The effects of oxidative stress on female reproduction: a review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06-29

AUTHORS

Ashok Agarwal, Anamar Aponte-Mellado, Beena J Premkumar, Amani Shaman, Sajal Gupta

ABSTRACT

Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility. More... »

PAGES

49

References to SciGraph publications

  • 2007-02-08. Control of human trophoblast function in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2005. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications in CELL STRESS AND CHAPERONES
  • 2005-07-14. Role of oxidative stress in female reproduction in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2009-05-28. Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2005-09-02. Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2009-07-14. Serum and follicular fluid organochlorine concentrations among women undergoing assisted reproduction technologies in ENVIRONMENTAL HEALTH
  • 2002-07. Levels of Environmental Contaminants in Human Follicular Fluid, Serum, and Seminal Plasma of Couples Undergoing In Vitro Fertilization in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2011-08-08. Hsp70: Anti-apoptotic and Tumorigenic Protein in MOLECULAR CHAPERONES
  • 1992-07. Endrin-induced increases in hepatic lipid peroxidation, membrane microviscosity, and DNA damage in rats in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2006-03-01. N‐Acetyl‐L‐cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor‐κB activation in alveolar macrophages by different mechanisms in ACTA PHARMACOLOGICA SINICA
  • 2010-05-10. Fetal loss and maternal serum levels of 2,2',4,4',5,5'-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure: a cohort study in Greenland and two European populations in ENVIRONMENTAL HEALTH
  • 2001-01. Oxidative stress, metabolism of ethanol and alcohol-related diseases in JOURNAL OF BIOMEDICAL SCIENCE
  • 2011-02-03. Organochlorine Pesticide Gradient Levels Among Maternal Adipose Tissue, Maternal Blood Serum and Umbilical Blood Serum in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2011-10. Occupational, Environmental and Lifestyle Factors Associated With Spontaneous Abortion in REPRODUCTIVE SCIENCES
  • 2003-07. Spontaneous abortion in spouses of greenhouse workers exposed to pesticides in ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
  • 2007-04. Heat shock genes — integrating cell survival and death in JOURNAL OF BIOSCIENCES
  • 2007. Hsp70B regulation and function in CELL STRESS AND CHAPERONES
  • 2004-07-10. Oxidative stress in the placenta in HISTOCHEMISTRY AND CELL BIOLOGY
  • 2004-09. Placental Oxidative Stress: From Miscarriage to Preeclampsia in REPRODUCTIVE SCIENCES
  • 2006-09-12. Effect of prepregnancy body mass index categories on obstetrical and neonatal outcomes in ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • 2000-05-01. Induction of Placental Heme Oxygenase-1 Is Protective Against TNFα-induced Cytotoxicity and Promotes Vessel Relaxation in MOLECULAR MEDICINE
  • 2008-10-30. Increased gonadotrophin stimulation does not improve IVF outcomes in patients with predicted poor ovarian reserve in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • 1995-09. Hypertension in mice lacking the gene for endothelial nitric oxide synthase in NATURE
  • 2009-05-04. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2001-01. Oxidative Stress and the Ovary in REPRODUCTIVE SCIENCES
  • 2008-08-28. Obstetrics in PASSING THE USMLE
  • 1990-11. Organochlorine residues in adipose tissue of canadians in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2007-06-01. Inflammatory pathways in the mechanism of parturition in BMC PREGNANCY AND CHILDBIRTH
  • 2001-01. Oxidative stress and the ovary. in REPRODUCTIVE SCIENCES
  • 2009-01-13. Acute exercise and oxidative stress: a 30 year history in DYNAMIC MEDICINE
  • 2010-01. Antioxidant Enzyme Expression, Lipid Peroxidation, and Protein Oxidation in Human Myometrium With Parturition in REPRODUCTIVE SCIENCES
  • 2006-08-06. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1477-7827-10-49

