Lipoprotein(a) is associated with necrotic core progression of non-culprit coronary lesions in statin-treated patients with angina pectoris View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04-01

AUTHORS

Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Kazuki Fukui, Shigeo Umezawa, Yuko Onishi, Tomoyuki Kunishima, Akira Sato, Toshihiro Nozato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Kiyoshi Hibi, Mitsuyasu Terashima, Ichiro Michishita

ABSTRACT

BackgroundStatin therapy results in regression and stabilization of coronary artery plaques, and reduces the incidence of coronary artery disease. However, statin therapy does not effectively halt the accumulation of necrotic core in all patients. The purpose of the present study was to identify the predictors associated with necrotic core progression during statin therapy.MethodsCoronary atherosclerosis in non-culprit lesions was evaluated using virtual histology intravascular ultrasound at baseline and 8 months after statin therapy. One hundred nineteen patients were divided into 2 groups based on necrotic core progression or regression during an 8-month follow-up period.ResultsPatients with necrotic core progression had higher serum lipoprotein(a) [Lp(a)] levels than patients with regression at baseline (16 mg/dL vs. 12 mg/dL, p = 0.02) and at the 8-month follow-up (17 mg/dL vs. 10 mg/dL, p = 0.006). Patients with necrotic core progression had a higher fibro-fatty plaque volume (1.28 mm3/mm vs. 0.73 mm3/mm, p = 0.002), and less necrotic core (0.56 mm3/mm vs. 1.04 mm3/mm, p < 0.0001) and dense calcium (0.35 mm3/mm vs. 0.56 mm3/mm, p = 0.006) plaque volumes at baseline than patients with regression. Multivariate logistic regression analysis showed that Lp(a) was a significant independent predictor associated with necrotic core progression during statin therapy (odds ratio [OR]: 3.514; 95% confidence interval [CI]: 1.338-9.228; p = 0.01).ConclusionsSerum Lp(a) is independently associated with necrotic core progression in statin-treated patients with angina pectoris. More... »

