Comparison of endometrial regenerative cells and bone marrow stromal cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-12

AUTHORS

Huan Wang, Ping Jin, Marianna Sabatino, Jiaqiang Ren, Sara Civini, Vladimir Bogin, Thomas E Ichim, David F Stroncek

ABSTRACT

BACKGROUND: Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared. METHODS: We compared micro RNA (miRNA) and gene expression profiles, soluble cytokine and growth factor levels and ability to inhibit ongoing mixed leukocyte reaction (MLR) of ERC and BMSC each derived from 6 healthy subjects. RESULTS: ERC and BMSC miRNA and gene expression profiles were similar, but not identical; more differences were noted in the expression of genes than in miRNAs. Genes overexpressed in ERCs were more likely to be in immune and inflammation pathways and those overexpressed in BMSCs were more likely to be in stem cell and cancer signaling pathways. In addition, the levels of IL-8 and ICAM-1 were greater in ERC supernatants while the levels of HGF, VEGF, IL-6, CXCL12, TGFB1 and TGFB2 were greater in BMSC supernatants. Additionally, ERC demonstrated greater inhibition of the proliferation of mixed leukocyte cultures. CONCLUSIONS: These results suggest that the in vivo effects of ERC and BMSC may differ. Multiple properties of stromal cells are responsible for their in vivo effectiveness and ERC may be more effective for some of the clinical applications and BMSC for others. Studies in animal models or clinical trials will be required to more fully characterize the differences between ERC and BMSC. More... »

