The effects of oxidative stress on female reproduction: a review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-06-29

AUTHORS

Ashok Agarwal, Anamar Aponte-Mellado, Beena J Premkumar, Amani Shaman, Sajal Gupta

ABSTRACT

Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility. More... »

PAGES

49

References to SciGraph publications

  • 2007-02-08. Control of human trophoblast function in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2005. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications in CELL STRESS AND CHAPERONES
  • 2005-07-14. Role of oxidative stress in female reproduction in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2009-05-28. Women with endometriosis improved their peripheral antioxidant markers after the application of a high antioxidant diet in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2005-09-02. Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2009-07-14. Serum and follicular fluid organochlorine concentrations among women undergoing assisted reproduction technologies in ENVIRONMENTAL HEALTH
  • 2002-07. Levels of Environmental Contaminants in Human Follicular Fluid, Serum, and Seminal Plasma of Couples Undergoing In Vitro Fertilization in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2011-08-08. Hsp70: Anti-apoptotic and Tumorigenic Protein in MOLECULAR CHAPERONES
  • 1992-07. Endrin-induced increases in hepatic lipid peroxidation, membrane microviscosity, and DNA damage in rats in ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2006-03-01. N‐Acetyl‐L‐cysteine and pyrrolidine dithiocarbamate inhibited nuclear factor‐κB activation in alveolar macrophages by different mechanisms in ACTA PHARMACOLOGICA SINICA
  • 2010-05-10. Fetal loss and maternal serum levels of 2,2',4,4',5,5'-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure: a cohort study in Greenland and two European populations in ENVIRONMENTAL HEALTH
  • 2001-01. Oxidative stress, metabolism of ethanol and alcohol-related diseases in JOURNAL OF BIOMEDICAL SCIENCE
  • 2011-02-03. Organochlorine Pesticide Gradient Levels Among Maternal Adipose Tissue, Maternal Blood Serum and Umbilical Blood Serum in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2011-10. Occupational, Environmental and Lifestyle Factors Associated With Spontaneous Abortion in REPRODUCTIVE SCIENCES
  • 2003-07. Spontaneous abortion in spouses of greenhouse workers exposed to pesticides in ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
  • 2007-04. Heat shock genes — integrating cell survival and death in JOURNAL OF BIOSCIENCES
  • 2007. Hsp70B regulation and function in CELL STRESS AND CHAPERONES
  • 2004-07-10. Oxidative stress in the placenta in HISTOCHEMISTRY AND CELL BIOLOGY
  • 2004-09. Placental Oxidative Stress: From Miscarriage to Preeclampsia in REPRODUCTIVE SCIENCES
  • 2006-09-12. Effect of prepregnancy body mass index categories on obstetrical and neonatal outcomes in ARCHIVES OF GYNECOLOGY AND OBSTETRICS
  • 2000-05-01. Induction of Placental Heme Oxygenase-1 Is Protective Against TNFα-induced Cytotoxicity and Promotes Vessel Relaxation in MOLECULAR MEDICINE
  • 2008-10-30. Increased gonadotrophin stimulation does not improve IVF outcomes in patients with predicted poor ovarian reserve in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
  • 1995-09. Hypertension in mice lacking the gene for endothelial nitric oxide synthase in NATURE
  • 2009-05-04. Follicular fluid content and oocyte quality: from single biochemical markers to metabolomics in REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
  • 2001-01. Oxidative Stress and the Ovary in REPRODUCTIVE SCIENCES
  • 2008-08-28. Obstetrics in PASSING THE USMLE
  • 1990-11. Organochlorine residues in adipose tissue of canadians in BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
  • 2007-06-01. Inflammatory pathways in the mechanism of parturition in BMC PREGNANCY AND CHILDBIRTH
  • 2001-01. Oxidative stress and the ovary. in REPRODUCTIVE SCIENCES
  • 2009-01-13. Acute exercise and oxidative stress: a 30 year history in DYNAMIC MEDICINE
  • 2010-01. Antioxidant Enzyme Expression, Lipid Peroxidation, and Protein Oxidation in Human Myometrium With Parturition in REPRODUCTIVE SCIENCES
  • 2006-08-06. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1477-7827-10-49

