Evaluation of health related quality of life in children with immune thrombocytopenia with the PedsQL™ 4.0 Generic Core Scales: a ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-12

AUTHORS

Marion Strullu, Josué Rakotonjanahary, Eliane Tarral, Christophe Savagner, Caroline Thomas, Françoise Méchinaud, Yves Reguerre, Sylvaine Poignant, Arnaud Boutet, Joachim Bassil, Dominique Médinger, Emmanuel Quemener, Nancy L Young, Petronela Rachieru, Robert J Klaassen, Isabelle Pellier

ABSTRACT

BACKGROUND: Immune thrombocytopenia (ITP) is a childhood disorder that is often life-altering for children and their parents. Health related quality of life (HRQL) has never been chronologically monitored in children with ITP. We initiated a prospective study to assess HRQL from diagnosis to six months and define factors that influence this outcome in children with ITP. METHODS: 73 children with acute ITP aged from 2 to 18 years were prospectively enrolled in the study. According to the presence of bleeding, they were or were not given a 4-day course of corticosteroid treatment. The PedsQL™ 4.0 Generic Core Scale was completed by children and parents upon their inclusion in the study and 6 months after diagnosis. RESULTS: Over the six month period, quality of life improved in terms of their global, physical and psychosocial well-being for 54.5%, 35.6% and 36.2% of patients respectively. This improvement is clinically relevant compared to scores at diagnosis, corresponding at least to a minimal clinically important difference (MCID). Factors such as sex, age, platelet count, bleeding scores, bone marrow aspiration and persistence of ITP at 6 months were not significantly associated with HRQL scores. However, preceding viral infection was identified to have an impact on HRQL. CONCLUSIONS: This first longitudinal study assessing HRQL in children with ITP reveals a global improvement in PedSQL™ 4.0. However, these results should be considered with caution since our data also confirm that self-report HRQL scores are not influenced by any analyzed biologic or clinical parameters. Others tools, such as Kids' ITP Tools, would probably be required to assess the HRQL of this population. TRIAL REGISTRATION: Trial registration clinical trials.gov Identifier: NCT00331357. More... »

PAGES

193

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-7525-11-193

DOI

http://dx.doi.org/10.1186/1477-7525-11-193

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013138872

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24225051


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