Ontology type: schema:ScholarlyArticle Open Access: True
2004-12
AUTHORSNaohiro Sata, Munetoshi Tsukahara, Masaru Koizumi, Koji Yoshizawa, Katsumi Kurihara, Hideo Nagai, Tsutomu Someya, Ken Saito
ABSTRACTBACKGROUND: Small-cell neuroendocrine carcinoma in the duodenum is an extremely rare neoplasm with poor prognosis. CASE PRESENTATION: A 57-year-old man presented with sudden onset gastrointestinal bleeding and fainting attacks. Duodenoscopy and hypotonic duodenography revealed a 3 x 3 cm protruding tumor with ulcerations situated opposite the ampulla of Vater in the second part of the duodenum. Local excision of the tumor was performed, followed by adjuvant chemotherapy with 5-fluoro uracil and leucovorin. Examination of the tumor by immunohistochemistry and electron microscopy indicated it to be neuroendocrine in nature, expressing synaptophysin and AE1/AE3, and containing dense core granules. The patient showed no sign of recurrence and has been disease-free for more than 48 months after surgery. CONCLUSIONS: Most cases of small-cell neuroendocrine carcinoma in the duodenum show rapid progression of the disease, and even radical surgery with or without chemotherapy do not prevent death. We report a rare subtype of small-cell neuroendocrine carcinoma. This subtype appears to have a much better prognosis, and may be amenable to local excision, if the lesion is away from the ampulla of Vater. More... »
PAGES28
http://scigraph.springernature.com/pub.10.1186/1477-7819-2-28
DOIhttp://dx.doi.org/10.1186/1477-7819-2-28
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15310407
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