    DOI

    http://dx.doi.org/10.1186/1477-7827-10-49

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022180024

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22748101


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Paediatrics and Reproductive Medicine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antioxidants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endometriosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Free Radicals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Infertility, Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxidative Stress", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pregnancy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reactive Oxygen Species", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Reproduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Reduction Behavior", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Agarwal", 
            "givenName": "Ashok", 
            "id": "sg:person.01044651613.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044651613.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Aponte-Mellado", 
            "givenName": "Anamar", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Premkumar", 
            "givenName": "Beena J", 
            "id": "sg:person.01055467124.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055467124.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shaman", 
            "givenName": "Amani", 
            "id": "sg:person.01123602324.13", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123602324.13"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA", 
              "id": "http://www.grid.ac/institutes/grid.239578.2", 
              "name": [
                "Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Gupta", 
            "givenName": "Sajal", 
            "id": "sg:person.01153070401.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153070401.50"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/978-1-61779-295-3_16", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027772517", 
              "https://doi.org/10.1007/978-1-61779-295-3_16"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-069x-9-22", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019681720", 
              "https://doi.org/10.1186/1476-069x-9-22"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-3-28", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019926167", 
              "https://doi.org/10.1186/1477-7827-3-28"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02255972", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030559576", 
              "https://doi.org/10.1007/bf02255972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12038-007-0059-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003095431", 
              "https://doi.org/10.1007/s12038-007-0059-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-7-54", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004230875", 
              "https://doi.org/10.1186/1477-7827-7-54"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2393-7-s1-s7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030670491", 
              "https://doi.org/10.1186/1471-2393-7-s1-s7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052369088", 
              "https://doi.org/10.1038/nm1452"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1177/1933719109348027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064078872", 
              "https://doi.org/10.1177/1933719109348027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1379/csc-278e.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006454620", 
              "https://doi.org/10.1379/csc-278e.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02897919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029395018", 
              "https://doi.org/10.1007/bf02897919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00418-004-0677-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012372338", 
              "https://doi.org/10.1007/s00418-004-0677-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00404-006-0219-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031019404", 
              "https://doi.org/10.1007/s00404-006-0219-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-5918-8-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027329388", 
              "https://doi.org/10.1186/1476-5918-8-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00244-001-0048-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002240446", 
              "https://doi.org/10.1007/s00244-001-0048-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/377239a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027266386", 
              "https://doi.org/10.1038/377239a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf03401783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074687746", 
              "https://doi.org/10.1007/bf03401783"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00225988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048006555", 
              "https://doi.org/10.1007/bf00225988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01700986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020517222", 
              "https://doi.org/10.1007/bf01700986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1379/csc-99r.1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010489903", 
              "https://doi.org/10.1379/csc-99r.1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-3-43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038867042", 
              "https://doi.org/10.1186/1477-7827-3-43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-68984-5_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043235029", 
              "https://doi.org/10.1007/978-0-387-68984-5_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1177/1071557601008001s13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083940470", 
              "https://doi.org/10.1177/1071557601008001s13"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/s1071-5576(00)00106-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054678877", 
