On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2005-12

AUTHORS

Sonja EN Wagenleiter, Peter Jagiello, Denis A Akkad, Larissa Arning, Thomas Griga, Wolfram Klein, Jörg T Epplen

ABSTRACT

Crohn's disease (CD) presents as an inflammatory barrier disease with characteristic destructive processes in the intestinal wall. Although the pathomechanisms of CD are still not exactly understood, there is evidence that, in addition to e.g. bacterial colonisation, genetic predisposition contributes to the development of CD. In order to search for predisposing genetic factors we scrutinised 245 microsatellite markers in a population-based linkage mapping study. These microsatellites cover gene loci the encoded protein of which take part in the regulation of apoptosis and (innate) immune processes. Respective loci contribute to the activation/suppression of apoptosis, are involved in signal transduction and cell cycle regulators or they belong to the tumor necrosis factor superfamily, caspase related genes or the BCL2 family. Furthermore, several cytokines as well as chemokines were included. The approach is based on three steps: analyzing pooled DNAs of patients and controls, verification of significantly differing microsatellite markers by genotyping individual DNA samples and, finally, additional reinvestigation of the respective gene in the region covered by the associated microsatellite by analysing single-nucleotide polymorphisms (SNPs). Using this step-wise process we were unable to demonstrate evidence for genetic predisposition of the chosen apoptosis- and immunity-related genes with respect to susceptibility for CD. More... »

PAGES

8

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-5751-4-8

DOI

http://dx.doi.org/10.1186/1477-5751-4-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008841187