    DOI

    http://dx.doi.org/10.1186/1477-7827-10-49

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022180024

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22748101


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Paediatrics and Reproductive Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antioxidants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endometriosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Free Radicals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infertility, Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxidative Stress", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pregnancy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reactive Oxygen Species", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Reduction Behavior", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agarwal", 
            "givenName": "Ashok", 
            "id": "sg:person.01044651613.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044651613.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aponte-Mellado", 
            "givenName": "Anamar", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Premkumar", 
            "givenName": "Beena J", 
            "id": "sg:person.01055467124.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055467124.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shaman", 
            "givenName": "Amani", 
            "id": "sg:person.01123602324.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123602324.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gupta", 
            "givenName": "Sajal", 
            "id": "sg:person.01153070401.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153070401.50"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/978-1-61779-295-3_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027772517", 
              "https://doi.org/10.1007/978-1-61779-295-3_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-069x-9-22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019681720", 
              "https://doi.org/10.1186/1476-069x-9-22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-3-28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019926167", 
              "https://doi.org/10.1186/1477-7827-3-28"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02255972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030559576", 
              "https://doi.org/10.1007/bf02255972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12038-007-0059-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003095431", 
              "https://doi.org/10.1007/s12038-007-0059-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-7-54", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004230875", 
              "https://doi.org/10.1186/1477-7827-7-54"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2393-7-s1-s7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030670491", 
              "https://doi.org/10.1186/1471-2393-7-s1-s7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052369088", 
              "https://doi.org/10.1038/nm1452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1177/1933719109348027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064078872", 
              "https://doi.org/10.1177/1933719109348027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1379/csc-278e.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006454620", 
              "https://doi.org/10.1379/csc-278e.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02897919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029395018", 
              "https://doi.org/10.1007/bf02897919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00418-004-0677-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012372338", 
              "https://doi.org/10.1007/s00418-004-0677-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00404-006-0219-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031019404", 
              "https://doi.org/10.1007/s00404-006-0219-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-5918-8-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027329388", 
              "https://doi.org/10.1186/1476-5918-8-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00244-001-0048-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002240446", 
              "https://doi.org/10.1007/s00244-001-0048-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377239a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027266386", 
              "https://doi.org/10.1038/377239a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03401783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074687746", 
              "https://doi.org/10.1007/bf03401783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00225988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048006555", 
              "https://doi.org/10.1007/bf00225988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01700986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020517222", 
              "https://doi.org/10.1007/bf01700986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1379/csc-99r.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010489903", 
              "https://doi.org/10.1379/csc-99r.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-3-43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038867042", 
              "https://doi.org/10.1186/1477-7827-3-43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-68984-5_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043235029", 
              "https://doi.org/10.1007/978-0-387-68984-5_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1177/1071557601008001s13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083940470", 
              "https://doi.org/10.1177/1071557601008001s13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1071-5576(00)00106-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054678877", 