              "https://doi.org/10.1016/s1071-5576(00)00106-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1016/j.jsgi.2004.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1054739680", 
              "https://doi.org/10.1016/j.jsgi.2004.03.003"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1745-7254.2006.00264.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042871962", 
              "https://doi.org/10.1111/j.1745-7254.2006.00264.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00128-011-0204-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001339893", 
              "https://doi.org/10.1007/s00128-011-0204-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10815-008-9266-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047880702", 
              "https://doi.org/10.1007/s10815-008-9266-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-069x-8-32", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011593470", 
              "https://doi.org/10.1186/1476-069x-8-32"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-7-40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028212423", 
              "https://doi.org/10.1186/1477-7827-7-40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1477-7827-5-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043089371", 
              "https://doi.org/10.1186/1477-7827-5-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1177/1933719111413298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064079100", 
              "https://doi.org/10.1177/1933719111413298"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-06-29", 
        "datePublishedReg": "2012-06-29", 
        "description": "Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.", 
        "genre": "article", 
        "id": "sg:pub.10.1186/1477-7827-10-49", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1031327", 
            "issn": [
              "1477-7827"
            ], 
            "name": "Reproductive Biology and Endocrinology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "10"
          }
        ], 
        "keywords": [
          "polycystic ovary syndrome", 
          "oxidative stress", 
          "antioxidant supplementation", 
          "excess free radical production", 
          "impact of OS", 
          "recurrent pregnancy loss", 
          "ART culture media", 
          "recreational drug use", 
          "female reproductive ability", 
          "reproductive physiological processes", 
          "free radical production", 
          "unexplained infertility", 
          "pregnancy complications", 
          "ovary syndrome", 
          "pro-oxidant molecules", 
          "lifestyle factors", 
          "cigarette smoking", 
          "possible benefits", 
          "pregnancy loss", 
          "spontaneous abortion", 
          "female infertility", 
          "clinical trials", 
          "production of ROS", 
          "body weight", 
          "ART success", 
          "drug use", 
          "reproductive function", 
          "reproductive disorders", 
          "infertility", 
          "reproductive techniques", 
          "reproductive diseases", 
          "alcohol use", 
          "adverse effects", 
          "conflicting results", 
          "precise mechanism", 
          "antioxidant defense", 
          "female reproduction", 
          "potential strategy", 
          "radical production", 
          "available literature", 
          "supplementation", 
          "oxidative state", 
          "sperm quality", 
          "reactive oxygen", 
          "females", 
          "further exploration", 
          "antioxidants", 
          "physiological processes", 
          "preeclampsia", 
          "endometriosis", 
          "complications", 
          "smoking", 
          "culture medium", 
          "reproductive ability", 
          "subfertility", 
          "pathogenesis", 
          "syndrome", 
          "disease", 
          "trials", 
          "disorders", 
          "key role", 
          "imbalance", 
          "nitrogen species", 
          "abortion", 
          "environmental pollutants", 
          "males", 
          "study", 
          "exposure", 
          "role", 
          "oocytes", 
          "benefits", 
          "animals", 
          "ROS", 
          "effect", 
          "humans", 
          "review", 
          "use", 
          "response", 
          "function", 
          "stress", 
          "factors", 
          "weight", 
          "likelihood", 
          "fertility", 
          "impact", 
          "date", 
          "loss", 
          "production", 
          "defense", 
          "mechanism", 
          "concern", 
          "ability", 
          "literature", 
          "addition", 
          "quality", 
          "strategies", 
          "number", 
          "success", 
          "hand", 
          "reactive species", 
          "investigation", 
          "results", 
          "molecules", 
          "state", 
          "reproduction", 
          "future", 
          "exploration", 
          "technique", 
          "article", 
          "medium", 
          "species", 
          "oxygen", 
          "extremes", 
          "process", 
          "pollutants"
        ], 
        "name": "The effects of oxidative stress on female reproduction: a review", 
        "pagination": "49", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1022180024"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1477-7827-10-49"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22748101"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1477-7827-10-49", 
          "https://app.dimensions.ai/details/publication/pub.1022180024"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-12-01T06:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_572.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1186/1477-7827-10-49"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-10-49'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-10-49'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-10-49'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-7827-10-49'


