Clinicopathological significance of cancer stem cells marked by CD133 and KAI1/CD82 expression in laryngeal squamous cell carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Lan Yu, Lei Zhou, Shiwu Wu, Xiaomeng Gong, Zhenzhong Feng, Li Ma, Bo Zhu, Nan Yao, Danna Wang, Huiming Dong

ABSTRACT

BACKGROUND: Presently, CD133 is one of the hottest markers to characterize cancer stem cells and KAI1/CD82 is reported as an important marker for the metastasis and prognosis of many cancers. The purpose of our study is to explore the relationship between cancer stem cells (CSCs) marked by CD133 and KAI1/CD82 expression and the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma (LSCC). METHODS: Immunohistochemical analysis was used to detect the expression of CD133 and KAI1/CD82 in 83 archival surgical specimens of human LSCC and 83 cases of normal laryngeal tissues. RESULTS: In LSCC, positive rates of 49.4% and 41.0% were obtained for CD133 and KAI1/CD82, respectively. The expression of CD133 in LSCC tissues was significantly higher than that in normal tissues (P<0.001), and the expression of CD133 was positively associated with pTNM stage (P=0.005), pathological grade (P=0.001), and lymph node metastasis (P<0.001). The reduced expression of KAI1/CD82 was present in LSCC tissues. The positive rate of KAI1/CD82 expression was negatively correlated with pTNM stage (P=0.014), pathological grade (P<0.001), and lymph node metastasis (P=0.007). A correlation analysis showed that there was a negative relationship between the expression of CD133 and KAI1/CD82 protein in LSCC tissues (P<0.001). By Kaplan-Meier analysis, the expression of CD133 was negatively correlated with overall survival (OS) (log-rank=40.949, P<0.001) and disease-free survival (DFS) (log-rank=39.307, P<0.001) time of LSCC. The expression of KAI1/CD82 was positively correlated with OS (log-rank=40.279, P<0.001) and DFS (log-rank=39.271, P<0.001) time of LSCC. Cox regression analysis: the expression of CD133 and KAI1/CD82, and pTNM stages were independent prognostic factors of LSCC (P<0.05). CONCLUSIONS: Thus the detection of CD133 and KAI1/CD82 proteins may be used as a potential indicator of LSCC prognosis. More... »

