Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Vincent Lavoué, Aurélie Thédrez, Jean Levêque, Fabrice Foucher, Sébastien Henno, Vincent Jauffret, Marc-Antoine Belaud-Rotureau, Veronique Catros, Florian Cabillic

ABSTRACT

Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an antitumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This review focuses on the immune response and immune suppression in EOC. The immunological roles of chemotherapy and surgery in EOC are also described. Finally, we detail pilot data supporting the efficiency of immunotherapy in the treatment of EOC and the emerging concept that immunomodulation aimed at counteracting the immunosuppressive microenvironment must be associated with immunotherapy strategies. More... »

PAGES

147

References to SciGraph publications

  • 2010-08. Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma in BRITISH JOURNAL OF CANCER
  • 2012-08. Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models in CLINICAL & EXPERIMENTAL METASTASIS
  • 2008-01. Creating immune privilege: active local suppression that benefits friends, but protects foes in NATURE REVIEWS IMMUNOLOGY
  • 2010-12. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines in BMC CANCER
  • 2007-07. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer in NATURE MEDICINE
  • 2002-08. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion in NATURE MEDICINE
  • 2010-12. Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes in MOLECULAR CANCER
  • 2004-12. Peritoneal inflammation – A microenvironment for Epithelial Ovarian Cancer (EOC) in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2006-10. Aberrant expression of MUC4 in ovarian carcinoma: diagnostic significance alone and in combination with MUC1 and MUC16 (CA125) in MODERN PATHOLOGY
  • 2007-05. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2001-12. Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells in NATURE MEDICINE
  • 2008-01. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy in NATURE MEDICINE
  • 2009-11. Intraepithelial CD8-positive T lymphocytes predict survival for patients with serous stage III ovarian carcinomas: relevance of clonal selection of T lymphocytes in BRITISH JOURNAL OF CANCER
  • 2009-03. Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2010-12. COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function in BMC CANCER
  • 2005-04. Functional Diversity and Plasticity of Human Dendritic Cell Subsets in INTERNATIONAL JOURNAL OF HEMATOLOGY
  • 2002-03. Vaccination with autologous tumour antigen-pulsed dendritic cells in advanced gynaecological malignancies: clinical and immunological evaluation of a phase I trial in CANCER IMMUNOLOGY, IMMUNOTHERAPY
  • 2010-08. Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer in BRITISH JOURNAL OF CANCER
  • 2003-05. Blockade of B7-H1 improves myeloid dendritic cell–mediated antitumor immunity in NATURE MEDICINE
  • 2009-03. Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss in MODERN PATHOLOGY
  • 2011-03. Immune parameters affecting the efficacy of chemotherapeutic regimens in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2011-12. Tumour macrophages as potential targets of bisphosphonates in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2010-12. MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells in MOLECULAR CANCER
  • 1998-12. Ovarian cancer-associated lymphocyte recognition of folate binding protein peptides in ANNALS OF SURGICAL ONCOLOGY
  • 2004-09. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1479-5876-11-147

    DOI

    http://dx.doi.org/10.1186/1479-5876-11-147

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010308538

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23763830


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line, Tumor", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression Regulation, Neoplastic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immune Tolerance", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Immunotherapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasms, Glandular and Epithelial", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ovarian Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Liver, Metabolisms and Cancer", 
              "id": "https://www.grid.ac/institutes/grid.462725.0", 
              "name": [
                "Lady Davis Institut, Jewish General Hospital, McGill University, H3T 1E2, Montreal, QC, Canada", 
                "Faculty of Medicine, University of Rennes 1, Rennes, France", 
                "Liver Metabolisms and Cancer, Inserm, UMR991, Rennes, France", 
                "Department of gynecologic surgery, Teaching Hospital of Rennes, Rennes, France", 
                "Service de chirurgie gyn\u00e9cologique, CHU H\u00f4pital Sud, 16 Bd de Bulgarie, 35 000, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lavou\u00e9", 
            "givenName": "Vincent", 
            "id": "sg:person.01370764031.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370764031.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Liver, Metabolisms and Cancer", 
              "id": "https://www.grid.ac/institutes/grid.462725.0", 
              "name": [
                "Faculty of Medicine, University of Rennes 1, Rennes, France", 
                "Liver Metabolisms and Cancer, Inserm, UMR991, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Th\u00e9drez", 
            "givenName": "Aur\u00e9lie", 
            "id": "sg:person.01250264123.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250264123.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Rennes 1", 
              "id": "https://www.grid.ac/institutes/grid.410368.8", 
              "name": [
                "Faculty of Medicine, University of Rennes 1, Rennes, France", 
                "Department of gynecologic surgery, Teaching Hospital of Rennes, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lev\u00eaque", 
            "givenName": "Jean", 
            "id": "sg:person.01206012023.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206012023.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Rennes 1", 
              "id": "https://www.grid.ac/institutes/grid.410368.8", 
              "name": [
                "Faculty of Medicine, University of Rennes 1, Rennes, France", 
                "Department of gynecologic surgery, Teaching Hospital of Rennes, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Foucher", 
            "givenName": "Fabrice", 
            "id": "sg:person.0707221623.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707221623.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of pathology, Teaching Hospital of Rennes, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Henno", 
            "givenName": "S\u00e9bastien", 
            "id": "sg:person.01023450223.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023450223.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Department of cell biology, Teaching Hospital of Rennes, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jauffret", 
            "givenName": "Vincent", 
            "id": "sg:person.011453155436.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011453155436.64"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Rennes 1", 
              "id": "https://www.grid.ac/institutes/grid.410368.8", 
              "name": [
                "Faculty of Medicine, University of Rennes 1, Rennes, France", 
                "Department of cell biology, Teaching Hospital of Rennes, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belaud-Rotureau", 
            "givenName": "Marc-Antoine", 
            "id": "sg:person.01107100257.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107100257.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Liver, Metabolisms and Cancer", 
              "id": "https://www.grid.ac/institutes/grid.462725.0", 
              "name": [
                "Faculty of Medicine, University of Rennes 1, Rennes, France", 
                "Liver Metabolisms and Cancer, Inserm, UMR991, Rennes, France", 
                "Department of cell biology, Teaching Hospital of Rennes, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Catros", 
            "givenName": "Veronique", 
            "id": "sg:person.01134652460.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134652460.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Liver, Metabolisms and Cancer", 
              "id": "https://www.grid.ac/institutes/grid.462725.0", 
              "name": [
                "Faculty of Medicine, University of Rennes 1, Rennes, France", 
                "Liver Metabolisms and Cancer, Inserm, UMR991, Rennes, France", 
                "Department of cell biology, Teaching Hospital of Rennes, Rennes, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cabillic", 
            "givenName": "Florian", 
