Comparison of intraoperative frozen section analysis for sentinel lymph node biopsy during breast cancer surgery for invasive lobular carcinoma and ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

James W Horvath, Gary E Barnett, Rafael E Jimenez, Donn C Young, Stephen P Povoski

ABSTRACT

BACKGROUND: Sentinel lymph node (SLN) biopsy is the standard of care for the surgical assessment of the axilla during breast cancer surgery. However, the diagnostic accuracy of intraoperative frozen section analysis for confirming metastatic involvement of SLNs in cases of invasive lobular carcinoma (ILC) versus that of invasive ductal carcinoma (IDC) has generated controversy secondary to a frequently low-grade cytologic appearance and an often discohesive pattern displayed by metastatic lymph nodes in ILC. In the current report, we present a comparison of intraoperative frozen section analysis for confirming the presence of metastatic disease within SLNs during breast cancer surgery for ILC and IDC. METHODS: We evaluated the results of 131 consecutive cases of ILC from 1997 to 2008 and 133 cases of IDC (selected by a random sequence generator program) from amongst 1163 consecutive cases of IDC from the same time period. All cases had at least one SLN that had both intraoperative frozen section analysis and confirmatory permanent section analysis performed. RESULTS: No statistically significant difference was found in the sensitivity (67% vs. 75%, P = 0.385), specificity (100% vs. 100%), accuracy (86% vs. 92%, P = 0.172), false negative rate (33% vs. 25%, P = 0.385), negative predictive value (81% vs. 89%, P = 0.158), and positive predictive value (100% vs. 100%) for frozen section analysis for confirming the presence of metastatic disease within SLNs during breast cancer surgery for ILC and IDC. CONCLUSION: Since there was no statistically significant difference in sensitivity, specificity, accuracy, false negative rate, negative predictive value, and positive predictive value between frozen section analysis of SLNs for patients with ILC and IDC, the clinical accuracy of confirming metastatic involvement of SLNs on frozen section analysis for ILC should not be considered inferior to the clinical accuracy for IDC. Therefore, frozen section analysis of all SLNs during breast cancer surgery in patients with ILC should remain the standard of care in order to reduce the risk of the need of a later, separate axillary lymph node dissection. More... »

PAGES

34

References to SciGraph publications

  • 2006-11. Prospective Randomized Clinical Trial Comparing Intradermal, Intraparenchymal, and Subareolar Injection Routes for Sentinel Lymph Node Mapping and Biopsy in Breast Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2002-04. Sentinel lymph node mapping and biopsy for breast cancer at a rural-based university medical center: Initial Experience with intraparenchymal and intradermal injection routes in BREAST CANCER
  • 2008-01. Sentinel Node Positivity Rates With and Without Frozen Section for Breast Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2000-08. Lymphatic mapping for breast cancer: experience at the Ohio State University in BREAST CANCER
  • 1997-11. Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma in BRITISH JOURNAL OF CANCER
  • 2005-01. Frozen section diagnosis for axillary sentinel lymph nodes: the first six years in MODERN PATHOLOGY
  • 2004-05. A Comparison of the Biological and Clinical Features of Invasive Lobular and Ductal Carcinomas of the Breast in BREAST CANCER RESEARCH AND TREATMENT
  • 2000-10. Is Routine Intraoperative Frozen-Section Examination of Sentinel Lymph Nodes in Breast Cancer Worthwhile? in ANNALS OF SURGICAL ONCOLOGY
  • 1987-10. The immunohistochemical detection of lymph node metastases from infiltrating lobular carcinoma of the breast in BRITISH JOURNAL OF CANCER
  • 1987-12. Micrometastases to axillary lymph nodes from invasive lobular carcinoma of breast: Detection by immunohistochemistry and prognostic significance in BRITISH JOURNAL OF CANCER
  • 2001-12. The Problem of the Accuracy of Intraoperative Examination of Axillary Sentinel Nodes in Breast Cancer in ANNALS OF SURGICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1186/1477-7819-7-34

