Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2006-12

AUTHORS

Koga Komatsu, F Gregory Buchanan, Michiro Otaka, Mario Jin, Masaru Odashima, Yohei Horikawa, Sumio Watanabe, Raymond N DuBois

ABSTRACT

BACKGROUND: Constitutive activation of MEK1 (caMEK) can induce the oncogenic transformation of normal intestinal epithelial cells. To define the genetic changes that occur during this process, we used oligonucleotide microarrays to determine which genes are regulated following the constitutive activation of MEK in normal intestinal epithelial cells. RESULTS: Microarray analysis was performed using Affymetrix GeneChip and total RNA from doxycycline inducible RIEtiCAMEK cells in the presence or absence of doxycycline. MEK-activation induced at least a three-fold difference in 115 gene transcripts (75 transcripts were up-regulated, and 40 transcripts were down-regulated). To verify whether these mRNAs are indeed regulated by the constitutive activation of MEK, RT-PCR analysis was performed using the samples from caMEK expressing RIE cells (RIEcCAMEK cells) as well as RIEtiCAMEK cells. The altered expression level of 69 gene transcripts was confirmed. Sixty-one of the differentially expressed genes have previously been implicated in cellular transformation or tumorogenesis. For the remaining 8 genes (or their human homolog), RT-PCR analysis was performed on RNA from human colon cancer cell lines and matched normal and tumor colon cancer tissues from human patients, revealing three novel targets (rat brain serine protease2, AMP deaminase 3, and cartilage link protein 1). CONCLUSION: Following MEK-activation, many tumor-associated genes were found to have significantly altered expression levels. However, we identified three genes that were differentially expressed in caMEK cells and human colorectal cancers, which have not been previously linked to cellular transformation or tumorogenesis. More... »

PAGES

63

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1186/1476-4598-5-63

DOI

http://dx.doi.org/10.1186/1476-4598-5-63

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033776610

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17112382


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epithelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Akita University", 
          "id": "https://www.grid.ac/institutes/grid.251924.9", 
          "name": [
            "Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Japan", 
            "Department of Gastroenterology/Internal Medicine, Akita University School of Medicine, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komatsu", 
        "givenName": "Koga", 
        "id": "sg:person.01246273632.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246273632.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine and Cancer Biology, Vanderbilt-Ingram Cancer Center, Nashville, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buchanan", 
        "givenName": "F Gregory", 
        "id": "sg:person.01217757103.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217757103.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Akita University", 
          "id": "https://www.grid.ac/institutes/grid.251924.9", 
          "name": [
            "Department of Gastroenterology/Internal Medicine, Akita University School of Medicine, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Otaka", 
        "givenName": "Michiro", 
        "id": "sg:person.01132045232.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132045232.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Akita University", 
          "id": "https://www.grid.ac/institutes/grid.251924.9", 
          "name": [
            "Department of Gastroenterology/Internal Medicine, Akita University School of Medicine, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Mario", 
        "id": "sg:person.0613614240.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613614240.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Akita University", 
          "id": "https://www.grid.ac/institutes/grid.251924.9", 
          "name": [
            "Department of Gastroenterology/Internal Medicine, Akita University School of Medicine, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Odashima", 
        "givenName": "Masaru", 
        "id": "sg:person.01334024263.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334024263.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Akita University", 
          "id": "https://www.grid.ac/institutes/grid.251924.9", 
          "name": [
            "Department of Gastroenterology/Internal Medicine, Akita University School of Medicine, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Horikawa", 
        "givenName": "Yohei", 
        "id": "sg:person.0705556226.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705556226.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Akita University", 
          "id": "https://www.grid.ac/institutes/grid.251924.9", 
          "name": [
            "Department of Gastroenterology/Internal Medicine, Akita University School of Medicine, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Sumio", 
        "id": "sg:person.013741710522.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013741710522.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Vanderbilt University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.412807.8", 
          "name": [
            "Departments of Medicine and Cancer Biology, Vanderbilt-Ingram Cancer Center, Nashville, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "DuBois", 
        "givenName": "Raymond N", 
        "id": "sg:person.0626301614.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626301614.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1998.tb00647.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000803562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.1998.tb00647.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000803562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0790-662", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001073995", 
          "https://doi.org/10.1038/nbt0790-662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35094017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002632915", 
          "https://doi.org/10.1038/35094017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35094017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002632915", 
          "https://doi.org/10.1038/35094017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90133-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004251712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt1296-1675", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005458398", 
          "https://doi.org/10.1038/nbt1296-1675"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-4644(20001201)79:3<355::aid-jcb20>3.0.co;2-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007245033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-004-2873-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011908235", 
          "https://doi.org/10.1007/s10585-004-2873-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m108677200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012308549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018894227169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018262363", 
          "https://doi.org/10.1023/a:1018894227169"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.00453.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018951402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature00766", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023536940", 
          "https://doi.org/10.1038/nature00766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.273.29.18165", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025233137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026242666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-0674(97)80061-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026339231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0290(2000)71:3<184::aid-bit1008>3.0.co;2-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026412747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m407403200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028831950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.36.25701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031496902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0463.2004.apm11204-0502.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031558251"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10408699891274200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033352610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035710963", 
          "https://doi.org/10.1038/sj.onc.1202367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1202367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035710963", 
          "https://doi.org/10.1038/sj.onc.1202367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64863-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039071960"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)00670-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039492208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(03)00670-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039492208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.c000684200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041849685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m202866200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043155979"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0009-9120(83)94432-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044740376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1023003616848", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044978636", 
          "https://doi.org/10.1023/a:1023003616848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-3806(03)00011-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048195926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0165-3806(03)00011-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048195926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-6980(02)00030-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048488434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048855788", 
          "https://doi.org/10.1038/sj.onc.1208517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1208517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048855788", 
          "https://doi.org/10.1038/sj.onc.1208517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.271.49.31612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050605794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050818541", 
          "https://doi.org/10.1038/ng892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050818541", 
          "https://doi.org/10.1038/ng892"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.crvi.2003.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051380530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m006132200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052409248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gastro.2005.06.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054735486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.270.5235.467", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062551475"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.8052857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062652101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074472579", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074801158", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075108947", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078311007", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079010052", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.9.9.7601337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082430408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083198113", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-12", 
    "datePublishedReg": "2006-12-01", 
    "description": "BACKGROUND: Constitutive activation of MEK1 (caMEK) can induce the oncogenic transformation of normal intestinal epithelial cells. To define the genetic changes that occur during this process, we used oligonucleotide microarrays to determine which genes are regulated following the constitutive activation of MEK in normal intestinal epithelial cells.\nRESULTS: Microarray analysis was performed using Affymetrix GeneChip and total RNA from doxycycline inducible RIEtiCAMEK cells in the presence or absence of doxycycline. MEK-activation induced at least a three-fold difference in 115 gene transcripts (75 transcripts were up-regulated, and 40 transcripts were down-regulated). To verify whether these mRNAs are indeed regulated by the constitutive activation of MEK, RT-PCR analysis was performed using the samples from caMEK expressing RIE cells (RIEcCAMEK cells) as well as RIEtiCAMEK cells. The altered expression level of 69 gene transcripts was confirmed. Sixty-one of the differentially expressed genes have previously been implicated in cellular transformation or tumorogenesis. For the remaining 8 genes (or their human homolog), RT-PCR analysis was performed on RNA from human colon cancer cell lines and matched normal and tumor colon cancer tissues from human patients, revealing three novel targets (rat brain serine protease2, AMP deaminase 3, and cartilage link protein 1).\nCONCLUSION: Following MEK-activation, many tumor-associated genes were found to have significantly altered expression levels. However, we identified three genes that were differentially expressed in caMEK cells and human colorectal cancers, which have not been previously linked to cellular transformation or tumorogenesis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1186/1476-4598-5-63", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2497652", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2435709", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2495079", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2634812", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438863", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1031030", 
        "issn": [
          "1476-4598"
        ], 
        "name": "Molecular Cancer", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "5"
      }
    ], 
    "name": "Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells", 
    "pagination": "63", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a0e64fb6566748f0b13a70f8683bf760c943d415bcdc1c5d52b4d7181ba5a1b7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17112382"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101147698"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1186/1476-4598-5-63"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033776610"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1186/1476-4598-5-63", 
      "https://app.dimensions.ai/details/publication/pub.1033776610"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1186%2F1476-4598-5-63"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-5-63'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-5-63'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-5-63'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1186/1476-4598-5-63'