PAGES

118

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-7819-12-118

DOI

http://dx.doi.org/10.1186/1477-7819-12-118

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004156972

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24758564


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AC133 Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Squamous Cell", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kangai-1 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laryngeal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphatic Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Grading", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Stem Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Lan", 
        "id": "sg:person.0732572271.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732572271.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Lei", 
        "id": "sg:person.01047020671.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047020671.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Shiwu", 
        "id": "sg:person.0701365200.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701365200.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gong", 
        "givenName": "Xiaomeng", 
        "id": "sg:person.01074135376.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074135376.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Zhenzhong", 
        "id": "sg:person.01200601705.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200601705.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Li", 
        "id": "sg:person.0750124705.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750124705.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Bo", 
        "id": "sg:person.01256477176.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256477176.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Nan", 
        "id": "sg:person.01324612376.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324612376.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Danna", 
        "id": "sg:person.01015613600.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015613600.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Surgical Oncology, the First Hospital Affiliated to Bengbu Medical College Anhui Province, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dong", 
        "givenName": "Huiming", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nature05372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002972347", 
          "https://doi.org/10.1038/nature05372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05372", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002972347", 
          "https://doi.org/10.1038/nature05372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0046391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005254851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0033544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010984295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2007.00584.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014273030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.25869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014549574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.anndiagpath.2003.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017575102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.med.58.062105.204854", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017697362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2011.287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017899154", 
          "https://doi.org/10.1038/bjc.2011.287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2012/376894", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018965198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020626779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020800104", 
          "https://doi.org/10.1038/nm1469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1469", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020800104", 
          "https://doi.org/10.1038/nm1469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35102167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021100179", 
          "https://doi.org/10.1038/35102167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35102167", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021100179", 
          "https://doi.org/10.1038/35102167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.11.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024283148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1171837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026672047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1171837", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026672047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026901039", 
          "https://doi.org/10.1038/nature05384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05384", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026901039", 
          "https://doi.org/10.1038/nature05384"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027226854", 
          "https://doi.org/10.1038/nature03128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027226854", 
          "https://doi.org/10.1038/nature03128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2499", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030818260", 
          "https://doi.org/10.1038/nrc2499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2008.08.023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031861133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m111.232637", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034463971"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-11-320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036159970", 
          "https://doi.org/10.1186/1471-2407-11-320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2012.10.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036415446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-12-96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039392444", 
          "https://doi.org/10.1186/1471-2407-12-96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tcb.2009.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042381600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-7819-9-43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043773436", 
          "https://doi.org/10.1186/1477-7819-9-43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-12-139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045465336", 
          "https://doi.org/10.1186/1471-2407-12-139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0020636", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045796033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1499-3872(11)60105-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048119999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4048/jbc.2012.15.1.15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049680702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.2016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050399733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2011.01894.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050665678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.juro.2009.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051188134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/scd.2008.0338", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059309918"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.7754374", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062649132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v17.i7.932", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071368064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5507/bp.2010.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072931489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074999541", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v10.i15.2245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076867043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.14670/hh-24.519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077851169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077941171", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077943074", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078148413", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078515818", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/0121511/aim.0012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078640269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083181326", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "BACKGROUND: Presently, CD133 is one of the hottest markers to characterize cancer stem cells and KAI1/CD82 is reported as an important marker for the metastasis and prognosis of many cancers. The purpose of our study is to explore the relationship between cancer stem cells (CSCs) marked by CD133 and KAI1/CD82 expression and the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma (LSCC).\nMETHODS: Immunohistochemical analysis was used to detect the expression of CD133 and KAI1/CD82 in 83 archival surgical specimens of human LSCC and 83 cases of normal laryngeal tissues.\nRESULTS: In LSCC, positive rates of 49.4% and 41.0% were obtained for CD133 and KAI1/CD82, respectively. The expression of CD133 in LSCC tissues was significantly higher than that in normal tissues (P<0.001), and the expression of CD133 was positively associated with pTNM stage (P=0.005), pathological grade (P=0.001), and lymph node metastasis (P<0.001). The reduced expression of KAI1/CD82 was present in LSCC tissues. The positive rate of KAI1/CD82 expression was negatively correlated with pTNM stage (P=0.014), pathological grade (P<0.001), and lymph node metastasis (P=0.007). A correlation analysis showed that there was a negative relationship between the expression of CD133 and KAI1/CD82 protein in LSCC tissues (P<0.001). By Kaplan-Meier analysis, the expression of CD133 was negatively correlated with overall survival (OS) (log-rank=40.949, P<0.001) and disease-free survival (DFS) (log-rank=39.307, P<0.001) time of LSCC. The expression of KAI1/CD82 was positively correlated with OS (log-rank=40.279, P<0.001) and DFS (log-rank=39.271, P<0.001) time of LSCC. Cox regression analysis: the expression of CD133 and KAI1/CD82, and pTNM stages were independent prognostic factors of LSCC (P<0.05).\nCONCLUSIONS: Thus the detection of CD133 and KAI1/CD82 proteins may be used as a potential indicator of LSCC prognosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1477-7819-12-118", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1032056", 
        "issn": [
          "1477-7819"
        ], 
        "name": "World Journal of Surgical Oncology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Clinicopathological significance of cancer stem cells marked by CD133 and KAI1/CD82 expression in laryngeal squamous cell carcinoma", 
    "pagination": "118", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "13cf16c136c7235619ce98daa9105fb611249b7635c06d9a904a12374d4b22ae"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24758564"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101170544"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1477-7819-12-118"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004156972"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1477-7819-12-118", 
      "https://app.dimensions.ai/details/publication/pub.1004156972"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:15", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1477-7819-12-118"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-7819-12-118'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-7819-12-118'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-7819-12-118'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-7819-12-118'


 

This table displays all metadata directly associated to this object as RDF triples.