    DOI

    http://dx.doi.org/10.1186/1477-7819-7-34

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020845337

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19317888


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Ductal, Breast", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carcinoma, Lobular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Frozen Sections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sensitivity and Specificity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sentinel Lymph Node Biopsy", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "The Ohio State University", 
              "id": "https://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Department of Pathology, The Ohio State University, 43210, Columbus, Ohio, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Horvath", 
            "givenName": "James W", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Ohio State University", 
              "id": "https://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Department of Pathology, The Ohio State University, 43210, Columbus, Ohio, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Barnett", 
            "givenName": "Gary E", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Ohio State University", 
              "id": "https://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Department of Pathology, The Ohio State University, 43210, Columbus, Ohio, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jimenez", 
            "givenName": "Rafael E", 
            "id": "sg:person.01313033035.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313033035.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Ohio State University", 
              "id": "https://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Center for Biostatistics, The Ohio State University, 43210, Columbus, Ohio, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Young", 
            "givenName": "Donn C", 
            "id": "sg:person.013122042747.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013122042747.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "The Ohio State University", 
              "id": "https://www.grid.ac/institutes/grid.261331.4", 
              "name": [
                "Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University, 43210, Columbus, Ohio, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Povoski", 
            "givenName": "Stephen P", 
            "id": "sg:person.01240351036.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240351036.37"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1023/b:brea.0000021038.97593.8b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003620872", 
              "https://doi.org/10.1023/b:brea.0000021038.97593.8b"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jjco/hyh023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003658612"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32831369cb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005010699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e32831369cb", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005010699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1986.219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009631014", 
              "https://doi.org/10.1038/bjc.1986.219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1986.219", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009631014", 
              "https://doi.org/10.1038/bjc.1986.219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000103072.34708.e3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009937869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.sla.0000103072.34708.e3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009937869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jso.10296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010567422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1987.301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011408246", 
              "https://doi.org/10.1038/bjc.1987.301"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014343177", 
              "https://doi.org/10.1038/modpathol.3800279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.3800279", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014343177", 
              "https://doi.org/10.1038/modpathol.3800279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-9776(03)00124-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015670909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10434-001-0817-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017600641", 
              "https://doi.org/10.1007/s10434-001-0817-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10434-001-0817-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017600641", 
              "https://doi.org/10.1007/s10434-001-0817-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jamcollsurg.2008.06.341", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018026450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2559.1999.00667.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018030771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1097-0142(19940315)73:6<1673::aid-cncr2820730620>3.0.co;2-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021074534"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.breast.2004.03.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021120487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/s0011-3840(04)00113-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022276568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181581f41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022713544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3181581f41", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022713544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-007-9600-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023893764", 
              "https://doi.org/10.1245/s10434-007-9600-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025513022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025513022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjsurg.2006.06.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026845472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9610(01)00794-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027913658"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0002-9610(02)00939-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029412700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/ejso.2002.1423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031656881"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.12.6425", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033773221"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10434-000-0651-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037731341", 
              "https://doi.org/10.1007/s10434-000-0651-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2168.1999.01054.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039273113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02967460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039428837", 