     

    This table displays all metadata directly associated to this object as RDF triples.

    378 TRIPLES      21 PREDICATES      183 URIs      143 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1477-7827-10-49 schema:about N1b27b951db6c48b0ba0a040bc9c00643
    2 N27f4d77fa3324695b0b2d9ddb4142049
    3 N3ee11aa7e40948008fbbd444a38b245c
    4 N83213de13905406dab74a2b7127cea22
    5 N877f7e3e54df4e01ae402a697c0f8a91
    6 N9b1ff4d97c9c4dc995847ee3ae721fbd
    7 Na03daf4887394bb39848fa38509675e9
    8 Nc556c4618b794482888da2236faac958
    9 Ne4acc522075644ee912bbe9122d6f5bc
    10 Ne959dec4403b4f079852639246c3ef5c
    11 Neccc1e90eb9447c4a069c074af76b579
    12 Nf741faeefa0e434fae263af0d6817c96
    13 anzsrc-for:11
    14 anzsrc-for:1114
    15 schema:author N57733789fa844d53b456e5e328c9307e
    16 schema:citation sg:pub.10.1007/978-0-387-68984-5_3
    17 sg:pub.10.1007/978-1-61779-295-3_16
    18 sg:pub.10.1007/bf00225988
    19 sg:pub.10.1007/bf01700986
    20 sg:pub.10.1007/bf02255972
    21 sg:pub.10.1007/bf02897919
    22 sg:pub.10.1007/bf03401783
    23 sg:pub.10.1007/s00128-011-0204-4
    24 sg:pub.10.1007/s00244-001-0048-8
    25 sg:pub.10.1007/s00404-006-0219-y
    26 sg:pub.10.1007/s00418-004-0677-x
    27 sg:pub.10.1007/s10815-008-9266-6
    28 sg:pub.10.1007/s12038-007-0059-3
    29 sg:pub.10.1016/j.jsgi.2004.03.003
    30 sg:pub.10.1016/s1071-5576(00)00106-4
    31 sg:pub.10.1038/377239a0
    32 sg:pub.10.1038/nm1452
    33 sg:pub.10.1111/j.1745-7254.2006.00264.x
    34 sg:pub.10.1177/1071557601008001s13
    35 sg:pub.10.1177/1933719109348027
    36 sg:pub.10.1177/1933719111413298
    37 sg:pub.10.1186/1471-2393-7-s1-s7
    38 sg:pub.10.1186/1476-069x-8-32
    39 sg:pub.10.1186/1476-069x-9-22
    40 sg:pub.10.1186/1476-5918-8-1
    41 sg:pub.10.1186/1477-7827-3-28
    42 sg:pub.10.1186/1477-7827-3-43
    43 sg:pub.10.1186/1477-7827-5-6
    44 sg:pub.10.1186/1477-7827-7-40
    45 sg:pub.10.1186/1477-7827-7-54
    46 sg:pub.10.1379/csc-278e.1
    47 sg:pub.10.1379/csc-99r.1
    48 schema:datePublished 2012-06-29
    49 schema:datePublishedReg 2012-06-29
    50 schema:description Oxidative stress (OS), a state characterized by an imbalance between pro-oxidant molecules including reactive oxygen and nitrogen species, and antioxidant defenses, has been identified to play a key role in the pathogenesis of subfertility in both males and females. The adverse effects of OS on sperm quality and functions have been well documented. In females, on the other hand, the impact of OS on oocytes and reproductive functions remains unclear. This imbalance between pro-oxidants and antioxidants can lead to a number of reproductive diseases such as endometriosis, polycystic ovary syndrome (PCOS), and unexplained infertility. Pregnancy complications such as spontaneous abortion, recurrent pregnancy loss, and preeclampsia, can also develop in response to OS. Studies have shown that extremes of body weight and lifestyle factors such as cigarette smoking, alcohol use, and recreational drug use can promote excess free radical production, which could affect fertility. Exposures to environmental pollutants are of increasing concern, as they too have been found to trigger oxidative states, possibly contributing to female infertility. This article will review the currently available literature on the roles of reactive species and OS in both normal and abnormal reproductive physiological processes. Antioxidant supplementation may be effective in controlling the production of ROS and continues to be explored as a potential strategy to overcome reproductive disorders associated with infertility. However, investigations conducted to date have been through animal or in vitro studies, which have produced largely conflicting results. The impact of OS on assisted reproductive techniques (ART) will be addressed, in addition to the possible benefits of antioxidant supplementation of ART culture media to increase the likelihood for ART success. Future randomized controlled clinical trials on humans are necessary to elucidate the precise mechanisms through which OS affects female reproductive abilities, and will facilitate further explorations of the possible benefits of antioxidants to treat infertility.
    51 schema:genre article
    52 schema:isAccessibleForFree true
    53 schema:isPartOf N5d42164945f241959fbd1eebc4f0a51d
    54 Naa5c799332b545f692d3481beb32157f
    55 sg:journal.1031327
    56 schema:keywords ART culture media
    57 ART success
    58 ROS
    59 ability
    60 abortion
    61 addition
    62 adverse effects
    63 alcohol use
    64 animals
    65 antioxidant defense