356 TRIPLES      21 PREDICATES      95 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1477-7819-12-118 schema:about N3580e06b139148379d11fa9274b5a88e
2 N4ccd3236fddd4d93ba453d94cec4a295
3 N71ad792c211144f0b50ce7096ee86a35
4 N7243ab0cf05741b68ecaa94425491723
5 N77b0b70a527e4ad3b3f40eac4caa7c60
6 N831bd0b7dff247b4aa2f18b1660f4023
7 N9348b1f4037947ffb49c5a923d54dc95
8 N986fa2cb3f6844909d70b1390e1a429b
9 N98d53cb8e05a4bff8416cf3baefab1db
10 N9aa47cbbc3674eb0b3150925ee4c845e
11 Na4129dbe45c54159a7942c48a1cc5e9f
12 Nb1e9c8ed65c94c35a1fc62eff52a00d5
13 Nb22107fe01ee456d81969f53132d1477
14 Nbc1b66d9aa4a4247bee1bf5d93563a12
15 Nc883a93afddf49c7ac2ef61c671e43bb
16 Ncccb029ebea04ee68b584d1a78902eaf
17 Ncfec3ddfc412427f9a0e964e85075300
18 Ne180a3e006634b1295a44d3b6bb5beb8
19 Ne5050ec8a6bd4f1d8ff65a1fc30a253a
20 Ne9a124e0b6994bbfb833e521ce20d79d
21 Nef1cdb5a3d314d1c9a3ba6401526ade0
22 Nf5f5f0c0fa5c4edeb1b39f8be45f107f
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author Nf0d66a299e8240c397dbf15201d9c8a5
26 schema:citation sg:pub.10.1038/35102167
27 sg:pub.10.1038/bjc.2011.287
28 sg:pub.10.1038/nature03128
29 sg:pub.10.1038/nature05372
30 sg:pub.10.1038/nature05384
31 sg:pub.10.1038/nm1469
32 sg:pub.10.1038/nrc2499
33 sg:pub.10.1186/1471-2407-11-320
34 sg:pub.10.1186/1471-2407-12-139
35 sg:pub.10.1186/1471-2407-12-96
36 sg:pub.10.1186/1477-7819-9-43
37 https://app.dimensions.ai/details/publication/pub.1074999541
38 https://app.dimensions.ai/details/publication/pub.1077941171
39 https://app.dimensions.ai/details/publication/pub.1077943074
40 https://app.dimensions.ai/details/publication/pub.1078148413
41 https://app.dimensions.ai/details/publication/pub.1078515818
42 https://app.dimensions.ai/details/publication/pub.1083181326
43 https://doi.org/0121511/aim.0012
44 https://doi.org/10.1002/cncr.25869
45 https://doi.org/10.1002/path.2016
46 https://doi.org/10.1016/j.anndiagpath.2003.11.002
47 https://doi.org/10.1016/j.bbrc.2006.11.029
48 https://doi.org/10.1016/j.canlet.2012.10.015
49 https://doi.org/10.1016/j.cellsig.2008.08.023
50 https://doi.org/10.1016/j.juro.2009.01.003
51 https://doi.org/10.1016/j.tcb.2009.06.004
52 https://doi.org/10.1016/s1499-3872(11)60105-7
53 https://doi.org/10.1074/jbc.m111.232637
54 https://doi.org/10.1089/scd.2008.0338
55 https://doi.org/10.1111/j.1349-7006.2007.00584.x
56 https://doi.org/10.1111/j.1349-7006.2011.01894.x
57 https://doi.org/10.1126/science.1171837
58 https://doi.org/10.1126/science.7754374
59 https://doi.org/10.1146/annurev.med.58.062105.204854
60 https://doi.org/10.1155/2012/376894
61 https://doi.org/10.1371/journal.pone.0020636
62 https://doi.org/10.1371/journal.pone.0033544
63 https://doi.org/10.1371/journal.pone.0046391
64 https://doi.org/10.14670/hh-24.519
65 https://doi.org/10.3322/caac.20138
66 https://doi.org/10.3748/wjg.v10.i15.2245
67 https://doi.org/10.3748/wjg.v17.i7.932
68 https://doi.org/10.4048/jbc.2012.15.1.15
69 https://doi.org/10.5507/bp.2010.048
70 schema:datePublished 2014-12
71 schema:datePublishedReg 2014-12-01
72 schema:description BACKGROUND: Presently, CD133 is one of the hottest markers to characterize cancer stem cells and KAI1/CD82 is reported as an important marker for the metastasis and prognosis of many cancers. The purpose of our study is to explore the relationship between cancer stem cells (CSCs) marked by CD133 and KAI1/CD82 expression and the clinicopathological characteristics of patients with laryngeal squamous cell carcinoma (LSCC). METHODS: Immunohistochemical analysis was used to detect the expression of CD133 and KAI1/CD82 in 83 archival surgical specimens of human LSCC and 83 cases of normal laryngeal tissues. RESULTS: In LSCC, positive rates of 49.4% and 41.0% were obtained for CD133 and KAI1/CD82, respectively. The expression of CD133 in LSCC tissues was significantly higher than that in normal tissues (P<0.001), and the expression of CD133 was positively associated with pTNM stage (P=0.005), pathological grade (P=0.001), and lymph node metastasis (P<0.001). The reduced expression of KAI1/CD82 was present in LSCC tissues. The positive rate of KAI1/CD82 expression was negatively correlated with pTNM stage (P=0.014), pathological grade (P<0.001), and lymph node metastasis (P=0.007). A correlation analysis showed that there was a negative relationship between the expression of CD133 and KAI1/CD82 protein in LSCC tissues (P<0.001). By Kaplan-Meier analysis, the expression of CD133 was negatively correlated with overall survival (OS) (log-rank=40.949, P<0.001) and disease-free survival (DFS) (log-rank=39.307, P<0.001) time of LSCC. The expression of KAI1/CD82 was positively correlated with OS (log-rank=40.279, P<0.001) and DFS (log-rank=39.271, P<0.001) time of LSCC. Cox regression analysis: the expression of CD133 and KAI1/CD82, and pTNM stages were independent prognostic factors of LSCC (P<0.05). CONCLUSIONS: Thus the detection of CD133 and KAI1/CD82 proteins may be used as a potential indicator of LSCC prognosis.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N5e9668f2acad462e93139eac80ac26b5
77 N71199e050aa74a088760475c25b438b1
78 sg:journal.1032056
79 schema:name Clinicopathological significance of cancer stem cells marked by CD133 and KAI1/CD82 expression in laryngeal squamous cell carcinoma
80 schema:pagination 118
81 schema:productId N938c9e501a614289b95d18fe19657bfe
82 N9678a07b90814144b56acd69864799f2
83 Nb2173ed937a3470796b55cc3b19957ae
84 Nfa8da6746b74421c8a686e1e80cb6b63
85 Nfd557901d5a6409cb1081b86cca34adb
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004156972
87 https://doi.org/10.1186/1477-7819-12-118
88 schema:sdDatePublished 2019-04-11T00:15
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N18562cb36429446a8c1dd7130d087d51
91 schema:url http://link.springer.com/10.1186%2F1477-7819-12-118
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N18562cb36429446a8c1dd7130d087d51 schema:name Springer Nature - SN SciGraph project
96 rdf:type schema:Organization
97 N3580e06b139148379d11fa9274b5a88e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Glycoproteins
99 rdf:type schema:DefinedTerm
100 N38724c1edeb442289705927a65a8fff2 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
101 schema:familyName Dong
102 schema:givenName Huiming
103 rdf:type schema:Person
104 N42911076573a494385faa9a383bb6319 rdf:first sg:person.01256477176.77
105 rdf:rest Nccaaa50ec2ca4cd19c15651beaca6ffc
106 N463983f383ff4309a5ce12f58efd45b9 rdf:first sg:person.01074135376.38
107 rdf:rest Na98cff1cf2d446b795cac4f1bda88aa7
108 N4ccd3236fddd4d93ba453d94cec4a295 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Aged, 80 and over
110 rdf:type schema:DefinedTerm
111 N4f7df0adb923489c866f34e609506209 rdf:first sg:person.01015613600.12
112 rdf:rest Ne5231e6090ce45a9af3fb65a46538603
113 N5e9668f2acad462e93139eac80ac26b5 schema:volumeNumber 12
114 rdf:type schema:PublicationVolume
115 N68424769f2444e2593ef894effc47729 rdf:first sg:person.01047020671.41
116 rdf:rest Nc77ce7e4041148c0bd5ce3ec8e1d74bb
117 N71199e050aa74a088760475c25b438b1 schema:issueNumber 1
118 rdf:type schema:PublicationIssue
119 N71ad792c211144f0b50ce7096ee86a35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Follow-Up Studies
121 rdf:type schema:DefinedTerm
122 N7243ab0cf05741b68ecaa94425491723 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Antigens, CD
124 rdf:type schema:DefinedTerm
125 N77b0b70a527e4ad3b3f40eac4caa7c60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Middle Aged
127 rdf:type schema:DefinedTerm
128 N831bd0b7dff247b4aa2f18b1660f4023 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Laryngeal Neoplasms
130 rdf:type schema:DefinedTerm
131 N9348b1f4037947ffb49c5a923d54dc95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Immunoenzyme Techniques
133 rdf:type schema:DefinedTerm
134 N938c9e501a614289b95d18fe19657bfe schema:name nlm_unique_id
135 schema:value 101170544
136 rdf:type schema:PropertyValue
137 N9678a07b90814144b56acd69864799f2 schema:name pubmed_id
138 schema:value 24758564