            "id": "sg:person.01177124560.64", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177124560.64"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2006.00468.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000246000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdf207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000530894"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2009.09.014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001113648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygyno.2009.01.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001335921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1470-2045(07)70142-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002921614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-09-0835", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003078824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31816dad10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003123623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cji.0b013e31816dad10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003123623"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/imm-100103689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003224207"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humimm.2003.08.345", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005380447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bcp.2010.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005490858"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.194.6.823", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006035130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-3924", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006199892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-06-438028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006226251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-2271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006363078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clim.2009.08.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006370437"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-03-0056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006478998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-04-2671", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006484321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-2449", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006932724"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-03-208249", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007354014"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20082492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007523058"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007925677", 
              "https://doi.org/10.1038/nri2233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdi112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008240994"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008467674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008467674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-01-329656", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008632322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-1016-03", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008821892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2004-12-4942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008984228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.22.3354", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009371322"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.surg.2008.12.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009474348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2009-09-246124", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009595417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1203486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010153811"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000292678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010208602"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012208897", 
              "https://doi.org/10.1038/nm1093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012208897", 
              "https://doi.org/10.1038/nm1093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9610(98)00299-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013139614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2005.03.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013222458"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0063322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013578925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0063322", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013578925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-008-0583-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013590338", 
              "https://doi.org/10.1007/s00262-008-0583-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0710441105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013845708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.10506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014034668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-07-1866", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014113831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygyno.2007.08.064", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014232736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1201-1339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015138087", 
              "https://doi.org/10.1038/nm1201-1339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1201-1339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015138087", 
              "https://doi.org/10.1038/nm1201-1339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1609", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015161098", 
              "https://doi.org/10.1038/nm1609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0897.2005.00330.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015532072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0897.2005.00330.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015532072"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.seminoncol.2006.03.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015861799"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygyno.2009.07.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016090214"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd007287.pub3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016264474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd007287.pub3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016264474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-4433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017201601"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa020177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017266513"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgr019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018039916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1699", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018225414", 
              "https://doi.org/10.1038/nm1699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.13.1953", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018728873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-05-1244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018914673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.immunol.21.120601.141040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019284442"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019635782", 
              "https://doi.org/10.1038/nm863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019635782", 
              "https://doi.org/10.1038/nm863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2008.17.8400", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019772638"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-9-177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020137358", 
              "https://doi.org/10.1186/1479-5876-9-177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygyno.2008.01.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020222166"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.25807", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020376754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0889-8588(03)00064-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020400095"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08820139.2012.689405", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020620461"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.1100274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021187234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2008.191", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021329795", 
              "https://doi.org/10.1038/modpathol.2008.191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.semcancer.2012.01.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021463998"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.24317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021512364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.24317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021512364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022722070", 
