Ontology type: schema:ScholarlyArticle Open Access: True
2014-04-01
AUTHORSTsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita
ABSTRACTBackgroundStatin therapy results in regression and stabilization of coronary artery plaques, and reduces the incidence of coronary artery disease. However, statin therapy does not effectively halt the accumulation of necrotic core in all patients. The purpose of the present study was to identify the predictors associated with necrotic core progression during statin therapy.MethodsCoronary atherosclerosis in non-culprit lesions was evaluated using virtual histology intravascular ultrasound at baseline and 8 months after statin therapy. One hundred nineteen patients were divided into 2 groups based on necrotic core progression or regression during an 8-month follow-up period.ResultsPatients with necrotic core progression had higher serum lipoprotein(a) [Lp(a)] levels than patients with regression at baseline (16 mg/dL vs. 12 mg/dL, p = 0.02) and at the 8-month follow-up (17 mg/dL vs. 10 mg/dL, p = 0.006). Patients with necrotic core progression had a higher fibro-fatty plaque volume (1.28 mm3/mm vs. 0.73 mm3/mm, p = 0.002), and less necrotic core (0.56 mm3/mm vs. 1.04 mm3/mm, p < 0.0001) and dense calcium (0.35 mm3/mm vs. 0.56 mm3/mm, p = 0.006) plaque volumes at baseline than patients with regression. Multivariate logistic regression analysis showed that Lp(a) was a significant independent predictor associated with necrotic core progression during statin therapy (odds ratio [OR]: 3.514; 95% confidence interval [CI]: 1.338-9.228; p = 0.01).ConclusionsSerum Lp(a) is independently associated with necrotic core progression in statin-treated patients with angina pectoris. More... »
PAGES59
http://scigraph.springernature.com/pub.10.1186/1476-511x-13-59
DOIhttp://dx.doi.org/10.1186/1476-511x-13-59
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1040719885
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24684829
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Angina Pectoris",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Coronary Artery Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Hydroxymethylglutaryl-CoA Reductase Inhibitors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lipoprotein(a)",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Plaque, Atherosclerotic",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.417368.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Nozue",
"givenName": "Tsuyoshi",
"id": "sg:person.01033145125.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033145125.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Yamamoto",
"givenName": "Shingo",
"id": "sg:person.0701553335.84",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701553335.84"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Yokohama Seamen\u2019s Insurance Hospital, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Cardiology, Yokohama Seamen\u2019s Insurance Hospital, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Tohyama",
"givenName": "Shinichi",
"id": "sg:person.01263622125.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263622125.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.419708.3",
"name": [
"Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Fukui",
"givenName": "Kazuki",
"id": "sg:person.0650622624.12",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650622624.12"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan",
"id": "http://www.grid.ac/institutes/grid.414150.5",
"name": [
"Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan"
],
"type": "Organization"
},
"familyName": "Umezawa",
"givenName": "Shigeo",
"id": "sg:person.01202737502.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737502.01"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan",
"id": "http://www.grid.ac/institutes/grid.414150.5",
"name": [
"Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan"
],
"type": "Organization"
},
"familyName": "Onishi",
"givenName": "Yuko",
"id": "sg:person.0765051224.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765051224.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan",
"id": "http://www.grid.ac/institutes/grid.264706.1",
"name": [
"Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan"
],
"type": "Organization"
},
"familyName": "Kunishima",
"givenName": "Tomoyuki",
"id": "sg:person.01155162765.62",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155162765.62"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan",
"id": "http://www.grid.ac/institutes/grid.417369.e",
"name": [
"Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan"
],
"type": "Organization"
},
"familyName": "Sato",
"givenName": "Akira",
"id": "sg:person.0717074353.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717074353.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.416698.4",
"name": [
"Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Nozato",
"givenName": "Toshihiro",
"id": "sg:person.0677360006.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677360006.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Ebina General Hospital, Ebina, Japan",
"id": "http://www.grid.ac/institutes/grid.459497.2",
"name": [
"Department of Cardiology, Ebina General Hospital, Ebina, Japan"
],
"type": "Organization"
},
"familyName": "Miyake",
"givenName": "Shogo",
"id": "sg:person.01215526224.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526224.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.410714.7",
"name": [
"Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Takeyama",
"givenName": "Youichi",
"id": "sg:person.01270662323.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270662323.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Tokai University School of Medicine, Isehara, Japan",
"id": "http://www.grid.ac/institutes/grid.265061.6",
