Regulation of oxygen transport during brain activation: stimulus-induced hemodynamic responses in human and animal cortices View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2003-12-20

AUTHORS

Akitoshi Seiyama, Junji Seki, Hiroki C Tanabe, Yasuhiro Ooi, Yasuhiko Satomura, Hisao Fujisaki, Toshio Yanagida

ABSTRACT

BackgroundThe correlation between regional changes in neuronal activity and changes in hemodynamics is a major issue for noninvasive neuroimaging techniques such as functional magnetic resonance imaging (fMRI) and near-infrared optical imaging (NIOI). A tight coupling of these changes has been assumed to elucidate brain function from data obtained with those techniques. In the present study, we investigated the relationship between neuronal activity and hemodynamic responses in the occipital cortex of humans during visual stimulation and in the somatosensory cortex of rats during peripheral nerve stimulation.MethodsThe temporal frequency dependence of macroscopic hemodynamic responses on visual stimuli was investigated in the occipital cortex of humans by simultaneous measurements made using fMRI and NIOI. The stimulus-intensity dependence of both microscopic hemodynamic changes and changes in neuronal activity in response to peripheral nerve stimulation was investigated in animal models by analyzing membrane potential (fluorescence), hemodynamic parameters (visible spectra and laser-Doppler flowmetry), and vessel diameter (image analyzer).ResultsAbove a certain level of stimulus-intensity, increases in regional cerebral blood flow (rCBF) were accompanied by a decrease in regional cerebral blood volume (rCBV), i.e., dissociation of rCBF and rCBV responses occurred in both the human and animal experiments. Furthermore, the animal experiments revealed that the distribution of increased rCBF and O2 spread well beyond the area of neuronal activation, and that the increases showed saturation in the activated area.ConclusionsThese results suggest that above a certain level of neuronal activity, a regulatory mechanism between regional cerebral blood flow (rCBF) and rCBV acts to prevent excess O2 inflow into the focally activated area. More... »

PAGES

6

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-5918-2-6

DOI

http://dx.doi.org/10.1186/1476-5918-2-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024097327