              "https://doi.org/10.1007/bf02967460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02967460", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039428837", 
              "https://doi.org/10.1007/bf02967460"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1979.tb03029.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040699247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2559.1979.tb03029.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040699247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041208242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.21133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041208242"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02967578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042608421", 
              "https://doi.org/10.1007/bf02967578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02967578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042608421", 
              "https://doi.org/10.1007/bf02967578"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1997.540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042841721", 
              "https://doi.org/10.1038/bjc.1997.540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1997.540", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042841721", 
              "https://doi.org/10.1038/bjc.1997.540"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1524-4741.2007.00468.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042928853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e328315ef1d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046174506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/cco.0b013e328315ef1d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046174506"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.20054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046818706"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<113::aid-cncr19>3.0.co;2-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049757054"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2168.1998.00746.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051933519"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.humpath.2007.11.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052113773"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjsurg.2004.06.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052327867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-006-9022-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053273803", 
              "https://doi.org/10.1245/s10434-006-9022-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-199522240-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053334062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-199522240-00012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053334062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1067/j.cpsurg.2004.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058146982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074836142", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076590107", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083122121", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2009-12", 
        "datePublishedReg": "2009-12-01", 
        "description": "BACKGROUND: Sentinel lymph node (SLN) biopsy is the standard of care for the surgical assessment of the axilla during breast cancer surgery. However, the diagnostic accuracy of intraoperative frozen section analysis for confirming metastatic involvement of SLNs in cases of invasive lobular carcinoma (ILC) versus that of invasive ductal carcinoma (IDC) has generated controversy secondary to a frequently low-grade cytologic appearance and an often discohesive pattern displayed by metastatic lymph nodes in ILC. In the current report, we present a comparison of intraoperative frozen section analysis for confirming the presence of metastatic disease within SLNs during breast cancer surgery for ILC and IDC.\nMETHODS: We evaluated the results of 131 consecutive cases of ILC from 1997 to 2008 and 133 cases of IDC (selected by a random sequence generator program) from amongst 1163 consecutive cases of IDC from the same time period. All cases had at least one SLN that had both intraoperative frozen section analysis and confirmatory permanent section analysis performed.\nRESULTS: No statistically significant difference was found in the sensitivity (67% vs. 75%, P = 0.385), specificity (100% vs. 100%), accuracy (86% vs. 92%, P = 0.172), false negative rate (33% vs. 25%, P = 0.385), negative predictive value (81% vs. 89%, P = 0.158), and positive predictive value (100% vs. 100%) for frozen section analysis for confirming the presence of metastatic disease within SLNs during breast cancer surgery for ILC and IDC.\nCONCLUSION: Since there was no statistically significant difference in sensitivity, specificity, accuracy, false negative rate, negative predictive value, and positive predictive value between frozen section analysis of SLNs for patients with ILC and IDC, the clinical accuracy of confirming metastatic involvement of SLNs on frozen section analysis for ILC should not be considered inferior to the clinical accuracy for IDC. Therefore, frozen section analysis of all SLNs during breast cancer surgery in patients with ILC should remain the standard of care in order to reduce the risk of the need of a later, separate axillary lymph node dissection.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1186/1477-7819-7-34", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1032056", 
            "issn": [
              "1477-7819"
            ], 
            "name": "World Journal of Surgical Oncology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "7"
          }
        ], 
        "name": "Comparison of intraoperative frozen section analysis for sentinel lymph node biopsy during breast cancer surgery for invasive lobular carcinoma and invasive ductal carcinoma", 
        "pagination": "34", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "6351d9950a2b650a9d3ee7e9960440083cc9794a9da74d99c116aa350e546b8d"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "19317888"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101170544"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1186/1477-7819-7-34"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1020845337"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1186/1477-7819-7-34", 
          "https://app.dimensions.ai/details/publication/pub.1020845337"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T02:00", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000512.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1186%2F1477-7819-7-34"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-7819-7-34'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-7819-7-34'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-7819-7-34'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-7819-7-34'


