JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromosomes, Human, Pair 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cluster Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Comparative Genomic Hybridization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Hybridization, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Chaperones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Urinary Bladder Neoplasms", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tumor Markers Group, Molecular Pathology Program, Spanish National Cancer Center, Melchor Fernandez Almagro 3, E-28029, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Tumor Markers Group, Molecular Pathology Program, Spanish National Cancer Center, Melchor Fernandez Almagro 3, E-28029, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "L\u00f3pez", 
        "givenName": "Virginia", 
        "id": "sg:person.013555710417.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013555710417.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathology Department, Hospital Universitario La Paz, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.81821.32", 
          "name": [
            "Pathology Department, Hospital Universitario La Paz, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonz\u00e1lez-Peramato", 
        "givenName": "Pilar", 
        "id": "sg:person.0631733653.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631733653.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Cytogenetics Group and Centre for Biomedical Research on Rare Diseases (CIBERER), Human Genetics Program, Spanish National Cancer Center, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Cytogenetics Group and Centre for Biomedical Research on Rare Diseases (CIBERER), Human Genetics Program, Spanish National Cancer Center, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suela", 
        "givenName": "Javier", 
        "id": "sg:person.0767025511.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767025511.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Urology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411098.5", 
          "name": [
            "Urology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Serrano", 
        "givenName": "Alvaro", 
        "id": "sg:person.01102760312.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102760312.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pathology Department, Fundaci\u00f3 Puigvert, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.418813.7", 
          "name": [
            "Pathology Department, Fundaci\u00f3 Puigvert, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Algaba", 
        "givenName": "Ferr\u00e1n", 
        "id": "sg:person.0621247262.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621247262.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Molecular Cytogenetics Group and Centre for Biomedical Research on Rare Diseases (CIBERER), Human Genetics Program, Spanish National Cancer Center, Madrid, Spain", 
          "id": "http://www.grid.ac/institutes/grid.7719.8", 
          "name": [
            "Molecular Cytogenetics Group and Centre for Biomedical Research on Rare Diseases (CIBERER), Human Genetics Program, Spanish National Cancer Center, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cigudosa", 
        "givenName": "Juan C", 
        "id": "sg:person.01246512175.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246512175.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitari de Bellvitge, Pathology Department, L\u2019Hospitalet de Llobregat, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411129.e", 
          "name": [
            "Hospital Universitari de Bellvitge, Pathology Department, L\u2019Hospitalet de Llobregat, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vidal", 
        "givenName": "August", 
        "id": "sg:person.01172032601.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172032601.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Oncology Department, Hospital del Mar, Barcelona, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411142.3", 
          "name": [
            "Oncology Department, Hospital del Mar, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bellmunt", 
        "givenName": "Joaquim", 
        "id": "sg:person.01174264563.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174264563.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Urology Department, Hospital Universitario de Salamanca, Salamanca, Spain", 
          "id": "http://www.grid.ac/institutes/grid.411258.b", 
          "name": [
            "Urology Department, Hospital Universitario de Salamanca, Salamanca, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heredero", 
        "givenName": "Oscar", 
        "id": "sg:person.01200002001.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200002001.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Proteomics Unit, CIC bioGUNE, Bizkaia Technology Park, E-48160, Derio, Spain", 
          "id": "http://www.grid.ac/institutes/grid.420175.5", 
          "name": [
            "Tumor Markers Group, Molecular Pathology Program, Spanish National Cancer Center, Melchor Fernandez Almagro 3, E-28029, Madrid, Spain", 
            "Proteomics Unit, CIC bioGUNE, Bizkaia Technology Park, E-48160, Derio, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00e1nchez-Carbayo", 
        "givenName": "Marta", 
        "id": "sg:person.01252101314.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252101314.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.onc.1207260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019344134", 
          "https://doi.org/10.1038/sj.onc.1207260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/30032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016762591", 
          "https://doi.org/10.1038/30032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003338532", 
          "https://doi.org/10.1038/sj.onc.1207128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-2-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027972824", 