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14687423


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Kansai Advanced Research Center, Communications Research Laboratory, 588-2 Iwaoka, 651-2492, Nishi-ku, Kobe, Hyogo, Japan", 
            "Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seiyama", 
        "givenName": "Akitoshi", 
        "id": "sg:person.014651563635.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014651563635.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, 565-8565, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, 565-8565, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seki", 
        "givenName": "Junji", 
        "id": "sg:person.01145553370.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145553370.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kansai Advanced Research Center, Communications Research Laboratory, 588-2 Iwaoka, 651-2492, Nishi-ku, Kobe, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.28312.3a", 
          "name": [
            "Kansai Advanced Research Center, Communications Research Laboratory, 588-2 Iwaoka, 651-2492, Nishi-ku, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tanabe", 
        "givenName": "Hiroki C", 
        "id": "sg:person.01024007633.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024007633.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pathogenesis and Control of Oral Disease, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Division of Pathogenesis and Control of Oral Disease, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ooi", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.01261436415.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261436415.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, 565-8565, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
            "Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, 565-8565, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Satomura", 
        "givenName": "Yasuhiko", 
        "id": "sg:person.01327551615.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327551615.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nikon Corp. Business Development Center, 1-6-3 Nishi-Ooi, 140-8601, Shinagawa, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.471244.0", 
          "name": [
            "Nikon Corp. Business Development Center, 1-6-3 Nishi-Ooi, 140-8601, Shinagawa, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujisaki", 
        "givenName": "Hisao", 
        "id": "sg:person.01207407050.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207407050.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Kansai Advanced Research Center, Communications Research Laboratory, 588-2 Iwaoka, 651-2492, Nishi-ku, Kobe, Hyogo, Japan", 
            "Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yanagida", 
        "givenName": "Toshio", 
        "id": "sg:person.015141357621.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015141357621.93"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/978-3-642-58716-0_1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1089523997", 
          "https://doi.org/10.1007/978-3-642-58716-0_1"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-12-20", 
    "datePublishedReg": "2003-12-20", 
    "description": "BackgroundThe correlation between regional changes in neuronal activity and changes in hemodynamics is a major issue for noninvasive neuroimaging techniques such as functional magnetic resonance imaging (fMRI) and near-infrared optical imaging (NIOI). A tight coupling of these changes has been assumed to elucidate brain function from data obtained with those techniques. In the present study, we investigated the relationship between neuronal activity and hemodynamic responses in the occipital cortex of humans during visual stimulation and in the somatosensory cortex of rats during peripheral nerve stimulation.MethodsThe temporal frequency dependence of macroscopic hemodynamic responses on visual stimuli was investigated in the occipital cortex of humans by simultaneous measurements made using fMRI and NIOI. The stimulus-intensity dependence of both microscopic hemodynamic changes and changes in neuronal activity in response to peripheral nerve stimulation was investigated in animal models by analyzing membrane potential (fluorescence), hemodynamic parameters (visible spectra and laser-Doppler flowmetry), and vessel diameter (image analyzer).ResultsAbove a certain level of stimulus-intensity, increases in regional cerebral blood flow (rCBF) were accompanied by a decrease in regional cerebral blood volume (rCBV), i.e., dissociation of rCBF and rCBV responses occurred in both the human and animal experiments. Furthermore, the animal experiments revealed that the distribution of increased rCBF and O2 spread well beyond the area of neuronal activation, and that the increases showed saturation in the activated area.ConclusionsThese results suggest that above a certain level of neuronal activity, a regulatory mechanism between regional cerebral blood flow (rCBF) and rCBV acts to prevent excess O2 inflow into the focally activated area.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1476-5918-2-6", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031276", 
        "issn": [
          "1476-5918"
        ], 
        "name": "Dynamic Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "2"
      }
    ], 
    "keywords": [
      "regional cerebral blood flow", 
      "regional cerebral blood volume", 
      "functional magnetic resonance imaging", 
      "cerebral blood flow", 
      "peripheral nerve stimulation", 
      "neuronal activity", 
      "hemodynamic response", 
      "nerve stimulation", 
      "occipital cortex", 
      "blood flow", 
      "animal experiments", 
      "stimulus intensity dependence", 
      "cerebral blood volume", 
      "magnetic resonance imaging", 
      "rCBV response", 
      "hemodynamic changes", 
      "noninvasive neuroimaging techniques", 
      "somatosensory cortex", 
      "hemodynamic parameters", 
      "neuronal activation", 
      "animal models", 
      "blood volume", 
      "resonance imaging", 
      "temporal frequency dependence", 
      "brain function", 
      "neuroimaging techniques", 
      "cortex", 
      "visual stimulation", 
      "ConclusionsThese results", 
      "brain activation", 
      "vessel diameter", 
      "animal cortex", 
      "stimulation", 
      "visual stimuli", 
      "activated area", 
      "present study", 
      "membrane potential", 
      "humans", 
      "activation", 
      "response", 
      "imaging", 
      "stimuli", 
      "hemodynamics", 
      "regulatory mechanisms", 
      "activity", 
      "rats", 
      "regional changes", 
      "oxygen transport", 
      "levels", 
      "changes", 
      "optical imaging", 
      "increase", 
      "decrease", 
      "study", 
      "area", 
      "regulation", 
      "correlation", 
      "volume", 
      "simultaneous measurement", 
      "mechanism", 
      "function", 
      "data", 
      "relationship", 
      "certain level", 
      "saturation", 
      "technique", 
      "potential", 
      "diameter", 
      "major issue", 
      "results", 
      "tight coupling", 
      "dissociation", 
      "flow", 
      "measurements", 
      "model", 
      "experiments", 
      "issues", 
      "parameters", 
      "transport", 
      "distribution", 
      "O2", 
      "inflow", 
      "dependence", 
      "coupling", 
      "frequency dependence"
    ], 
    "name": "Regulation of oxygen transport during brain activation: stimulus-induced hemodynamic responses in human and animal cortices", 
    "pagination": "6", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1024097327"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1476-5918-2-6"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "14687423"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1476-5918-2-6", 
      "https://app.dimensions.ai/details/publication/pub.1024097327"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_377.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1476-5918-2-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1476-5918-2-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1476-5918-2-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1476-5918-2-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1476-5918-2-6'


 

This table displays all metadata directly associated to this object as RDF triples.

