Protein-C deficiency presenting as pulmonary embolism and myocardial infarction in the same patient View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Syed Maqbool, Vishal Rastogi, Ashok Seth, Satbir Singh, Vijay Kumar, Arif Mustaqueem

ABSTRACT

Plasma protein-C exerts anticoagulatory effects by inactivating factors V and VIII. Hereditary protein C deficiency is transmitted as an autosomal dominant disorder. Homozygous individuals usually develop purpura fulminans as newborns; heterozygous protein C-deficient individuals are at increased risk for venous thrombosis and pulmonary embolism. However, arterial thrombosis occurring as a result of congenital protein-C deficiency is still controversial. We describe a young patient with heterozygous protein-C deficiency who experienced both pulmonary embolism as well as myocardial infarction due to thrombotic occlusion without underlying major risk factors. Acute myocardial infarction in young without underlying major risk factors may be evaluated for protein c deficiency. More... »

PAGES

19

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-9560-11-19

DOI

http://dx.doi.org/10.1186/1477-9560-11-19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009217604

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24228720


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