              "https://doi.org/10.1016/s1071-5576(00)00106-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.jsgi.2004.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054739680", 
              "https://doi.org/10.1016/j.jsgi.2004.03.003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1745-7254.2006.00264.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042871962", 
              "https://doi.org/10.1111/j.1745-7254.2006.00264.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00128-011-0204-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001339893", 
              "https://doi.org/10.1007/s00128-011-0204-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10815-008-9266-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047880702", 
              "https://doi.org/10.1007/s10815-008-9266-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-069x-8-32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011593470", 
              "https://doi.org/10.1186/1476-069x-8-32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-7-40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028212423", 
              "https://doi.org/10.1186/1477-7827-7-40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-5-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043089371", 
              "https://doi.org/10.1186/1477-7827-5-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1177/1933719111413298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064079100", 
              "https://doi.org/10.1177/1933719111413298"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-06-29", 
        "datePublishedReg": "2012-06-29", 
        "description": "Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/1477-7827-10-49", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1031327", 
            "issn": [
              "1477-7827"
            ], 
            "name": "Reproductive Biology and Endocrinology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "keywords": [
          "polycystic ovary syndrome", 
          "oxidative stress", 
          "antioxidant supplementation", 
          "excess free radical production", 
          "impact of OS", 
          "recurrent pregnancy loss", 
          "ART culture media", 
          "recreational drug use", 
          "female reproductive ability", 
          "reproductive physiological processes", 
          "free radical production", 
          "unexplained infertility", 
          "pregnancy complications", 
          "ovary syndrome", 
          "pro-oxidant molecules", 
          "lifestyle factors", 
          "cigarette smoking", 
          "possible benefits", 
          "pregnancy loss", 
          "spontaneous abortion", 
          "female infertility", 
          "clinical trials", 
          "production of ROS", 
          "body weight", 
          "ART success", 
          "drug use", 
          "reproductive function", 
          "reproductive disorders", 
          "infertility", 
          "reproductive techniques", 
          "reproductive diseases", 
          "alcohol use", 
          "adverse effects", 
          "conflicting results", 
          "precise mechanism", 
          "antioxidant defense", 
          "female reproduction", 
          "potential strategy", 
          "radical production", 
          "available literature", 
          "supplementation", 
          "oxidative state", 
          "sperm quality", 
          "reactive oxygen", 
          "females", 
          "further exploration", 
          "antioxidants", 
          "physiological processes", 
          "preeclampsia", 
          "endometriosis", 
          "complications", 
          "smoking", 
          "culture medium", 
          "reproductive ability", 
          "subfertility", 
          "pathogenesis", 
          "syndrome", 
          "disease", 
          "trials", 
          "disorders", 
          "key role", 
          "imbalance", 
          "nitrogen species", 
          "abortion", 
          "environmental pollutants", 
          "males", 
          "study", 
          "exposure", 
          "role", 
          "oocytes", 
          "benefits", 
          "animals", 
          "ROS", 
          "effect", 
          "humans", 
          "review", 
          "use", 
          "response", 
          "function", 
          "stress", 
          "factors", 
          "weight", 
          "likelihood", 
          "fertility", 
          "impact", 
          "date", 
          "loss", 
          "production", 
          "defense", 
          "mechanism", 
          "concern", 
          "ability", 
          "literature", 
          "addition", 
          "quality", 
          "strategies", 
          "number", 
          "success", 
          "hand", 
          "reactive species", 
          "investigation", 
          "results", 
          "molecules", 
          "state", 
          "reproduction", 
          "future", 
          "exploration", 
          "technique", 
          "article", 
          "medium", 
          "species", 
          "oxygen", 
          "extremes", 
          "process", 
          "pollutants"
        ], 
        "name": "The effects of oxidative stress on female reproduction: a review", 
        "pagination": "49", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1022180024"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1477-7827-10-49"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22748101"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1477-7827-10-49", 
          "https://app.dimensions.ai/details/publication/pub.1022180024"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_572.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/1477-7827-10-49"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-10-49'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-10-49'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-10-49'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-10-49'