              "https://doi.org/10.1186/1471-2407-10-163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3322/caac.20006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022825825"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-2214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023319199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-03-006700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023369319"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.2012.04657.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023649903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2005.03.2813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023675556"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-12-2199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023752004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0509182102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024910000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci35180", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025112763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0712237105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025851911"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-065x.2008.00614.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025941044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2012-06-437558", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026375900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-0126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026377720"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-06-1183", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026427580"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jgm.2604", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026783890"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdl357", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027238481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.coi.2008.05.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027394030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-09-1652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027992290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/14651858.cd007287.pub2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028186712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20111413", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028219993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0703342104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028306530"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2009.27.2369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028531791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygyno.2007.10.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028970342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci39065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029495630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci39065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029495630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02303486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029613676", 
              "https://doi.org/10.1007/bf02303486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02303486", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029613676", 
              "https://doi.org/10.1007/bf02303486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20100269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030884960"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08820139.2012.676122", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030965505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0023348", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031581947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20050930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031714848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10585-012-9473-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032039026", 
              "https://doi.org/10.1007/s10585-012-9473-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrclinonc.2010.223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032822416", 
              "https://doi.org/10.1038/nrclinonc.2010.223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-001-0255-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032848375", 
              "https://doi.org/10.1007/s00262-001-0255-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/jca.5047", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032971209"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.193.7.839", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033089077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-2409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033144295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-2409", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033144295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-10-0700", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033433579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-006-0225-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034297538", 
              "https://doi.org/10.1007/s00262-006-0225-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00262-006-0225-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034297538", 
              "https://doi.org/10.1007/s00262-006-0225-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000386035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034552884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1003345107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035413015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci40269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036150645"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-12-0569", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037639220"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1532/ijh97.05012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037976745", 
              "https://doi.org/10.1532/ijh97.05012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-11-0367", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039019966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2009.00911.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039435764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1582-4934.2009.00911.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039435764"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/cimm.1993.1233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040269537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/gyno.2000.5926", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040397012"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/annonc/mdh021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040542030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1309/15b66dqmfyym78cj", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040992238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/onci.21245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041155526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cji.0000175468.19742.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041200409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cji.0000175468.19742.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041200409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.cji.0000175468.19742.10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041200409"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molimm.2008.08.266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041240565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-07-4619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041532108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci21583", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041748772"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20050915", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041968746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1535-7163.mct-05-0334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042010621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1200690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042896583"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043110107", 
              "https://doi.org/10.1038/nm730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm730", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043110107", 
              "https://doi.org/10.1038/nm730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-2106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043298237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-199410000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043605505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00002371-199410000-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043605505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605274", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044200932", 
              "https://doi.org/10.1038/sj.bjc.6605274"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.27353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045695943"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-9-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045822292", 
              "https://doi.org/10.1186/1476-4598-9-11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0006412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046357745"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0611533104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046431490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2006-07-036863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047353383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa1200694", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047413837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/djq362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047480855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-4174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047557144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047878649", 
              "https://doi.org/10.1038/modpathol.3800646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800646", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047878649", 
              "https://doi.org/10.1038/modpathol.3800646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/2159-8290.cd-12-0548", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048289744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048790610", 
              "https://doi.org/10.1038/sj.bjc.6605820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-08-0479", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049923192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-1690", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050710618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-9-118", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050850311", 