204 TRIPLES      21 PREDICATES      111 URIs      102 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1476-5918-2-6 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N5c0fd9e9cecb464fa07b4c18cc053e15
4 schema:citation sg:pub.10.1007/978-3-642-58716-0_1
5 schema:datePublished 2003-12-20
6 schema:datePublishedReg 2003-12-20
7 schema:description BackgroundThe correlation between regional changes in neuronal activity and changes in hemodynamics is a major issue for noninvasive neuroimaging techniques such as functional magnetic resonance imaging (fMRI) and near-infrared optical imaging (NIOI). A tight coupling of these changes has been assumed to elucidate brain function from data obtained with those techniques. In the present study, we investigated the relationship between neuronal activity and hemodynamic responses in the occipital cortex of humans during visual stimulation and in the somatosensory cortex of rats during peripheral nerve stimulation.MethodsThe temporal frequency dependence of macroscopic hemodynamic responses on visual stimuli was investigated in the occipital cortex of humans by simultaneous measurements made using fMRI and NIOI. The stimulus-intensity dependence of both microscopic hemodynamic changes and changes in neuronal activity in response to peripheral nerve stimulation was investigated in animal models by analyzing membrane potential (fluorescence), hemodynamic parameters (visible spectra and laser-Doppler flowmetry), and vessel diameter (image analyzer).ResultsAbove a certain level of stimulus-intensity, increases in regional cerebral blood flow (rCBF) were accompanied by a decrease in regional cerebral blood volume (rCBV), i.e., dissociation of rCBF and rCBV responses occurred in both the human and animal experiments. Furthermore, the animal experiments revealed that the distribution of increased rCBF and O2 spread well beyond the area of neuronal activation, and that the increases showed saturation in the activated area.ConclusionsThese results suggest that above a certain level of neuronal activity, a regulatory mechanism between regional cerebral blood flow (rCBF) and rCBV acts to prevent excess O2 inflow into the focally activated area.
8 schema:genre article
9 schema:isAccessibleForFree true
10 schema:isPartOf N1107f57afc454c01a3eaac29f47bf640
11 Nde80eeecdcf640848fd304b47c67f592
12 sg:journal.1031276
13 schema:keywords ConclusionsThese results
14 O2
15 activated area
16 activation
17 activity
18 animal cortex
19 animal experiments
20 animal models
21 area
22 blood flow
23 blood volume
24 brain activation
25 brain function
26 cerebral blood flow
27 cerebral blood volume
28 certain level
29 changes
30 correlation
31 cortex
32 coupling
33 data
34 decrease
35 dependence
36 diameter
37 dissociation
38 distribution
39 experiments
40 flow
41 frequency dependence
42 function
43 functional magnetic resonance imaging
44 hemodynamic changes
45 hemodynamic parameters
46 hemodynamic response
47 hemodynamics
48 humans
49 imaging
50 increase
51 inflow
52 issues
53 levels
54 magnetic resonance imaging
55 major issue
56 measurements
57 mechanism
58 membrane potential
59 model
60 nerve stimulation
61 neuroimaging techniques
62 neuronal activation
63 neuronal activity
64 noninvasive neuroimaging techniques
65 occipital cortex
66 optical imaging
67 oxygen transport
68 parameters
69 peripheral nerve stimulation
70 potential
71 present study
72 rCBV response
73 rats
74 regional cerebral blood flow
75 regional cerebral blood volume
76 regional changes
77 regulation
78 regulatory mechanisms
79 relationship
80 resonance imaging
81 response
82 results
83 saturation
84 simultaneous measurement
85 somatosensory cortex
86 stimulation
87 stimuli
88 stimulus intensity dependence
89 study
90 technique
91 temporal frequency dependence
92 tight coupling
93 transport
94 vessel diameter
95 visual stimulation
96 visual stimuli
97 volume
98 schema:name Regulation of oxygen transport during brain activation: stimulus-induced hemodynamic responses in human and animal cortices
99 schema:pagination 6
100 schema:productId N31f6f1b343834c66b52826d65da8e155
101 N4e55eef1b36243789ec8bc8835ca2ab1
102 N5abfd90bd6d44eeb87c92f411017b004
103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024097327
104 https://doi.org/10.1186/1476-5918-2-6
105 schema:sdDatePublished 2022-09-02T15:50
106 schema:sdLicense https://scigraph.springernature.com/explorer/license/
107 schema:sdPublisher Na02d5cf075c8475e88242d942e0a0294
108 schema:url https://doi.org/10.1186/1476-5918-2-6
109 sgo:license sg:explorer/license/
110 sgo:sdDataset articles
111 rdf:type schema:ScholarlyArticle
112 N0e1a6fedbda64753ac8816a8a6e66eb3 rdf:first sg:person.01024007633.08
113 rdf:rest N1127b21d7f7645ac8e8b613110a5a6e6
114 N1107f57afc454c01a3eaac29f47bf640 schema:volumeNumber 2
115 rdf:type schema:PublicationVolume
116 N1127b21d7f7645ac8e8b613110a5a6e6 rdf:first sg:person.01261436415.13