PAGES

207

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1479-5876-10-207

DOI

http://dx.doi.org/10.1186/1479-5876-10-207

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023335384

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23038994


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endometrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Culture Test, Mixed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mesenchymal Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reverse Transcriptase Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Institutes of Health Clinical Center", 
          "id": "https://www.grid.ac/institutes/grid.410305.3", 
          "name": [
            "Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Huan", 
        "id": "sg:person.0606725652.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606725652.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health Clinical Center", 
          "id": "https://www.grid.ac/institutes/grid.410305.3", 
          "name": [
            "Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Ping", 
        "id": "sg:person.01004747320.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004747320.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health Clinical Center", 
          "id": "https://www.grid.ac/institutes/grid.410305.3", 
          "name": [
            "Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sabatino", 
        "givenName": "Marianna", 
        "id": "sg:person.0671317664.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671317664.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health Clinical Center", 
          "id": "https://www.grid.ac/institutes/grid.410305.3", 
          "name": [
            "Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ren", 
        "givenName": "Jiaqiang", 
        "id": "sg:person.011271475327.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011271475327.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health Clinical Center", 
          "id": "https://www.grid.ac/institutes/grid.410305.3", 
          "name": [
            "Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Civini", 
        "givenName": "Sara", 
        "id": "sg:person.01037402652.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037402652.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "MediStem Inc, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bogin", 
        "givenName": "Vladimir", 
        "id": "sg:person.01171635164.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171635164.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "MediStem Inc, San Diego, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ichim", 
        "givenName": "Thomas E", 
        "id": "sg:person.0674333307.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674333307.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institutes of Health Clinical Center", 
          "id": "https://www.grid.ac/institutes/grid.410305.3", 
          "name": [
            "Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA", 
            "Department of Transfusion Medicine, Cell Processing Section, 10 Center Drive-MSC-1288, Building 10, Room 3C720, 20892-1288, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stroncek", 
        "givenName": "David F", 
        "id": "sg:person.010511471377.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010511471377.03"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.8755-8920.2001.450403.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000639043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/0712-rm-356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000878720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/0712-rm-356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000878720"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-5-57", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008086667", 
          "https://doi.org/10.1186/1479-5876-5-57"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008480163", 
          "https://doi.org/10.1038/ni1021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008480163", 
          "https://doi.org/10.1038/ni1021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)16104-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008553097"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/hep.21839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008843411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.10.074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011135053"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellbi.2007.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011571262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/stem.613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019261341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/term.515", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019461827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/980353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022893725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/14653240600855905", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025538709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2010.214841", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026909451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.200900193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027117408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bies.200900193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027117408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar2116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032169750", 
          "https://doi.org/10.1186/ar2116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-011-1306-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035058744", 
          "https://doi.org/10.1007/s00441-011-1306-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00441-011-1306-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035058744", 
          "https://doi.org/10.1007/s00441-011-1306-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040620191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2005-0342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040620191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lt.21965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041375400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lt.21965", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041375400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2184.1970.tb00347.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041841169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.284.5411.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2006.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044654317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-6-45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044928254", 
          "https://doi.org/10.1186/1479-5876-6-45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-540-78281-0_7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044982559", 
          "https://doi.org/10.1007/978-3-540-78281-0_7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2353/ajpath.2009.080705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047554037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3324/haematol.13699", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049745135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)60690-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050238865"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-7-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051762071", 
          "https://doi.org/10.1186/1479-5876-7-15"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000214462.63943.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052009886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.tp.0000214462.63943.14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052009886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/000000007783464939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052102902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3727/000000007783464939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052102902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2007.0217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059309755"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2011.0030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059310331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.teb.2011.0488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059317037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.276.5309.71", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062556263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1615/critrevimmunol.v25.i5.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068131876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/cc.8.4.7731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072300567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.179.3.1595", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077447886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/117693510700300022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077901890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/117693510700300022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077901890"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-12", 
    "datePublishedReg": "2012-12-01", 
    "description": "BACKGROUND: Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared.\nMETHODS: We compared micro RNA (miRNA) and gene expression profiles, soluble cytokine and growth factor levels and ability to inhibit ongoing mixed leukocyte reaction (MLR) of ERC and BMSC each derived from 6 healthy subjects.\nRESULTS: ERC and BMSC miRNA and gene expression profiles were similar, but not identical; more differences were noted in the expression of genes than in miRNAs. Genes overexpressed in ERCs were more likely to be in immune and inflammation pathways and those overexpressed in BMSCs were more likely to be in stem cell and cancer signaling pathways. In addition, the levels of IL-8 and ICAM-1 were greater in ERC supernatants while the levels of HGF, VEGF, IL-6, CXCL12, TGFB1 and TGFB2 were greater in BMSC supernatants. Additionally, ERC demonstrated greater inhibition of the proliferation of mixed leukocyte cultures.\nCONCLUSIONS: These results suggest that the in vivo effects of ERC and BMSC may differ. Multiple properties of stromal cells are responsible for their in vivo effectiveness and ERC may be more effective for some of the clinical applications and BMSC for others. Studies in animal models or clinical trials will be required to more fully characterize the differences between ERC and BMSC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1479-5876-10-207", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032886", 
        "issn": [
          "1479-5876"
        ], 
        "name": "Journal of Translational Medicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "10"
      }
    ], 
    "name": "Comparison of endometrial regenerative cells and bone marrow stromal cells", 
    "pagination": "207", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6f2d3693439ceb83e090d076077b411abf157c37752501f2958f354bd2158272"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23038994"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101190741"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1479-5876-10-207"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1023335384"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1479-5876-10-207", 
      "https://app.dimensions.ai/details/publication/pub.1023335384"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:51", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1479-5876-10-207"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-10-207'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-10-207'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-10-207'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1479-5876-10-207'


 

This table displays all metadata directly associated to this object as RDF triples.