     

    This table displays all metadata directly associated to this object as RDF triples.

    281 TRIPLES      21 PREDICATES      84 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1186/1477-7819-7-34 schema:about N05220507faae4909aef9241003c49ae8
    2 N053cb4150e184e708484cf5f43de8a3d
    3 N29b04a44e5644e85824ca3c131b5ec59
    4 N2f876387ef544729ac4cd0d5efb2ec11
    5 N3b718a013b3146ba8f665579736d723c
    6 N881a0604c40e4cc29b413fc536081ed3
    7 N8e2ad8eb3d90452d802bafe90aabb9cd
    8 N9071807c14974586b44366fc41f024af
    9 Nda576b84804f4a10860da1e71a413cfc
    10 Ndc9917bc21744170bec4bd5e69abdb46
    11 Nf77e07ba64a745fdb87cca39f81922c1
    12 Nf8ac6d5230ce4afa940d1b6829e967c9
    13 anzsrc-for:11
    14 anzsrc-for:1112
    15 schema:author Ne442e166f252426a976ecadcdddcab77
    16 schema:citation sg:pub.10.1007/bf02967460
    17 sg:pub.10.1007/bf02967578
    18 sg:pub.10.1007/s10434-000-0651-3
    19 sg:pub.10.1007/s10434-001-0817-7
    20 sg:pub.10.1023/b:brea.0000021038.97593.8b
    21 sg:pub.10.1038/bjc.1986.219
    22 sg:pub.10.1038/bjc.1987.301
    23 sg:pub.10.1038/bjc.1997.540
    24 sg:pub.10.1038/modpathol.3800279
    25 sg:pub.10.1245/s10434-006-9022-z
    26 sg:pub.10.1245/s10434-007-9600-8
    27 https://app.dimensions.ai/details/publication/pub.1074836142
    28 https://app.dimensions.ai/details/publication/pub.1076590107
    29 https://app.dimensions.ai/details/publication/pub.1083122121
    30 https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<113::aid-cncr19>3.0.co;2-8
    31 https://doi.org/10.1002/1097-0142(19940315)73:6<1673::aid-cncr2820730620>3.0.co;2-b
    32 https://doi.org/10.1002/cncr.20054
    33 https://doi.org/10.1002/cncr.21071
    34 https://doi.org/10.1002/cncr.21133
    35 https://doi.org/10.1002/jso.10296
    36 https://doi.org/10.1016/j.amjsurg.2004.06.019
    37 https://doi.org/10.1016/j.amjsurg.2006.06.020
    38 https://doi.org/10.1016/j.breast.2004.03.004
    39 https://doi.org/10.1016/j.humpath.2007.11.017
    40 https://doi.org/10.1016/j.jamcollsurg.2008.06.341
    41 https://doi.org/10.1016/s0002-9610(01)00794-2
    42 https://doi.org/10.1016/s0002-9610(02)00939-x
    43 https://doi.org/10.1016/s0960-9776(03)00124-3
    44 https://doi.org/10.1046/j.1365-2168.1998.00746.x
    45 https://doi.org/10.1046/j.1365-2168.1999.01054.x
    46 https://doi.org/10.1046/j.1365-2559.1999.00667.x
    47 https://doi.org/10.1053/ejso.2002.1423
    48 https://doi.org/10.1067/j.cpsurg.2004.09.002
    49 https://doi.org/10.1067/s0011-3840(04)00113-3
    50 https://doi.org/10.1093/jjco/hyh023
    51 https://doi.org/10.1097/00000658-199522240-00012
    52 https://doi.org/10.1097/01.sla.0000103072.34708.e3
    53 https://doi.org/10.1097/cco.0b013e32831369cb
    54 https://doi.org/10.1097/cco.0b013e328315ef1d
    55 https://doi.org/10.1097/sla.0b013e3181581f41
    56 https://doi.org/10.1111/j.1365-2559.1979.tb03029.x
    57 https://doi.org/10.1111/j.1524-4741.2007.00468.x
    58 https://doi.org/10.1200/jco.2007.12.6425
    59 schema:datePublished 2009-12
    60 schema:datePublishedReg 2009-12-01
    61 schema:description BACKGROUND: Sentinel lymph node (SLN) biopsy is the standard of care for the surgical assessment of the axilla during breast cancer surgery. However, the diagnostic accuracy of intraoperative frozen section analysis for confirming metastatic involvement of SLNs in cases of invasive lobular carcinoma (ILC) versus that of invasive ductal carcinoma (IDC) has generated controversy secondary to a frequently low-grade cytologic appearance and an often discohesive pattern displayed by metastatic lymph nodes in ILC. In the current report, we present a comparison of intraoperative frozen section analysis for confirming the presence of metastatic disease within SLNs during breast cancer surgery for ILC and IDC. METHODS: We evaluated the results of 131 consecutive cases of ILC from 1997 to 2008 and 133 cases of IDC (selected by a random sequence generator program) from amongst 1163 consecutive cases of IDC from the same time period. All cases had at least one SLN that had both intraoperative frozen section analysis and confirmatory permanent section analysis performed. RESULTS: No statistically significant difference was found in the sensitivity (67% vs. 75%, P = 0.385), specificity (100% vs. 100%), accuracy (86% vs. 92%, P = 0.172), false negative rate (33% vs. 25%, P = 0.385), negative predictive value (81% vs. 89%, P = 0.158), and positive predictive value (100% vs. 100%) for frozen section analysis for confirming the presence of metastatic