     

    This table displays all metadata directly associated to this object as RDF triples.

    378 TRIPLES      21 PREDICATES      183 URIs      143 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1477-7827-10-49 schema:about N17ea1b8f2d604bdfa084bb4a01a6785e
    2 N3e4be4a6624f458a92f1449ad255f7d3
    3 N4c035fcec3ca45048101b0af4d92f0c3
    4 N5db192ed9bca433a9b466f14a6a5f0a1
    5 N813c2cf37fb941c69cea81262518c864
    6 Na2a89bd292ae4b9c9b211d2d03227dd3
    7 Nc74750d23f124799b12791ff205ec51c
    8 Nd63e5b8a172e40fbb2ed306e921d1f0c
    9 Ndec7471986a2498d8f0fb19e80dbba30
    10 Ne60ec0091df54a9b893013829bc873a8
    11 Nf01733508732459e97e108ff39eb1cd5
    12 Nf841eade483441caa3b401fdd3292bee
    13 anzsrc-for:11
    14 anzsrc-for:1114
    15 schema:author Nbd64cc1552694cb4b14f54dc73d69bbb
    16 schema:citation sg:pub.10.1007/978-0-387-68984-5_3
    17 sg:pub.10.1007/978-1-61779-295-3_16
    18 sg:pub.10.1007/bf00225988
    19 sg:pub.10.1007/bf01700986
    20 sg:pub.10.1007/bf02255972
    21 sg:pub.10.1007/bf02897919
    22 sg:pub.10.1007/bf03401783
    23 sg:pub.10.1007/s00128-011-0204-4
    24 sg:pub.10.1007/s00244-001-0048-8
    25 sg:pub.10.1007/s00404-006-0219-y
    26 sg:pub.10.1007/s00418-004-0677-x
    27 sg:pub.10.1007/s10815-008-9266-6
    28 sg:pub.10.1007/s12038-007-0059-3
    29 sg:pub.10.1016/j.jsgi.2004.03.003
    30 sg:pub.10.1016/s1071-5576(00)00106-4
    31 sg:pub.10.1038/377239a0
    32 sg:pub.10.1038/nm1452
    33 sg:pub.10.1111/j.1745-7254.2006.00264.x
    34 sg:pub.10.1177/1071557601008001s13
    35 sg:pub.10.1177/1933719109348027
    36 sg:pub.10.1177/1933719111413298
    37 sg:pub.10.1186/1471-2393-7-s1-s7
    38 sg:pub.10.1186/1476-069x-8-32
    39 sg:pub.10.1186/1476-069x-9-22
    40 sg:pub.10.1186/1476-5918-8-1
    41 sg:pub.10.1186/1477-7827-3-28
    42 sg:pub.10.1186/1477-7827-3-43
    43 sg:pub.10.1186/1477-7827-5-6
    44 sg:pub.10.1186/1477-7827-7-40
    45 sg:pub.10.1186/1477-7827-7-54
    46 sg:pub.10.1379/csc-278e.1
    47 sg:pub.10.1379/csc-99r.1
    48 schema:datePublished 2012-06-29
    49 schema:datePublishedReg 2012-06-29
    50 schema:description Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.
    51 schema:genre article
    52 schema:isAccessibleForFree true
    53 schema:isPartOf N3696a441de1747a5b8cdb0f9a9e6a5e7
    54 N5d7b952687b24423842a1814d5213f67
    55 sg:journal.1031327
    56 schema:keywords ART culture media
    57 ART success
    58 ROS
    59 ability
    60 abortion
    61 addition
    62 adverse effects
    63 alcohol use
    64 animals
    65 antioxidant defense
    66 antioxidant supplementation
    67 antioxidants
    68 article
    69 available literature
    70 benefits
    71 body weight
    72 cigarette smoking
    73 clinical trials
    74 complications
    75 concern
    76 conflicting results
    77 culture medium
    78 date
    79 defense
    80 disease
    81 disorders
    82 drug use
    83 effect
    84 endometriosis
    85 environmental pollutants
    86 excess free radical production
    87 exploration
    88 exposure
    89 extremes
    90 factors
    91 female infertility
    92 female reproduction
    93 female reproductive ability
    94 females
    95 fertility
    96 free radical production
    97 function
    98 further exploration
    99 future
    100 hand
    101 humans
    102 imbalance
    103 impact
    104 impact of OS
    105 infertility
    106 investigation
    107 key role
    108 lifestyle factors
    109 likelihood
    110 literature
    111 loss
    112 males
    113 mechanism
    114 medium
    115 molecules
    116 nitrogen species
    117 number
    118 oocytes
    119 ovary syndrome
    120 oxidative state
    121 oxidative stress
    122 oxygen
    123 pathogenesis
    124 physiological processes
    125 pollutants
    126 polycystic ovary syndrome
    127 possible benefits
    128 potential strategy
    129 precise mechanism
    130 preeclampsia
    131 pregnancy complications
    132 pregnancy loss
    133 pro-oxidant molecules
    134 process
    135 production
    136 production of ROS
    137 quality
    138 radical production
    139 reactive oxygen
    140 reactive species
    141 recreational drug use
    142 recurrent pregnancy loss
    143 reproduction
    144 reproductive ability
    145 reproductive diseases
    146 reproductive disorders
    147 reproductive function
    148 reproductive physiological processes
    149 reproductive techniques
    150 response
    151 results
    152 review
    153 role
    154 smoking
    155 species
    156 sperm quality
    157 spontaneous abortion
    158 state
    159 strategies
    160 stress
    161 study
    162 subfertility
    163 success
    164 supplementation
    165 syndrome
    166 technique
    167 trials
    168 unexplained infertility
    169 use
    170 weight
    171 schema:name The effects of oxidative stress on female reproduction: a review
    172 schema:pagination 49
    173 schema:productId N77d62870092540f9bf4b7db6ac53502e
    174 N8a5fa87e9a884269b6ef660659191e54
    175 Na0c9cea782c64bca9504cd8a6dd7ce9d
    176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022180024
    177 https://doi.org/10.1186/1477-7827-10-49
    178 schema:sdDatePublished 2022-12-01T06:30
    179 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    180 schema:sdPublisher N93b8ea6d90a649eb806c30abd4c75f96
    181 schema:url https://doi.org/10.1186/1477-7827-10-49
    182 sgo:license sg:explorer/license/