276 TRIPLES      21 PREDICATES      75 URIs      30 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1479-5876-10-207 schema:about N28acc0a29290417290eccfe994fe98c0
2 N3c6120d6a3264f1d93bffe59ade12189
3 N43729be729164b27ba0c3c507d29c395
4 N6668a3254ba04f52bd18c33df4c48ef3
5 N757f975694544f669279e759624e5abb
6 N7c67c79c44904ab4bc5af1e13b253e1f
7 N7ebcb92a58c1403fa67d7b659f6e117f
8 Nb7d3e3c221aa4e149c734c5860c98e6b
9 Nd2dbc3ccb8214a96bc4c23f714b3bb3b
10 anzsrc-for:11
11 anzsrc-for:1112
12 schema:author Neab6711ff52447138cbdd59ef380a754
13 schema:citation sg:pub.10.1007/978-3-540-78281-0_7
14 sg:pub.10.1007/s00441-011-1306-3
15 sg:pub.10.1038/ni1021
16 sg:pub.10.1186/1479-5876-5-57
17 sg:pub.10.1186/1479-5876-6-45
18 sg:pub.10.1186/1479-5876-7-15
19 sg:pub.10.1186/ar2116
20 https://doi.org/10.1002/bies.200900193
21 https://doi.org/10.1002/hep.21839
22 https://doi.org/10.1002/lt.21965
23 https://doi.org/10.1002/stem.613
24 https://doi.org/10.1002/term.515
25 https://doi.org/10.1016/j.bbrc.2009.10.074
26 https://doi.org/10.1016/j.cellbi.2007.12.007
27 https://doi.org/10.1016/j.it.2006.10.004
28 https://doi.org/10.1016/s0140-6736(04)16104-7
29 https://doi.org/10.1016/s0140-6736(08)60690-x
30 https://doi.org/10.1080/14653240600855905
31 https://doi.org/10.1089/scd.2007.0217
32 https://doi.org/10.1089/scd.2011.0030
33 https://doi.org/10.1089/ten.teb.2011.0488
34 https://doi.org/10.1097/01.tp.0000214462.63943.14
35 https://doi.org/10.1111/j.1365-2184.1970.tb00347.x
36 https://doi.org/10.1111/j.8755-8920.2001.450403.x
37 https://doi.org/10.1126/science.276.5309.71
38 https://doi.org/10.1126/science.284.5411.143
39 https://doi.org/10.1136/gut.2010.214841
40 https://doi.org/10.1155/2012/980353
41 https://doi.org/10.1177/117693510700300022
42 https://doi.org/10.1615/critrevimmunol.v25.i5.50
43 https://doi.org/10.1634/stemcells.2005-0342
44 https://doi.org/10.2353/ajpath.2009.080705
45 https://doi.org/10.3181/0712-rm-356
46 https://doi.org/10.3324/haematol.13699
47 https://doi.org/10.3727/000000007783464939
48 https://doi.org/10.4049/jimmunol.179.3.1595
49 https://doi.org/10.4161/cc.8.4.7731
50 schema:datePublished 2012-12
51 schema:datePublishedReg 2012-12-01
52 schema:description BACKGROUND: Endometrial regenerative cells (ERC) and bone marrow stromal cells (BMSC) are being used in clinical trials. While they have been reported to have similar characteristics, they have not been directly compared. METHODS: We compared micro RNA (miRNA) and gene expression profiles, soluble cytokine and growth factor levels and ability to inhibit ongoing mixed leukocyte reaction (MLR) of ERC and BMSC each derived from 6 healthy subjects. RESULTS: ERC and BMSC miRNA and gene expression profiles were similar, but not identical; more differences were noted in the expression of genes than in miRNAs. Genes overexpressed in ERCs were more likely to be in immune and inflammation pathways and those overexpressed in BMSCs were more likely to be in stem cell and cancer signaling pathways. In addition, the levels of IL-8 and ICAM-1 were greater in ERC supernatants while the levels of HGF, VEGF, IL-6, CXCL12, TGFB1 and TGFB2 were greater in BMSC supernatants. Additionally, ERC demonstrated greater inhibition of the proliferation of mixed leukocyte cultures. CONCLUSIONS: These results suggest that the in vivo effects of ERC and BMSC may differ. Multiple properties of stromal cells are responsible for their in vivo effectiveness and ERC may be more effective for some of the clinical applications and BMSC for others. Studies in animal models or clinical trials will be required to more fully characterize the differences between ERC and BMSC.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N54319197dbb4435e9d8f431a0f8a85c4
57 N7ac6c157e41a4a9b9de50df95a92dfc3
58 sg:journal.1032886
59 schema:name Comparison of endometrial regenerative cells and bone marrow stromal cells
60 schema:pagination 207
61 schema:productId N03ae3086d6f0445fac84606f85774fd0
62 N2256677220ea46ceab9f3e6246923b59
63 N48e2d1a89d9e49bc8c955cf2818a07ad
64 Na60ba52b4ba8488e8da0df967bff8d8f
65 Ned725e69cade48859692ad754e6e47ab
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023335384
67 https://doi.org/10.1186/1479-5876-10-207
68 schema:sdDatePublished 2019-04-10T15:51
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher Neceb0f3a9d10449cac93d638d8292b11
71 schema:url http://link.springer.com/10.1186%2F1479-5876-10-207
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N03ae3086d6f0445fac84606f85774fd0 schema:name doi
76 schema:value 10.1186/1479-5876-10-207
77 rdf:type schema:PropertyValue
78 N2020b6044b4e400eb05dd9bdc94b4f33 rdf:first sg:person.01037402652.74
79 rdf:rest Ndcca58b3dd814aa1bf6cde2baf3daf5e
80 N2256677220ea46ceab9f3e6246923b59 schema:name dimensions_id
81 schema:value pub.1023335384
82 rdf:type schema:PropertyValue
83 N28acc0a29290417290eccfe994fe98c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Endometrium
85 rdf:type schema:DefinedTerm
86 N3c6120d6a3264f1d93bffe59ade12189 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Cytokines
88 rdf:type schema:DefinedTerm
89 N3e8a9ab922c948c488361adf59414d37 rdf:first sg:person.0671317664.41
90 rdf:rest Nfb3b09f8d94e46e8941abcbd666a8335