              "https://doi.org/10.1186/1476-4598-9-118"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20101956", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051064621"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051150000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051150000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051150000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051150000"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-3755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051176843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1479-5876-2-23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051356563", 
              "https://doi.org/10.1186/1479-5876-2-23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-05-1299", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051402054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6605814", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051475797", 
              "https://doi.org/10.1038/sj.bjc.6605814"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.176.11.6752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052522554"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa061652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-3792", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052651256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/gyno.2000.6042", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052885037"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053035444", 
              "https://doi.org/10.1186/1471-2407-10-464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/08830185.2011.567362", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053164419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scitranslmed.3003330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062687309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2002.06.171", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203009"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2003.10.104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064203914"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14712598.2013.770836", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067588750"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/092986712800099785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069162466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/138161209787582165", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069166883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/imt.11.20", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069333222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ijo_00000830", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071518810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/cc.9.2.10430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072301116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074470258", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074718119", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.168.2.689", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074975189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075266224", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.175.3.1483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077085934"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.7.4763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077298099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.178.5.2883", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077375026"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.180.11.7338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077650993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077933064", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077933064", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078029886", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079903815", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082765719", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083096682", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083347481", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-12", 
        "datePublishedReg": "2013-12-01", 
        "description": "Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an antitumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This review focuses on the immune response and immune suppression in EOC. The immunological roles of chemotherapy and surgery in EOC are also described. Finally, we detail pilot data supporting the efficiency of immunotherapy in the treatment of EOC and the emerging concept that immunomodulation aimed at counteracting the immunosuppressive microenvironment must be associated with immunotherapy strategies.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1479-5876-11-147", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1032886", 
            "issn": [
              "1479-5876"
            ], 
            "name": "Journal of Translational Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "11"
          }
        ], 
        "name": "Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer", 
        "pagination": "147", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "311c6111708afc592db2911a8411009e030cb2ef22942febe574bee2ce9bb90e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "23763830"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101190741"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1479-5876-11-147"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010308538"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1479-5876-11-147", 
          "https://app.dimensions.ai/details/publication/pub.1010308538"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:15", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000510.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1479-5876-11-147"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-11-147'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-11-147'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-11-147'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-11-147'


     

    This table displays all metadata directly associated to this object as RDF triples.

    713 TRIPLES      21 PREDICATES      212 URIs      31 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1479-5876-11-147 schema:about N1d16731010204195acab9b4a7d25573d
    2 N27e556767a2b4a289aaf74e9fd62c926
    3 N28562f3096424890a3f0efc3989e3c0b
    4 N599d37791b5e426ba29fae73e7eb043c
    5 N786130bcbdec4b259f41e379a46fb7e6
    6 N84f8ebad9feb406084765ebef484abed
    7 N88e02e7820474946aaffce7fda58dae0
    8 N910561ee1534419592f2852805607932
    9 Nc72e457efb6b401bb36a95d502acb05c
    10 Neffb6f0c3c0948ed95765c61da8e5042
    11 anzsrc-for:11
    12 anzsrc-for:1112
    13 schema:author N28d81f45a49a4fe094812c059d0d7db2
    14 schema:citation sg:pub.10.1007/bf02303486
    15 sg:pub.10.1007/s00262-001-0255-1
    16 sg:pub.10.1007/s00262-006-0225-8
    17 sg:pub.10.1007/s00262-008-0583-5
    18 sg:pub.10.1007/s10585-012-9473-5
    19 sg:pub.10.1038/modpathol.2008.191
    20 sg:pub.10.1038/modpathol.3800646
    21 sg:pub.10.1038/nm1093
    22 sg:pub.10.1038/nm1201-1339
    23 sg:pub.10.1038/nm1609
    24 sg:pub.10.1038/nm1699
    25 sg:pub.10.1038/nm730
    26 sg:pub.10.1038/nm863
    27 sg:pub.10.1038/nrclinonc.2010.223
    28 sg:pub.10.1038/nri2233
    29 sg:pub.10.1038/sj.bjc.6605274
    30 sg:pub.10.1038/sj.bjc.6605814
    31 sg:pub.10.1038/sj.bjc.6605820
    32 sg:pub.10.1186/1471-2407-10-163
    33 sg:pub.10.1186/1471-2407-10-464
    34 sg:pub.10.1186/1476-4598-9-11
    35 sg:pub.10.1186/1476-4598-9-118
    36 sg:pub.10.1186/1479-5876-2-23
    37 sg:pub.10.1186/1479-5876-9-177
    38 sg:pub.10.1532/ijh97.05012
    39 https://app.dimensions.ai/details/publication/pub.1074470258
    40 https://app.dimensions.ai/details/publication/pub.1074718119
    41 https://app.dimensions.ai/details/publication/pub.1075266224
    42 https://app.dimensions.ai/details/publication/pub.1077933064
    43 https://app.dimensions.ai/details/publication/pub.1078029886
    44 https://app.dimensions.ai/details/publication/pub.1079903815
    45 https://app.dimensions.ai/details/publication/pub.1082765719
    46 https://app.dimensions.ai/details/publication/pub.1083096682
    47 https://app.dimensions.ai/details/publication/pub.1083347481
    48 https://doi.org/10.1002/14651858.cd007287.pub2
    49 https://doi.org/10.1002/14651858.cd007287.pub3
    50 https://doi.org/10.1002/cncr.10506
    51 https://doi.org/10.1002/cncr.24317
    52 https://doi.org/10.1002/ijc.24597
    53 https://doi.org/10.1002/ijc.25423
    54 https://doi.org/10.1002/ijc.25807
    55 https://doi.org/10.1002/ijc.27353
    56 https://doi.org/10.1002/jgm.2604
    57 https://doi.org/10.1006/cimm.1993.1233
    58 https://doi.org/10.1006/gyno.2000.5926
    59 https://doi.org/10.1006/gyno.2000.6042
    60 https://doi.org/10.1016/j.bcp.2010.05.002
    61 https://doi.org/10.1016/j.clim.2009.08.007
    62 https://doi.org/10.1016/j.coi.2008.05.007
    63 https://doi.org/10.1016/j.humimm.2003.08.345
    64 https://doi.org/10.1016/j.immuni.2005.03.013
    65 https://doi.org/10.1016/j.immuni.2009.09.014
    66 https://doi.org/10.1016/j.molimm.2008.08.266
    67 https://doi.org/10.1016/j.semcancer.2012.01.011
    68 https://doi.org/10.1016/j.surg.2008.12.013
    69 https://doi.org/10.1016/j.ygyno.2007.08.064
    70 https://doi.org/10.1016/j.ygyno.2007.10.016
    71 https://doi.org/10.1016/j.ygyno.2008.01.010
    72 https://doi.org/10.1016/j.ygyno.2009.01.008
    73 https://doi.org/10.1016/j.ygyno.2009.07.015
    74 https://doi.org/10.1016/s0002-9610(98)00299-2
    75 https://doi.org/10.1016/s0889-8588(03)00064-9
    76 https://doi.org/10.1016/s1470-2045(07)70142-0
    77 https://doi.org/10.1053/j.seminoncol.2006.03.012
