The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-12

AUTHORS

Ahmet Yildiz, M Akif Cakar, Murat Baskurt, Barıs Okcun, Deniz Guzelsoy, Ugur Coskun

ABSTRACT

BACKGROUND: Statins improve the endothelial function in patients with coronary artery disease (CAD). However, they contribute to the substantial decrease in coronary heart disease by reducing plasma cholesterol levels. They also, reduce oxidative stress, stabilize the atherosclerotic plaque and inhibit inflammatory response. These functions of statins have been briefly described as pleiotropic effects. The aim of our study was to evaluate the effect of atorvastatin therapy on endothelial functions in patients with CAD. METHODS: Fourty-nine patients (40 men, 9 women, mean age 59 +/- 11 years) with diagnosed CAD were selected as the study group. The patients were given 10 mg/day atorvastatin for 12 weeks. If the target cholesterol levels has not been achieved 6 weeks after the treatment, then the daily atorvastatin dosage has been increased. The endothelial function was evaluated by flow mediated dilatation (FMD) of the brachial artery. RESULTS: It has been figured out that 12 weeks later, atorvastatin caused a statistically significant decrease in the plasma levels of LDL-cholesterol and total cholesterol (p < 0,0001). Meanwhile, it was determined that the FMD got statistically significant improved 12 weeks after the atorvastatin therapy (8,1%-4,2%, p < 0,001). However there was no statistically significant change in non-endothelium dependent dilatation (NID). CONCLUSION: Endothelium derived vasodilatation (EBD), which was non-invasively detected via brachial artery ultrasonography, had statistically significant improvment within 12 weeks of atorvastatin therapy whereas non-endothelium dependent dilatation (NID) had no change. More... »

PAGES

51

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-7120-5-51

DOI

http://dx.doi.org/10.1186/1476-7120-5-51

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015363858

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18163915


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticholesteremic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atorvastatin Calcium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "C-Reactive Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Angiography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelium, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heptanoic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrroles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ultrasonography", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Cardiology, Gazi Hospital, \u0130zmir, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yildiz", 
        "givenName": "Ahmet", 
        "id": "sg:person.0751645236.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751645236.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Cardiology, Institute of Cardiology, \u0130stanbul University, \u0130stanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cakar", 
        "givenName": "M Akif", 
        "id": "sg:person.01177023775.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177023775.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Cardiology, Institute of Cardiology, \u0130stanbul University, \u0130stanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baskurt", 
        "givenName": "Murat", 
        "id": "sg:person.01067652101.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067652101.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Cardiology, Institute of Cardiology, \u0130stanbul University, \u0130stanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okcun", 
        "givenName": "Bar\u0131s", 
        "id": "sg:person.01000545244.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000545244.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Cardiology, Institute of Cardiology, \u0130stanbul University, \u0130stanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guzelsoy", 
        "givenName": "Deniz", 
        "id": "sg:person.0621524432.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621524432.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istanbul University", 
          "id": "https://www.grid.ac/institutes/grid.9601.e", 
          "name": [
            "Department of Cardiology, Institute of Cardiology, \u0130stanbul University, \u0130stanbul, Turkey"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Coskun", 
        "givenName": "Ugur", 
        "id": "sg:person.01107140333.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107140333.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci116634", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000858672"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(05)80033-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001164799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0021-9150(97)00319-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014923711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.83.2.391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016204420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.15.1440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017823835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)93147-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018847241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0140-6736(92)93147-f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018847241"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.25.3227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020438334"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199502233320802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026917734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.87.6.1781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028812751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(96)00597-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029499942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1992.03480010078028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031323074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(01)01746-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031448054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(90)90619-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032926229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(95)00327-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035374682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199010183231606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040466177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(01)02095-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046822394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)91342-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051151665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)91342-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051151665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.97.8.716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053201363"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.267.1.70", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054153694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/euhj.1997.0724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057073649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.94.3.258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063337326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.94.7.1503", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063337510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.95.5.1126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063337876"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/138161207780831220", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069166231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074766719", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvb.21.12.1867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074963084"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077417235", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-12", 
    "datePublishedReg": "2007-12-01", 
    "description": "BACKGROUND: Statins improve the endothelial function in patients with coronary artery disease (CAD). However, they contribute to the substantial decrease in coronary heart disease by reducing plasma cholesterol levels. They also, reduce oxidative stress, stabilize the atherosclerotic plaque and inhibit inflammatory response. These functions of statins have been briefly described as pleiotropic effects. The aim of our study was to evaluate the effect of atorvastatin therapy on endothelial functions in patients with CAD.\nMETHODS: Fourty-nine patients (40 men, 9 women, mean age 59 +/- 11 years) with diagnosed CAD were selected as the study group. The patients were given 10 mg/day atorvastatin for 12 weeks. If the target cholesterol levels has not been achieved 6 weeks after the treatment, then the daily atorvastatin dosage has been increased. The endothelial function was evaluated by flow mediated dilatation (FMD) of the brachial artery.\nRESULTS: It has been figured out that 12 weeks later, atorvastatin caused a statistically significant decrease in the plasma levels of LDL-cholesterol and total cholesterol (p < 0,0001). Meanwhile, it was determined that the FMD got statistically significant improved 12 weeks after the atorvastatin therapy (8,1%-4,2%, p < 0,001). However there was no statistically significant change in non-endothelium dependent dilatation (NID).\nCONCLUSION: Endothelium derived vasodilatation (EBD), which was non-invasively detected via brachial artery ultrasonography, had statistically significant improvment within 12 weeks of atorvastatin therapy whereas non-endothelium dependent dilatation (NID) had no change.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1476-7120-5-51", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031661", 
        "issn": [
          "1476-7120"
        ], 
        "name": "Cardiovascular Ultrasound", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "The effects of atorvastatin therapy on endothel\u0131al function in patients with coronary artery disease", 
    "pagination": "51", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "49340149305b05f37202a10e3753b5ce2487253ac8dd527611010927f0314618"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18163915"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101159952"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1476-7120-5-51"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015363858"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1476-7120-5-51", 
      "https://app.dimensions.ai/details/publication/pub.1015363858"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:42", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000511.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1476-7120-5-51"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1476-7120-5-51'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1476-7120-5-51'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1476-7120-5-51'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1476-7120-5-51'


