A long-term survivor of repeated inguinal nodes recurrence of papillary serous adenocarcinoma of CUP: case report View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-08-25

AUTHORS

Takeshi Todoroki, Souichiro Murata, Yuji Nakagawa, Nobuhiro Ohkohchi, Yukio Morishita

ABSTRACT

BackgroundTumor spread beyond the peritoneal cavity in cases of papillary serous adenocarcinoma of the unknown primary (CUP) is a rare late event and carries a poor prognosis.Case presentationA 71-year-old female was referred to our hospital because of a large right inguinal tumor with biopsy evidence of carcinoma as well as an elevated serum CA125 (cancer antigen 125). She underwent complete resection of the right inguinal tumor and multiple pelvic tumors, which involved the rectum, ovary and uterus. Pathological examination revealed the tumors to be metastases of a papillary serous adenocarcinoma with a psammoma body of CUP. On the 28th postoperative day, newly developed asymptomatic small left inguinal node metastases in the setting of a normal CA125 level were removed. Four and a half years after the primary resection, the CA125 level increased again and newly developed asymptomatic metastases were found in the right deep inguinal nodes and extirpated at that time. All surgical resections followed the modified FAM (5FU, Adriamycin; ADM, MMC) regimen, including protracted dairy oral administration of UFT or 5'-FDUR, Cimetidine and PSK (protein-bound polysaccharide K) as an immunomodulator or biological response modifier in conjunction with intermittent one-day continuous infusion (ADM+MMC) or intermittent single bolus injection of ADM+MMC. At present, the patient has been living in good health for almost 7 years with no evidence of relapse.ConclusionAggressive resection surgery followed by effective adjuvant chemotherapy is necessary for surviving long time without relapse of poorly prognostic patients with metastases outside of the abdominal cavity from peritoneal papillary serous adenocarcinomas. More... »

PAGES

22

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-7800-3-22

DOI

http://dx.doi.org/10.1186/1477-7800-3-22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046246106

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16930493


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Todoroki", 
        "givenName": "Takeshi", 
        "id": "sg:person.011557753737.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011557753737.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murata", 
        "givenName": "Souichiro", 
        "id": "sg:person.0764727601.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764727601.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakagawa", 
        "givenName": "Yuji", 
        "id": "sg:person.0647623043.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647623043.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohkohchi", 
        "givenName": "Nobuhiro", 
        "id": "sg:person.0716260254.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716260254.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morishita", 
        "givenName": "Yukio", 
        "id": "sg:person.01152146711.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152146711.50"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.bjc.6601619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034778524", 
          "https://doi.org/10.1038/sj.bjc.6601619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050120863", 
          "https://doi.org/10.1038/sj.bjc.6601085"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-08-25", 
    "datePublishedReg": "2006-08-25", 
    "description": "BackgroundTumor spread beyond the peritoneal cavity in cases of papillary serous adenocarcinoma of the unknown primary (CUP) is a rare late event and carries a poor prognosis.Case presentationA 71-year-old female was referred to our hospital because of a large right inguinal tumor with biopsy evidence of carcinoma as well as an elevated serum CA125 (cancer antigen 125). She underwent complete resection of the right inguinal tumor and multiple pelvic tumors, which involved the rectum, ovary and uterus. Pathological examination revealed the tumors to be metastases of a papillary serous adenocarcinoma with a psammoma body of CUP. On the 28th postoperative day, newly developed asymptomatic small left inguinal node metastases in the setting of a normal CA125 level were removed. Four and a half years after the primary resection, the CA125 level increased again and newly developed asymptomatic metastases were found in the right deep inguinal nodes and extirpated at that time. All surgical resections followed the modified FAM (5FU, Adriamycin; ADM, MMC) regimen, including protracted dairy oral administration of UFT or 5'-FDUR, Cimetidine and PSK (protein-bound polysaccharide K) as an immunomodulator or biological response modifier in conjunction with intermittent one-day continuous infusion (ADM+MMC) or intermittent single bolus injection of ADM+MMC. At present, the patient has been living in good health for almost 7 years with no evidence of relapse.ConclusionAggressive resection surgery followed by effective adjuvant chemotherapy is necessary for surviving long time without relapse of poorly prognostic patients with metastases outside of the abdominal cavity from peritoneal papillary serous adenocarcinomas.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1477-7800-3-22", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1033908", 
        "issn": [
          "1477-7800"
        ], 
        "name": "International Seminars in Surgical Oncology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "3"
      }
    ], 
    "keywords": [
      "papillary serous adenocarcinoma", 
      "right inguinal tumor", 
      "serous adenocarcinoma", 
      "CA125 levels", 
      "inguinal tumor", 
      "elevated serum CA125", 
      "inguinal node metastases", 
      "normal CA125 levels", 
      "deep inguinal nodes", 
      "effective adjuvant chemotherapy", 
      "evidence of relapse", 
      "long-term survivors", 
      "single bolus injection", 
      "FAM regimen", 
      "adjuvant chemotherapy", 
      "node recurrence", 
      "biopsy evidence", 
      "primary resection", 
      "Case presentationA", 
      "postoperative day", 
      "asymptomatic metastases", 
      "inguinal nodes", 
      "surgical resection", 
      "unknown primary", 
      "complete resection", 
      "node metastasis", 
      "prognostic patients", 
      "serum CA125", 
      "pathological examination", 
      "poor prognosis", 
      "resection surgery", 
      "pelvic tumors", 
      "continuous infusion", 
      "case report", 
      "oral administration", 
      "bolus injection", 
      "peritoneal cavity", 
      "abdominal cavity", 
      "psammoma bodies", 
      "adenocarcinoma", 
      "metastasis", 
      "resection", 
      "tumors", 
      "good health", 
      "relapse", 
      "patients", 
      "half years", 
      "late event", 
      "BackgroundTumor", 
      "regimen", 
      "chemotherapy", 
      "surgery", 
      "prognosis", 
      "carcinoma", 
      "CA125", 
      "UFT", 
      "immunomodulators", 
      "recurrence", 
      "biological responses", 
      "cimetidine", 
      "hospital", 
      "uterus", 
      "infusion", 
      "rectum", 
      "years", 
      "survivors", 
      "administration", 
      "evidence", 
      "levels", 
      "injection", 
      "examination", 
      "health", 
      "females", 
      "days", 
      "report", 
      "cavity", 
      "cup", 
      "primary", 
      "setting", 
      "response", 
      "cases", 
      "long time", 
      "time", 
      "events", 
      "body", 
      "nodes", 
      "conjunction", 
      "present", 
      "PSK"
    ], 
    "name": "A long-term survivor of repeated inguinal nodes recurrence of papillary serous adenocarcinoma of CUP: case report", 
    "pagination": "22", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046246106"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1477-7800-3-22"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16930493"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1477-7800-3-22", 
      "https://app.dimensions.ai/details/publication/pub.1046246106"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_423.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1477-7800-3-22"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-7800-3-22'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-7800-3-22'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-7800-3-22'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-7800-3-22'