    78 https://doi.org/10.1056/nejmoa020177
    79 https://doi.org/10.1056/nejmoa061652
    80 https://doi.org/10.1056/nejmoa1200690
    81 https://doi.org/10.1056/nejmoa1200694
    82 https://doi.org/10.1073/pnas.0509182102
    83 https://doi.org/10.1073/pnas.0611533104
    84 https://doi.org/10.1073/pnas.0703342104
    85 https://doi.org/10.1073/pnas.0710441105
    86 https://doi.org/10.1073/pnas.0712237105
    87 https://doi.org/10.1073/pnas.1003345107
    88 https://doi.org/10.1081/imm-100103689
    89 https://doi.org/10.1084/jem.193.7.839
    90 https://doi.org/10.1084/jem.194.6.823
    91 https://doi.org/10.1084/jem.20050915
    92 https://doi.org/10.1084/jem.20050930
    93 https://doi.org/10.1084/jem.20082492
    94 https://doi.org/10.1084/jem.20100269
    95 https://doi.org/10.1084/jem.20101956
    96 https://doi.org/10.1084/jem.20111413
    97 https://doi.org/10.1093/annonc/mdf207
    98 https://doi.org/10.1093/annonc/mdh021
    99 https://doi.org/10.1093/annonc/mdi112
    100 https://doi.org/10.1093/annonc/mdl357
    101 https://doi.org/10.1093/carcin/bgr019
    102 https://doi.org/10.1093/jnci/djq362
    103 https://doi.org/10.1097/00002371-199410000-00004
    104 https://doi.org/10.1097/01.cji.0000175468.19742.10
    105 https://doi.org/10.1097/cji.0b013e31816dad10
    106 https://doi.org/10.1111/j.1365-2249.2012.04657.x
    107 https://doi.org/10.1111/j.1582-4934.2009.00911.x
    108 https://doi.org/10.1111/j.1600-065x.2006.00468.x
    109 https://doi.org/10.1111/j.1600-065x.2008.00614.x
    110 https://doi.org/10.1111/j.1600-0897.2005.00330.x
    111 https://doi.org/10.1126/science.1203486
    112 https://doi.org/10.1126/scitranslmed.3003330
    113 https://doi.org/10.1146/annurev.immunol.21.120601.141040
    114 https://doi.org/10.1158/0008-5472.can-04-3792
    115 https://doi.org/10.1158/0008-5472.can-04-3924
    116 https://doi.org/10.1158/0008-5472.can-05-1299
    117 https://doi.org/10.1158/0008-5472.can-05-3755
    118 https://doi.org/10.1158/0008-5472.can-06-1690
    119 https://doi.org/10.1158/0008-5472.can-06-4174
    120 https://doi.org/10.1158/0008-5472.can-07-1866
    121 https://doi.org/10.1158/0008-5472.can-08-2106
    122 https://doi.org/10.1158/0008-5472.can-09-0835
    123 https://doi.org/10.1158/0008-5472.can-11-0367
    124 https://doi.org/10.1158/0008-5472.can-11-2449
    125 https://doi.org/10.1158/0008-5472.can-12-0569
    126 https://doi.org/10.1158/0008-5472.can-12-2271
    127 https://doi.org/10.1158/0008-5472.can-12-2409
    128 https://doi.org/10.1158/1078-0432.ccr-03-0056
    129 https://doi.org/10.1158/1078-0432.ccr-04-2671
    130 https://doi.org/10.1158/1078-0432.ccr-05-1244
    131 https://doi.org/10.1158/1078-0432.ccr-06-1183
    132 https://doi.org/10.1158/1078-0432.ccr-07-4433
    133 https://doi.org/10.1158/1078-0432.ccr-07-4619
    134 https://doi.org/10.1158/1078-0432.ccr-08-0126
    135 https://doi.org/10.1158/1078-0432.ccr-08-0479
    136 https://doi.org/10.1158/1078-0432.ccr-09-1652
    137 https://doi.org/10.1158/1078-0432.ccr-10-0700
    138 https://doi.org/10.1158/1078-0432.ccr-1016-03
    139 https://doi.org/10.1158/1078-0432.ccr-12-2199
    140 https://doi.org/10.1158/1078-0432.ccr-12-2214
    141 https://doi.org/10.1158/1535-7163.mct-05-0334
    142 https://doi.org/10.1158/2159-8290.cd-12-0548
    143 https://doi.org/10.1159/000292678
    144 https://doi.org/10.1159/000386035
    145 https://doi.org/10.1172/jci21583
    146 https://doi.org/10.1172/jci35180
    147 https://doi.org/10.1172/jci39065
    148 https://doi.org/10.1172/jci40269
    149 https://doi.org/10.1182/blood-2004-12-4942
    150 https://doi.org/10.1182/blood-2006-03-006700
    151 https://doi.org/10.1182/blood-2006-07-036863
    152 https://doi.org/10.1182/blood-2009-03-208249
    153 https://doi.org/10.1182/blood-2009-09-246124
    154 https://doi.org/10.1182/blood-2011-01-329656
    155 https://doi.org/10.1182/blood-2012-06-437558
    156 https://doi.org/10.1182/blood-2012-06-438028
    157 https://doi.org/10.1200/jco.2002.06.171
    158 https://doi.org/10.1200/jco.2003.10.104
    159 https://doi.org/10.1200/jco.2005.03.2813
    160 https://doi.org/10.1200/jco.2007.13.1953
    161 https://doi.org/10.1200/jco.2008.17.8400
    162 https://doi.org/10.1200/jco.2009.22.3354
    163 https://doi.org/10.1200/jco.2009.27.2369
    164 https://doi.org/10.1309/15b66dqmfyym78cj
    165 https://doi.org/10.1371/journal.pone.0006412
    166 https://doi.org/10.1371/journal.pone.0023348
    167 https://doi.org/10.1371/journal.pone.0063322
    168 https://doi.org/10.1517/14712598.2013.770836
    169 https://doi.org/10.2174/092986712800099785
    170 https://doi.org/10.2174/138161209787582165
    171 https://doi.org/10.2217/imt.11.20
    172 https://doi.org/10.3109/08820139.2012.676122
    173 https://doi.org/10.3109/08820139.2012.689405
    174 https://doi.org/10.3109/08830185.2011.567362
    175 https://doi.org/10.3322/caac.20006
    176 https://doi.org/10.3892/ijo_00000830
    177 https://doi.org/10.4049/jimmunol.1100274
    178 https://doi.org/10.4049/jimmunol.168.2.689
    179 https://doi.org/10.4049/jimmunol.175.3.1483
    180 https://doi.org/10.4049/jimmunol.176.11.6752
    181 https://doi.org/10.4049/jimmunol.177.7.4763
    182 https://doi.org/10.4049/jimmunol.178.5.2883
    183 https://doi.org/10.4049/jimmunol.180.11.7338
    184 https://doi.org/10.4161/cc.9.2.10430
    185 https://doi.org/10.4161/onci.21245
    186 https://doi.org/10.7150/jca.5047
    187 schema:datePublished 2013-12
    188 schema:datePublishedReg 2013-12-01
    189 schema:description Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an antitumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This review focuses on the immune response and immune suppression in EOC. The immunological roles of chemotherapy and surgery in EOC are also described. Finally, we detail pilot data supporting the efficiency of immunotherapy in the treatment of EOC and the emerging concept that immunomodulation aimed at counteracting the immunosuppressive microenvironment must be associated with immunotherapy strategies.
    190 schema:genre research_article
    191 schema:inLanguage en
    192 schema:isAccessibleForFree true
    193 schema:isPartOf N30747fc4b7394f1da73c8832e1308ded
    194 N3c6b6901fe6d463a857776ec775d655b
    195 sg:journal.1032886
    196 schema:name Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer
    197 schema:pagination 147
    198 schema:productId N334b022f6f5842faae667074a94039ae
    199 N465b04102e9e475d95b292d979042366
    200 N6f89318fb3a84dcd98ecb79b9ac956e6
    201 Nbfa4e8a0910142619c6de2018ed36cc4
    202 Nef5c17ad2d9746788d71d3f5a9ff0c09
    203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010308538
    204 https://doi.org/10.1186/1479-5876-11-147
    205 schema:sdDatePublished 2019-04-11T00:15
    206 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    207 schema:sdPublisher N18a4eecc0490446da87c1f70a400cc64
    208 schema:url http://link.springer.com/10.1186%2F1479-5876-11-147
    209 sgo:license sg:explorer/license/
    210 sgo:sdDataset articles
    211 rdf:type schema:ScholarlyArticle
    212 N18a4eecc0490446da87c1f70a400cc64 schema:name Springer Nature - SN SciGraph project
    213 rdf:type schema:Organization
    214 N1d16731010204195acab9b4a7d25573d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    215 schema:name Female
    216 rdf:type schema:DefinedTerm
    217 N27e556767a2b4a289aaf74e9fd62c926 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Immune Tolerance
    219 rdf:type schema:DefinedTerm
    220 N28562f3096424890a3f0efc3989e3c0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    221 schema:name Neoplasms, Glandular and Epithelial
    222 rdf:type schema:DefinedTerm
    223 N28d81f45a49a4fe094812c059d0d7db2 rdf:first sg:person.01370764031.08
    224 rdf:rest N7d617ea44924421b8677072d84a6f63d
    225 N2e3c71bcd5bd4367a95bc40c1fb82b12 rdf:first sg:person.0707221623.06
    226 rdf:rest N50dcace4b14846abaae7fe3a74c3167b
    227 N30747fc4b7394f1da73c8832e1308ded schema:issueNumber 1
    228 rdf:type schema:PublicationIssue
    229 N334b022f6f5842faae667074a94039ae schema:name pubmed_id
    230 schema:value 23763830
    231 rdf:type schema:PropertyValue
    232 N3c6b6901fe6d463a857776ec775d655b schema:volumeNumber 11
    233 rdf:type schema:PublicationVolume
    234 N465b04102e9e475d95b292d979042366 schema:name nlm_unique_id
    235 schema:value 101190741
    236 rdf:type schema:PropertyValue
    237 N50dcace4b14846abaae7fe3a74c3167b rdf:first sg:person.01023450223.24
    238 rdf:rest Nc3e2d97bf03e4823bb3f66cd0db6634a
    239 N51dc6afbe2dd413a9f5f412e6fac7b5f schema:name Department of pathology, Teaching Hospital of Rennes, Rennes, France
    240 rdf:type schema:Organization
    241 N599d37791b5e426ba29fae73e7eb043c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Ovarian Neoplasms
    243 rdf:type schema:DefinedTerm
    244 N66507b1382134f32a54c06ad5b6dc4eb rdf:first sg:person.01177124560.64
    245 rdf:rest rdf:nil
    246 N6f89318fb3a84dcd98ecb79b9ac956e6 schema:name doi
    247 schema:value 10.1186/1479-5876-11-147
    248 rdf:type schema:PropertyValue
    249 N76dbe24ce29e49edaf6e1c07b87e2e10 schema:name Department of cell biology, Teaching Hospital of Rennes, Rennes, France
    250 rdf:type schema:Organization
    251 N786130bcbdec4b259f41e379a46fb7e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    252 schema:name Immunotherapy
    253 rdf:type schema:DefinedTerm
    254 N7d617ea44924421b8677072d84a6f63d rdf:first sg:person.01250264123.39
    255 rdf:rest Nac7c14cb68f64943849845194b14f923
    256 N80fd5ed4778c4584b88f609c04c79ed1 rdf:first sg:person.01107100257.32
    257 rdf:rest Nf54cbc1448aa478bafc79d9ebf741c2c
    258 N84f8ebad9feb406084765ebef484abed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    259 schema:name Cell Line, Tumor
    260 rdf:type schema:DefinedTerm