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16318629


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "B-Cell Maturation Antigen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crohn Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Markers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Department of Human Genetics, Ruhr-University, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagenleiter", 
        "givenName": "Sonja EN", 
        "id": "sg:person.01116377761.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116377761.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Institute for Clinical Molecular Biology, University Schleswig-Holstein, Kiel, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jagiello", 
        "givenName": "Peter", 
        "id": "sg:person.01170611362.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170611362.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Department of Human Genetics, Ruhr-University, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akkad", 
        "givenName": "Denis A", 
        "id": "sg:person.01231727624.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231727624.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Department of Human Genetics, Ruhr-University, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arning", 
        "givenName": "Larissa", 
        "id": "sg:person.0642220103.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642220103.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BG University Hospital Bergmannsheil GmbH", 
          "id": "https://www.grid.ac/institutes/grid.412471.5", 
          "name": [
            "Department of Gastroenterology, University Hospital Bergmannsheil, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griga", 
        "givenName": "Thomas", 
        "id": "sg:person.01365064244.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365064244.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Department of Human Genetics, Ruhr-University, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klein", 
        "givenName": "Wolfram", 
        "id": "sg:person.01161527616.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161527616.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ruhr University Bochum", 
          "id": "https://www.grid.ac/institutes/grid.5570.7", 
          "name": [
            "Department of Human Genetics, Ruhr-University, Bochum, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Epplen", 
        "givenName": "J\u00f6rg T", 
        "id": "sg:person.01340360167.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340360167.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1111/j.1572-0241.2002.07107.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004141431", 
          "https://doi.org/10.1111/j.1572-0241.2002.07107.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001574-200307000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004370967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001574-200307000-00005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004370967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpg.2004.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006781480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00384-004-0639-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007865025", 
          "https://doi.org/10.1007/s00384-004-0639-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000016893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009117030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-004-1092-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010576372", 
          "https://doi.org/10.1007/s00439-004-1092-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-004-1092-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010576372", 
          "https://doi.org/10.1007/s00439-004-1092-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2003.033613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012658883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11894-003-0038-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015839329", 
          "https://doi.org/10.1007/s11894-003-0038-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365520310003147", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024679482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/003655202753416867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025277356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001574-200407000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027072136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00001574-200407000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027072136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027526483", 
          "https://doi.org/10.1038/ng1544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1544", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027526483", 
          "https://doi.org/10.1038/ng1544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2003.037911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029399162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029904969", 
          "https://doi.org/10.1038/sj.gene.6363779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029904969", 
          "https://doi.org/10.1038/sj.gene.6363779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030806509", 
          "https://doi.org/10.1038/35079114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079114", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030806509", 
          "https://doi.org/10.1038/35079114"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360950", 
          "https://doi.org/10.1038/35079107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35079107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031360950", 
          "https://doi.org/10.1038/35079107"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-004-0569-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033646371", 
          "https://doi.org/10.1007/s00109-004-0569-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-004-0569-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033646371", 
          "https://doi.org/10.1007/s00109-004-0569-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)00382-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033794812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(03)00382-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033794812"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2004.040824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042217100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.50.2.206", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042786646"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1530509100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044620917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(95)90599-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044650773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-200005000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049473242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00024382-200005000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049473242"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2003.030205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051295363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/381000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058673096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/107999003322485099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059207133"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v11.i3.415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071363481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074487452", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075248960", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076975434", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082961857", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083108729", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-12", 
    "datePublishedReg": "2005-12-01", 
    "description": "Crohn's disease (CD) presents as an inflammatory barrier disease with characteristic destructive processes in the intestinal wall. Although the pathomechanisms of CD are still not exactly understood, there is evidence that, in addition to e.g. bacterial colonisation, genetic predisposition contributes to the development of CD. In order to search for predisposing genetic factors we scrutinised 245 microsatellite markers in a population-based linkage mapping study. These microsatellites cover gene loci the encoded protein of which take part in the regulation of apoptosis and (innate) immune processes. Respective loci contribute to the activation/suppression of apoptosis, are involved in signal transduction and cell cycle regulators or they belong to the tumor necrosis factor superfamily, caspase related genes or the BCL2 family. Furthermore, several cytokines as well as chemokines were included. The approach is based on three steps: analyzing pooled DNAs of patients and controls, verification of significantly differing microsatellite markers by genotyping individual DNA samples and, finally, additional reinvestigation of the respective gene in the region covered by the associated microsatellite by analysing single-nucleotide polymorphisms (SNPs). Using this step-wise process we were unable to demonstrate evidence for genetic predisposition of the chosen apoptosis- and immunity-related genes with respect to susceptibility for CD.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1477-5751-4-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031281", 
        "issn": [
          "1477-5751", 
          "1477-5751"
        ], 
        "name": "Journal of Negative Results in BioMedicine", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "4"
      }
    ], 
    "name": "On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors", 
    "pagination": "8", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2a1f5f226b0f807ab45c65ddd6ddeff9bf1a9634fb9a9bedb3c6ba19df8dd531"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16318629"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101152210"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1477-5751-4-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1008841187"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1477-5751-4-8", 
      "https://app.dimensions.ai/details/publication/pub.1008841187"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1477-5751-4-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-5751-4-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-5751-4-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-5751-4-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-5751-4-8'


 

This table displays all metadata directly associated to this object as RDF triples.

