Responsiveness and minimal important differences for patient reported outcomes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-12

AUTHORS

Dennis A Revicki, David Cella, Ron D Hays, Jeff A Sloan, William R Lenderking, Neil K Aaronson

ABSTRACT

Patient reported outcomes provide the patient's perspective on the effectiveness of treatment. The draft Food and Drug Administration guidance on patient reported outcomes for labeling and promotional claims raises a number of method and measurement issues that require further clarification, including methods of determining responsiveness and minimal important differences. For clinical trials, instruments need to be based on a clear conceptual framework, have evidence supporting content validity and acceptable psychometric qualities. The measures must also have evidence documenting responsiveness and interpretation guidelines (i.e., minimal important difference) to be most useful as effectiveness endpoints in clinical trials. The recommended approach is to estimate the minimal important difference based on several anchor-based methods, with relevant clinical or patient-based indicators, and to examine various distribution-based estimates (i.e., effect size, standardized response mean, standard error of measurement) as supportive information, and then to triangulate on a single value or small range of values for the MID. Confidence in a specific MID value evolves over time and is confirmed by additional research evidence, including clinical trial experience. The MID may vary by population and context, and no one MID will be valid for all study applications involving a PRO instrument. Responsiveness and MID must be demonstrated and documented for the particular study population, and these measurement characteristics are needed for PRO labeling and promotional claims. More... »

PAGES

70

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-7525-4-70

DOI

http://dx.doi.org/10.1186/1477-7525-4-70

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021198267

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17005038


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Clinical Trials as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endpoint Determination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Evidence-Based Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Patient Satisfaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Product Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Psychometrics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Reproducibility of Results", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Surveys and Questionnaires", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "United States Food and Drug Administration", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Express Scripts Holding Company (United States)", 
          "id": "https://www.grid.ac/institutes/grid.429261.a", 
          "name": [
            "Center for Health Outcomes Research, United Biosource Corporation, 7101 Wisconsin Ave., Suite 600, 20814, Bethesda, MD, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Revicki", 
        "givenName": "Dennis A", 
        "id": "sg:person.01053512220.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053512220.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "NorthShore University HealthSystem", 
          "id": "https://www.grid.ac/institutes/grid.240372.0", 
          "name": [
            "Evanston Northwestern Healthcare, Center on Outcomes Research and Education, Evanston, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cella", 
        "givenName": "David", 
        "id": "sg:person.012000260477.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012000260477.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of California Los Angeles", 
          "id": "https://www.grid.ac/institutes/grid.19006.3e", 
          "name": [
            "UCLA Division of General Internal Medicine and Health Services Research, 911 Broxton Plaza, Room 110, 90024, Los Angeles, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hays", 
        "givenName": "Ron D", 
        "id": "sg:person.011301642537.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011301642537.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sloan", 
        "givenName": "Jeff A", 
        "id": "sg:person.010037302137.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010037302137.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pfizer (United States)", 
          "id": "https://www.grid.ac/institutes/grid.410513.2", 
          "name": [
            "Worldwide Outcomes Research, Pfizer Inc., Eastern Point Road, 06340, Groton, CT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lenderking", 
        "givenName": "William R", 
        "id": "sg:person.01252606652.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252606652.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Antoni van Leeuwenhoek Hospital", 
          "id": "https://www.grid.ac/institutes/grid.430814.a", 
          "name": [
            "Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aaronson", 
        "givenName": "Neil K", 
        "id": "sg:person.01325740302.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325740302.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1008996223999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002685260", 