    261 N88e02e7820474946aaffce7fda58dae0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    262 schema:name Humans
    263 rdf:type schema:DefinedTerm
    264 N910561ee1534419592f2852805607932 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    265 schema:name Gene Expression Regulation, Neoplastic
    266 rdf:type schema:DefinedTerm
    267 Nac7c14cb68f64943849845194b14f923 rdf:first sg:person.01206012023.14
    268 rdf:rest N2e3c71bcd5bd4367a95bc40c1fb82b12
    269 Nbfa4e8a0910142619c6de2018ed36cc4 schema:name dimensions_id
    270 schema:value pub.1010308538
    271 rdf:type schema:PropertyValue
    272 Nc3e2d97bf03e4823bb3f66cd0db6634a rdf:first sg:person.011453155436.64
    273 rdf:rest N80fd5ed4778c4584b88f609c04c79ed1
    274 Nc72e457efb6b401bb36a95d502acb05c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    275 schema:name Carcinoma
    276 rdf:type schema:DefinedTerm
    277 Nef5c17ad2d9746788d71d3f5a9ff0c09 schema:name readcube_id
    278 schema:value 311c6111708afc592db2911a8411009e030cb2ef22942febe574bee2ce9bb90e
    279 rdf:type schema:PropertyValue
    280 Neffb6f0c3c0948ed95765c61da8e5042 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    281 schema:name Treatment Outcome
    282 rdf:type schema:DefinedTerm
    283 Nf54cbc1448aa478bafc79d9ebf741c2c rdf:first sg:person.01134652460.43
    284 rdf:rest N66507b1382134f32a54c06ad5b6dc4eb
    285 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    286 schema:name Medical and Health Sciences
    287 rdf:type schema:DefinedTerm
    288 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    289 schema:name Oncology and Carcinogenesis
    290 rdf:type schema:DefinedTerm
    291 sg:journal.1032886 schema:issn 1479-5876
    292 schema:name Journal of Translational Medicine
    293 rdf:type schema:Periodical
    294 sg:person.01023450223.24 schema:affiliation N51dc6afbe2dd413a9f5f412e6fac7b5f
    295 schema:familyName Henno
    296 schema:givenName Sébastien
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023450223.24
    298 rdf:type schema:Person
    299 sg:person.01107100257.32 schema:affiliation https://www.grid.ac/institutes/grid.410368.8
    300 schema:familyName Belaud-Rotureau
    301 schema:givenName Marc-Antoine
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107100257.32
    303 rdf:type schema:Person
    304 sg:person.01134652460.43 schema:affiliation https://www.grid.ac/institutes/grid.462725.0
    305 schema:familyName Catros
    306 schema:givenName Veronique
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134652460.43
    308 rdf:type schema:Person
    309 sg:person.011453155436.64 schema:affiliation N76dbe24ce29e49edaf6e1c07b87e2e10
    310 schema:familyName Jauffret
    311 schema:givenName Vincent
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011453155436.64
    313 rdf:type schema:Person
    314 sg:person.01177124560.64 schema:affiliation https://www.grid.ac/institutes/grid.462725.0
    315 schema:familyName Cabillic
    316 schema:givenName Florian
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177124560.64
    318 rdf:type schema:Person
    319 sg:person.01206012023.14 schema:affiliation https://www.grid.ac/institutes/grid.410368.8
    320 schema:familyName Levêque
    321 schema:givenName Jean
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206012023.14
    323 rdf:type schema:Person
    324 sg:person.01250264123.39 schema:affiliation https://www.grid.ac/institutes/grid.462725.0
    325 schema:familyName Thédrez
    326 schema:givenName Aurélie
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250264123.39
    328 rdf:type schema:Person
    329 sg:person.01370764031.08 schema:affiliation https://www.grid.ac/institutes/grid.462725.0
    330 schema:familyName Lavoué
    331 schema:givenName Vincent
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370764031.08
    333 rdf:type schema:Person
    334 sg:person.0707221623.06 schema:affiliation https://www.grid.ac/institutes/grid.410368.8
    335 schema:familyName Foucher
    336 schema:givenName Fabrice
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0707221623.06
    338 rdf:type schema:Person
    339 sg:pub.10.1007/bf02303486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029613676
    340 https://doi.org/10.1007/bf02303486
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1007/s00262-001-0255-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032848375
    343 https://doi.org/10.1007/s00262-001-0255-1
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1007/s00262-006-0225-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034297538
    346 https://doi.org/10.1007/s00262-006-0225-8
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1007/s00262-008-0583-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013590338
    349 https://doi.org/10.1007/s00262-008-0583-5
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1007/s10585-012-9473-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032039026
    352 https://doi.org/10.1007/s10585-012-9473-5
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/modpathol.2008.191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021329795
    355 https://doi.org/10.1038/modpathol.2008.191
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/modpathol.3800646 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047878649
    358 https://doi.org/10.1038/modpathol.3800646
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/nm1093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012208897
    361 https://doi.org/10.1038/nm1093
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nm1201-1339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015138087
    364 https://doi.org/10.1038/nm1201-1339
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1038/nm1609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015161098
    367 https://doi.org/10.1038/nm1609
    368 rdf:type schema:CreativeWork
    369 sg:pub.10.1038/nm1699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018225414
    370 https://doi.org/10.1038/nm1699
    371 rdf:type schema:CreativeWork
    372 sg:pub.10.1038/nm730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043110107
    373 https://doi.org/10.1038/nm730
    374 rdf:type schema:CreativeWork
    375 sg:pub.10.1038/nm863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019635782
    376 https://doi.org/10.1038/nm863
    377 rdf:type schema:CreativeWork
    378 sg:pub.10.1038/nrclinonc.2010.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032822416
    379 https://doi.org/10.1038/nrclinonc.2010.223
    380 rdf:type schema:CreativeWork
    381 sg:pub.10.1038/nri2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007925677
    382 https://doi.org/10.1038/nri2233
    383 rdf:type schema:CreativeWork
    384 sg:pub.10.1038/sj.bjc.6605274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044200932
    385 https://doi.org/10.1038/sj.bjc.6605274
    386 rdf:type schema:CreativeWork
    387 sg:pub.10.1038/sj.bjc.6605814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051475797
    388 https://doi.org/10.1038/sj.bjc.6605814
    389 rdf:type schema:CreativeWork
    390 sg:pub.10.1038/sj.bjc.6605820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048790610
    391 https://doi.org/10.1038/sj.bjc.6605820
    392 rdf:type schema:CreativeWork
    393 sg:pub.10.1186/1471-2407-10-163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022722070
    394 https://doi.org/10.1186/1471-2407-10-163
    395 rdf:type schema:CreativeWork
    396 sg:pub.10.1186/1471-2407-10-464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053035444
    397 https://doi.org/10.1186/1471-2407-10-464
    398 rdf:type schema:CreativeWork
    399 sg:pub.10.1186/1476-4598-9-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045822292
    400 https://doi.org/10.1186/1476-4598-9-11
    401 rdf:type schema:CreativeWork
    402 sg:pub.10.1186/1476-4598-9-118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050850311
    403 https://doi.org/10.1186/1476-4598-9-118
    404 rdf:type schema:CreativeWork
    405 sg:pub.10.1186/1479-5876-2-23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051356563
    406 https://doi.org/10.1186/1479-5876-2-23
    407 rdf:type schema:CreativeWork
    408 sg:pub.10.1186/1479-5876-9-177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020137358
    409 https://doi.org/10.1186/1479-5876-9-177
    410 rdf:type schema:CreativeWork
    411 sg:pub.10.1532/ijh97.05012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037976745
    412 https://doi.org/10.1532/ijh97.05012
    413 rdf:type schema:CreativeWork
    414 https://app.dimensions.ai/details/publication/pub.1074470258 schema:CreativeWork
    415 https://app.dimensions.ai/details/publication/pub.1074718119 schema:CreativeWork
    416 https://app.dimensions.ai/details/publication/pub.1075266224 schema:CreativeWork
    417 https://app.dimensions.ai/details/publication/pub.1077933064 schema:CreativeWork
    418 https://app.dimensions.ai/details/publication/pub.1078029886 schema:CreativeWork
    419 https://app.dimensions.ai/details/publication/pub.1079903815 schema:CreativeWork
    420 https://app.dimensions.ai/details/publication/pub.1082765719 schema:CreativeWork
    421 https://app.dimensions.ai/details/publication/pub.1083096682 schema:CreativeWork
    422 https://app.dimensions.ai/details/publication/pub.1083347481 schema:CreativeWork
    423 https://doi.org/10.1002/14651858.cd007287.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028186712
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1002/14651858.cd007287.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016264474
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1002/cncr.10506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014034668
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1002/cncr.24317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021512364