PAGES

59

Journal

TITLE

Lipids in Health and Disease

ISSUE

1

VOLUME

13

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-511x-13-59

DOI

http://dx.doi.org/10.1186/1476-511x-13-59

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040719885

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24684829


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angina Pectoris", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Coronary Artery Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxymethylglutaryl-CoA Reductase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipoprotein(a)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plaque, Atherosclerotic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417368.f", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nozue", 
        "givenName": "Tsuyoshi", 
        "id": "sg:person.01033145125.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033145125.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Shingo", 
        "id": "sg:person.0701553335.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701553335.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Yokohama Seamen\u2019s Insurance Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Department of Cardiology, Yokohama Seamen\u2019s Insurance Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tohyama", 
        "givenName": "Shinichi", 
        "id": "sg:person.01263622125.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263622125.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419708.3", 
          "name": [
            "Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukui", 
        "givenName": "Kazuki", 
        "id": "sg:person.0650622624.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650622624.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414150.5", 
          "name": [
            "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Umezawa", 
        "givenName": "Shigeo", 
        "id": "sg:person.01202737502.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737502.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.414150.5", 
          "name": [
            "Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Onishi", 
        "givenName": "Yuko", 
        "id": "sg:person.0765051224.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765051224.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.264706.1", 
          "name": [
            "Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kunishima", 
        "givenName": "Tomoyuki", 
        "id": "sg:person.01155162765.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155162765.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417369.e", 
          "name": [
            "Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Akira", 
        "id": "sg:person.0717074353.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717074353.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416698.4", 
          "name": [
            "Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nozato", 
        "givenName": "Toshihiro", 
        "id": "sg:person.0677360006.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677360006.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Ebina General Hospital, Ebina, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459497.2", 
          "name": [
            "Department of Cardiology, Ebina General Hospital, Ebina, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyake", 
        "givenName": "Shogo", 
        "id": "sg:person.01215526224.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526224.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410714.7", 
          "name": [
            "Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeyama", 
        "givenName": "Youichi", 
        "id": "sg:person.01270662323.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270662323.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tokai University School of Medicine, Isehara, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Cardiology, Tokai University School of Medicine, Isehara, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morino", 
        "givenName": "Yoshihiro", 
        "id": "sg:person.0746622734.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746622734.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tokyo Women\u2019s Medical University, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410818.4", 
          "name": [
            "Department of Cardiology, Tokyo Women\u2019s Medical University, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamauchi", 
        "givenName": "Takao", 
        "id": "sg:person.0726420725.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726420725.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.461876.a", 
          "name": [
            "Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muramatsu", 
        "givenName": "Toshiya", 
        "id": "sg:person.01225552506.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.413045.7", 
          "name": [
            "Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hibi", 