260 TRIPLES      21 PREDICATES      72 URIs      32 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1477-5751-4-8 schema:about N15ff53c821184e90bd549e7c393e8b21
2 N1d9658bb4ec849b6b59b65dc506b3a06
3 N23a2240f1bf74ff6beaec228b990e763
4 N2bd3c210995a47fab7bf3eae7e314210
5 N39723466d2674376bc85ce191bb1c68c
6 N948d5e34e3f94fa399f4407a502c3176
7 Naa39a3ca8709487580b4667f511812a4
8 Nab15ef1a68f94561b530c72e9b3c9f86
9 Nb7d6b39cf9b0465ba241ca272264c632
10 Ne4885609dff346809acd8d8d076e4876
11 Nfb4c1f0e16b844f285b7b6f21385f428
12 anzsrc-for:06
13 anzsrc-for:0604
14 schema:author Nec63b26e9c5e4da8b83c343c3adaa074
15 schema:citation sg:pub.10.1007/s00109-004-0569-5
16 sg:pub.10.1007/s00384-004-0639-8
17 sg:pub.10.1007/s00439-004-1092-z
18 sg:pub.10.1007/s11894-003-0038-2
19 sg:pub.10.1038/35079107
20 sg:pub.10.1038/35079114
21 sg:pub.10.1038/ng1544
22 sg:pub.10.1038/sj.gene.6363779
23 sg:pub.10.1111/j.1572-0241.2002.07107.x
24 https://app.dimensions.ai/details/publication/pub.1074487452
25 https://app.dimensions.ai/details/publication/pub.1075248960
26 https://app.dimensions.ai/details/publication/pub.1076975434
27 https://app.dimensions.ai/details/publication/pub.1082961857
28 https://app.dimensions.ai/details/publication/pub.1083108729
29 https://doi.org/10.1016/0016-5085(95)90599-5
30 https://doi.org/10.1016/j.bpg.2004.01.003
31 https://doi.org/10.1016/s0016-5085(03)00382-2
32 https://doi.org/10.1073/pnas.1530509100
33 https://doi.org/10.1080/003655202753416867
34 https://doi.org/10.1080/00365520310003147
35 https://doi.org/10.1086/381000
36 https://doi.org/10.1089/107999003322485099
37 https://doi.org/10.1097/00001574-200307000-00005
38 https://doi.org/10.1097/00001574-200407000-00003
39 https://doi.org/10.1097/00024382-200005000-00003
40 https://doi.org/10.1136/gut.2003.030205
41 https://doi.org/10.1136/gut.2003.033613
42 https://doi.org/10.1136/gut.2003.037911
43 https://doi.org/10.1136/gut.2004.040824
44 https://doi.org/10.1136/gut.50.2.206
45 https://doi.org/10.1159/000016893
46 https://doi.org/10.3748/wjg.v11.i3.415
47 schema:datePublished 2005-12
48 schema:datePublishedReg 2005-12-01
49 schema:description Crohn's disease (CD) presents as an inflammatory barrier disease with characteristic destructive processes in the intestinal wall. Although the pathomechanisms of CD are still not exactly understood, there is evidence that, in addition to e.g. bacterial colonisation, genetic predisposition contributes to the development of CD. In order to search for predisposing genetic factors we scrutinised 245 microsatellite markers in a population-based linkage mapping study. These microsatellites cover gene loci the encoded protein of which take part in the regulation of apoptosis and (innate) immune processes. Respective loci contribute to the activation/suppression of apoptosis, are involved in signal transduction and cell cycle regulators or they belong to the tumor necrosis factor superfamily, caspase related genes or the BCL2 family. Furthermore, several cytokines as well as chemokines were included. The approach is based on three steps: analyzing pooled DNAs of patients and controls, verification of significantly differing microsatellite markers by genotyping individual DNA samples and, finally, additional reinvestigation of the respective gene in the region covered by the associated microsatellite by analysing single-nucleotide polymorphisms (SNPs). Using this step-wise process we were unable to demonstrate evidence for genetic predisposition of the chosen apoptosis- and immunity-related genes with respect to susceptibility for CD.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf Nacba84c2bed74b38a2e8be1b3f787f44
54 Nbf85182958024be5a854db8afd7d884a
55 sg:journal.1031281
56 schema:name On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors
57 schema:pagination 8
58 schema:productId N1064a47f457b4e329443003c70291edc
59 N38190ba196924f879baa9d39215ded0f
60 N4552b8465168416790e33fe1d06d6e88
61 Nc17ff8c7f5e64e1e9f196b73bb2d8bb7
62 Nebed754cfdfd4a83ade8342845b4b630
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008841187
64 https://doi.org/10.1186/1477-5751-4-8
65 schema:sdDatePublished 2019-04-10T17:31
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N9b762d40fe034a49b2b83235f323fa88
68 schema:url http://link.springer.com/10.1186%2F1477-5751-4-8
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N1064a47f457b4e329443003c70291edc schema:name doi
73 schema:value 10.1186/1477-5751-4-8
74 rdf:type schema:PropertyValue
75 N134d3ef2d9d74e119b014bdb911cbdac rdf:first sg:person.0642220103.52
76 rdf:rest N15d8524679a54c769044873ef2210d0d
77 N15d8524679a54c769044873ef2210d0d rdf:first sg:person.01365064244.39
78 rdf:rest N5657657afec54a0189a5d408bc9b8c09
79 N15ff53c821184e90bd549e7c393e8b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Nuclear Proteins
81 rdf:type schema:DefinedTerm