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1002/ijc.24597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051150000
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1002/ijc.25423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008467674
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1002/ijc.25807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020376754
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1002/ijc.27353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045695943
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1002/jgm.2604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026783890
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1006/cimm.1993.1233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040269537
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1006/gyno.2000.5926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040397012
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1006/gyno.2000.6042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052885037
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.bcp.2010.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005490858
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/j.clim.2009.08.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006370437
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/j.coi.2008.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027394030
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/j.humimm.2003.08.345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005380447
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/j.immuni.2005.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013222458
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/j.immuni.2009.09.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001113648
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/j.molimm.2008.08.266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041240565
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/j.semcancer.2012.01.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021463998
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/j.surg.2008.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009474348
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.ygyno.2007.08.064 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014232736
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/j.ygyno.2007.10.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028970342
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/j.ygyno.2008.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020222166
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/j.ygyno.2009.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001335921
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/j.ygyno.2009.07.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016090214
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/s0002-9610(98)00299-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013139614
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/s0889-8588(03)00064-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020400095
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1016/s1470-2045(07)70142-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002921614
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1053/j.seminoncol.2006.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015861799
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1056/nejmoa020177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017266513
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1056/nejmoa061652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052581109
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1056/nejmoa1200690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042896583
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1056/nejmoa1200694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047413837
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1073/pnas.0509182102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024910000
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1073/pnas.0611533104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046431490
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1073/pnas.0703342104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028306530
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1073/pnas.0710441105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013845708
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1073/pnas.0712237105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025851911
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1073/pnas.1003345107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035413015
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1081/imm-100103689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003224207
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1084/jem.193.7.839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033089077
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1084/jem.194.6.823 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006035130
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1084/jem.20050915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041968746
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1084/jem.20050930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031714848
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1084/jem.20082492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007523058
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1084/jem.20100269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030884960
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1084/jem.20101956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051064621
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1084/jem.20111413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028219993
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1093/annonc/mdf207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000530894
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1093/annonc/mdh021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040542030
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1093/annonc/mdi112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008240994
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1093/annonc/mdl357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027238481
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1093/carcin/bgr019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018039916
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1093/jnci/djq362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047480855
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1097/00002371-199410000-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043605505
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1097/01.cji.0000175468.19742.10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041200409
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1097/cji.0b013e31816dad10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003123623
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1111/j.1365-2249.2012.04657.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023649903
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1111/j.1582-4934.2009.00911.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039435764
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1111/j.1600-065x.2006.00468.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000246000
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1111/j.1600-065x.2008.00614.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025941044
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1111/j.1600-0897.2005.00330.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1015532072
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1126/science.1203486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010153811
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1126/scitranslmed.3003330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062687309
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1146/annurev.immunol.21.120601.141040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019284442
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1158/0008-5472.can-04-3792 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052651256
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1158/0008-5472.can-04-3924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006199892
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1158/0008-5472.can-05-1299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051402054
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1158/0008-5472.can-05-3755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051176843
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1158/0008-5472.can-06-1690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050710618
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1158/0008-5472.can-06-4174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047557144
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1158/0008-5472.can-07-1866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014113831
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1158/0008-5472.can-08-2106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043298237
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1158/0008-5472.can-09-0835 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003078824
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1158/0008-5472.can-11-0367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039019966
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1158/0008-5472.can-11-2449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006932724
