Mode of antiviral action of silver nanoparticles against HIV-1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01-20

AUTHORS

Humberto H Lara, Nilda V Ayala-Nuñez, Liliana Ixtepan-Turrent, Cristina Rodriguez-Padilla

ABSTRACT

BackgroundSilver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays.ResultsOur data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cell-free virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle.ConclusionsThese properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains. More... »

PAGES

1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1477-3155-8-1

DOI

http://dx.doi.org/10.1186/1477-3155-8-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010934518

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20145735


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Technology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratorio de Inmunolog\u00eda y Virolog\u00eda, Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.411455.0", 
          "name": [
            "Laboratorio de Inmunolog\u00eda y Virolog\u00eda, Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lara", 
        "givenName": "Humberto H", 
        "id": "sg:person.0712526275.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712526275.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratorio de Inmunolog\u00eda y Virolog\u00eda, Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.411455.0", 
          "name": [
            "Laboratorio de Inmunolog\u00eda y Virolog\u00eda, Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ayala-Nu\u00f1ez", 
        "givenName": "Nilda V", 
        "id": "sg:person.0670067601.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670067601.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratorio de Inmunolog\u00eda y Virolog\u00eda, Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.411455.0", 
          "name": [
            "Laboratorio de Inmunolog\u00eda y Virolog\u00eda, Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ixtepan-Turrent", 
        "givenName": "Liliana", 
        "id": "sg:person.0736203001.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736203001.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratorio de Inmunolog\u00eda y Virolog\u00eda, Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico", 
          "id": "http://www.grid.ac/institutes/grid.411455.0", 
          "name": [
            "Laboratorio de Inmunolog\u00eda y Virolog\u00eda, Departamento de Microbiolog\u00eda e Inmunolog\u00eda, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodriguez-Padilla", 
        "givenName": "Cristina", 
        "id": "sg:person.01155602521.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155602521.42"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1385/1-59259-245-7:207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019909761", 
          "https://doi.org/10.1385/1-59259-245-7:207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11671-008-9128-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041604535", 
          "https://doi.org/10.1007/s11671-008-9128-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11274-009-0211-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022212120", 
          "https://doi.org/10.1007/s11274-009-0211-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-3155-3-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006786501", 
          "https://doi.org/10.1186/1477-3155-3-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31405", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038246480", 
          "https://doi.org/10.1038/31405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2334-1-17", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049705467", 
          "https://doi.org/10.1186/1471-2334-1-17"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1742-4690-5-12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036035198", 
          "https://doi.org/10.1186/1742-4690-5-12"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat2099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001408815", 
          "https://doi.org/10.1038/nmat2099"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-01-20", 
    "datePublishedReg": "2010-01-20", 
    "description": "BackgroundSilver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays.ResultsOur data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cell-free virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle.ConclusionsThese properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1477-3155-8-1", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031280", 
        "issn": [
          "1477-3155"
        ], 
        "name": "Journal of Nanobiotechnology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "8"
      }
    ], 
    "keywords": [
      "HIV-1", 
      "antiviral action", 
      "virucidal agents", 
      "effective virucidal agent", 
      "HIV-1 life cycle", 
      "cell-free virus", 
      "cell-associated virus", 
      "broad-spectrum agents", 
      "HIV inhibitory activity", 
      "anti-HIV activity", 
      "non-cytotoxic concentrations", 
      "post-entry stage", 
      "virion binding", 
      "viral replication", 
      "antiviral activity", 
      "ResultsOur data", 
      "viral entry", 
      "virus", 
      "agents", 
      "early stages", 
      "gp120", 
      "activity", 
      "infectivity", 
      "inhibitors", 
      "action", 
      "assays", 
      "stage", 
      "replication", 
      "wide variety", 
      "study", 
      "silver nanoparticles", 
      "binding", 
      "entry", 
      "resistance", 
      "panel", 
      "concentration", 
      "manner", 
      "mechanism", 
      "data", 
      "fusion", 
      "BackgroundSilver nanoparticles", 
      "life cycle", 
      "variety", 
      "nanoparticles", 
      "cycle", 
      "mode", 
      "properties"
    ], 
    "name": "Mode of antiviral action of silver nanoparticles against HIV-1", 
    "pagination": "1", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010934518"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1477-3155-8-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20145735"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1477-3155-8-1", 
      "https://app.dimensions.ai/details/publication/pub.1010934518"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:28", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_517.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1477-3155-8-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1477-3155-8-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1477-3155-8-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1477-3155-8-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1477-3155-8-1'


 

This table displays all metadata directly associated to this object as RDF triples.