 

This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      21 PREDICATES      71 URIs      36 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1476-7120-5-51 schema:about N03e356bd7e0c4708afa9a84ddb4e20fe
2 N1cc05ea776d94fcfb4dbd650a8dea2a3
3 N1fcb77f0cb60468f8c1202d7f2a18eb7
4 N20a53cc578484f278d0fd372cd31485a
5 N20c8b5d130ab41c8af81805c2b2cfcae
6 N41550467de464f32945fbb10d32706e6
7 N5a67b8c514714c0c98f465dc9e634d3f
8 N62aa5294985748e09dea623e877276fb
9 N6785bd369b0f4589bc91480f645b5089
10 N6c2f0dea7755466295aecb8b1f20ad35
11 N70feb7f294f843f5a2c7e7e5523a3fb0
12 N89afb8a606f742d2bdcb1d99952de436
13 N9451c980bc2f4aafa505ef5fc9e40257
14 Nef030bff80414a698a0e92d81443d2fd
15 Nf8772daef0004fb8af97604a1c61ad4e
16 anzsrc-for:11
17 anzsrc-for:1102
18 schema:author Ne3c863563df44fd08e510ca4b5fedf02
19 schema:citation https://app.dimensions.ai/details/publication/pub.1074766719
20 https://app.dimensions.ai/details/publication/pub.1077417235
21 https://doi.org/10.1001/jama.1992.03480010078028
22 https://doi.org/10.1001/jama.267.1.70
23 https://doi.org/10.1016/0140-6736(92)93147-f
24 https://doi.org/10.1016/0735-1097(90)90619-z
25 https://doi.org/10.1016/0735-1097(95)00327-4
26 https://doi.org/10.1016/s0002-9149(01)02095-1
27 https://doi.org/10.1016/s0002-9149(05)80033-5
28 https://doi.org/10.1016/s0002-9149(96)00597-8
29 https://doi.org/10.1016/s0021-9150(97)00319-5
30 https://doi.org/10.1016/s0140-6736(94)91342-0
31 https://doi.org/10.1016/s0735-1097(01)01746-6
32 https://doi.org/10.1053/euhj.1997.0724
33 https://doi.org/10.1056/nejm199010183231606
34 https://doi.org/10.1056/nejm199502233320802
35 https://doi.org/10.1161/01.cir.83.2.391
36 https://doi.org/10.1161/01.cir.87.6.1781
37 https://doi.org/10.1161/01.cir.94.3.258
38 https://doi.org/10.1161/01.cir.94.7.1503
39 https://doi.org/10.1161/01.cir.95.5.1126
40 https://doi.org/10.1161/01.cir.97.15.1440
41 https://doi.org/10.1161/01.cir.97.8.716
42 https://doi.org/10.1161/01.cir.99.25.3227
43 https://doi.org/10.1161/atvb.21.12.1867
44 https://doi.org/10.1172/jci116634
45 https://doi.org/10.2174/138161207780831220
46 schema:datePublished 2007-12
47 schema:datePublishedReg 2007-12-01
48 schema:description BACKGROUND: Statins improve the endothelial function in patients with coronary artery disease (CAD). However, they contribute to the substantial decrease in coronary heart disease by reducing plasma cholesterol levels. They also, reduce oxidative stress, stabilize the atherosclerotic plaque and inhibit inflammatory response. These functions of statins have been briefly described as pleiotropic effects. The aim of our study was to evaluate the effect of atorvastatin therapy on endothelial functions in patients with CAD. METHODS: Fourty-nine patients (40 men, 9 women, mean age 59 +/- 11 years) with diagnosed CAD were selected as the study group. The patients were given 10 mg/day atorvastatin for 12 weeks. If the target cholesterol levels has not been achieved 6 weeks after the treatment, then the daily atorvastatin dosage has been increased. The endothelial function was evaluated by flow mediated dilatation (FMD) of the brachial artery. RESULTS: It has been figured out that 12 weeks later, atorvastatin caused a statistically significant decrease in the plasma levels of LDL-cholesterol and total cholesterol (p < 0,0001). Meanwhile, it was determined that the FMD got statistically significant improved 12 weeks after the atorvastatin therapy (8,1%-4,2%, p < 0,001). However there was no statistically significant change in non-endothelium dependent dilatation (NID). CONCLUSION: Endothelium derived vasodilatation (EBD), which was non-invasively detected via brachial artery ultrasonography, had statistically significant improvment within 12 weeks of atorvastatin therapy whereas non-endothelium dependent dilatation (NID) had no change.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree true
52 schema:isPartOf N2fe0ad247d8c40538a4b749e4b6ec678
53 Na3fd8f2ee95748fc9512f0ba7133a979
54 sg:journal.1031661
55 schema:name The effects of atorvastatin therapy on endothelıal function in patients with coronary artery disease
56 schema:pagination 51
57 schema:productId N06e326bf466641fdac5c034d7cabe88f
58 N37800f4a20474dbb95e4b5816b035b6f
59 N59535c9a7c8d488883c2ba014eb7d4a1
60 Nbbcb6f64632649ee96d0db2ca58bab19
61 Nc0ebdb1d418243889566eb7f1419cdd7
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015363858
63 https://doi.org/10.1186/1476-7120-5-51
64 schema:sdDatePublished 2019-04-10T16:42
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N69fde2ed3bcc4985a450a313ff4c4c77
67 schema:url http://link.springer.com/10.1186%2F1476-7120-5-51