        "givenName": "Kiyoshi", 
        "id": "sg:person.01162702725.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162702725.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cardiovascular Imaging Center, Toyohashi, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Cardiovascular Imaging Center, Toyohashi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Terashima", 
        "givenName": "Mitsuyasu", 
        "id": "sg:person.0716062020.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716062020.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417368.f", 
          "name": [
            "Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Michishita", 
        "givenName": "Ichiro", 
        "id": "sg:person.0732262025.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2014-04-01", 
    "datePublishedReg": "2014-04-01", 
    "description": "BackgroundStatin therapy results in regression and stabilization of coronary artery plaques, and reduces the incidence of coronary artery disease. However, statin therapy does not effectively halt the accumulation of necrotic core in all patients. The purpose of the present study was to identify the predictors associated with necrotic core progression during statin therapy.MethodsCoronary atherosclerosis in non-culprit lesions was evaluated using virtual histology intravascular ultrasound at baseline and 8\u00a0months after statin therapy. One hundred nineteen patients were divided into 2 groups based on necrotic core progression or regression during an 8-month follow-up period.ResultsPatients with necrotic core progression had higher serum lipoprotein(a) [Lp(a)] levels than patients with regression at baseline (16\u00a0mg/dL vs. 12\u00a0mg/dL, p\u2009=\u20090.02) and at the 8-month follow-up (17\u00a0mg/dL vs. 10\u00a0mg/dL, p\u2009=\u20090.006). Patients with necrotic core progression had a higher fibro-fatty plaque volume (1.28\u00a0mm3/mm vs. 0.73\u00a0mm3/mm, p\u2009=\u20090.002), and less necrotic core (0.56\u00a0mm3/mm vs. 1.04\u00a0mm3/mm, p\u2009<\u20090.0001) and dense calcium (0.35\u00a0mm3/mm vs. 0.56\u00a0mm3/mm, p\u2009=\u20090.006) plaque volumes at baseline than patients with regression. Multivariate logistic regression analysis showed that Lp(a) was a significant independent predictor associated with necrotic core progression during statin therapy (odds ratio [OR]: 3.514; 95% confidence interval [CI]: 1.338-9.228; p\u2009=\u20090.01).ConclusionsSerum Lp(a) is independently associated with necrotic core progression in statin-treated patients with angina pectoris.", 
    "genre": "article", 
    "id": "sg:pub.10.1186/1476-511x-13-59", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1031029", 
        "issn": [
          "1476-511X"
        ], 
        "name": "Lipids in Health and Disease", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "13"
      }
    ], 
    "keywords": [
      "necrotic core progression", 
      "statin therapy", 
      "angina pectoris", 
      "plaque volume", 
      "non-culprit coronary lesions", 
      "necrotic core", 
      "virtual histology intravascular ultrasound", 
      "multivariate logistic regression analysis", 
      "less necrotic core", 
      "non-culprit lesions", 
      "coronary artery disease", 
      "significant independent predictors", 
      "coronary artery plaques", 
      "logistic regression analysis", 
      "artery disease", 
      "independent predictors", 
      "coronary lesions", 
      "artery plaques", 
      "intravascular ultrasound", 
      "patients", 
      "therapy", 
      "progression", 
      "baseline", 
      "pectoris", 
      "statins", 
      "regression analysis", 
      "lesions", 
      "present study", 
      "predictors", 
      "regression", 
      "ConclusionsSerum", 
      "ResultsPatients", 
      "atherosclerosis", 
      "follow", 
      "plaques", 
      "incidence", 
      "disease", 
      "months", 
      "ultrasound", 
      "volume", 
      "group", 
      "period", 
      "levels", 
      "study", 
      "accumulation", 
      "purpose", 
      "analysis", 
      "stabilization", 
      "core"
    ], 
    "name": "Lipoprotein(a) is associated with necrotic core progression of non-culprit coronary lesions in statin-treated patients with angina pectoris", 
    "pagination": "59", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1040719885"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1476-511x-13-59"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24684829"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1476-511x-13-59", 
      "https://app.dimensions.ai/details/publication/pub.1040719885"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_642.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1186/1476-511x-13-59"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1476-511x-13-59'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1476-511x-13-59'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1476-511x-13-59'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1476-511x-13-59'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      85 URIs      77 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1476-511x-13-59 schema:about N1864840c758d4843b56800154ae3868f