disease within SLNs during breast cancer surgery for ILC and IDC. CONCLUSION: Since there was no statistically significant difference in sensitivity, specificity, accuracy, false negative rate, negative predictive value, and positive predictive value between frozen section analysis of SLNs for patients with ILC and IDC, the clinical accuracy of confirming metastatic involvement of SLNs on frozen section analysis for ILC should not be considered inferior to the clinical accuracy for IDC. Therefore, frozen section analysis of all SLNs during breast cancer surgery in patients with ILC should remain the standard of care in order to reduce the risk of the need of a later, separate axillary lymph node dissection.
    62 schema:genre research_article
    63 schema:inLanguage en
    64 schema:isAccessibleForFree true
    65 schema:isPartOf N105b966ade024820a48a721635c20d59
    66 N17acb3ea93d04550a92110f52ecaa2a3
    67 sg:journal.1032056
    68 schema:name Comparison of intraoperative frozen section analysis for sentinel lymph node biopsy during breast cancer surgery for invasive lobular carcinoma and invasive ductal carcinoma
    69 schema:pagination 34
    70 schema:productId N19484bb4b4214119ae2e8c5385fd0bca
    71 N47f21ab2e5684792a2e99d49145315d7
    72 Nbb78d8c1494440bbaf0f37b04ef07d10
    73 Nd3b078f5c42e4996b9d693b99266e974
    74 Nfd26118387894d16846bc9333e4e6da1
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020845337
    76 https://doi.org/10.1186/1477-7819-7-34
    77 schema:sdDatePublished 2019-04-11T02:00
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher N7e49e986cc3f4e0386138d54402b9984
    80 schema:url http://link.springer.com/10.1186%2F1477-7819-7-34
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N05220507faae4909aef9241003c49ae8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Sensitivity and Specificity
    86 rdf:type schema:DefinedTerm
    87 N053cb4150e184e708484cf5f43de8a3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    88 schema:name Carcinoma, Ductal, Breast
    89 rdf:type schema:DefinedTerm
    90 N105b966ade024820a48a721635c20d59 schema:volumeNumber 7
    91 rdf:type schema:PublicationVolume
    92 N17acb3ea93d04550a92110f52ecaa2a3 schema:issueNumber 1
    93 rdf:type schema:PublicationIssue
    94 N19484bb4b4214119ae2e8c5385fd0bca schema:name pubmed_id
    95 schema:value 19317888
    96 rdf:type schema:PropertyValue
    97 N29b04a44e5644e85824ca3c131b5ec59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Middle Aged
    99 rdf:type schema:DefinedTerm
    100 N2f876387ef544729ac4cd0d5efb2ec11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    101 schema:name Humans
    102 rdf:type schema:DefinedTerm
    103 N37970da4084444fb89fe793f3c0d5ec9 rdf:first sg:person.01240351036.37
    104 rdf:rest rdf:nil
    105 N3b718a013b3146ba8f665579736d723c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Frozen Sections
    107 rdf:type schema:DefinedTerm
    108 N47f21ab2e5684792a2e99d49145315d7 schema:name nlm_unique_id
    109 schema:value 101170544
    110 rdf:type schema:PropertyValue
    111 N68d2bf4a8016499baa40cc07801bd2bb schema:affiliation https://www.grid.ac/institutes/grid.261331.4
    112 schema:familyName Barnett
    113 schema:givenName Gary E
    114 rdf:type schema:Person
    115 N7e49e986cc3f4e0386138d54402b9984 schema:name Springer Nature - SN SciGraph project
    116 rdf:type schema:Organization
    117 N881a0604c40e4cc29b413fc536081ed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Adult
    119 rdf:type schema:DefinedTerm
    120 N8e2ad8eb3d90452d802bafe90aabb9cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Aged, 80 and over
    122 rdf:type schema:DefinedTerm
    123 N9071807c14974586b44366fc41f024af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Breast Neoplasms
    125 rdf:type schema:DefinedTerm
    126 Nb7a1fa095dbe48d5aff5c16b66d999b6 rdf:first sg:person.013122042747.72
    127 rdf:rest N37970da4084444fb89fe793f3c0d5ec9
    128 Nbb78d8c1494440bbaf0f37b04ef07d10 schema:name readcube_id
    129 schema:value 6351d9950a2b650a9d3ee7e9960440083cc9794a9da74d99c116aa350e546b8d
    130 rdf:type schema:PropertyValue
    131 Ncd7e661ef7bb4482992b7a6851cf3916 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
    132 schema:familyName Horvath
    133 schema:givenName James W
    134 rdf:type schema:Person
    135 Nd3b078f5c42e4996b9d693b99266e974 schema:name dimensions_id
    136 schema:value pub.1020845337
    137 rdf:type schema:PropertyValue
    138 Nda576b84804f4a10860da1e71a413cfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Aged