    183 sgo:sdDataset articles
    184 rdf:type schema:ScholarlyArticle
    185 N0cdce106d04e40869949a6aee5b53286 rdf:first N48ab35a16c874e6f88decd5da4285b9e
    186 rdf:rest N30deaf9eebaf423b890d885bfc30e5e4
    187 N17ea1b8f2d604bdfa084bb4a01a6785e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Risk Reduction Behavior
    189 rdf:type schema:DefinedTerm
    190 N30deaf9eebaf423b890d885bfc30e5e4 rdf:first sg:person.01055467124.12
    191 rdf:rest Nc5a1837bdb33477f9385e73d4d059590
    192 N3696a441de1747a5b8cdb0f9a9e6a5e7 schema:issueNumber 1
    193 rdf:type schema:PublicationIssue
    194 N3e4be4a6624f458a92f1449ad255f7d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    195 schema:name Reactive Oxygen Species
    196 rdf:type schema:DefinedTerm
    197 N48ab35a16c874e6f88decd5da4285b9e schema:affiliation grid-institutes:grid.239578.2
    198 schema:familyName Aponte-Mellado
    199 schema:givenName Anamar
    200 rdf:type schema:Person
    201 N4c035fcec3ca45048101b0af4d92f0c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Animals
    203 rdf:type schema:DefinedTerm
    204 N5d7b952687b24423842a1814d5213f67 schema:volumeNumber 10
    205 rdf:type schema:PublicationVolume
    206 N5db192ed9bca433a9b466f14a6a5f0a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Oxidative Stress
    208 rdf:type schema:DefinedTerm
    209 N77d62870092540f9bf4b7db6ac53502e schema:name doi
    210 schema:value 10.1186/1477-7827-10-49
    211 rdf:type schema:PropertyValue
    212 N813c2cf37fb941c69cea81262518c864 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Infertility, Female
    214 rdf:type schema:DefinedTerm
    215 N8a5fa87e9a884269b6ef660659191e54 schema:name pubmed_id
    216 schema:value 22748101
    217 rdf:type schema:PropertyValue
    218 N93b8ea6d90a649eb806c30abd4c75f96 schema:name Springer Nature - SN SciGraph project
    219 rdf:type schema:Organization
    220 Na0c9cea782c64bca9504cd8a6dd7ce9d schema:name dimensions_id
    221 schema:value pub.1022180024
    222 rdf:type schema:PropertyValue
    223 Na2a89bd292ae4b9c9b211d2d03227dd3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    224 schema:name Humans
    225 rdf:type schema:DefinedTerm
    226 Nbd64cc1552694cb4b14f54dc73d69bbb rdf:first sg:person.01044651613.35
    227 rdf:rest N0cdce106d04e40869949a6aee5b53286
    228 Nc5a1837bdb33477f9385e73d4d059590 rdf:first sg:person.01123602324.13
    229 rdf:rest Nf49b03129ceb4b4e8acd6c3deb6161dd
    230 Nc74750d23f124799b12791ff205ec51c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    231 schema:name Free Radicals
    232 rdf:type schema:DefinedTerm
    233 Nd63e5b8a172e40fbb2ed306e921d1f0c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Female
    235 rdf:type schema:DefinedTerm
    236 Ndec7471986a2498d8f0fb19e80dbba30 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Endometriosis
    238 rdf:type schema:DefinedTerm
    239 Ne60ec0091df54a9b893013829bc873a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    240 schema:name Pregnancy
    241 rdf:type schema:DefinedTerm
    242 Nf01733508732459e97e108ff39eb1cd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    243 schema:name Antioxidants
    244 rdf:type schema:DefinedTerm
    245 Nf49b03129ceb4b4e8acd6c3deb6161dd rdf:first sg:person.01153070401.50
    246 rdf:rest rdf:nil
    247 Nf841eade483441caa3b401fdd3292bee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    248 schema:name Reproduction
    249 rdf:type schema:DefinedTerm
    250 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    251 schema:name Medical and Health Sciences
    252 rdf:type schema:DefinedTerm
    253 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
    254 schema:name Paediatrics and Reproductive Medicine
    255 rdf:type schema:DefinedTerm
    256 sg:journal.1031327 schema:issn 1477-7827
    257 schema:name Reproductive Biology and Endocrinology
    258 schema:publisher Springer Nature
    259 rdf:type schema:Periodical
    260 sg:person.01044651613.35 schema:affiliation grid-institutes:grid.239578.2
    261 schema:familyName Agarwal
    262 schema:givenName Ashok
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044651613.35
    264 rdf:type schema:Person
    265 sg:person.01055467124.12 schema:affiliation grid-institutes:grid.239578.2
    266 schema:familyName Premkumar
    267 schema:givenName Beena J
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055467124.12
    269 rdf:type schema:Person
    270 sg:person.01123602324.13 schema:affiliation grid-institutes:grid.239578.2
    271 schema:familyName Shaman
    272 schema:givenName Amani
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123602324.13
    274 rdf:type schema:Person
    275 sg:person.01153070401.50 schema:affiliation grid-institutes:grid.239578.2
    276 schema:familyName Gupta
    277 schema:givenName Sajal
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153070401.50
    279 rdf:type schema:Person
    280 sg:pub.10.1007/978-0-387-68984-5_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043235029
    281 https://doi.org/10.1007/978-0-387-68984-5_3
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/978-1-61779-295-3_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027772517
    284 https://doi.org/10.1007/978-1-61779-295-3_16
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/bf00225988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048006555
    287 https://doi.org/10.1007/bf00225988