 

This table displays all metadata directly associated to this object as RDF triples.

187 TRIPLES      21 PREDICATES      116 URIs      106 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1477-7800-3-22 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N7ac177bbc5844c51a4f2546ad4055a56
4 schema:citation sg:pub.10.1038/sj.bjc.6601085
5 sg:pub.10.1038/sj.bjc.6601619
6 schema:datePublished 2006-08-25
7 schema:datePublishedReg 2006-08-25
8 schema:description BackgroundTumor spread beyond the peritoneal cavity in cases of papillary serous adenocarcinoma of the unknown primary (CUP) is a rare late event and carries a poor prognosis.Case presentationA 71-year-old female was referred to our hospital because of a large right inguinal tumor with biopsy evidence of carcinoma as well as an elevated serum CA125 (cancer antigen 125). She underwent complete resection of the right inguinal tumor and multiple pelvic tumors, which involved the rectum, ovary and uterus. Pathological examination revealed the tumors to be metastases of a papillary serous adenocarcinoma with a psammoma body of CUP. On the 28th postoperative day, newly developed asymptomatic small left inguinal node metastases in the setting of a normal CA125 level were removed. Four and a half years after the primary resection, the CA125 level increased again and newly developed asymptomatic metastases were found in the right deep inguinal nodes and extirpated at that time. All surgical resections followed the modified FAM (5FU, Adriamycin; ADM, MMC) regimen, including protracted dairy oral administration of UFT or 5'-FDUR, Cimetidine and PSK (protein-bound polysaccharide K) as an immunomodulator or biological response modifier in conjunction with intermittent one-day continuous infusion (ADM+MMC) or intermittent single bolus injection of ADM+MMC. At present, the patient has been living in good health for almost 7 years with no evidence of relapse.ConclusionAggressive resection surgery followed by effective adjuvant chemotherapy is necessary for surviving long time without relapse of poorly prognostic patients with metastases outside of the abdominal cavity from peritoneal papillary serous adenocarcinomas.
9 schema:genre article
10 schema:isAccessibleForFree true
11 schema:isPartOf N6310d0b01f7046ac95456c42b1ffbdfc
12 N9a915f50d9aa4a9b84cde55c9a5024a7
13 sg:journal.1033908
14 schema:keywords BackgroundTumor
15 CA125
16 CA125 levels
17 Case presentationA
18 FAM regimen
19 PSK
20 UFT
21 abdominal cavity
22 adenocarcinoma
23 adjuvant chemotherapy
24 administration
25 asymptomatic metastases
26 biological responses
27 biopsy evidence
28 body
29 bolus injection
30 carcinoma
31 case report
32 cases
33 cavity
34 chemotherapy
35 cimetidine
36 complete resection
37 conjunction
38 continuous infusion
39 cup
40 days
41 deep inguinal nodes
42 effective adjuvant chemotherapy
43 elevated serum CA125
44 events
45 evidence
46 evidence of relapse
47 examination
48 females
49 good health
50 half years
51 health
52 hospital
53 immunomodulators
54 infusion
55 inguinal node metastases
56 inguinal nodes
57 inguinal tumor
58 injection
59 late event
60 levels
61 long time
62 long-term survivors
63 metastasis
64 node metastasis
65 node recurrence
66 nodes
67 normal CA125 levels
68 oral administration
69 papillary serous adenocarcinoma
70 pathological examination
71 patients
72 pelvic tumors
73 peritoneal cavity
74 poor prognosis
75 postoperative day
76 present
77 primary
78 primary resection
79 prognosis
80 prognostic patients
81 psammoma bodies
82 rectum
83 recurrence
84 regimen
85 relapse
86 report
87 resection
88 resection surgery
89 response
90 right inguinal tumor
91 serous adenocarcinoma
92 serum CA125
93 setting
94 single bolus injection
95 surgery
96 surgical resection
97 survivors
98 time
99 tumors
100 unknown primary
101 uterus
102 years
103 schema:name A long-term survivor of repeated inguinal nodes recurrence of papillary serous adenocarcinoma of CUP: case report
104 schema:pagination 22
105 schema:productId N2b635745b8974147be6eb83b56a22c1b
