Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-12

AUTHORS

Ester Lara, Vincenzo Calvanese, Covadonga Huidobro, Agustin F Fernández, Ángela Moncada-Pazos, Álvaro J Obaya, Oscar Aguilera, José Manuel González-Sancho, Laura Sánchez, Aurora Astudillo, Alberto Muñoz, Carlos López-Otín, Manel Esteller, Mario F Fraga

ABSTRACT

BACKGROUND: Wnt factors control cell differentiation through semi-independent molecular cascades known as the beta-catenin-dependent (canonical) and -independent (non-canonical) Wnt signalling pathways. Genetic and epigenetic alteration of components of the canonical Wnt signalling pathway is one of the primary mechanisms underlying colon cancer. Despite increasing evidence of the role of the non-canonical pathways in tumourigenesis, however, the underlying molecular mechanisms are poorly understood. RESULTS: Here we report that the receptor tyrosine kinase-like orphan receptor 2 (ROR2), a transmembrane receptor for Wnt factors that activates non-canonical pathways, is frequently repressed by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumours. By restoring ROR2 activity in colon cancer cells harbouring ROR2 promoter hypermethylation, we show that the role of ROR2 in colon cancer cells is mediated, at least in part, by canonical Wnt and that its epigenetic-dependent loss can be pro-tumourigenic. CONCLUSIONS: Our data show the importance of epigenetic alterations of ROR2 in colon cancer, highlighting the close interconnection between canonical and non-canonical Wnt signalling pathways in this type of tumour. More... »

PAGES

170

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-4598-9-170

DOI

http://dx.doi.org/10.1186/1476-4598-9-170

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024699098

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20591152


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-9-170'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-9-170'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-9-170'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-9-170'


 

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