          "https://doi.org/10.1023/a:1008996223999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1081-1206(10)61242-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002839661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-4356(03)00044-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003169137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-4356(03)00044-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003169137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlr.0000062554.74615.4c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005387261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.mlr.0000062554.74615.4c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005387261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199007000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008647068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199007000-00008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008647068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jclinepi.2005.07.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010354263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(89)90005-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015419669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0197-2456(89)90005-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015419669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015276414526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019271543", 
          "https://doi.org/10.1023/a:1015276414526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4065/77.4.371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028107238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11136-004-0705-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029091380", 
          "https://doi.org/10.1007/s11136-004-0705-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0895-4356(99)00071-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035644105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-198903001-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036096589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-198903001-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036096589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9681(87)90069-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036788289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/cbo9780511545856.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036956693"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1524-4733.1999.02210.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048242515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cct.2004.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048729240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4065/77.6.561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053043524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199905000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060223759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199905000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060223759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199905000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060223759"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-12", 
    "datePublishedReg": "2006-12-01", 
    "description": "Patient reported outcomes provide the patient's perspective on the effectiveness of treatment. The draft Food and Drug Administration guidance on patient reported outcomes for labeling and promotional claims raises a number of method and measurement issues that require further clarification, including methods of determining responsiveness and minimal important differences. For clinical trials, instruments need to be based on a clear conceptual framework, have evidence supporting content validity and acceptable psychometric qualities. The measures must also have evidence documenting responsiveness and interpretation guidelines (i.e., minimal important difference) to be most useful as effectiveness endpoints in clinical trials. The recommended approach is to estimate the minimal important difference based on several anchor-based methods, with relevant clinical or patient-based indicators, and to examine various distribution-based estimates (i.e., effect size, standardized response mean, standard error of measurement) as supportive information, and then to triangulate on a single value or small range of values for the MID. Confidence in a specific MID value evolves over time and is confirmed by additional research evidence, including clinical trial experience. The MID may vary by population and context, and no one MID will be valid for all study applications involving a PRO instrument. Responsiveness and MID must be demonstrated and documented for the particular study population, and these measurement characteristics are needed for PRO labeling and promotional claims.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1477-7525-4-70", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031326", 
        "issn": [
          "1477-7525"
        ], 
        "name": "Health and Quality of Life Outcomes", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "Responsiveness and minimal important differences for patient reported outcomes", 
    "pagination": "70", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "64ffbbd03564e563a88566903ec467ed137f733cf5d328aad5af900441219445"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17005038"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101153626"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1477-7525-4-70"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021198267"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1477-7525-4-70", 
      "https://app.dimensions.ai/details/publication/pub.1021198267"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000512.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1477-7525-4-70"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-7525-4-70'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-7525-4-70'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-7525-4-70'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-7525-4-70'