    140 rdf:type schema:DefinedTerm
    141 Ndc9917bc21744170bec4bd5e69abdb46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Carcinoma, Lobular
    143 rdf:type schema:DefinedTerm
    144 Ndddf39ac88f0437babdf993b33e71110 rdf:first N68d2bf4a8016499baa40cc07801bd2bb
    145 rdf:rest Ndee8e7bbdac0447ca59c1db5dea32468
    146 Ndee8e7bbdac0447ca59c1db5dea32468 rdf:first sg:person.01313033035.62
    147 rdf:rest Nb7a1fa095dbe48d5aff5c16b66d999b6
    148 Ne442e166f252426a976ecadcdddcab77 rdf:first Ncd7e661ef7bb4482992b7a6851cf3916
    149 rdf:rest Ndddf39ac88f0437babdf993b33e71110
    150 Nf77e07ba64a745fdb87cca39f81922c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Sentinel Lymph Node Biopsy
    152 rdf:type schema:DefinedTerm
    153 Nf8ac6d5230ce4afa940d1b6829e967c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Female
    155 rdf:type schema:DefinedTerm
    156 Nfd26118387894d16846bc9333e4e6da1 schema:name doi
    157 schema:value 10.1186/1477-7819-7-34
    158 rdf:type schema:PropertyValue
    159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Medical and Health Sciences
    161 rdf:type schema:DefinedTerm
    162 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    163 schema:name Oncology and Carcinogenesis
    164 rdf:type schema:DefinedTerm
    165 sg:journal.1032056 schema:issn 1477-7819
    166 schema:name World Journal of Surgical Oncology
    167 rdf:type schema:Periodical
    168 sg:person.01240351036.37 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
    169 schema:familyName Povoski
    170 schema:givenName Stephen P
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240351036.37
    172 rdf:type schema:Person
    173 sg:person.013122042747.72 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
    174 schema:familyName Young
    175 schema:givenName Donn C
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013122042747.72
    177 rdf:type schema:Person
    178 sg:person.01313033035.62 schema:affiliation https://www.grid.ac/institutes/grid.261331.4
    179 schema:familyName Jimenez
    180 schema:givenName Rafael E
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313033035.62
    182 rdf:type schema:Person
    183 sg:pub.10.1007/bf02967460 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039428837
    184 https://doi.org/10.1007/bf02967460
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1007/bf02967578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042608421
    187 https://doi.org/10.1007/bf02967578
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1007/s10434-000-0651-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037731341
    190 https://doi.org/10.1007/s10434-000-0651-3
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1007/s10434-001-0817-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017600641
    193 https://doi.org/10.1007/s10434-001-0817-7
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1023/b:brea.0000021038.97593.8b schema:sameAs https://app.dimensions.ai/details/publication/pub.1003620872
    196 https://doi.org/10.1023/b:brea.0000021038.97593.8b
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/bjc.1986.219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009631014
    199 https://doi.org/10.1038/bjc.1986.219
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/bjc.1987.301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011408246
    202 https://doi.org/10.1038/bjc.1987.301
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/bjc.1997.540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042841721
    205 https://doi.org/10.1038/bjc.1997.540
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/modpathol.3800279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014343177
    208 https://doi.org/10.1038/modpathol.3800279
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1245/s10434-006-9022-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1053273803
    211 https://doi.org/10.1245/s10434-006-9022-z
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1245/s10434-007-9600-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023893764
    214 https://doi.org/10.1245/s10434-007-9600-8
    215 rdf:type schema:CreativeWork
    216 https://app.dimensions.ai/details/publication/pub.1074836142 schema:CreativeWork
    217 https://app.dimensions.ai/details/publication/pub.1076590107 schema:CreativeWork
    218 https://app.dimensions.ai/details/publication/pub.1083122121 schema:CreativeWork