    66 antioxidant supplementation
    67 antioxidants
    68 article
    69 available literature
    70 benefits
    71 body weight
    72 cigarette smoking
    73 clinical trials
    74 complications
    75 concern
    76 conflicting results
    77 culture medium
    78 date
    79 defense
    80 disease
    81 disorders
    82 drug use
    83 effect
    84 endometriosis
    85 environmental pollutants
    86 excess free radical production
    87 exploration
    88 exposure
    89 extremes
    90 factors
    91 female infertility
    92 female reproduction
    93 female reproductive ability
    94 females
    95 fertility
    96 free radical production
    97 function
    98 further exploration
    99 future
    100 hand
    101 humans
    102 imbalance
    103 impact
    104 impact of OS
    105 infertility
    106 investigation
    107 key role
    108 lifestyle factors
    109 likelihood
    110 literature
    111 loss
    112 males
    113 mechanism
    114 medium
    115 molecules
    116 nitrogen species
    117 number
    118 oocytes
    119 ovary syndrome
    120 oxidative state
    121 oxidative stress
    122 oxygen
    123 pathogenesis
    124 physiological processes
    125 pollutants
    126 polycystic ovary syndrome
    127 possible benefits
    128 potential strategy
    129 precise mechanism
    130 preeclampsia
    131 pregnancy complications
    132 pregnancy loss
    133 pro-oxidant molecules
    134 process
    135 production
    136 production of ROS
    137 quality
    138 radical production
    139 reactive oxygen
    140 reactive species
    141 recreational drug use
    142 recurrent pregnancy loss
    143 reproduction
    144 reproductive ability
    145 reproductive diseases
    146 reproductive disorders
    147 reproductive function
    148 reproductive physiological processes
    149 reproductive techniques
    150 response
    151 results
    152 review
    153 role
    154 smoking
    155 species
    156 sperm quality
    157 spontaneous abortion
    158 state
    159 strategies
    160 stress
    161 study
    162 subfertility
    163 success
    164 supplementation
    165 syndrome
    166 technique
    167 trials
    168 unexplained infertility
    169 use
    170 weight
    171 schema:name The effects of oxidative stress on female reproduction: a review
    172 schema:pagination 49
    173 schema:productId N484fb6058f934367a302d0a699a6e3d2
    174 N7a18fb0e185c4eb69e138d735cf5443a
    175 N849206fd68254f2a9394f8667b298f69
    176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022180024
    177 https://doi.org/10.1186/1477-7827-10-49
    178 schema:sdDatePublished 2022-12-01T06:30
    179 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    180 schema:sdPublisher N7bfc003aae844e2385abe32551a9febd
    181 schema:url https://doi.org/10.1186/1477-7827-10-49
    182 sgo:license sg:explorer/license/
    183 sgo:sdDataset articles
    184 rdf:type schema:ScholarlyArticle
    185 N1b27b951db6c48b0ba0a040bc9c00643 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Humans
    187 rdf:type schema:DefinedTerm
    188 N27f4d77fa3324695b0b2d9ddb4142049 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Free Radicals
    190 rdf:type schema:DefinedTerm
    191 N3ee11aa7e40948008fbbd444a38b245c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Animals
    193 rdf:type schema:DefinedTerm
    194 N484fb6058f934367a302d0a699a6e3d2 schema:name doi
    195 schema:value 10.1186/1477-7827-10-49
    196 rdf:type schema:PropertyValue
    197 N57733789fa844d53b456e5e328c9307e rdf:first sg:person.01044651613.35
    198 rdf:rest N74350713662f40d1a23709795e82c048
    199 N5d42164945f241959fbd1eebc4f0a51d schema:issueNumber 1
    200 rdf:type schema:PublicationIssue
    201 N74350713662f40d1a23709795e82c048 rdf:first Nd9caf080cc084c3e9bf18d738d4fe136
    202 rdf:rest N8227d85689d34ab5a05342dd3d051df3
    203 N7a18fb0e185c4eb69e138d735cf5443a schema:name pubmed_id
    204 schema:value 22748101
    205 rdf:type schema:PropertyValue
    206 N7bfc003aae844e2385abe32551a9febd schema:name Springer Nature - SN SciGraph project
    207 rdf:type schema:Organization
    208 N8227d85689d34ab5a05342dd3d051df3 rdf:first sg:person.01055467124.12
    209 rdf:rest N9b6305861b4742b198a18e32f97cab44
    210 N83213de13905406dab74a2b7127cea22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Antioxidants
    212 rdf:type schema:DefinedTerm
    213 N849206fd68254f2a9394f8667b298f69 schema:name dimensions_id
    214 schema:value pub.1022180024
    215 rdf:type schema:PropertyValue
    216 N877f7e3e54df4e01ae402a697c0f8a91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    217 schema:name Endometriosis