 

This table displays all metadata directly associated to this object as RDF triples.

231 TRIPLES      21 PREDICATES      61 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1477-7525-4-70 schema:about N0b5e8f4c017941eaafa5683fbb0d98d3
2 N164e888ca3c34e85ba2e8fe708115a80
3 N20c89470b3864d339eac740df0c87490
4 N261b908e06ad4eb8abebf7883ffd6e6e
5 N56edd12d26004a95bac8fa4695a07c93
6 N6dec61cc27f14f30bef03af855036054
7 N79395c8e429c4955baeb7d3063e99a4d
8 N7ad8c95ddf5f41f4a4eae66b5e8c7a25
9 Nb25a0cd7acb84c61928a1c7fc387305c
10 Nb90c0652d60547d993bdc17253a5d38f
11 Nc14c2f8467ac426e928097c3c3272c16
12 Nd42ab99933264931b508684ad99c4a11
13 Nd8d2860080a949748ceac78d678f95e4
14 Nda3080794dc94d1287c8a7d9c16ddddf
15 anzsrc-for:11
16 anzsrc-for:1117
17 schema:author N7424c5a60813461bbaec502877e28d58
18 schema:citation sg:pub.10.1007/s11136-004-0705-2
19 sg:pub.10.1023/a:1008996223999
20 sg:pub.10.1023/a:1015276414526
21 https://doi.org/10.1016/0021-9681(87)90069-5
22 https://doi.org/10.1016/0197-2456(89)90005-6
23 https://doi.org/10.1016/j.cct.2004.09.003
24 https://doi.org/10.1016/j.jclinepi.2005.07.008
25 https://doi.org/10.1016/s0895-4356(03)00044-1
26 https://doi.org/10.1016/s0895-4356(99)00071-2
27 https://doi.org/10.1016/s1081-1206(10)61242-2
28 https://doi.org/10.1017/cbo9780511545856.019
29 https://doi.org/10.1046/j.1524-4733.1999.02210.x
30 https://doi.org/10.1097/00005650-198903001-00015
31 https://doi.org/10.1097/00005650-199007000-00008
32 https://doi.org/10.1097/00005650-199905000-00006
33 https://doi.org/10.1097/01.mlr.0000062554.74615.4c
34 https://doi.org/10.4065/77.4.371
35 https://doi.org/10.4065/77.6.561
36 schema:datePublished 2006-12
37 schema:datePublishedReg 2006-12-01
38 schema:description Patient reported outcomes provide the patient's perspective on the effectiveness of treatment. The draft Food and Drug Administration guidance on patient reported outcomes for labeling and promotional claims raises a number of method and measurement issues that require further clarification, including methods of determining responsiveness and minimal important differences. For clinical trials, instruments need to be based on a clear conceptual framework, have evidence supporting content validity and acceptable psychometric qualities. The measures must also have evidence documenting responsiveness and interpretation guidelines (i.e., minimal important difference) to be most useful as effectiveness endpoints in clinical trials. The recommended approach is to estimate the minimal important difference based on several anchor-based methods, with relevant clinical or patient-based indicators, and to examine various distribution-based estimates (i.e., effect size, standardized response mean, standard error of measurement) as supportive information, and then to triangulate on a single value or small range of values for the MID. Confidence in a specific MID value evolves over time and is confirmed by additional research evidence, including clinical trial experience. The MID may vary by population and context, and no one MID will be valid for all study applications involving a PRO instrument. Responsiveness and MID must be demonstrated and documented for the particular study population, and these measurement characteristics are needed for PRO labeling and promotional claims.
39 schema:genre research_article
40 schema:inLanguage en
41 schema:isAccessibleForFree true
42 schema:isPartOf N3721cde45d064c1884604483ea880fd7
43 N429ac6173534404189a563f66bcda70b
44 sg:journal.1031326
45 schema:name Responsiveness and minimal important differences for patient reported outcomes
46 schema:pagination 70
47 schema:productId N33069ad3bd964e37beee417afbef2868
48 N92a6d40646a34a28a9c1095d638dfe3f
49 Na65d6c65d0e540f88ec243dd9b6fcd9c
50 Nd0eed1af74434f3d9f8c48c480d06b4f
51 Ndcf47a791da448dc95ea16d57357c414
52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021198267
53 https://doi.org/10.1186/1477-7525-4-70
54 schema:sdDatePublished 2019-04-10T13:16
55 schema:sdLicense https://scigraph.springernature.com/explorer/license/
56 schema:sdPublisher Ncd776776eb7342a4b25d3cf1cdaf845d
57 schema:url http://link.springer.com/10.1186%2F1477-7525-4-70
58 sgo:license sg:explorer/license/
59 sgo:sdDataset articles
60 rdf:type schema:ScholarlyArticle
61 N0b5e8f4c017941eaafa5683fbb0d98d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name United States
63 rdf:type schema:DefinedTerm
64 N164e888ca3c34e85ba2e8fe708115a80 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Humans
66 rdf:type schema:DefinedTerm
67 N1f202b54c14743379b94d9f4e128f481 rdf:first sg:person.012000260477.10