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/bf01700986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020517222
    290 https://doi.org/10.1007/bf01700986
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/bf02255972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030559576
    293 https://doi.org/10.1007/bf02255972
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/bf02897919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029395018
    296 https://doi.org/10.1007/bf02897919
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/bf03401783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074687746
    299 https://doi.org/10.1007/bf03401783
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s00128-011-0204-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001339893
    302 https://doi.org/10.1007/s00128-011-0204-4
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/s00244-001-0048-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002240446
    305 https://doi.org/10.1007/s00244-001-0048-8
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s00404-006-0219-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1031019404
    308 https://doi.org/10.1007/s00404-006-0219-y
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s00418-004-0677-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012372338
    311 https://doi.org/10.1007/s00418-004-0677-x
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/s10815-008-9266-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047880702
    314 https://doi.org/10.1007/s10815-008-9266-6
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1007/s12038-007-0059-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003095431
    317 https://doi.org/10.1007/s12038-007-0059-3
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1016/j.jsgi.2004.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054739680
    320 https://doi.org/10.1016/j.jsgi.2004.03.003
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1016/s1071-5576(00)00106-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054678877
    323 https://doi.org/10.1016/s1071-5576(00)00106-4
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/377239a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027266386
    326 https://doi.org/10.1038/377239a0
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nm1452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052369088
    329 https://doi.org/10.1038/nm1452
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1111/j.1745-7254.2006.00264.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042871962
    332 https://doi.org/10.1111/j.1745-7254.2006.00264.x
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1177/1071557601008001s13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083940470
    335 https://doi.org/10.1177/1071557601008001s13
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1177/1933719109348027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064078872
    338 https://doi.org/10.1177/1933719109348027
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1177/1933719111413298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064079100
    341 https://doi.org/10.1177/1933719111413298
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1186/1471-2393-7-s1-s7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030670491
    344 https://doi.org/10.1186/1471-2393-7-s1-s7
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1186/1476-069x-8-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011593470
    347 https://doi.org/10.1186/1476-069x-8-32
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1186/1476-069x-9-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019681720
    350 https://doi.org/10.1186/1476-069x-9-22
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1186/1476-5918-8-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027329388
    353 https://doi.org/10.1186/1476-5918-8-1
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1186/1477-7827-3-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019926167
    356 https://doi.org/10.1186/1477-7827-3-28
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1186/1477-7827-3-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038867042
    359 https://doi.org/10.1186/1477-7827-3-43
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1186/1477-7827-5-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043089371
    362 https://doi.org/10.1186/1477-7827-5-6
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1186/1477-7827-7-40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028212423
    365 https://doi.org/10.1186/1477-7827-7-40
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1186/1477-7827-7-54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004230875
    368 https://doi.org/10.1186/1477-7827-7-54
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1379/csc-278e.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006454620
    371 https://doi.org/10.1379/csc-278e.1
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1379/csc-99r.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010489903
    374 https://doi.org/10.1379/csc-99r.1
    375 rdf:type schema:CreativeWork
    376 grid-institutes:grid.239578.2 schema:alternateName Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
    377 schema:name Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
    378 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...