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N03e356bd7e0c4708afa9a84ddb4e20fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Coronary Angiography
73 rdf:type schema:DefinedTerm
74 N06e326bf466641fdac5c034d7cabe88f schema:name doi
75 schema:value 10.1186/1476-7120-5-51
76 rdf:type schema:PropertyValue
77 N0f5490f367e64e0aa13ee5d242fada11 rdf:first sg:person.01000545244.26
78 rdf:rest N2145246365764165816d31ba4732671e
79 N1cc05ea776d94fcfb4dbd650a8dea2a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Middle Aged
81 rdf:type schema:DefinedTerm
82 N1fcb77f0cb60468f8c1202d7f2a18eb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Heptanoic Acids
84 rdf:type schema:DefinedTerm
85 N20a53cc578484f278d0fd372cd31485a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Pyrroles
87 rdf:type schema:DefinedTerm
88 N20c8b5d130ab41c8af81805c2b2cfcae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Treatment Outcome
90 rdf:type schema:DefinedTerm
91 N2145246365764165816d31ba4732671e rdf:first sg:person.0621524432.73
92 rdf:rest Necd9323289f24e48911ffa957b638d7d
93 N25f3b07efacb4ba6af528d4b9a7c0409 rdf:first sg:person.01177023775.30
94 rdf:rest Nc53611f9b6b84a57ae3fb862ae66800c
95 N2fe0ad247d8c40538a4b749e4b6ec678 schema:volumeNumber 5
96 rdf:type schema:PublicationVolume
97 N37800f4a20474dbb95e4b5816b035b6f schema:name readcube_id
98 schema:value 49340149305b05f37202a10e3753b5ce2487253ac8dd527611010927f0314618
99 rdf:type schema:PropertyValue
100 N41550467de464f32945fbb10d32706e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Anticholesteremic Agents
102 rdf:type schema:DefinedTerm
103 N59535c9a7c8d488883c2ba014eb7d4a1 schema:name dimensions_id
104 schema:value pub.1015363858
105 rdf:type schema:PropertyValue
106 N5a67b8c514714c0c98f465dc9e634d3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Male
108 rdf:type schema:DefinedTerm
109 N62aa5294985748e09dea623e877276fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Ultrasonography
111 rdf:type schema:DefinedTerm
112 N6785bd369b0f4589bc91480f645b5089 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name C-Reactive Protein
114 rdf:type schema:DefinedTerm
115 N69fde2ed3bcc4985a450a313ff4c4c77 schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 N6c2f0dea7755466295aecb8b1f20ad35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Atorvastatin Calcium
119 rdf:type schema:DefinedTerm
120 N70feb7f294f843f5a2c7e7e5523a3fb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Cholesterol
122 rdf:type schema:DefinedTerm
123 N89afb8a606f742d2bdcb1d99952de436 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Coronary Disease
125 rdf:type schema:DefinedTerm
126 N9451c980bc2f4aafa505ef5fc9e40257 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Humans
128 rdf:type schema:DefinedTerm
129 Na3fd8f2ee95748fc9512f0ba7133a979 schema:issueNumber 1
130 rdf:type schema:PublicationIssue
131 Nbbcb6f64632649ee96d0db2ca58bab19 schema:name nlm_unique_id
132 schema:value 101159952
133 rdf:type schema:PropertyValue
134 Nc0ebdb1d418243889566eb7f1419cdd7 schema:name pubmed_id
135 schema:value 18163915
136 rdf:type schema:PropertyValue
137 Nc53611f9b6b84a57ae3fb862ae66800c rdf:first sg:person.01067652101.92
138 rdf:rest N0f5490f367e64e0aa13ee5d242fada11
139 Nd348d6de656e414d916c02347fddcdf7 schema:name Department of Cardiology, Gazi Hospital, İzmir, Turkey
140 rdf:type schema:Organization
141 Ne3c863563df44fd08e510ca4b5fedf02 rdf:first sg:person.0751645236.81
142 rdf:rest N25f3b07efacb4ba6af528d4b9a7c0409
143 Necd9323289f24e48911ffa957b638d7d rdf:first sg:person.01107140333.32
144 rdf:rest rdf:nil
145 Nef030bff80414a698a0e92d81443d2fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Endothelium, Vascular
147 rdf:type schema:DefinedTerm
148 Nf8772daef0004fb8af97604a1c61ad4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Female
150 rdf:type schema:DefinedTerm
151 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
152 schema:name Medical and Health Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
155 schema:name Cardiorespiratory Medicine and Haematology
156 rdf:type schema:DefinedTerm
157 sg:journal.1031661 schema:issn 1476-7120
158 schema:name Cardiovascular Ultrasound
159 rdf:type schema:Periodical
160 sg:person.01000545244.26 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
161 schema:familyName Okcun
162 schema:givenName Barıs
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000545244.26
164 rdf:type schema:Person
165 sg:person.01067652101.92 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
166 schema:familyName Baskurt
167 schema:givenName Murat
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01067652101.92
169 rdf:type schema:Person
170 sg:person.01107140333.32 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