91 N43729be729164b27ba0c3c507d29c395 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Mesenchymal Stromal Cells
93 rdf:type schema:DefinedTerm
94 N48e2d1a89d9e49bc8c955cf2818a07ad schema:name pubmed_id
95 schema:value 23038994
96 rdf:type schema:PropertyValue
97 N54319197dbb4435e9d8f431a0f8a85c4 schema:volumeNumber 10
98 rdf:type schema:PublicationVolume
99 N5550b64ac53042dd801d586667291a6d rdf:first sg:person.0674333307.06
100 rdf:rest Nb752fe6954da41019f6e7f43588457b9
101 N6668a3254ba04f52bd18c33df4c48ef3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Reverse Transcriptase Polymerase Chain Reaction
103 rdf:type schema:DefinedTerm
104 N757f975694544f669279e759624e5abb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Female
106 rdf:type schema:DefinedTerm
107 N7ac6c157e41a4a9b9de50df95a92dfc3 schema:issueNumber 1
108 rdf:type schema:PublicationIssue
109 N7c67c79c44904ab4bc5af1e13b253e1f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Real-Time Polymerase Chain Reaction
111 rdf:type schema:DefinedTerm
112 N7ebcb92a58c1403fa67d7b659f6e117f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Humans
114 rdf:type schema:DefinedTerm
115 Na60ba52b4ba8488e8da0df967bff8d8f schema:name nlm_unique_id
116 schema:value 101190741
117 rdf:type schema:PropertyValue
118 Naf112a86b5ba4db895426af9e52fa99c schema:name MediStem Inc, San Diego, CA, USA
119 rdf:type schema:Organization
120 Nb752fe6954da41019f6e7f43588457b9 rdf:first sg:person.010511471377.03
121 rdf:rest rdf:nil
122 Nb7d3e3c221aa4e149c734c5860c98e6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Lymphocyte Culture Test, Mixed
124 rdf:type schema:DefinedTerm
125 Nc1bb717096704cf2b5354f18f1bee1f0 rdf:first sg:person.01004747320.24
126 rdf:rest N3e8a9ab922c948c488361adf59414d37
127 Nd2dbc3ccb8214a96bc4c23f714b3bb3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Case-Control Studies
129 rdf:type schema:DefinedTerm
130 Ndcca58b3dd814aa1bf6cde2baf3daf5e rdf:first sg:person.01171635164.65
131 rdf:rest N5550b64ac53042dd801d586667291a6d
132 Neab6711ff52447138cbdd59ef380a754 rdf:first sg:person.0606725652.29
133 rdf:rest Nc1bb717096704cf2b5354f18f1bee1f0
134 Neceb0f3a9d10449cac93d638d8292b11 schema:name Springer Nature - SN SciGraph project
135 rdf:type schema:Organization
136 Ned725e69cade48859692ad754e6e47ab schema:name readcube_id
137 schema:value 6f2d3693439ceb83e090d076077b411abf157c37752501f2958f354bd2158272
138 rdf:type schema:PropertyValue
139 Nef353d2595184287b792e8bc8fcb120e schema:name MediStem Inc, San Diego, CA, USA
140 rdf:type schema:Organization
141 Nfb3b09f8d94e46e8941abcbd666a8335 rdf:first sg:person.011271475327.87
142 rdf:rest N2020b6044b4e400eb05dd9bdc94b4f33
143 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
144 schema:name Medical and Health Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
147 schema:name Oncology and Carcinogenesis
148 rdf:type schema:DefinedTerm
149 sg:journal.1032886 schema:issn 1479-5876
150 schema:name Journal of Translational Medicine
151 rdf:type schema:Periodical
152 sg:person.01004747320.24 schema:affiliation https://www.grid.ac/institutes/grid.410305.3
153 schema:familyName Jin
154 schema:givenName Ping
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004747320.24
156 rdf:type schema:Person
157 sg:person.01037402652.74 schema:affiliation https://www.grid.ac/institutes/grid.410305.3
158 schema:familyName Civini
159 schema:givenName Sara
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01037402652.74
161 rdf:type schema:Person
162 sg:person.010511471377.03 schema:affiliation https://www.grid.ac/institutes/grid.410305.3
163 schema:familyName Stroncek
164 schema:givenName David F
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010511471377.03
166 rdf:type schema:Person
167 sg:person.011271475327.87 schema:affiliation https://www.grid.ac/institutes/grid.410305.3
168 schema:familyName Ren
169 schema:givenName Jiaqiang
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011271475327.87
171 rdf:type schema:Person
172 sg:person.01171635164.65 schema:affiliation Naf112a86b5ba4db895426af9e52fa99c
173 schema:familyName Bogin
174 schema:givenName Vladimir
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171635164.65
176 rdf:type schema:Person
177 sg:person.0606725652.29 schema:affiliation https://www.grid.ac/institutes/grid.410305.3
178 schema:familyName Wang
179 schema:givenName Huan
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606725652.29
181 rdf:type schema:Person
182 sg:person.0671317664.41 schema:affiliation https://www.grid.ac/institutes/grid.410305.3
183 schema:familyName Sabatino
184 schema:givenName Marianna
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671317664.41
186 rdf:type schema:Person
187 sg:person.0674333307.06 schema:affiliation Nef353d2595184287b792e8bc8fcb120e
188 schema:familyName Ichim
189 schema:givenName Thomas E
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674333307.06
191 rdf:type schema:Person
192 sg:pub.10.1007/978-3-540-78281-0_7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044982559
193 https://doi.org/10.1007/978-3-540-78281-0_7
194 rdf:type schema:CreativeWork
195 sg:pub.10.1007/s00441-011-1306-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035058744
196 https://doi.org/10.1007/s00441-011-1306-3