139 rdf:type schema:PropertyValue
140 N986fa2cb3f6844909d70b1390e1a429b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Neoplasm Grading
142 rdf:type schema:DefinedTerm
143 N98d53cb8e05a4bff8416cf3baefab1db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name AC133 Antigen
145 rdf:type schema:DefinedTerm
146 N9aa47cbbc3674eb0b3150925ee4c845e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Neoplastic Stem Cells
148 rdf:type schema:DefinedTerm
149 Na4129dbe45c54159a7942c48a1cc5e9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Survival Rate
151 rdf:type schema:DefinedTerm
152 Na682c1db6412460d8edb00c1fe7c78bd rdf:first sg:person.0750124705.38
153 rdf:rest N42911076573a494385faa9a383bb6319
154 Na98cff1cf2d446b795cac4f1bda88aa7 rdf:first sg:person.01200601705.15
155 rdf:rest Na682c1db6412460d8edb00c1fe7c78bd
156 Nb1e9c8ed65c94c35a1fc62eff52a00d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Biomarkers, Tumor
158 rdf:type schema:DefinedTerm
159 Nb2173ed937a3470796b55cc3b19957ae schema:name dimensions_id
160 schema:value pub.1004156972
161 rdf:type schema:PropertyValue
162 Nb22107fe01ee456d81969f53132d1477 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Kangai-1 Protein
164 rdf:type schema:DefinedTerm
165 Nbc1b66d9aa4a4247bee1bf5d93563a12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Adult
167 rdf:type schema:DefinedTerm
168 Nc77ce7e4041148c0bd5ce3ec8e1d74bb rdf:first sg:person.0701365200.30
169 rdf:rest N463983f383ff4309a5ce12f58efd45b9
170 Nc883a93afddf49c7ac2ef61c671e43bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Prognosis
172 rdf:type schema:DefinedTerm
173 Nccaaa50ec2ca4cd19c15651beaca6ffc rdf:first sg:person.01324612376.70
174 rdf:rest N4f7df0adb923489c866f34e609506209
175 Ncccb029ebea04ee68b584d1a78902eaf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Male
177 rdf:type schema:DefinedTerm
178 Ncfec3ddfc412427f9a0e964e85075300 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Aged
180 rdf:type schema:DefinedTerm
181 Ne180a3e006634b1295a44d3b6bb5beb8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Female
183 rdf:type schema:DefinedTerm
184 Ne5050ec8a6bd4f1d8ff65a1fc30a253a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Humans
186 rdf:type schema:DefinedTerm
187 Ne5231e6090ce45a9af3fb65a46538603 rdf:first N38724c1edeb442289705927a65a8fff2
188 rdf:rest rdf:nil
189 Ne9a124e0b6994bbfb833e521ce20d79d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Peptides
191 rdf:type schema:DefinedTerm
192 Nef1cdb5a3d314d1c9a3ba6401526ade0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Carcinoma, Squamous Cell
194 rdf:type schema:DefinedTerm
195 Nf0d66a299e8240c397dbf15201d9c8a5 rdf:first sg:person.0732572271.87
196 rdf:rest N68424769f2444e2593ef894effc47729
197 Nf5f5f0c0fa5c4edeb1b39f8be45f107f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Lymphatic Metastasis
199 rdf:type schema:DefinedTerm
200 Nfa8da6746b74421c8a686e1e80cb6b63 schema:name readcube_id
201 schema:value 13cf16c136c7235619ce98daa9105fb611249b7635c06d9a904a12374d4b22ae
202 rdf:type schema:PropertyValue
203 Nfd557901d5a6409cb1081b86cca34adb schema:name doi
204 schema:value 10.1186/1477-7819-12-118
205 rdf:type schema:PropertyValue
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
210 schema:name Oncology and Carcinogenesis
211 rdf:type schema:DefinedTerm
212 sg:journal.1032056 schema:issn 1477-7819
213 schema:name World Journal of Surgical Oncology
214 rdf:type schema:Periodical
215 sg:person.01015613600.12 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
216 schema:familyName Wang
217 schema:givenName Danna
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015613600.12
219 rdf:type schema:Person
220 sg:person.01047020671.41 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
221 schema:familyName Zhou
222 schema:givenName Lei
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047020671.41
224 rdf:type schema:Person
225 sg:person.01074135376.38 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
