Prognostic significance of WT1 expression in soft tissue sarcoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-07-16

AUTHORS

Ahrong Kim, Eun Young Park, Kyungbin Kim, Jeong Hee Lee, Dong Hoon Shin, Jee Yeon Kim, Do Youn Park, Chang Hun Lee, Mee Young Sol, Kyung Un Choi, Jeung Il Kim, In Sook Lee

ABSTRACT

BACKGROUND: Soft tissue sarcomas (STS) are rare. We evaluated the WT1 protein expression level in various types of STS and elucidated the value of WT1 as a prognostic factor and a possible therapeutic target. METHODS: Immunohistochemical staining for WT1 was performed in 87 cases of STS using formalin-fixed, paraffin-embedded blocks. The correlation between WT1 expression and clinicopathological factors was analyzed. Survival analysis was conducted in 67 patients. We assessed the validity of WT1 immunohistochemistry as an index of WT1 protein expression using Western blot analysis. RESULTS: WT1 expression was noted in 47 cases (54.0%). Most rhabdomyosarcomas and malignant peripheral nerve sheath tumors showed WT1 expression (91.7% and 71.4%, respectively; P = 0.005). WT1 expression was related to higher FNCLCC histologic grade and AJCC tumor stage. In the group with high grade STS, strong WT1 expression was correlated with better survival (P = 0.025). The immunohistochemical results were correlated quantitatively with the staining score and the concentration of the Western blot band. CONCLUSIONS: This study demonstrates that various types of STS show positive immunostaining for WT1 and that WT1 expression has a prognostic significance. So STS should be considered candidates for WT1 peptide--based immunotherapy. More... »

PAGES

214-214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-7819-12-214

DOI

http://dx.doi.org/10.1186/1477-7819-12-214

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048078588

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25026998


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34 schema:description BACKGROUND: Soft tissue sarcomas (STS) are rare. We evaluated the WT1 protein expression level in various types of STS and elucidated the value of WT1 as a prognostic factor and a possible therapeutic target. METHODS: Immunohistochemical staining for WT1 was performed in 87 cases of STS using formalin-fixed, paraffin-embedded blocks. The correlation between WT1 expression and clinicopathological factors was analyzed. Survival analysis was conducted in 67 patients. We assessed the validity of WT1 immunohistochemistry as an index of WT1 protein expression using Western blot analysis. RESULTS: WT1 expression was noted in 47 cases (54.0%). Most rhabdomyosarcomas and malignant peripheral nerve sheath tumors showed WT1 expression (91.7% and 71.4%, respectively; P = 0.005). WT1 expression was related to higher FNCLCC histologic grade and AJCC tumor stage. In the group with high grade STS, strong WT1 expression was correlated with better survival (P = 0.025). The immunohistochemical results were correlated quantitatively with the staining score and the concentration of the Western blot band. CONCLUSIONS: This study demonstrates that various types of STS show positive immunostaining for WT1 and that WT1 expression has a prognostic significance. So STS should be considered candidates for WT1 peptide--based immunotherapy.
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44 STS
45 WT1
46 WT1 expression
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49 WT1 protein expression
50 WT1 protein expression level
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53 analysis
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65 expression
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67 factors
68 formalin
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71 group
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75 immunohistochemical results
76 immunohistochemical staining
77 immunohistochemistry
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79 immunotherapy
80 index
81 levels
82 malignant peripheral nerve sheath tumor
83 nerve sheath tumors
84 paraffin
85 patients
86 peptides
87 peripheral nerve sheath tumors
88 positive immunostaining
89 possible therapeutic target
90 prognostic factors
91 prognostic significance
92 protein expression
93 protein expression levels
94 results
95 rhabdomyosarcoma
96 sarcoma
97 scores
98 sheath tumors
99 significance
100 soft tissue
101 soft tissue sarcomas
102 stage
103 staining
104 strong WT1 expression
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