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/ni1021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008480163
199 https://doi.org/10.1038/ni1021
200 rdf:type schema:CreativeWork
201 sg:pub.10.1186/1479-5876-5-57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008086667
202 https://doi.org/10.1186/1479-5876-5-57
203 rdf:type schema:CreativeWork
204 sg:pub.10.1186/1479-5876-6-45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044928254
205 https://doi.org/10.1186/1479-5876-6-45
206 rdf:type schema:CreativeWork
207 sg:pub.10.1186/1479-5876-7-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051762071
208 https://doi.org/10.1186/1479-5876-7-15
209 rdf:type schema:CreativeWork
210 sg:pub.10.1186/ar2116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032169750
211 https://doi.org/10.1186/ar2116
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/bies.200900193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027117408
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/hep.21839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008843411
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/lt.21965 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041375400
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/stem.613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019261341
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1002/term.515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019461827
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.bbrc.2009.10.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011135053
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.cellbi.2007.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011571262
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.it.2006.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044654317
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0140-6736(04)16104-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008553097
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0140-6736(08)60690-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050238865
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1080/14653240600855905 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025538709
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1089/scd.2007.0217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309755
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1089/scd.2011.0030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059310331
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1089/ten.teb.2011.0488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059317037
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1097/01.tp.0000214462.63943.14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052009886
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1111/j.1365-2184.1970.tb00347.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1041841169
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1111/j.8755-8920.2001.450403.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000639043
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1126/science.276.5309.71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062556263
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1126/science.284.5411.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379237
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1136/gut.2010.214841 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026909451
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1155/2012/980353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022893725
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1177/117693510700300022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077901890
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1615/critrevimmunol.v25.i5.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068131876
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1634/stemcells.2005-0342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040620191
260 rdf:type schema:CreativeWork
261 https://doi.org/10.2353/ajpath.2009.080705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047554037
262 rdf:type schema:CreativeWork
263 https://doi.org/10.3181/0712-rm-356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000878720
264 rdf:type schema:CreativeWork
265 https://doi.org/10.3324/haematol.13699 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049745135
266 rdf:type schema:CreativeWork
267 https://doi.org/10.3727/000000007783464939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052102902
268 rdf:type schema:CreativeWork
269 https://doi.org/10.4049/jimmunol.179.3.1595 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077447886
270 rdf:type schema:CreativeWork
271 https://doi.org/10.4161/cc.8.4.7731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072300567
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.410305.3 schema:alternateName National Institutes of Health Clinical Center
274 schema:name Department of Transfusion Medicine, Cell Processing Section, 10 Center Drive-MSC-1288, Building 10, Room 3C720, 20892-1288, Bethesda, MD, USA
275 Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA
276 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...