226 schema:familyName Gong
227 schema:givenName Xiaomeng
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074135376.38
229 rdf:type schema:Person
230 sg:person.01200601705.15 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
231 schema:familyName Feng
232 schema:givenName Zhenzhong
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200601705.15
234 rdf:type schema:Person
235 sg:person.01256477176.77 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
236 schema:familyName Zhu
237 schema:givenName Bo
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256477176.77
239 rdf:type schema:Person
240 sg:person.01324612376.70 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
241 schema:familyName Yao
242 schema:givenName Nan
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324612376.70
244 rdf:type schema:Person
245 sg:person.0701365200.30 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
246 schema:familyName Wu
247 schema:givenName Shiwu
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701365200.30
249 rdf:type schema:Person
250 sg:person.0732572271.87 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
251 schema:familyName Yu
252 schema:givenName Lan
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732572271.87
254 rdf:type schema:Person
255 sg:person.0750124705.38 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
256 schema:familyName Ma
257 schema:givenName Li
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750124705.38
259 rdf:type schema:Person
260 sg:pub.10.1038/35102167 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021100179
261 https://doi.org/10.1038/35102167
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/bjc.2011.287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017899154
264 https://doi.org/10.1038/bjc.2011.287
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/nature03128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027226854
267 https://doi.org/10.1038/nature03128
268 rdf:type schema:CreativeWork
269 sg:pub.10.1038/nature05372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002972347
270 https://doi.org/10.1038/nature05372
271 rdf:type schema:CreativeWork
272 sg:pub.10.1038/nature05384 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026901039
273 https://doi.org/10.1038/nature05384
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/nm1469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020800104
276 https://doi.org/10.1038/nm1469
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/nrc2499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030818260
279 https://doi.org/10.1038/nrc2499
280 rdf:type schema:CreativeWork
281 sg:pub.10.1186/1471-2407-11-320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036159970
282 https://doi.org/10.1186/1471-2407-11-320
283 rdf:type schema:CreativeWork
284 sg:pub.10.1186/1471-2407-12-139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045465336
285 https://doi.org/10.1186/1471-2407-12-139
286 rdf:type schema:CreativeWork
287 sg:pub.10.1186/1471-2407-12-96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039392444
288 https://doi.org/10.1186/1471-2407-12-96
289 rdf:type schema:CreativeWork
290 sg:pub.10.1186/1477-7819-9-43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043773436
291 https://doi.org/10.1186/1477-7819-9-43
292 rdf:type schema:CreativeWork
293 https://app.dimensions.ai/details/publication/pub.1074999541 schema:CreativeWork
294 https://app.dimensions.ai/details/publication/pub.1077941171 schema:CreativeWork
295 https://app.dimensions.ai/details/publication/pub.1077943074 schema:CreativeWork
296 https://app.dimensions.ai/details/publication/pub.1078148413 schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1078515818 schema:CreativeWork
298 https://app.dimensions.ai/details/publication/pub.1083181326 schema:CreativeWork
299 https://doi.org/0121511/aim.0012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078640269
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1002/cncr.25869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014549574