82 N1d9658bb4ec849b6b59b65dc506b3a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Apoptosis
84 rdf:type schema:DefinedTerm
85 N23a2240f1bf74ff6beaec228b990e763 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Polymorphism, Single Nucleotide
87 rdf:type schema:DefinedTerm
88 N2532ce18f29140859e65388e556096cd rdf:first sg:person.01231727624.94
89 rdf:rest N134d3ef2d9d74e119b014bdb911cbdac
90 N2bd3c210995a47fab7bf3eae7e314210 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name B-Cell Maturation Antigen
92 rdf:type schema:DefinedTerm
93 N33d17c6732754fb69d02d222523d3c55 rdf:first sg:person.01170611362.95
94 rdf:rest N2532ce18f29140859e65388e556096cd
95 N38190ba196924f879baa9d39215ded0f schema:name pubmed_id
96 schema:value 16318629
97 rdf:type schema:PropertyValue
98 N39723466d2674376bc85ce191bb1c68c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Crohn Disease
100 rdf:type schema:DefinedTerm
101 N4552b8465168416790e33fe1d06d6e88 schema:name dimensions_id
102 schema:value pub.1008841187
103 rdf:type schema:PropertyValue
104 N5657657afec54a0189a5d408bc9b8c09 rdf:first sg:person.01161527616.90
105 rdf:rest Ncef3470e7da64403967ea48ca43cf51d
106 N948d5e34e3f94fa399f4407a502c3176 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Trans-Activators
108 rdf:type schema:DefinedTerm
109 N9b762d40fe034a49b2b83235f323fa88 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 Naa39a3ca8709487580b4667f511812a4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Alleles
113 rdf:type schema:DefinedTerm
114 Nab15ef1a68f94561b530c72e9b3c9f86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 Nacba84c2bed74b38a2e8be1b3f787f44 schema:issueNumber 1
118 rdf:type schema:PublicationIssue
119 Nb7d6b39cf9b0465ba241ca272264c632 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Genotype
121 rdf:type schema:DefinedTerm
122 Nbf85182958024be5a854db8afd7d884a schema:volumeNumber 4
123 rdf:type schema:PublicationVolume
124 Nc17ff8c7f5e64e1e9f196b73bb2d8bb7 schema:name readcube_id
125 schema:value 2a1f5f226b0f807ab45c65ddd6ddeff9bf1a9634fb9a9bedb3c6ba19df8dd531
126 rdf:type schema:PropertyValue
127 Ncef3470e7da64403967ea48ca43cf51d rdf:first sg:person.01340360167.55
128 rdf:rest rdf:nil
129 Ne4885609dff346809acd8d8d076e4876 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Genetic Markers
131 rdf:type schema:DefinedTerm
132 Nebed754cfdfd4a83ade8342845b4b630 schema:name nlm_unique_id
133 schema:value 101152210
134 rdf:type schema:PropertyValue
135 Nec63b26e9c5e4da8b83c343c3adaa074 rdf:first sg:person.01116377761.22
136 rdf:rest N33d17c6732754fb69d02d222523d3c55
137 Nfb4c1f0e16b844f285b7b6f21385f428 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Genetic Predisposition to Disease
139 rdf:type schema:DefinedTerm
140 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
141 schema:name Biological Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
144 schema:name Genetics
145 rdf:type schema:DefinedTerm
146 sg:journal.1031281 schema:issn 1477-5751
147 schema:name Journal of Negative Results in BioMedicine
148 rdf:type schema:Periodical
149 sg:person.01116377761.22 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
150 schema:familyName Wagenleiter
151 schema:givenName Sonja EN
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116377761.22
153 rdf:type schema:Person
154 sg:person.01161527616.90 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
155 schema:familyName Klein
156 schema:givenName Wolfram
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161527616.90
158 rdf:type schema:Person
159 sg:person.01170611362.95 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
160 schema:familyName Jagiello
161 schema:givenName Peter
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170611362.95
163 rdf:type schema:Person
164 sg:person.01231727624.94 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
165 schema:familyName Akkad
166 schema:givenName Denis A
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231727624.94
168 rdf:type schema:Person
169 sg:person.01340360167.55 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
170 schema:familyName Epplen
171 schema:givenName Jörg T
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340360167.55
173 rdf:type schema:Person
174 sg:person.01365064244.39 schema:affiliation https://www.grid.ac/institutes/grid.412471.5
175 schema:familyName Griga
176 schema:givenName Thomas
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365064244.39
178 rdf:type schema:Person
179 sg:person.0642220103.52 schema:affiliation https://www.grid.ac/institutes/grid.5570.7
180 schema:familyName Arning
181 schema:givenName Larissa
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642220103.52
183 rdf:type schema:Person
184 sg:pub.10.1007/s00109-004-0569-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033646371
185 https://doi.org/10.1007/s00109-004-0569-5