    218 rdf:type schema:DefinedTerm
    219 N9b1ff4d97c9c4dc995847ee3ae721fbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    220 schema:name Female
    221 rdf:type schema:DefinedTerm
    222 N9b6305861b4742b198a18e32f97cab44 rdf:first sg:person.01123602324.13
    223 rdf:rest Nb69a1053adee4ac9a7c309e1c71e7925
    224 Na03daf4887394bb39848fa38509675e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Oxidative Stress
    226 rdf:type schema:DefinedTerm
    227 Naa5c799332b545f692d3481beb32157f schema:volumeNumber 10
    228 rdf:type schema:PublicationVolume
    229 Nb69a1053adee4ac9a7c309e1c71e7925 rdf:first sg:person.01153070401.50
    230 rdf:rest rdf:nil
    231 Nc556c4618b794482888da2236faac958 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    232 schema:name Reactive Oxygen Species
    233 rdf:type schema:DefinedTerm
    234 Nd9caf080cc084c3e9bf18d738d4fe136 schema:affiliation grid-institutes:grid.239578.2
    235 schema:familyName Aponte-Mellado
    236 schema:givenName Anamar
    237 rdf:type schema:Person
    238 Ne4acc522075644ee912bbe9122d6f5bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    239 schema:name Risk Reduction Behavior
    240 rdf:type schema:DefinedTerm
    241 Ne959dec4403b4f079852639246c3ef5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    242 schema:name Infertility, Female
    243 rdf:type schema:DefinedTerm
    244 Neccc1e90eb9447c4a069c074af76b579 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    245 schema:name Reproduction
    246 rdf:type schema:DefinedTerm
    247 Nf741faeefa0e434fae263af0d6817c96 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    248 schema:name Pregnancy
    249 rdf:type schema:DefinedTerm
    250 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    251 schema:name Medical and Health Sciences
    252 rdf:type schema:DefinedTerm
    253 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
    254 schema:name Paediatrics and Reproductive Medicine
    255 rdf:type schema:DefinedTerm
    256 sg:journal.1031327 schema:issn 1477-7827
    257 schema:name Reproductive Biology and Endocrinology
    258 schema:publisher Springer Nature
    259 rdf:type schema:Periodical
    260 sg:person.01044651613.35 schema:affiliation grid-institutes:grid.239578.2
    261 schema:familyName Agarwal
    262 schema:givenName Ashok
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044651613.35
    264 rdf:type schema:Person
    265 sg:person.01055467124.12 schema:affiliation grid-institutes:grid.239578.2
    266 schema:familyName Premkumar
    267 schema:givenName Beena J
    268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055467124.12
    269 rdf:type schema:Person
    270 sg:person.01123602324.13 schema:affiliation grid-institutes:grid.239578.2
    271 schema:familyName Shaman
    272 schema:givenName Amani
    273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123602324.13
    274 rdf:type schema:Person
    275 sg:person.01153070401.50 schema:affiliation grid-institutes:grid.239578.2
    276 schema:familyName Gupta
    277 schema:givenName Sajal
    278 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01153070401.50
    279 rdf:type schema:Person
    280 sg:pub.10.1007/978-0-387-68984-5_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043235029
    281 https://doi.org/10.1007/978-0-387-68984-5_3
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/978-1-61779-295-3_16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027772517
    284 https://doi.org/10.1007/978-1-61779-295-3_16
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/bf00225988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048006555
    287 https://doi.org/10.1007/bf00225988
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/bf01700986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020517222
    290 https://doi.org/10.1007/bf01700986
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/bf02255972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030559576
    293 https://doi.org/10.1007/bf02255972
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/bf02897919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029395018
    296 https://doi.org/10.1007/bf02897919
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/bf03401783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074687746
    299 https://doi.org/10.1007/bf03401783
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s00128-011-0204-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001339893
    302 https://doi.org/10.1007/s00128-011-0204-4