    219 https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<113::aid-cncr19>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049757054
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1002/1097-0142(19940315)73:6<1673::aid-cncr2820730620>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1021074534
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1002/cncr.20054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046818706
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1002/cncr.21071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025513022
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1002/cncr.21133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041208242
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1002/jso.10296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010567422
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1016/j.amjsurg.2004.06.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052327867
    232 rdf:type schema:CreativeWork
    233 https://doi.org/10.1016/j.amjsurg.2006.06.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026845472
    234 rdf:type schema:CreativeWork
    235 https://doi.org/10.1016/j.breast.2004.03.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021120487
    236 rdf:type schema:CreativeWork
    237 https://doi.org/10.1016/j.humpath.2007.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052113773
    238 rdf:type schema:CreativeWork
    239 https://doi.org/10.1016/j.jamcollsurg.2008.06.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018026450
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1016/s0002-9610(01)00794-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027913658
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1016/s0002-9610(02)00939-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029412700
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1016/s0960-9776(03)00124-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015670909
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1046/j.1365-2168.1998.00746.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051933519
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1046/j.1365-2168.1999.01054.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1039273113
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1046/j.1365-2559.1999.00667.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018030771
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1053/ejso.2002.1423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031656881
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1067/j.cpsurg.2004.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058146982
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1067/s0011-3840(04)00113-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022276568
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1093/jjco/hyh023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003658612
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1097/00000658-199522240-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053334062
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1097/01.sla.0000103072.34708.e3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009937869
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1097/cco.0b013e32831369cb schema:sameAs https://app.dimensions.ai/details/publication/pub.1005010699
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1097/cco.0b013e328315ef1d schema:sameAs https://app.dimensions.ai/details/publication/pub.1046174506
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1097/sla.0b013e3181581f41 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022713544
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1111/j.1365-2559.1979.tb03029.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040699247
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1111/j.1524-4741.2007.00468.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042928853
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1200/jco.2007.12.6425 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033773221
    276 rdf:type schema:CreativeWork
    277 https://www.grid.ac/institutes/grid.261331.4 schema:alternateName The Ohio State University
    278 schema:name Center for Biostatistics, The Ohio State University, 43210, Columbus, Ohio, USA
    279 Department of Pathology, The Ohio State University, 43210, Columbus, Ohio, USA
    280 Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University, 43210, Columbus, Ohio, USA
    281 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...