002/cncr.23669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018879892
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/ijc.25429 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023754056
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1002/pros.10215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043736500
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1002/pros.20549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050705680
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1006/scbi.2001.0373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014170849
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/1074-7613(95)90125-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049355847
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.ccr.2005.01.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042837436
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0022-1759(00)00329-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010089262
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s1470-2045(12)70006-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022625227
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s1470-2045(12)70007-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045422353
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1056/nejmoa040720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029249997
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1056/nejmoa1001294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017807249
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1056/nejmoa1003466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052212829
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1056/nejmoa1014618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018044872
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1056/nejmoa1207506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044642614
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1073/pnas.0910341107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045039443
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1073/pnas.95.3.1178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014211724
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1073/pnas.96.26.15074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053180856
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1084/jem.180.1.25 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030822225
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1084/jem.190.3.355 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046049906
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1089/10430349950017347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202880
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1128/jvi.00137-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004088701
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1158/0008-5472.can-04-0757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017331759
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1158/0008-5472.can-07-0573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017791574
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1158/0008-5472.can-08-4102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052789534
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1158/1078-0432.ccr-09-3243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044664845
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1158/1078-0432.ccr-10-3402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012318522
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1158/1078-0432.ccr-11-0407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006484617
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1172/jci27745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001407871
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1172/jci31184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018967538
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1172/jci31202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013653524
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1182/blood-2002-07-2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039563454
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1182/blood-2006-12-062422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045631068
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1182/blood-2007-11-125435 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031638407
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1200/jco.2010.34.3996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018423185
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1200/jco.2011.35.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002866902
381 rdf:type schema:CreativeWork
382 https://doi.org/10.3322/caac.20073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042069193
383 rdf:type schema:CreativeWork
384 https://doi.org/10.4049/jimmunol.0803400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053652672
385 rdf:type schema:CreativeWork
386 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
387 schema:name Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA
388 Department of Pathology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA
389 Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.268397.1 schema:alternateName Yamaguchi University
392 schema:name Department of Digestive Surgery & Surgical Oncology, Yamaguchi University, Yamaguchi University Graduate School of Medicine, 755-8505, Yamaguchi, Japan
393 Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.416704.0 schema:alternateName Saitama Red Cross Hospital
396 schema:name Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA
397 Saitama Red Cross Hospital, 338-8553, Saitama, Japan
398 rdf:type schema:Organization
399 https://www.grid.ac/institutes/grid.419971.3 schema:alternateName Bristol-Myers Squibb (United States)
400 schema:name Bristol-Myers Squibb, 08543, Princeton, NJ, USA
401 Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.469474.c schema:alternateName Johns Hopkins Medicine
404 schema:name Department of Oncology, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA
405 Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University, School of Medicine, 21231, Baltimore, Maryland, USA
406 Departments of Oncology, Immunology, and Urology, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans Street, CRB 410, 21231, Baltimore, MD, USA
407 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...