117 rdf:rest Nc75e349497ee450483fe913cad35c9ce
118 N31f6f1b343834c66b52826d65da8e155 schema:name doi
119 schema:value 10.1186/1476-5918-2-6
120 rdf:type schema:PropertyValue
121 N4e55eef1b36243789ec8bc8835ca2ab1 schema:name pubmed_id
122 schema:value 14687423
123 rdf:type schema:PropertyValue
124 N5abfd90bd6d44eeb87c92f411017b004 schema:name dimensions_id
125 schema:value pub.1024097327
126 rdf:type schema:PropertyValue
127 N5c0fd9e9cecb464fa07b4c18cc053e15 rdf:first sg:person.014651563635.32
128 rdf:rest N7f46510598f944e6bbd8949feb6e7407
129 N7f46510598f944e6bbd8949feb6e7407 rdf:first sg:person.01145553370.42
130 rdf:rest N0e1a6fedbda64753ac8816a8a6e66eb3
131 Na02d5cf075c8475e88242d942e0a0294 schema:name Springer Nature - SN SciGraph project
132 rdf:type schema:Organization
133 Nbb6de8dc8eec4badbe4c78c45f57c045 rdf:first sg:person.015141357621.93
134 rdf:rest rdf:nil
135 Nc75e349497ee450483fe913cad35c9ce rdf:first sg:person.01327551615.58
136 rdf:rest Nd3df0dafd3d74781a670dc4a9bcc24fa
137 Nd3df0dafd3d74781a670dc4a9bcc24fa rdf:first sg:person.01207407050.34
138 rdf:rest Nbb6de8dc8eec4badbe4c78c45f57c045
139 Nde80eeecdcf640848fd304b47c67f592 schema:issueNumber 1
140 rdf:type schema:PublicationIssue
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
145 schema:name Neurosciences
146 rdf:type schema:DefinedTerm
147 sg:journal.1031276 schema:issn 1476-5918
148 schema:name Dynamic Medicine
149 schema:publisher Springer Nature
150 rdf:type schema:Periodical
151 sg:person.01024007633.08 schema:affiliation grid-institutes:grid.28312.3a
152 schema:familyName Tanabe
153 schema:givenName Hiroki C
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024007633.08
155 rdf:type schema:Person
156 sg:person.01145553370.42 schema:affiliation grid-institutes:grid.410796.d
157 schema:familyName Seki
158 schema:givenName Junji
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145553370.42
160 rdf:type schema:Person
161 sg:person.01207407050.34 schema:affiliation grid-institutes:grid.471244.0
162 schema:familyName Fujisaki
163 schema:givenName Hisao
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207407050.34
165 rdf:type schema:Person
166 sg:person.01261436415.13 schema:affiliation grid-institutes:grid.136593.b
167 schema:familyName Ooi
168 schema:givenName Yasuhiro
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261436415.13
170 rdf:type schema:Person
171 sg:person.01327551615.58 schema:affiliation grid-institutes:grid.410796.d
172 schema:familyName Satomura
173 schema:givenName Yasuhiko
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327551615.58
175 rdf:type schema:Person
176 sg:person.014651563635.32 schema:affiliation grid-institutes:grid.136593.b
177 schema:familyName Seiyama
178 schema:givenName Akitoshi
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014651563635.32
180 rdf:type schema:Person
181 sg:person.015141357621.93 schema:affiliation grid-institutes:grid.136593.b
182 schema:familyName Yanagida
183 schema:givenName Toshio
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015141357621.93
185 rdf:type schema:Person
186 sg:pub.10.1007/978-3-642-58716-0_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1089523997
187 https://doi.org/10.1007/978-3-642-58716-0_1
188 rdf:type schema:CreativeWork
189 grid-institutes:grid.136593.b schema:alternateName Division of Pathogenesis and Control of Oral Disease, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, 565-0871, Suita, Osaka, Japan
190 Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan
191 schema:name Division of Pathogenesis and Control of Oral Disease, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, 565-0871, Suita, Osaka, Japan
192 Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan
193 Kansai Advanced Research Center, Communications Research Laboratory, 588-2 Iwaoka, 651-2492, Nishi-ku, Kobe, Hyogo, Japan
194 rdf:type schema:Organization
195 grid-institutes:grid.28312.3a schema:alternateName Kansai Advanced Research Center, Communications Research Laboratory, 588-2 Iwaoka, 651-2492, Nishi-ku, Kobe, Hyogo, Japan
196 schema:name Kansai Advanced Research Center, Communications Research Laboratory, 588-2 Iwaoka, 651-2492, Nishi-ku, Kobe, Hyogo, Japan
197 rdf:type schema:Organization
198 grid-institutes:grid.410796.d schema:alternateName Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, 565-8565, Suita, Osaka, Japan
199 schema:name Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, 565-8565, Suita, Osaka, Japan
200 Division of Physiology and Biosignaling, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan
201 rdf:type schema:Organization
202 grid-institutes:grid.471244.0 schema:alternateName Nikon Corp. Business Development Center, 1-6-3 Nishi-Ooi, 140-8601, Shinagawa, Tokyo, Japan
203 schema:name Nikon Corp. Business Development Center, 1-6-3 Nishi-Ooi, 140-8601, Shinagawa, Tokyo, Japan
204 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...