Eag and HERG potassium channels as novel therapeutic targets in cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Viren Asher, Heidi Sowter, Robert Shaw, Anish Bali, Raheela Khan

ABSTRACT

Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. Inhibition of these channels has been shown to reduce proliferation both in vitro and vivo studies identifying potassium channel modulators as putative inhibitors of tumour progression. Eag channels in view of their restricted expression in normal tissue may emerge as novel tumour biomarkers. More... »

PAGES

113

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1477-7819-8-113

    DOI

    http://dx.doi.org/10.1186/1477-7819-8-113

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1050430569

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21190577


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