Epidermal growth factor mediates spermatogonial proliferation in newt testis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02-06

AUTHORS

Keisuke Abé, Ko Eto, Shin-ichi Abé

ABSTRACT

The complex processes of spermatogenesis are regulated by various factors. The aim of the current study is to determine the effect of epidermal growth factor (EGF) on spermatogonial proliferation and clarify the mechanism causing the proliferation in newt testis. In the organ culture, EGF stimulated spermatogonial proliferation, but not their differentiation into spermatocytes. cDNA cloning identified 3 members of the EGF receptors, ErbB1, ErbB2, and ErbB4, in the testis. RT-PCR showed that all the receptors cloned were expressed in both Sertoli and germ cells at the spermatogonial stage. In the organ cultures with inhibitors for the EGF receptors, mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K), the EGF-induced spermatogonial proliferation was suppressed. Furthermore, when the organ culture was exposed to EGF, the expressions of stem cell factor (SCF), immunoglobulin-like domain containing neuregulin1 (Ig-NRG1), and ErbB4 mRNA were increased. These results suggested that, since the spermatogonia are sequestered within cysts by the blood-testis barrier consisted of Sertoli cells, EGF possibly mediates spermatogonial proliferation in an endocrine manner through the receptors including ErbB1, ErbB2, and ErbB4 expressed on Sertoli cells via activation of MAPK cascade or/and PI3K cascade by elevating the expressions of SCF, Ig-NRG1, and ErbB4. More... »

PAGES

7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-7827-6-7

DOI

http://dx.doi.org/10.1186/1477-7827-6-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051405207

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18254942


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "ErbB Receptors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, erbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuregulin-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-kit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Salamandridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Spermatogonia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stem Cell Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Testis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences,, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, 860-8555, Kumamoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Biological Sciences,, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, 860-8555, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ab\u00e9", 
        "givenName": "Keisuke", 
        "id": "sg:person.0724007045.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724007045.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences,, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, 860-8555, Kumamoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Biological Sciences,, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, 860-8555, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eto", 
        "givenName": "Ko", 
        "id": "sg:person.01062427654.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062427654.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences,, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, 860-8555, Kumamoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.274841.c", 
          "name": [
            "Department of Biological Sciences,, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, 860-8555, Kumamoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ab\u00e9", 
        "givenName": "Shin-ichi", 
        "id": "sg:person.013355464561.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013355464561.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10735-007-9089-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028169684", 
          "https://doi.org/10.1007/s10735-007-9089-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/309418a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009921132", 
          "https://doi.org/10.1038/309418a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00240-004-0418-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018460469", 
          "https://doi.org/10.1007/s00240-004-0418-6"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-02-06", 
    "datePublishedReg": "2008-02-06", 
    "description": "The complex processes of spermatogenesis are regulated by various factors. The aim of the current study is to determine the effect of epidermal growth factor (EGF) on spermatogonial proliferation and clarify the mechanism causing the proliferation in newt testis. In the organ culture, EGF stimulated spermatogonial proliferation, but not their differentiation into spermatocytes. cDNA cloning identified 3 members of the EGF receptors, ErbB1, ErbB2, and ErbB4, in the testis. RT-PCR showed that all the receptors cloned were expressed in both Sertoli and germ cells at the spermatogonial stage. In the organ cultures with inhibitors for the EGF receptors, mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K), the EGF-induced spermatogonial proliferation was suppressed. Furthermore, when the organ culture was exposed to EGF, the expressions of stem cell factor (SCF), immunoglobulin-like domain containing neuregulin1 (Ig-NRG1), and ErbB4 mRNA were increased. These results suggested that, since the spermatogonia are sequestered within cysts by the blood-testis barrier consisted of Sertoli cells, EGF possibly mediates spermatogonial proliferation in an endocrine manner through the receptors including ErbB1, ErbB2, and ErbB4 expressed on Sertoli cells via activation of MAPK cascade or/and PI3K cascade by elevating the expressions of SCF, Ig-NRG1, and ErbB4.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1477-7827-6-7", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5820371", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5949638", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031327", 
        "issn": [
          "1477-7827"
        ], 
        "name": "Reproductive Biology and Endocrinology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "6"
      }
    ], 
    "keywords": [
      "epidermal growth factor", 
      "stem cell factor", 
      "organ culture", 
      "growth factor", 
      "spermatogonial proliferation", 
      "Sertoli cells", 
      "newt testis", 
      "expression of SCF", 
      "EGF receptor", 
      "blood-testis barrier", 
      "ErbB4 mRNA", 
      "endocrine manner", 
      "RT-PCR", 
      "PI3K", 
      "receptors", 
      "cell factor", 
      "ErbB4", 
      "spermatogonial stage", 
      "proliferation", 
      "testis", 
      "germ cells", 
      "ErbB1", 
      "current study", 
      "cells", 
      "immunoglobulin-like domains", 
      "factors", 
      "protein kinase", 
      "expression", 
      "cysts", 
      "Sertoli", 
      "mitogen", 
      "inhibitors", 
      "activation", 
      "spermatogenesis", 
      "culture", 
      "spermatogonia", 
      "mRNA", 
      "aim", 
      "MAPK cascade", 
      "spermatocytes", 
      "kinase", 
      "differentiation", 
      "cDNA cloning", 
      "study", 
      "cascade", 
      "complex process", 
      "effect", 
      "barriers", 
      "manner", 
      "mechanism", 
      "stage", 
      "members", 
      "results", 
      "cloning", 
      "domain", 
      "process"
    ], 
    "name": "Epidermal growth factor mediates spermatogonial proliferation in newt testis", 
    "pagination": "7", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051405207"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1477-7827-6-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18254942"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1477-7827-6-7", 
      "https://app.dimensions.ai/details/publication/pub.1051405207"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_458.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1477-7827-6-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-6-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-6-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-6-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-6-7'