186 rdf:type schema:CreativeWork
187 sg:pub.10.1007/s00384-004-0639-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007865025
188 https://doi.org/10.1007/s00384-004-0639-8
189 rdf:type schema:CreativeWork
190 sg:pub.10.1007/s00439-004-1092-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1010576372
191 https://doi.org/10.1007/s00439-004-1092-z
192 rdf:type schema:CreativeWork
193 sg:pub.10.1007/s11894-003-0038-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015839329
194 https://doi.org/10.1007/s11894-003-0038-2
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/35079107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031360950
197 https://doi.org/10.1038/35079107
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/35079114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030806509
200 https://doi.org/10.1038/35079114
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/ng1544 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027526483
203 https://doi.org/10.1038/ng1544
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/sj.gene.6363779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029904969
206 https://doi.org/10.1038/sj.gene.6363779
207 rdf:type schema:CreativeWork
208 sg:pub.10.1111/j.1572-0241.2002.07107.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004141431
209 https://doi.org/10.1111/j.1572-0241.2002.07107.x
210 rdf:type schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1074487452 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1075248960 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1076975434 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082961857 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1083108729 schema:CreativeWork
216 https://doi.org/10.1016/0016-5085(95)90599-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044650773
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.bpg.2004.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006781480
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/s0016-5085(03)00382-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033794812
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1073/pnas.1530509100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044620917
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1080/003655202753416867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025277356
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1080/00365520310003147 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024679482
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1086/381000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058673096
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1089/107999003322485099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059207133
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1097/00001574-200307000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004370967
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1097/00001574-200407000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027072136
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1097/00024382-200005000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049473242
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1136/gut.2003.030205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051295363
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1136/gut.2003.033613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012658883
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1136/gut.2003.037911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029399162
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1136/gut.2004.040824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042217100
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1136/gut.50.2.206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042786646
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1159/000016893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009117030
249 rdf:type schema:CreativeWork
250 https://doi.org/10.3748/wjg.v11.i3.415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071363481
251 rdf:type schema:CreativeWork
252 https://www.grid.ac/institutes/grid.412468.d schema:alternateName University Hospital Schleswig-Holstein
253 schema:name Institute for Clinical Molecular Biology, University Schleswig-Holstein, Kiel, Germany
254 rdf:type schema:Organization
255 https://www.grid.ac/institutes/grid.412471.5 schema:alternateName BG University Hospital Bergmannsheil GmbH
256 schema:name Department of Gastroenterology, University Hospital Bergmannsheil, Bochum, Germany
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.5570.7 schema:alternateName Ruhr University Bochum
259 schema:name Department of Human Genetics, Ruhr-University, Bochum, Germany
260 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...