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/s00244-001-0048-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002240446
    305 https://doi.org/10.1007/s00244-001-0048-8
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s00404-006-0219-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1031019404
    308 https://doi.org/10.1007/s00404-006-0219-y
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s00418-004-0677-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012372338
    311 https://doi.org/10.1007/s00418-004-0677-x
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/s10815-008-9266-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047880702
    314 https://doi.org/10.1007/s10815-008-9266-6
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1007/s12038-007-0059-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003095431
    317 https://doi.org/10.1007/s12038-007-0059-3
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1016/j.jsgi.2004.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054739680
    320 https://doi.org/10.1016/j.jsgi.2004.03.003
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1016/s1071-5576(00)00106-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054678877
    323 https://doi.org/10.1016/s1071-5576(00)00106-4
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/377239a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027266386
    326 https://doi.org/10.1038/377239a0
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/nm1452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052369088
    329 https://doi.org/10.1038/nm1452
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1111/j.1745-7254.2006.00264.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042871962
    332 https://doi.org/10.1111/j.1745-7254.2006.00264.x
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1177/1071557601008001s13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083940470
    335 https://doi.org/10.1177/1071557601008001s13
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1177/1933719109348027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064078872
    338 https://doi.org/10.1177/1933719109348027
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1177/1933719111413298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064079100
    341 https://doi.org/10.1177/1933719111413298
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1186/1471-2393-7-s1-s7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030670491
    344 https://doi.org/10.1186/1471-2393-7-s1-s7
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1186/1476-069x-8-32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011593470
    347 https://doi.org/10.1186/1476-069x-8-32
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1186/1476-069x-9-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019681720
    350 https://doi.org/10.1186/1476-069x-9-22
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1186/1476-5918-8-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027329388
    353 https://doi.org/10.1186/1476-5918-8-1
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1186/1477-7827-3-28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019926167
    356 https://doi.org/10.1186/1477-7827-3-28
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1186/1477-7827-3-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038867042
    359 https://doi.org/10.1186/1477-7827-3-43
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1186/1477-7827-5-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043089371
    362 https://doi.org/10.1186/1477-7827-5-6
    363 rdf:type schema:CreativeWork
    364 sg:pub.10.1186/1477-7827-7-40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028212423
    365 https://doi.org/10.1186/1477-7827-7-40
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1186/1477-7827-7-54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004230875
    368 https://doi.org/10.1186/1477-7827-7-54
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1379/csc-278e.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006454620
    371 https://doi.org/10.1379/csc-278e.1
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1379/csc-99r.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010489903
    374 https://doi.org/10.1379/csc-99r.1
    375 rdf:type schema:CreativeWork
    376 grid-institutes:grid.239578.2 schema:alternateName Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
    377 schema:name Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA
    378 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...