2 N635f94664f03406fb02ca3bad2a76c9c
3 N7964d8b424814d96b9c2b59b57e03848
4 Naedafa6c784847898b8e4d58b9c6812f
5 Nb053bb201a48479aa4eeff0599fe8329
6 Nbe75a76f441f48ad94d37d7fd09016b5
7 Ncf00b746764341f7a90d3470472c3fec
8 Ne9668f7434f44baf8e8e52c0b5cf5a22
9 Nf417680564dc42d0b40769c16a3422dc
10 Nf8c1068ba5ed435cbcf5d4ebe1c70103
11 anzsrc-for:11
12 anzsrc-for:1102
13 schema:author N8444573a421a4b4d859fda70883f9c0a
14 schema:datePublished 2014-04-01
15 schema:datePublishedReg 2014-04-01
16 schema:description BackgroundStatin therapy results in regression and stabilization of coronary artery plaques, and reduces the incidence of coronary artery disease. However, statin therapy does not effectively halt the accumulation of necrotic core in all patients. The purpose of the present study was to identify the predictors associated with necrotic core progression during statin therapy.MethodsCoronary atherosclerosis in non-culprit lesions was evaluated using virtual histology intravascular ultrasound at baseline and 8 months after statin therapy. One hundred nineteen patients were divided into 2 groups based on necrotic core progression or regression during an 8-month follow-up period.ResultsPatients with necrotic core progression had higher serum lipoprotein(a) [Lp(a)] levels than patients with regression at baseline (16 mg/dL vs. 12 mg/dL, p = 0.02) and at the 8-month follow-up (17 mg/dL vs. 10 mg/dL, p = 0.006). Patients with necrotic core progression had a higher fibro-fatty plaque volume (1.28 mm3/mm vs. 0.73 mm3/mm, p = 0.002), and less necrotic core (0.56 mm3/mm vs. 1.04 mm3/mm, p < 0.0001) and dense calcium (0.35 mm3/mm vs. 0.56 mm3/mm, p = 0.006) plaque volumes at baseline than patients with regression. Multivariate logistic regression analysis showed that Lp(a) was a significant independent predictor associated with necrotic core progression during statin therapy (odds ratio [OR]: 3.514; 95% confidence interval [CI]: 1.338-9.228; p = 0.01).ConclusionsSerum Lp(a) is independently associated with necrotic core progression in statin-treated patients with angina pectoris.
17 schema:genre article
18 schema:inLanguage en
19 schema:isAccessibleForFree true
20 schema:isPartOf N534cf86d7fe545fb95c2daa668370189
21 Nea73fff0153045469486b4293dc5575d
22 sg:journal.1031029
23 schema:keywords ConclusionsSerum
24 ResultsPatients
25 accumulation
26 analysis
27 angina pectoris
28 artery disease
29 artery plaques
30 atherosclerosis
31 baseline
32 core
33 coronary artery disease
34 coronary artery plaques
35 coronary lesions
36 disease
37 follow
38 group
39 incidence
40 independent predictors
41 intravascular ultrasound
42 lesions
43 less necrotic core
44 levels
45 logistic regression analysis
46 months
47 multivariate logistic regression analysis
48 necrotic core
49 necrotic core progression
50 non-culprit coronary lesions
51 non-culprit lesions
52 patients
53 pectoris
54 period
55 plaque volume
56 plaques
57 predictors
58 present study
59 progression
60 purpose
61 regression
62 regression analysis
63 significant independent predictors
64 stabilization
65 statin therapy
66 statins
67 study
68 therapy
69 ultrasound
70 virtual histology intravascular ultrasound
71 volume
72 schema:name Lipoprotein(a) is associated with necrotic core progression of non-culprit coronary lesions in statin-treated patients with angina pectoris
73 schema:pagination 59
74 schema:productId N8c8efe719eb74c5d852f93b5bc8a1faf
75 Nadc7a68049394e60bd1baa70e9cb9de3
76 Nb466d0c56e044612ba6593b2dce0345c
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040719885
78 https://doi.org/10.1186/1476-511x-13-59
79 schema:sdDatePublished 2022-05-20T07:30
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N8c3cab41177b44e89aa754672172ed03
82 schema:url https://doi.org/10.1186/1476-511x-13-59
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N10dded94db1f43dcb3a7d1076b4226ae rdf:first sg:person.01270662323.35
87 rdf:rest N87e4a663191e48188ae5878c950de191
88 N12080bf271af48c1bc2411038b9ca3d9 rdf:first sg:person.0732262025.70
89 rdf:rest rdf:nil
90 N1864840c758d4843b56800154ae3868f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Lipoprotein(a)
92 rdf:type schema:DefinedTerm
93 N188faafbcbbc4d7292f4307d4062e0dd rdf:first sg:person.01263622125.63
94 rdf:rest N8d58d84758f2443e921efdfb0f229926
95 N379637514f184ce09a74b1a4f32b4d4b rdf:first sg:person.0677360006.66
96 rdf:rest N694f3aabc10c45d284b9d060105d21b6
97 N39b1fbf0a86743c99c465879fd00d75e rdf:first sg:person.0716062020.45
98 rdf:rest N12080bf271af48c1bc2411038b9ca3d9
99 N534cf86d7fe545fb95c2daa668370189 schema:issueNumber 1
100 rdf:type schema:PublicationIssue
101 N635f94664f03406fb02ca3bad2a76c9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Coronary Artery Disease
103 rdf:type schema:DefinedTerm
104 N694f3aabc10c45d284b9d060105d21b6 rdf:first sg:person.01215526224.39
105 rdf:rest N10dded94db1f43dcb3a7d1076b4226ae
106 N7964d8b424814d96b9c2b59b57e03848 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Hydroxymethylglutaryl-CoA Reductase Inhibitors