 

This table displays all metadata directly associated to this object as RDF triples.

218 TRIPLES      21 PREDICATES      102 URIs      91 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1477-7827-6-7 schema:about N0aeb97a8cae64bbf868a9077e7446df6
2 N12aedf369cc64c4fa3e7efb92024df87
3 N1523ac4c24ea4277bfb55273772fd714
4 N292cb186ba8f4c90b3d611835e4879cb
5 N3c2d7575fd654c81a49d66153d5fbf37
6 N3e68e1a238874a12ac374ebeeec2faec
7 N5c66b5a7bab74e95a1a94e1619ea5c7a
8 N7413069b3e6c40e68c4154e89b1f7240
9 N751775d98b6f4df29498ca36d22e310d
10 N798cd9ab51134974af77dcc952a03e85
11 N896e202c48104692a7327527f15fd00d
12 N9a4b7aae041a42f29ff07f800be58dc9
13 Nbef4c26a76f74537bde5d953b8935b56
14 Nc5858b8b34a943af86e1dd9c91ce5bde
15 Nd367c2a69c6f4d7b8cf138b71bc79fdf
16 Ndba7ee160743414f99304da033de43fc
17 Nef64a5e75f44460a8b6271d1de59b9af
18 Nf89d5a1bcb1742619d939a52edcbf869
19 anzsrc-for:06
20 anzsrc-for:0601
21 schema:author N95c41c3951f7441da8acebb8d7ff826f
22 schema:citation sg:pub.10.1007/s00240-004-0418-6
23 sg:pub.10.1007/s10735-007-9089-2
24 sg:pub.10.1038/309418a0
25 schema:datePublished 2008-02-06
26 schema:datePublishedReg 2008-02-06
27 schema:description The complex processes of spermatogenesis are regulated by various factors. The aim of the current study is to determine the effect of epidermal growth factor (EGF) on spermatogonial proliferation and clarify the mechanism causing the proliferation in newt testis. In the organ culture, EGF stimulated spermatogonial proliferation, but not their differentiation into spermatocytes. cDNA cloning identified 3 members of the EGF receptors, ErbB1, ErbB2, and ErbB4, in the testis. RT-PCR showed that all the receptors cloned were expressed in both Sertoli and germ cells at the spermatogonial stage. In the organ cultures with inhibitors for the EGF receptors, mitogen-activated protein kinase (MAPK), and phosphoinositide 3-kinase (PI3K), the EGF-induced spermatogonial proliferation was suppressed. Furthermore, when the organ culture was exposed to EGF, the expressions of stem cell factor (SCF), immunoglobulin-like domain containing neuregulin1 (Ig-NRG1), and ErbB4 mRNA were increased. These results suggested that, since the spermatogonia are sequestered within cysts by the blood-testis barrier consisted of Sertoli cells, EGF possibly mediates spermatogonial proliferation in an endocrine manner through the receptors including ErbB1, ErbB2, and ErbB4 expressed on Sertoli cells via activation of MAPK cascade or/and PI3K cascade by elevating the expressions of SCF, Ig-NRG1, and ErbB4.
28 schema:genre article
29 schema:isAccessibleForFree true
30 schema:isPartOf N414da2c2a8b3420a9188e58f10ef80c4
31 Na27cd5139a2947068717533bd2c5eef6
32 sg:journal.1031327
33 schema:keywords EGF receptor
34 ErbB1
35 ErbB4
36 ErbB4 mRNA
37 MAPK cascade
38 PI3K
39 RT-PCR
40 Sertoli
41 Sertoli cells
42 activation
43 aim
44 barriers
45 blood-testis barrier
46 cDNA cloning
47 cascade
48 cell factor
49 cells
50 cloning
51 complex process
52 culture
53 current study
54 cysts
55 differentiation
56 domain
57 effect
58 endocrine manner
59 epidermal growth factor
60 expression
61 expression of SCF
62 factors
63 germ cells
64 growth factor
65 immunoglobulin-like domains
66 inhibitors
67 kinase
68 mRNA
69 manner
70 mechanism
71 members