68 rdf:rest N7b43faba270d4b338fc1e3e8be302cf1
69 N20c89470b3864d339eac740df0c87490 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Psychometrics
71 rdf:type schema:DefinedTerm
72 N261b908e06ad4eb8abebf7883ffd6e6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Product Labeling
74 rdf:type schema:DefinedTerm
75 N33069ad3bd964e37beee417afbef2868 schema:name dimensions_id
76 schema:value pub.1021198267
77 rdf:type schema:PropertyValue
78 N3721cde45d064c1884604483ea880fd7 schema:volumeNumber 4
79 rdf:type schema:PublicationVolume
80 N429ac6173534404189a563f66bcda70b schema:issueNumber 1
81 rdf:type schema:PublicationIssue
82 N56edd12d26004a95bac8fa4695a07c93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Patient Satisfaction
84 rdf:type schema:DefinedTerm
85 N6dec61cc27f14f30bef03af855036054 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Evidence-Based Medicine
87 rdf:type schema:DefinedTerm
88 N7424c5a60813461bbaec502877e28d58 rdf:first sg:person.01053512220.29
89 rdf:rest N1f202b54c14743379b94d9f4e128f481
90 N79395c8e429c4955baeb7d3063e99a4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Surveys and Questionnaires
92 rdf:type schema:DefinedTerm
93 N7ad8c95ddf5f41f4a4eae66b5e8c7a25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Treatment Outcome
95 rdf:type schema:DefinedTerm
96 N7b43faba270d4b338fc1e3e8be302cf1 rdf:first sg:person.011301642537.47
97 rdf:rest Nbfbae702b9b249c3bf76a66231c790fb
98 N92a6d40646a34a28a9c1095d638dfe3f schema:name doi
99 schema:value 10.1186/1477-7525-4-70
100 rdf:type schema:PropertyValue
101 Na65d6c65d0e540f88ec243dd9b6fcd9c schema:name readcube_id
102 schema:value 64ffbbd03564e563a88566903ec467ed137f733cf5d328aad5af900441219445
103 rdf:type schema:PropertyValue
104 Nb25a0cd7acb84c61928a1c7fc387305c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Drug Labeling
106 rdf:type schema:DefinedTerm
107 Nb751c97ed6ef4466869a12ab29bbf1d6 rdf:first sg:person.01325740302.22
108 rdf:rest rdf:nil
109 Nb90c0652d60547d993bdc17253a5d38f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name United States Food and Drug Administration
111 rdf:type schema:DefinedTerm
112 Nbfbae702b9b249c3bf76a66231c790fb rdf:first sg:person.010037302137.14
113 rdf:rest Neaa56b2bf62846b58eab49c927ea7aec
114 Nc14c2f8467ac426e928097c3c3272c16 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Quality of Life
116 rdf:type schema:DefinedTerm
117 Ncd776776eb7342a4b25d3cf1cdaf845d schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 Nd0eed1af74434f3d9f8c48c480d06b4f schema:name nlm_unique_id
120 schema:value 101153626
121 rdf:type schema:PropertyValue
122 Nd42ab99933264931b508684ad99c4a11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Clinical Trials as Topic
124 rdf:type schema:DefinedTerm
125 Nd8d2860080a949748ceac78d678f95e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Reproducibility of Results
127 rdf:type schema:DefinedTerm
128 Nda3080794dc94d1287c8a7d9c16ddddf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Endpoint Determination
130 rdf:type schema:DefinedTerm
131 Ndcf47a791da448dc95ea16d57357c414 schema:name pubmed_id
132 schema:value 17005038
133 rdf:type schema:PropertyValue
134 Neaa56b2bf62846b58eab49c927ea7aec rdf:first sg:person.01252606652.22
135 rdf:rest Nb751c97ed6ef4466869a12ab29bbf1d6
136 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
137 schema:name Medical and Health Sciences
138 rdf:type schema:DefinedTerm
139 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
140 schema:name Public Health and Health Services
141 rdf:type schema:DefinedTerm
142 sg:journal.1031326 schema:issn 1477-7525
143 schema:name Health and Quality of Life Outcomes
144 rdf:type schema:Periodical
145 sg:person.010037302137.14 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
146 schema:familyName Sloan
147 schema:givenName Jeff A
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010037302137.14
149 rdf:type schema:Person
150 sg:person.01053512220.29 schema:affiliation https://www.grid.ac/institutes/grid.429261.a
151 schema:familyName Revicki
152 schema:givenName Dennis A
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053512220.29
154 rdf:type schema:Person
155 sg:person.011301642537.47 schema:affiliation https://www.grid.ac/institutes/grid.19006.3e
156 schema:familyName Hays
157 schema:givenName Ron D
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011301642537.47
159 rdf:type schema:Person
160 sg:person.012000260477.10 schema:affiliation https://www.grid.ac/institutes/grid.240372.0
161 schema:familyName Cella
162 schema:givenName David
