Probucol inhibits the initiation of atherosclerosis in cholesterol-fed rabbits View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11-04

AUTHORS

Manabu Niimi, Yuka Keyamura, Masanori Nozako, Takashi Koyama, Masayuki Kohashi, Reiko Yasufuku, Tomohiro Yoshikawa, Jianglin Fan

ABSTRACT

BackgroundProbucol and statin are often prescribed for treating atherosclerosis. These two drugs exhibit different mechanisms but it is unknown whether they have the same anti-atherogenic properties. In the current study, we examined whether these two drugs at optimal doses could inhibit the initiation of atherosclerosis in cholesterol-fed rabbits in the same way.MethodsNew Zealand White rabbits were fed a cholesterol-rich diet for 5 weeks to produce the early-stage lesions of atherosclerosis. Drug-treated rabbits were administered either probucol or atorvastatin and serum lipids and aortic atherosclerotic lesions were compared with those in a control group.ResultsAtorvastatin treatment significantly reduced serum total cholesterol levels while probucol treatment led to significant reduction of high-density lipoprotein cholesterol levels without changing total cholesterol levels compared with those in the control group. Compared with the control, probucol treatment led to 65% (p < 0.01) reduction while atorvastatin treatment led to 23% (p = 0.426) reduction of the aortic lesion area. Histological and immunohistochemical analyses revealed that the lesions of the probucol-treated group were characterized by remarkable reduction of monocyte adherence to endothelial cells and macrophage accumulation in the intima compared with those of both atorvastatin and control groups. Furthermore, low-density lipoprotein (LDL) isolated from the probucol group exhibited prominent anti-oxidative reaction, which was not present in LDL isolated from either the atorvastatin-treated or the control group.ConclusionsThis study suggests that probucol inhibits the initiation of atherosclerosis by reducing monocyte adherence and infiltration into the subintima. Anti-oxidization of LDL by probucol protects more effectively against early-stage lesion formation than statin-mediated lipid-lowering effects. More... »

PAGES

166

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URI

http://scigraph.springernature.com/pub.10.1186/1476-511x-12-166

DOI

http://dx.doi.org/10.1186/1476-511x-12-166

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006015983

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24188322


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