72 mitogen
73 newt testis
74 organ culture
75 process
76 proliferation
77 protein kinase
78 receptors
79 results
80 spermatocytes
81 spermatogenesis
82 spermatogonia
83 spermatogonial proliferation
84 spermatogonial stage
85 stage
86 stem cell factor
87 study
88 testis
89 schema:name Epidermal growth factor mediates spermatogonial proliferation in newt testis
90 schema:pagination 7
91 schema:productId Nba27ccd6a376439ab39eb84b80ccecd2
92 Nceed6631818c4390a450d7fa509f1148
93 Nd7776f872a5947eda431722a92940a2c
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051405207
95 https://doi.org/10.1186/1477-7827-6-7
96 schema:sdDatePublished 2022-09-02T15:54
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher N4c6cc3f2e97248a3b4afa1116af0b29c
99 schema:url https://doi.org/10.1186/1477-7827-6-7
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N0aeb97a8cae64bbf868a9077e7446df6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Molecular Sequence Data
105 rdf:type schema:DefinedTerm
106 N12aedf369cc64c4fa3e7efb92024df87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Stem Cell Factor
108 rdf:type schema:DefinedTerm
109 N1523ac4c24ea4277bfb55273772fd714 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Epidermal Growth Factor
111 rdf:type schema:DefinedTerm
112 N260e6af9d05945608f73ac2984a365ad rdf:first sg:person.01062427654.09
113 rdf:rest N6313c0fcdf9c43e3869fbe25b8341b38
114 N292cb186ba8f4c90b3d611835e4879cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Sequence Homology, Amino Acid
116 rdf:type schema:DefinedTerm
117 N3c2d7575fd654c81a49d66153d5fbf37 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Neuregulin-1
119 rdf:type schema:DefinedTerm
120 N3e68e1a238874a12ac374ebeeec2faec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Proto-Oncogene Proteins c-kit
122 rdf:type schema:DefinedTerm
123 N414da2c2a8b3420a9188e58f10ef80c4 schema:issueNumber 1
124 rdf:type schema:PublicationIssue
125 N4c6cc3f2e97248a3b4afa1116af0b29c schema:name Springer Nature - SN SciGraph project
126 rdf:type schema:Organization
127 N5c66b5a7bab74e95a1a94e1619ea5c7a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Genes, erbB-2
129 rdf:type schema:DefinedTerm
130 N6313c0fcdf9c43e3869fbe25b8341b38 rdf:first sg:person.013355464561.36
131 rdf:rest rdf:nil
132 N7413069b3e6c40e68c4154e89b1f7240 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name ErbB Receptors
134 rdf:type schema:DefinedTerm
135 N751775d98b6f4df29498ca36d22e310d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Salamandridae
137 rdf:type schema:DefinedTerm
138 N798cd9ab51134974af77dcc952a03e85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Signal Transduction
140 rdf:type schema:DefinedTerm
141 N896e202c48104692a7327527f15fd00d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Receptor, ErbB-4
143 rdf:type schema:DefinedTerm
144 N95c41c3951f7441da8acebb8d7ff826f rdf:first sg:person.0724007045.31
145 rdf:rest N260e6af9d05945608f73ac2984a365ad
146 N9a4b7aae041a42f29ff07f800be58dc9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Gene Expression Regulation
148 rdf:type schema:DefinedTerm
149 Na27cd5139a2947068717533bd2c5eef6 schema:volumeNumber 6
150 rdf:type schema:PublicationVolume
151 Nba27ccd6a376439ab39eb84b80ccecd2 schema:name dimensions_id
152 schema:value pub.1051405207