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012000260477.10
164 rdf:type schema:Person
165 sg:person.01252606652.22 schema:affiliation https://www.grid.ac/institutes/grid.410513.2
166 schema:familyName Lenderking
167 schema:givenName William R
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252606652.22
169 rdf:type schema:Person
170 sg:person.01325740302.22 schema:affiliation https://www.grid.ac/institutes/grid.430814.a
171 schema:familyName Aaronson
172 schema:givenName Neil K
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325740302.22
174 rdf:type schema:Person
175 sg:pub.10.1007/s11136-004-0705-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029091380
176 https://doi.org/10.1007/s11136-004-0705-2
177 rdf:type schema:CreativeWork
178 sg:pub.10.1023/a:1008996223999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002685260
179 https://doi.org/10.1023/a:1008996223999
180 rdf:type schema:CreativeWork
181 sg:pub.10.1023/a:1015276414526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019271543
182 https://doi.org/10.1023/a:1015276414526
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/0021-9681(87)90069-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036788289
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/0197-2456(89)90005-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015419669
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.cct.2004.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048729240
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.jclinepi.2005.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010354263
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/s0895-4356(03)00044-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003169137
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0895-4356(99)00071-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035644105
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s1081-1206(10)61242-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002839661
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1017/cbo9780511545856.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036956693
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1046/j.1524-4733.1999.02210.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048242515
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/00005650-198903001-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036096589
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/00005650-199007000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008647068
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/00005650-199905000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060223759
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1097/01.mlr.0000062554.74615.4c schema:sameAs https://app.dimensions.ai/details/publication/pub.1005387261
209 rdf:type schema:CreativeWork
210 https://doi.org/10.4065/77.4.371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028107238
211 rdf:type schema:CreativeWork
212 https://doi.org/10.4065/77.6.561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053043524
213 rdf:type schema:CreativeWork
214 https://www.grid.ac/institutes/grid.19006.3e schema:alternateName University of California Los Angeles
215 schema:name UCLA Division of General Internal Medicine and Health Services Research, 911 Broxton Plaza, Room 110, 90024, Los Angeles, CA, USA
216 rdf:type schema:Organization
217 https://www.grid.ac/institutes/grid.240372.0 schema:alternateName NorthShore University HealthSystem
218 schema:name Evanston Northwestern Healthcare, Center on Outcomes Research and Education, Evanston, IL, USA
219 rdf:type schema:Organization
220 https://www.grid.ac/institutes/grid.410513.2 schema:alternateName Pfizer (United States)
221 schema:name Worldwide Outcomes Research, Pfizer Inc., Eastern Point Road, 06340, Groton, CT, USA
222 rdf:type schema:Organization
223 https://www.grid.ac/institutes/grid.429261.a schema:alternateName Express Scripts Holding Company (United States)
224 schema:name Center for Health Outcomes Research, United Biosource Corporation, 7101 Wisconsin Ave., Suite 600, 20814, Bethesda, MD, USA
225 rdf:type schema:Organization
226 https://www.grid.ac/institutes/grid.430814.a schema:alternateName Antoni van Leeuwenhoek Hospital
227 schema:name Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands
228 rdf:type schema:Organization
229 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
230 schema:name Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, 55905, Rochester, MN, USA
231 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...