Exogenous endothelial cells as accelerators of hematopoietic reconstitution View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

J Christopher Mizer, Thomas E Ichim, Doru T Alexandrescu, Constantin A Dasanu, Famela Ramos, Andrew Turner, Erik J Woods, Vladimir Bogin, Michael P Murphy, David Koos, Amit N Patel

ABSTRACT

Despite the successes of recombinant hematopoietic-stimulatory factors at accelerating bone marrow reconstitution and shortening the neutropenic period post-transplantation, significant challenges remain such as cost, inability to reconstitute thrombocytic lineages, and lack of efficacy in conditions such as aplastic anemia. A possible means of accelerating hematopoietic reconstitution would be administration of cells capable of secreting hematopoietic growth factors. Advantages of this approach would include: a) ability to regulate secretion of cytokines based on biological need; b) long term, localized production of growth factors, alleviating need for systemic administration of factors that possess unintended adverse effects; and c) potential to actively repair the hematopoietic stem cell niche. Here we overview the field of hematopoietic growth factors, discuss previous experiences with mesenchymal stem cells (MSC) in accelerating hematopoiesis, and conclude by putting forth the rationale of utilizing exogenous endothelial cells as a novel cellular therapy for acceleration of hematopoietic recovery. More... »

PAGES

231

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1479-5876-10-231

    DOI

    http://dx.doi.org/10.1186/1479-5876-10-231

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047412968

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23171397


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