MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Chun-Zhi Zhang, Jun-Xia Zhang, An-Ling Zhang, Zhen-Dong Shi, Lei Han, Zhi-Fan Jia, Wei-Dong Yang, Guang-Xiu Wang, Tao Jiang, Yong-Ping You, Pei-Yu Pu, Jin-Quan Cheng, Chun-Sheng Kang

ABSTRACT

BACKGROUND: MiR-221 and miR-222 (miR-221/222) are frequently up-regulated in various types of human malignancy including glioblastoma. Recent studies have reported that miR-221/222 regulate cell growth and cell cycle progression by targeting p27 and p57. However the underlying mechanism involved in cell survival modulation of miR-221/222 remains elusive. RESULTS: Here we showed that miR-221/222 inhibited cell apoptosis by targeting pro-apoptotic gene PUMA in human glioma cells. Enforced expression of miR-22/222 induced cell survival whereas knockdown of miR-221/222 rendered cells to apoptosis. Further, miR-221/222 reduced PUMA protein levels by targeting PUMA-3'UTR. Introducing PUMA cDNA without 3'UTR abrogated miR-221/222-induced cell survival. Notably, knockdown of miR-221/222 induces PUMA expression and cell apoptosis and considerably decreases tumor growth in xenograft model. Finally, there was an inverse relationship between PUMA and miR-221/222 expression in glioma tissues. CONCLUSION: To our knowledge, these data indicate for the first time that miR-221/222 directly regulate apoptosis by targeting PUMA in glioblastoma and that miR-221/222 could be potential therapeutic targets for glioblastoma intervention. More... »

PAGES

229

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-4598-9-229

DOI

http://dx.doi.org/10.1186/1476-4598-9-229

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000672243

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20813046


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Download the RDF metadata as:  json-ld nt turtle xml License info

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