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1158/0008-5472.can-12-0569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037639220
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1158/0008-5472.can-12-2271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006363078
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1158/0008-5472.can-12-2409 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033144295
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1158/1078-0432.ccr-03-0056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006478998
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1158/1078-0432.ccr-04-2671 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006484321
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1158/1078-0432.ccr-05-1244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018914673
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1158/1078-0432.ccr-06-1183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026427580
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1158/1078-0432.ccr-07-4433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017201601
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1158/1078-0432.ccr-07-4619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041532108
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1158/1078-0432.ccr-08-0126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026377720
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1158/1078-0432.ccr-08-0479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049923192
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1158/1078-0432.ccr-09-1652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027992290
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1158/1078-0432.ccr-10-0700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033433579
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1158/1078-0432.ccr-1016-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008821892
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1158/1078-0432.ccr-12-2199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023752004
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1158/1078-0432.ccr-12-2214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023319199
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1158/1535-7163.mct-05-0334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042010621
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1158/2159-8290.cd-12-0548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048289744
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1159/000292678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010208602
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1159/000386035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034552884
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1172/jci21583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041748772
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1172/jci35180 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025112763
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1172/jci39065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029495630
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1172/jci40269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036150645
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1182/blood-2004-12-4942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008984228
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1182/blood-2006-03-006700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023369319
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1182/blood-2006-07-036863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047353383
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1182/blood-2009-03-208249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007354014
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1182/blood-2009-09-246124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009595417
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1182/blood-2011-01-329656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008632322
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1182/blood-2012-06-437558 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026375900
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1182/blood-2012-06-438028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006226251
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1200/jco.2002.06.171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203009
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1200/jco.2003.10.104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203914
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1200/jco.2005.03.2813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023675556
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1200/jco.2007.13.1953 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018728873
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1200/jco.2008.17.8400 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019772638
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1200/jco.2009.22.3354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009371322
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1200/jco.2009.27.2369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028531791
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1309/15b66dqmfyym78cj schema:sameAs https://app.dimensions.ai/details/publication/pub.1040992238
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1371/journal.pone.0006412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046357745
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1371/journal.pone.0023348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031581947
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.1371/journal.pone.0063322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013578925
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.1517/14712598.2013.770836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067588750
    664 rdf:type schema:CreativeWork
    665 https://doi.org/10.2174/092986712800099785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069162466
    666 rdf:type schema:CreativeWork
    667 https://doi.org/10.2174/138161209787582165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069166883
    668 rdf:type schema:CreativeWork
    669 https://doi.org/10.2217/imt.11.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069333222
    670 rdf:type schema:CreativeWork
    671 https://doi.org/10.3109/08820139.2012.676122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030965505
    672 rdf:type schema:CreativeWork
    673 https://doi.org/10.3109/08820139.2012.689405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020620461
    674 rdf:type schema:CreativeWork
    675 https://doi.org/10.3109/08830185.2011.567362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053164419
    676 rdf:type schema:CreativeWork
    677 https://doi.org/10.3322/caac.20006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022825825
    678 rdf:type schema:CreativeWork
    679 https://doi.org/10.3892/ijo_00000830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071518810
    680 rdf:type schema:CreativeWork
    681 https://doi.org/10.4049/jimmunol.1100274 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021187234
    682 rdf:type schema:CreativeWork
    683 https://doi.org/10.4049/jimmunol.168.2.689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074975189
    684 rdf:type schema:CreativeWork
    685 https://doi.org/10.4049/jimmunol.175.3.1483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077085934
    686 rdf:type schema:CreativeWork
    687 https://doi.org/10.4049/jimmunol.176.11.6752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052522554
    688 rdf:type schema:CreativeWork
    689 https://doi.org/10.4049/jimmunol.177.7.4763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077298099
    690 rdf:type schema:CreativeWork
    691 https://doi.org/10.4049/jimmunol.178.5.2883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077375026
    692 rdf:type schema:CreativeWork
    693 https://doi.org/10.4049/jimmunol.180.11.7338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077650993
    694 rdf:type schema:CreativeWork
    695 https://doi.org/10.4161/cc.9.2.10430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072301116
    696 rdf:type schema:CreativeWork
    697 https://doi.org/10.4161/onci.21245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041155526
    698 rdf:type schema:CreativeWork
    699 https://doi.org/10.7150/jca.5047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032971209
    700 rdf:type schema:CreativeWork
    701 https://www.grid.ac/institutes/grid.410368.8 schema:alternateName University of Rennes 1
    702 schema:name Department of cell biology, Teaching Hospital of Rennes, Rennes, France
    703 Department of gynecologic surgery, Teaching Hospital of Rennes, Rennes, France
    704 Faculty of Medicine, University of Rennes 1, Rennes, France
    705 rdf:type schema:Organization
    706 https://www.grid.ac/institutes/grid.462725.0 schema:alternateName Liver, Metabolisms and Cancer
    707 schema:name Department of cell biology, Teaching Hospital of Rennes, Rennes, France
    708 Department of gynecologic surgery, Teaching Hospital of Rennes, Rennes, France
    709 Faculty of Medicine, University of Rennes 1, Rennes, France
    710 Lady Davis Institut, Jewish General Hospital, McGill University, H3T 1E2, Montreal, QC, Canada
    711 Liver Metabolisms and Cancer, Inserm, UMR991, Rennes, France
    712 Service de chirurgie gynécologique, CHU Hôpital Sud, 16 Bd de Bulgarie, 35 000, Rennes, France
    713 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...