153 rdf:type schema:PropertyValue
154 Nbef4c26a76f74537bde5d953b8935b56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Animals
156 rdf:type schema:DefinedTerm
157 Nc5858b8b34a943af86e1dd9c91ce5bde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Cell Proliferation
159 rdf:type schema:DefinedTerm
160 Nceed6631818c4390a450d7fa509f1148 schema:name doi
161 schema:value 10.1186/1477-7827-6-7
162 rdf:type schema:PropertyValue
163 Nd367c2a69c6f4d7b8cf138b71bc79fdf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Spermatogonia
165 rdf:type schema:DefinedTerm
166 Nd7776f872a5947eda431722a92940a2c schema:name pubmed_id
167 schema:value 18254942
168 rdf:type schema:PropertyValue
169 Ndba7ee160743414f99304da033de43fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Male
171 rdf:type schema:DefinedTerm
172 Nef64a5e75f44460a8b6271d1de59b9af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Testis
174 rdf:type schema:DefinedTerm
175 Nf89d5a1bcb1742619d939a52edcbf869 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Amino Acid Sequence
177 rdf:type schema:DefinedTerm
178 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
179 schema:name Biological Sciences
180 rdf:type schema:DefinedTerm
181 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
182 schema:name Biochemistry and Cell Biology
183 rdf:type schema:DefinedTerm
184 sg:grant.5820371 http://pending.schema.org/fundedItem sg:pub.10.1186/1477-7827-6-7
185 rdf:type schema:MonetaryGrant
186 sg:grant.5949638 http://pending.schema.org/fundedItem sg:pub.10.1186/1477-7827-6-7
187 rdf:type schema:MonetaryGrant
188 sg:journal.1031327 schema:issn 1477-7827
189 schema:name Reproductive Biology and Endocrinology
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.01062427654.09 schema:affiliation grid-institutes:grid.274841.c
193 schema:familyName Eto
194 schema:givenName Ko
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062427654.09
196 rdf:type schema:Person
197 sg:person.013355464561.36 schema:affiliation grid-institutes:grid.274841.c
198 schema:familyName Abé
199 schema:givenName Shin-ichi
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013355464561.36
201 rdf:type schema:Person
202 sg:person.0724007045.31 schema:affiliation grid-institutes:grid.274841.c
203 schema:familyName Abé
204 schema:givenName Keisuke
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724007045.31
206 rdf:type schema:Person
207 sg:pub.10.1007/s00240-004-0418-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018460469
208 https://doi.org/10.1007/s00240-004-0418-6
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/s10735-007-9089-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028169684
211 https://doi.org/10.1007/s10735-007-9089-2
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/309418a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009921132
214 https://doi.org/10.1038/309418a0
215 rdf:type schema:CreativeWork
216 grid-institutes:grid.274841.c schema:alternateName Department of Biological Sciences,, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, 860-8555, Kumamoto, Japan
217 schema:name Department of Biological Sciences,, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, 860-8555, Kumamoto, Japan
218 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...