"name": [
"Department of Cardiology, Tokai University School of Medicine, Isehara, Japan"
],
"type": "Organization"
},
"familyName": "Morino",
"givenName": "Yoshihiro",
"id": "sg:person.0746622734.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746622734.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Tokyo Women\u2019s Medical University, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.410818.4",
"name": [
"Department of Cardiology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Yamauchi",
"givenName": "Takao",
"id": "sg:person.0726420725.83",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726420725.83"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.461876.a",
"name": [
"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Muramatsu",
"givenName": "Toshiya",
"id": "sg:person.01225552506.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.413045.7",
"name": [
"Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Hibi",
"givenName": "Kiyoshi",
"id": "sg:person.01162702725.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162702725.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiovascular Imaging Center, Toyohashi, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Cardiovascular Imaging Center, Toyohashi, Japan"
],
"type": "Organization"
},
"familyName": "Terashima",
"givenName": "Mitsuyasu",
"id": "sg:person.0716062020.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716062020.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan",
"id": "http://www.grid.ac/institutes/grid.417368.f",
"name": [
"Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Michishita",
"givenName": "Ichiro",
"id": "sg:person.0732262025.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70"
],
"type": "Person"
}
],
"datePublished": "2014-04-01",
"datePublishedReg": "2014-04-01",
"description": "BackgroundStatin therapy results in regression and stabilization of coronary artery plaques, and reduces the incidence of coronary artery disease. However, statin therapy does not effectively halt the accumulation of necrotic core in all patients. The purpose of the present study was to identify the predictors associated with necrotic core progression during statin therapy.MethodsCoronary atherosclerosis in non-culprit lesions was evaluated using virtual histology intravascular ultrasound at baseline and 8\u00a0months after statin therapy. One hundred nineteen patients were divided into 2 groups based on necrotic core progression or regression during an 8-month follow-up period.ResultsPatients with necrotic core progression had higher serum lipoprotein(a) [Lp(a)] levels than patients with regression at baseline (16\u00a0mg/dL vs. 12\u00a0mg/dL, p\u2009=\u20090.02) and at the 8-month follow-up (17\u00a0mg/dL vs. 10\u00a0mg/dL, p\u2009=\u20090.006). Patients with necrotic core progression had a higher fibro-fatty plaque volume (1.28\u00a0mm3/mm vs. 0.73\u00a0mm3/mm, p\u2009=\u20090.002), and less necrotic core (0.56\u00a0mm3/mm vs. 1.04\u00a0mm3/mm, p\u2009<\u20090.0001) and dense calcium (0.35\u00a0mm3/mm vs. 0.56\u00a0mm3/mm, p\u2009=\u20090.006) plaque volumes at baseline than patients with regression. Multivariate logistic regression analysis showed that Lp(a) was a significant independent predictor associated with necrotic core progression during statin therapy (odds ratio [OR]: 3.514; 95% confidence interval [CI]: 1.338-9.228; p\u2009=\u20090.01).ConclusionsSerum Lp(a) is independently associated with necrotic core progression in statin-treated patients with angina pectoris.",
"genre": "article",
"id": "sg:pub.10.1186/1476-511x-13-59",
"inLanguage": "en",
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1031029",
"issn": [
"1476-511X"
],
"name": "Lipids in Health and Disease",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "13"
}
],
"keywords": [
"necrotic core progression",
"statin therapy",
"angina pectoris",
"plaque volume",
"non-culprit coronary lesions",
"necrotic core",
"virtual histology intravascular ultrasound",
"multivariate logistic regression analysis",
"less necrotic core",
"non-culprit lesions",
"coronary artery disease",
"significant independent predictors",
"coronary artery plaques",
"logistic regression analysis",
"artery disease",
"independent predictors",
"coronary lesions",
"artery plaques",
"intravascular ultrasound",
"patients",
"therapy",
"progression",
"baseline",
"pectoris",
"statins",
"regression analysis",
"lesions",
"present study",
"predictors",
"regression",
"ConclusionsSerum",
"ResultsPatients",
"atherosclerosis",
"follow",
"plaques",
"incidence",
"disease",
"months",
"ultrasound",
"volume",
"group",
"period",
"levels",
"study",
"accumulation",
"purpose",
"analysis",
"stabilization",
"core"
],
"name": "Lipoprotein(a) is associated with necrotic core progression of non-culprit coronary lesions in statin-treated patients with angina pectoris",
"pagination": "59",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1040719885"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1186/1476-511x-13-59"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"24684829"
]
}
],
"sameAs": [
"https://doi.org/10.1186/1476-511x-13-59",
"https://app.dimensions.ai/details/publication/pub.1040719885"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:30",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_642.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1186/1476-511x-13-59"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1476-511x-13-59'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1476-511x-13-59'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1476-511x-13-59'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1476-511x-13-59'
This table displays all metadata directly associated to this object as RDF triples.
302 TRIPLES
21 PREDICATES
85 URIs
77 LITERALS
17 BLANK NODES