156 TRIPLES      21 PREDICATES      79 URIs      64 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1477-3155-8-1 schema:about anzsrc-for:10
2 schema:author N3082078b080d4a42b549d98464958e39
3 schema:citation sg:pub.10.1007/s11274-009-0211-3
4 sg:pub.10.1007/s11671-008-9128-2
5 sg:pub.10.1038/31405
6 sg:pub.10.1038/nmat2099
7 sg:pub.10.1186/1471-2334-1-17
8 sg:pub.10.1186/1477-3155-3-6
9 sg:pub.10.1186/1742-4690-5-12
10 sg:pub.10.1385/1-59259-245-7:207
11 schema:datePublished 2010-01-20
12 schema:datePublishedReg 2010-01-20
13 schema:description BackgroundSilver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays.ResultsOur data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cell-free virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle.ConclusionsThese properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains.
14 schema:genre article
15 schema:isAccessibleForFree true
16 schema:isPartOf N20a1821157f848b48001fb738f16d3db
17 N28174ca4c56144a282f95f41728f568d
18 sg:journal.1031280
19 schema:keywords BackgroundSilver nanoparticles
20 HIV inhibitory activity
21 HIV-1
22 HIV-1 life cycle
23 ResultsOur data
24 action
25 activity
26 agents
27 anti-HIV activity
28 antiviral action
29 antiviral activity
30 assays
31 binding
32 broad-spectrum agents
33 cell-associated virus
34 cell-free virus
35 concentration
36 cycle
37 data
38 early stages
39 effective virucidal agent
40 entry
41 fusion
42 gp120
43 infectivity
44 inhibitors
45 life cycle
46 manner
47 mechanism
48 mode
49 nanoparticles
50 non-cytotoxic concentrations
51 panel
52 post-entry stage
53 properties
54 replication
55 resistance
56 silver nanoparticles
57 stage
58 study
59 variety
60 viral entry
61 viral replication
62 virion binding
63 virucidal agents
64 virus
65 wide variety
66 schema:name Mode of antiviral action of silver nanoparticles against HIV-1
67 schema:pagination 1
68 schema:productId N1ddf205dc4a643e1bdc4610ec027103f
69 N6f62e890c33449879af74cf3ca1137ce
70 Na9584601ee794f48bd7c660f7ea5a58b
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010934518
72 https://doi.org/10.1186/1477-3155-8-1
73 schema:sdDatePublished 2022-12-01T06:28
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher Nbcad8e21c74f4d44bc701a898a8f4475
76 schema:url https://doi.org/10.1186/1477-3155-8-1
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N1d29430938d8421188b0f958a7fe5bbe rdf:first sg:person.01155602521.42
81 rdf:rest rdf:nil
82 N1ddf205dc4a643e1bdc4610ec027103f schema:name doi
83 schema:value 10.1186/1477-3155-8-1
84 rdf:type schema:PropertyValue
85 N20a1821157f848b48001fb738f16d3db schema:volumeNumber 8
86 rdf:type schema:PublicationVolume
87 N28174ca4c56144a282f95f41728f568d schema:issueNumber 1
88 rdf:type schema:PublicationIssue
89 N3082078b080d4a42b549d98464958e39 rdf:first sg:person.0712526275.52
90 rdf:rest Ne69cf5ba63cf43f8969d4e81e9102b2b
91 N6f62e890c33449879af74cf3ca1137ce schema:name pubmed_id
92 schema:value 20145735
93 rdf:type schema:PropertyValue
94 Na9584601ee794f48bd7c660f7ea5a58b schema:name dimensions_id
95 schema:value pub.1010934518
96 rdf:type schema:PropertyValue
97 Nbcad8e21c74f4d44bc701a898a8f4475 schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 Ncea6b8d84a9249a9934f6c29ac68d88e rdf:first sg:person.0736203001.29
100 rdf:rest N1d29430938d8421188b0f958a7fe5bbe
101 Ne69cf5ba63cf43f8969d4e81e9102b2b rdf:first sg:person.0670067601.58
102 rdf:rest Ncea6b8d84a9249a9934f6c29ac68d88e
103 anzsrc-for:10 schema:inDefinedTermSet anzsrc-for:
104 schema:name Technology
105 rdf:type schema:DefinedTerm
106 sg:journal.1031280 schema:issn 1477-3155
107 schema:name Journal of Nanobiotechnology
108 schema:publisher Springer Nature
109 rdf:type schema:Periodical
110 sg:person.01155602521.42 schema:affiliation grid-institutes:grid.411455.0
111 schema:familyName Rodriguez-Padilla
112 schema:givenName Cristina
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155602521.42
114 rdf:type schema:Person
115 sg:person.0670067601.58 schema:affiliation grid-institutes:grid.411455.0
116 schema:familyName Ayala-Nuñez
117 schema:givenName Nilda V
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670067601.58
119 rdf:type schema:Person
120 sg:person.0712526275.52 schema:affiliation grid-institutes:grid.411455.0
121 schema:familyName Lara
122 schema:givenName Humberto H
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0712526275.52
124 rdf:type schema:Person
125 sg:person.0736203001.29 schema:affiliation grid-institutes:grid.411455.0
126 schema:familyName Ixtepan-Turrent
127 schema:givenName Liliana
128 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736203001.29
129 rdf:type schema:Person
130 sg:pub.10.1007/s11274-009-0211-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022212120
131 https://doi.org/10.1007/s11274-009-0211-3
132 rdf:type schema:CreativeWork
133 sg:pub.10.1007/s11671-008-9128-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041604535
134 https://doi.org/10.1007/s11671-008-9128-2
135 rdf:type schema:CreativeWork
136 sg:pub.10.1038/31405 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038246480
137 https://doi.org/10.1038/31405
138 rdf:type schema:CreativeWork
139 sg:pub.10.1038/nmat2099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001408815
140 https://doi.org/10.1038/nmat2099
141 rdf:type schema:CreativeWork
142 sg:pub.10.1186/1471-2334-1-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049705467
143 https://doi.org/10.1186/1471-2334-1-17
144 rdf:type schema:CreativeWork
145 sg:pub.10.1186/1477-3155-3-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006786501
146 https://doi.org/10.1186/1477-3155-3-6
147 rdf:type schema:CreativeWork
148 sg:pub.10.1186/1742-4690-5-12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036035198
149 https://doi.org/10.1186/1742-4690-5-12
150 rdf:type schema:CreativeWork
151 sg:pub.10.1385/1-59259-245-7:207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019909761
152 https://doi.org/10.1385/1-59259-245-7:207
153 rdf:type schema:CreativeWork
154 grid-institutes:grid.411455.0 schema:alternateName Laboratorio de Inmunología y Virología, Departamento de Microbiología e Inmunología, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico
155 schema:name Laboratorio de Inmunología y Virología, Departamento de Microbiología e Inmunología, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, San Nicolas de los Garza, Mexico
156 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...