171 schema:familyName Coskun
172 schema:givenName Ugur
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107140333.32
174 rdf:type schema:Person
175 sg:person.01177023775.30 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
176 schema:familyName Cakar
177 schema:givenName M Akif
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177023775.30
179 rdf:type schema:Person
180 sg:person.0621524432.73 schema:affiliation https://www.grid.ac/institutes/grid.9601.e
181 schema:familyName Guzelsoy
182 schema:givenName Deniz
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621524432.73
184 rdf:type schema:Person
185 sg:person.0751645236.81 schema:affiliation Nd348d6de656e414d916c02347fddcdf7
186 schema:familyName Yildiz
187 schema:givenName Ahmet
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751645236.81
189 rdf:type schema:Person
190 https://app.dimensions.ai/details/publication/pub.1074766719 schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1077417235 schema:CreativeWork
192 https://doi.org/10.1001/jama.1992.03480010078028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031323074
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1001/jama.267.1.70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054153694
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/0140-6736(92)93147-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1018847241
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/0735-1097(90)90619-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1032926229
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/0735-1097(95)00327-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035374682
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/s0002-9149(01)02095-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046822394
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/s0002-9149(05)80033-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001164799
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s0002-9149(96)00597-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029499942
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0021-9150(97)00319-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014923711
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s0140-6736(94)91342-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051151665
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0735-1097(01)01746-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031448054
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1053/euhj.1997.0724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057073649
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1056/nejm199010183231606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040466177
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1056/nejm199502233320802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026917734
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1161/01.cir.83.2.391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016204420
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1161/01.cir.87.6.1781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028812751
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1161/01.cir.94.3.258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337326
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1161/01.cir.94.7.1503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337510
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1161/01.cir.95.5.1126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337876
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1161/01.cir.97.15.1440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017823835
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1161/01.cir.97.8.716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053201363
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1161/01.cir.99.25.3227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020438334
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1161/atvb.21.12.1867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074963084
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1172/jci116634 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000858672
239 rdf:type schema:CreativeWork
240 https://doi.org/10.2174/138161207780831220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069166231
241 rdf:type schema:CreativeWork
242 https://www.grid.ac/institutes/grid.9601.e schema:alternateName Istanbul University
243 schema:name Department of Cardiology, Institute of Cardiology, İstanbul University, İstanbul, Turkey
244 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...