          "https://doi.org/10.1186/1471-2407-2-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03194636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040256482", 
          "https://doi.org/10.1007/bf03194636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1210934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014957619", 
          "https://doi.org/10.1038/sj.onc.1210934"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/2524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026409761", 
          "https://doi.org/10.1038/2524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-5956-2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038853837", 
          "https://doi.org/10.1186/1477-5956-2-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1923", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009415129", 
          "https://doi.org/10.1038/ng1923"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013223130", 
          "https://doi.org/10.1038/ng1569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1200868", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017340718", 
          "https://doi.org/10.1038/sj.onc.1200868"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08-01", 
    "datePublishedReg": "2013-08-01", 
    "description": "BackgroundArray-CGH represents a comprehensive tool to discover genomic disease alterations that could potentially be applied to body fluids. In this report, we aimed at applying array-CGH to urinary samples to characterize bladder cancer.MethodsUrinary DNA from bladder cancer patients and controls were hybridized on 44K oligonucleotide arrays. Validation analyses of identified regions and candidates included fluorescent in situ hybridization (FISH) and immunohistochemistry in an independent set of bladder tumors spotted on custom-made tissue arrays (n\u2009=\u2009181).ResultsQuality control of array-CGH provided high reproducibility in dilution experiments and when comparing reference pools. The most frequent genomic alterations (minimal recurrent regions) among bladder cancer urinary specimens included gains at 1q and 5p, and losses at 10p and 11p. Supervised hierarchical clustering identified the gain at 1q23.3-q24.1 significantly correlated to stage (p\u2009=\u20090.011), and grade (p\u2009=\u20090.002). The amplification and overexpression of Prefoldin (PFND2), a selected candidate mapping to 1q23.3-q24.1, correlated to increasing stage and tumor grade by means of custom-designed and optimized FISH (p\u2009=\u20090.013 and p\u2009=\u20090.023, respectively), and immunohistochemistry (p \u22640.0005 and p\u2009=\u20090.011, respectively), in an independent set of bladder tumors included in tissue arrays. Moreover, PFND2 overexpression was significantly associated with poor disease-specific survival (p \u22640.0005). PFND2 was amplified and overexpressed in bladder tumors belonging to patients providing urinary specimens where 1q23.3q24.1 amplification was detected by array-CGH.ConclusionsGenomic profiles of urinary DNA mirrowed bladder tumors. Molecular profiling of urinary DNA using array-CGH contributed to further characterize genomic alterations involved in bladder cancer progression. PFND2 was identified as a tumor stratification and clinical outcome prognostic biomarker for bladder cancer patients.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1479-5876-11-182", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "11"
      }
    ], 
    "keywords": [
      "bladder cancer patients", 
      "bladder tumors", 
      "bladder cancer", 
      "urinary DNA", 
      "cancer patients", 
      "tissue arrays", 
      "poor disease-specific survival", 
      "disease-specific survival", 
      "genomic alterations", 
      "frequent genomic alterations", 
      "bladder cancer progression", 
      "array CGH", 
      "tumor grade", 
      "urinary specimens", 
      "prognostic biomarker", 
      "urinary samples", 
      "patients", 
      "tumors", 
      "tumor stratification", 
      "molecular profiling", 
      "cancer progression", 
      "comparative genomic hybridization array", 
      "cancer", 
      "immunohistochemistry", 
      "disease alterations", 
      "alterations", 
      "K oligonucleotide array", 
      "situ hybridization", 
      "overexpression", 
      "body fluids", 
      "reference pool", 
      "grade", 
      "validation analysis", 
      "hybridization arrays", 
      "progression", 
      "biomarkers", 
      "survival", 
      "control", 
      "oligonucleotide arrays", 
      "report", 
      "DNA", 
      "amplification", 
      "q24.1", 
      "stratification", 
      "dilution experiments", 
      "high reproducibility", 
      "comprehensive tool", 
      "specimens", 
      "profiling", 
      "gain", 
      "loss", 
      "hierarchical clustering", 
      "fluid", 
      "profile", 
      "independent set", 
      "candidates", 
      "hybridization", 
      "stage", 
      "samples", 
      "identification", 
      "reproducibility", 
      "pool", 
      "fluorescent", 
      "analysis", 
      "prefoldin", 
      "fish", 
      "tool", 
      "means", 
      "region", 
      "array", 
      "mapping", 
      "clustering", 
      "candidate mappings", 
      "experiments", 
      "set"
    ], 
    "name": "Identification of prefoldin amplification (1q23.3-q24.1) in bladder cancer using comparative genomic hybridization (CGH) arrays of urinary DNA", 
    "pagination": "182", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003261713"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1479-5876-11-182"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23914742"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1479-5876-11-182", 
      "https://app.dimensions.ai/details/publication/pub.1003261713"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_610.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1479-5876-11-182"
  }
]

Download the RDF metadata as:  json-ld nt turtle xml License info

This table displays all metadata directly associated to this object as RDF triples.

319 TRIPLES      22 PREDICATES      125 URIs      106 LITERALS      20 BLANK NODES