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1002/path.2016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050399733
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1016/j.anndiagpath.2003.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017575102
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1016/j.bbrc.2006.11.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024283148
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1016/j.canlet.2012.10.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036415446
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1016/j.cellsig.2008.08.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031861133
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.juro.2009.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051188134
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.tcb.2009.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042381600
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/s1499-3872(11)60105-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048119999
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1074/jbc.m111.232637 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034463971
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1089/scd.2008.0338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309918
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1111/j.1349-7006.2007.00584.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014273030
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1111/j.1349-7006.2011.01894.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050665678
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1126/science.1171837 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026672047
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1126/science.7754374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649132
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1146/annurev.med.58.062105.204854 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017697362
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1155/2012/376894 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018965198
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1371/journal.pone.0020636 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045796033
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1371/journal.pone.0033544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010984295
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1371/journal.pone.0046391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005254851
340 rdf:type schema:CreativeWork
341 https://doi.org/10.14670/hh-24.519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077851169
342 rdf:type schema:CreativeWork
343 https://doi.org/10.3322/caac.20138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020626779
344 rdf:type schema:CreativeWork
345 https://doi.org/10.3748/wjg.v10.i15.2245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076867043
346 rdf:type schema:CreativeWork
347 https://doi.org/10.3748/wjg.v17.i7.932 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071368064
348 rdf:type schema:CreativeWork
349 https://doi.org/10.4048/jbc.2012.15.1.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049680702
350 rdf:type schema:CreativeWork
351 https://doi.org/10.5507/bp.2010.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072931489
352 rdf:type schema:CreativeWork
353 https://www.grid.ac/institutes/grid.252957.e schema:alternateName Bengbu Medical College
354 schema:name Department of Pathology, the First Hospital Affiliated to Bengbu Medical College, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China
355 Department of Surgical Oncology, the First Hospital Affiliated to Bengbu Medical College Anhui Province, Bengbu Medical College, 800 Zhihuai Ave, Longzihu, Bengbu, Anhui, China
356 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...