106 N5ff7897d6324475e967715e6e28ff223
107 Nbc7beb870bc841d094be277297721b85
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046246106
109 https://doi.org/10.1186/1477-7800-3-22
110 schema:sdDatePublished 2022-09-02T15:52
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher Nccddaacda81440fd9894487e0fa07cbe
113 schema:url https://doi.org/10.1186/1477-7800-3-22
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N02ef48bfc0a74906bb074913e4062df2 rdf:first sg:person.0764727601.09
118 rdf:rest N6c07e79bf1c647098ffd714333f58929
119 N2b635745b8974147be6eb83b56a22c1b schema:name doi
120 schema:value 10.1186/1477-7800-3-22
121 rdf:type schema:PropertyValue
122 N5ff7897d6324475e967715e6e28ff223 schema:name pubmed_id
123 schema:value 16930493
124 rdf:type schema:PropertyValue
125 N6310d0b01f7046ac95456c42b1ffbdfc schema:volumeNumber 3
126 rdf:type schema:PublicationVolume
127 N6c07e79bf1c647098ffd714333f58929 rdf:first sg:person.0647623043.59
128 rdf:rest Ncd36fbc3b81d4972bec95a2ff89ebfc3
129 N7ac177bbc5844c51a4f2546ad4055a56 rdf:first sg:person.011557753737.86
130 rdf:rest N02ef48bfc0a74906bb074913e4062df2
131 N9a915f50d9aa4a9b84cde55c9a5024a7 schema:issueNumber 1
132 rdf:type schema:PublicationIssue
133 Na1979ad0b5a94e8994f8a69d87bd8a74 rdf:first sg:person.01152146711.50
134 rdf:rest rdf:nil
135 Nbc7beb870bc841d094be277297721b85 schema:name dimensions_id
136 schema:value pub.1046246106
137 rdf:type schema:PropertyValue
138 Nccddaacda81440fd9894487e0fa07cbe schema:name Springer Nature - SN SciGraph project
139 rdf:type schema:Organization
140 Ncd36fbc3b81d4972bec95a2ff89ebfc3 rdf:first sg:person.0716260254.52
141 rdf:rest Na1979ad0b5a94e8994f8a69d87bd8a74
142 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
143 schema:name Medical and Health Sciences
144 rdf:type schema:DefinedTerm
145 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
146 schema:name Oncology and Carcinogenesis
147 rdf:type schema:DefinedTerm
148 sg:journal.1033908 schema:issn 1477-7800
149 schema:name International Seminars in Surgical Oncology
150 schema:publisher Springer Nature
151 rdf:type schema:Periodical
152 sg:person.01152146711.50 schema:affiliation grid-institutes:grid.20515.33
153 schema:familyName Morishita
154 schema:givenName Yukio
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152146711.50
156 rdf:type schema:Person
157 sg:person.011557753737.86 schema:affiliation grid-institutes:grid.20515.33
158 schema:familyName Todoroki
159 schema:givenName Takeshi
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011557753737.86
161 rdf:type schema:Person
162 sg:person.0647623043.59 schema:affiliation grid-institutes:grid.20515.33
163 schema:familyName Nakagawa
164 schema:givenName Yuji
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647623043.59
166 rdf:type schema:Person
167 sg:person.0716260254.52 schema:affiliation grid-institutes:grid.20515.33
168 schema:familyName Ohkohchi
169 schema:givenName Nobuhiro
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716260254.52
171 rdf:type schema:Person
172 sg:person.0764727601.09 schema:affiliation grid-institutes:grid.20515.33
173 schema:familyName Murata
174 schema:givenName Souichiro
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0764727601.09
176 rdf:type schema:Person
177 sg:pub.10.1038/sj.bjc.6601085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050120863
178 https://doi.org/10.1038/sj.bjc.6601085
179 rdf:type schema:CreativeWork
180 sg:pub.10.1038/sj.bjc.6601619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034778524
181 https://doi.org/10.1038/sj.bjc.6601619
182 rdf:type schema:CreativeWork
183 grid-institutes:grid.20515.33 schema:alternateName Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan
184 Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan
185 schema:name Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan
186 Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, 305-8575, Tsukuba-Shi, Japan
187 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...