108 rdf:type schema:DefinedTerm
109 N7a456b200f8445168ec6a093a71b12c4 rdf:first sg:person.01155162765.62
110 rdf:rest Na5c2061f964446af91cf2b295709e579
111 N8444573a421a4b4d859fda70883f9c0a rdf:first sg:person.01033145125.12
112 rdf:rest Nbdb554d518564b6aa6dd92f6e6e28c1c
113 N87e4a663191e48188ae5878c950de191 rdf:first sg:person.0746622734.07
114 rdf:rest N89d3b14b6ef7437db7dc8d79ae9528d7
115 N89d3b14b6ef7437db7dc8d79ae9528d7 rdf:first sg:person.0726420725.83
116 rdf:rest N8d5b314008bb4fc5bc5ef8c53c68fcba
117 N8c3cab41177b44e89aa754672172ed03 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N8c8efe719eb74c5d852f93b5bc8a1faf schema:name pubmed_id
120 schema:value 24684829
121 rdf:type schema:PropertyValue
122 N8d58d84758f2443e921efdfb0f229926 rdf:first sg:person.0650622624.12
123 rdf:rest Nb2c66c70640947cabff7f4a938a5d7d3
124 N8d5b314008bb4fc5bc5ef8c53c68fcba rdf:first sg:person.01225552506.20
125 rdf:rest Nc822b943d1df4e489453e977475b41cd
126 Na5c2061f964446af91cf2b295709e579 rdf:first sg:person.0717074353.90
127 rdf:rest N379637514f184ce09a74b1a4f32b4d4b
128 Nadc7a68049394e60bd1baa70e9cb9de3 schema:name dimensions_id
129 schema:value pub.1040719885
130 rdf:type schema:PropertyValue
131 Naedafa6c784847898b8e4d58b9c6812f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Aged
133 rdf:type schema:DefinedTerm
134 Nb053bb201a48479aa4eeff0599fe8329 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Plaque, Atherosclerotic
136 rdf:type schema:DefinedTerm
137 Nb2c66c70640947cabff7f4a938a5d7d3 rdf:first sg:person.01202737502.01
138 rdf:rest Ndee572a61d744d7590ea095da3cc88f9
139 Nb466d0c56e044612ba6593b2dce0345c schema:name doi
140 schema:value 10.1186/1476-511x-13-59
141 rdf:type schema:PropertyValue
142 Nbdb554d518564b6aa6dd92f6e6e28c1c rdf:first sg:person.0701553335.84
143 rdf:rest N188faafbcbbc4d7292f4307d4062e0dd
144 Nbe75a76f441f48ad94d37d7fd09016b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Female
146 rdf:type schema:DefinedTerm
147 Nc822b943d1df4e489453e977475b41cd rdf:first sg:person.01162702725.19
148 rdf:rest N39b1fbf0a86743c99c465879fd00d75e
149 Ncf00b746764341f7a90d3470472c3fec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Male
151 rdf:type schema:DefinedTerm
152 Ndee572a61d744d7590ea095da3cc88f9 rdf:first sg:person.0765051224.75
153 rdf:rest N7a456b200f8445168ec6a093a71b12c4
154 Ne9668f7434f44baf8e8e52c0b5cf5a22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Angina Pectoris
156 rdf:type schema:DefinedTerm
157 Nea73fff0153045469486b4293dc5575d schema:volumeNumber 13
158 rdf:type schema:PublicationVolume
159 Nf417680564dc42d0b40769c16a3422dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Humans
161 rdf:type schema:DefinedTerm
162 Nf8c1068ba5ed435cbcf5d4ebe1c70103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Middle Aged
164 rdf:type schema:DefinedTerm
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
169 schema:name Cardiorespiratory Medicine and Haematology
170 rdf:type schema:DefinedTerm
171 sg:journal.1031029 schema:issn 1476-511X
172 schema:name Lipids in Health and Disease
173 schema:publisher Springer Nature
174 rdf:type schema:Periodical
175 sg:person.01033145125.12 schema:affiliation grid-institutes:grid.417368.f
176 schema:familyName Nozue
177 schema:givenName Tsuyoshi
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033145125.12
179 rdf:type schema:Person
180 sg:person.01155162765.62 schema:affiliation grid-institutes:grid.264706.1
181 schema:familyName Kunishima
182 schema:givenName Tomoyuki
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155162765.62
184 rdf:type schema:Person
185 sg:person.01162702725.19 schema:affiliation grid-institutes:grid.413045.7
186 schema:familyName Hibi
187 schema:givenName Kiyoshi
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162702725.19
189 rdf:type schema:Person
190 sg:person.01202737502.01 schema:affiliation grid-institutes:grid.414150.5
191 schema:familyName Umezawa
192 schema:givenName Shigeo
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202737502.01
194 rdf:type schema:Person
195 sg:person.01215526224.39 schema:affiliation grid-institutes:grid.459497.2
196 schema:familyName Miyake
197 schema:givenName Shogo
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215526224.39
199 rdf:type schema:Person
200 sg:person.01225552506.20 schema:affiliation grid-institutes:grid.461876.a
201 schema:familyName Muramatsu
202 schema:givenName Toshiya
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01225552506.20
204 rdf:type schema:Person
205 sg:person.01263622125.63 schema:affiliation grid-institutes:None
206 schema:familyName Tohyama
207 schema:givenName Shinichi
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263622125.63
209 rdf:type schema:Person
210 sg:person.01270662323.35 schema:affiliation grid-institutes:grid.410714.7
211 schema:familyName Takeyama
212 schema:givenName Youichi
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270662323.35
214 rdf:type schema:Person
215 sg:person.0650622624.12 schema:affiliation grid-institutes:grid.419708.3
216 schema:familyName Fukui
217 schema:givenName Kazuki
