Bony metastases from breast cancer - a study of foetal antigen 2 as a blood tumour marker View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Kwok-Leung Cheung, Ray K Iles, John F R Robertson

ABSTRACT

BACKGROUND: Foetal antigen 2 (FA-2), first isolated in the amniotic fluid, was shown to be the circulating form of the aminopropeptide of the alpha 1 chain of procollagen type I. Serum concentrations of FA-2 appeared to be elevated in a number of disorders of bone metabolism. This paper is the first report of its role as a marker of bone metabolism in metastatic breast cancer. METHODS: Serum FA-2 concentrations were measured by radioimmunoassay in 153 women with different stages of breast cancer and in 34 normal controls. RESULTS: Serum FA-2 was significantly elevated in women with bony metastases (p < 0.015). Its levels were not significantly different among women with non-bony metastases, with non-metastatic disease, as well as among normal controls. CONCLUSIONS: FA-2 is a promising blood marker of bone metabolism. Further studies to delineate its role in the diagnosis and management of bony metastases from breast cancer are required. More... »

PAGES

38

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-7819-8-38

DOI

http://dx.doi.org/10.1186/1477-7819-8-38

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008393031

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20465790


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