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650622624.12
219 rdf:type schema:Person
220 sg:person.0677360006.66 schema:affiliation grid-institutes:grid.416698.4
221 schema:familyName Nozato
222 schema:givenName Toshihiro
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677360006.66
224 rdf:type schema:Person
225 sg:person.0701553335.84 schema:affiliation grid-institutes:None
226 schema:familyName Yamamoto
227 schema:givenName Shingo
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701553335.84
229 rdf:type schema:Person
230 sg:person.0716062020.45 schema:affiliation grid-institutes:None
231 schema:familyName Terashima
232 schema:givenName Mitsuyasu
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716062020.45
234 rdf:type schema:Person
235 sg:person.0717074353.90 schema:affiliation grid-institutes:grid.417369.e
236 schema:familyName Sato
237 schema:givenName Akira
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717074353.90
239 rdf:type schema:Person
240 sg:person.0726420725.83 schema:affiliation grid-institutes:grid.410818.4
241 schema:familyName Yamauchi
242 schema:givenName Takao
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726420725.83
244 rdf:type schema:Person
245 sg:person.0732262025.70 schema:affiliation grid-institutes:grid.417368.f
246 schema:familyName Michishita
247 schema:givenName Ichiro
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732262025.70
249 rdf:type schema:Person
250 sg:person.0746622734.07 schema:affiliation grid-institutes:grid.265061.6
251 schema:familyName Morino
252 schema:givenName Yoshihiro
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746622734.07
254 rdf:type schema:Person
255 sg:person.0765051224.75 schema:affiliation grid-institutes:grid.414150.5
256 schema:familyName Onishi
257 schema:givenName Yuko
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765051224.75
259 rdf:type schema:Person
260 grid-institutes:None schema:alternateName Cardiovascular Imaging Center, Toyohashi, Japan
261 Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan
262 Department of Cardiology, Yokohama Seamen’s Insurance Hospital, Yokohama, Japan
263 schema:name Cardiovascular Imaging Center, Toyohashi, Japan
264 Department of Cardiology, Tsurumi Nishiguchi Hospital, Yokohama, Japan
265 Department of Cardiology, Yokohama Seamen’s Insurance Hospital, Yokohama, Japan
266 rdf:type schema:Organization
267 grid-institutes:grid.264706.1 schema:alternateName Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan
268 schema:name Fourth Department of Internal Medicine, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan
269 rdf:type schema:Organization
270 grid-institutes:grid.265061.6 schema:alternateName Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
271 schema:name Department of Cardiology, Tokai University School of Medicine, Isehara, Japan
272 rdf:type schema:Organization
273 grid-institutes:grid.410714.7 schema:alternateName Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan
274 schema:name Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan
275 rdf:type schema:Organization
276 grid-institutes:grid.410818.4 schema:alternateName Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
277 schema:name Department of Cardiology, Tokyo Women’s Medical University, Tokyo, Japan
278 rdf:type schema:Organization
279 grid-institutes:grid.413045.7 schema:alternateName Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
280 schema:name Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
281 rdf:type schema:Organization
282 grid-institutes:grid.414150.5 schema:alternateName Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
283 schema:name Department of Cardiology, Hiratsuka Kyosai Hospital, Hiratsuka, Japan
284 rdf:type schema:Organization
285 grid-institutes:grid.416698.4 schema:alternateName Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan
286 schema:name Department of Cardiology, National Hospital Organization, Disaster Medical Center, Tokyo, Japan
287 rdf:type schema:Organization
288 grid-institutes:grid.417368.f schema:alternateName Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan
289 schema:name Division of Cardiology, Department of Internal Medicine, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, 247-8581, Yokohama, Japan
290 rdf:type schema:Organization
291 grid-institutes:grid.417369.e schema:alternateName Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan
292 schema:name Cardiovascular Center, Yokosuka Kyosai Hospital, Yokosuka, Japan
293 rdf:type schema:Organization
294 grid-institutes:grid.419708.3 schema:alternateName Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
295 schema:name Department of Cardiology, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan
296 rdf:type schema:Organization
297 grid-institutes:grid.459497.2 schema:alternateName Department of Cardiology, Ebina General Hospital, Ebina, Japan
298 schema:name Department of Cardiology, Ebina General Hospital, Ebina, Japan
299 rdf:type schema:Organization
300 grid-institutes:grid.461876.a schema:alternateName Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan
301 schema:name Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...