 

This table displays all metadata directly associated to this object as RDF triples.

328 TRIPLES      21 PREDICATES      88 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1186/1476-4598-5-63 schema:about N18635fe7eec145599d91841559e78f07
2 N25ac8093f28840068077e01ebb9df506
3 N386b55c022484d5590a3f0189e6719e8
4 N4f17307db46846b5a7a11bc5b220375f
5 N54e58c9ee2bf409181378f3acdc9f243
6 N62ebcd7d6fb64c3588925d90dd0c4ca9
7 N9eb104524e48447a8652b6f8dd17182d
8 Na2ca5e90547d4f24b24b2b56ebae7510
9 Naa4d066d3adc4c679f79c6b76567a047
10 Nb4fb8755b8a94af780168da4338353df
11 Nb976dd55a48c4d0583f5c092071eb634
12 Ncb4dde90e10943d5ae6f666f66c69030
13 Ncb4fab36e01048a3ac6c33a11abaf8f7
14 Ne85e6b628d4e4d649ffedd276d50c843
15 Nebf3fee3aa1e4607ab10cf9d1868cad9
16 Nf5e6ca31c2bc48d89bcdae4120d3b77a
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author Na3e9eb9b2eb4468fba70ba6c43b7fbe3
20 schema:citation sg:pub.10.1007/s10585-004-2873-4
21 sg:pub.10.1023/a:1018894227169
22 sg:pub.10.1023/a:1023003616848
23 sg:pub.10.1038/35094017
24 sg:pub.10.1038/nature00766
25 sg:pub.10.1038/nbt0790-662
26 sg:pub.10.1038/nbt1296-1675
27 sg:pub.10.1038/ng892
28 sg:pub.10.1038/sj.onc.1202367
29 sg:pub.10.1038/sj.onc.1208517
30 https://app.dimensions.ai/details/publication/pub.1074472579
31 https://app.dimensions.ai/details/publication/pub.1074801158
32 https://app.dimensions.ai/details/publication/pub.1075108947
33 https://app.dimensions.ai/details/publication/pub.1078311007
34 https://app.dimensions.ai/details/publication/pub.1079010052
35 https://app.dimensions.ai/details/publication/pub.1083198113
36 https://doi.org/10.1002/1097-0290(2000)71:3<184::aid-bit1008>3.0.co;2-w
37 https://doi.org/10.1002/1097-4644(20001201)79:3<355::aid-jcb20>3.0.co;2-0
38 https://doi.org/10.1016/0092-8674(94)90133-3
39 https://doi.org/10.1016/j.crvi.2003.09.007
40 https://doi.org/10.1016/j.gastro.2005.06.003
41 https://doi.org/10.1016/s0002-9440(10)64863-8
42 https://doi.org/10.1016/s0006-291x(03)00670-3
43 https://doi.org/10.1016/s0009-9120(83)94432-6
44 https://doi.org/10.1016/s0090-6980(02)00030-8
45 https://doi.org/10.1016/s0165-3806(03)00011-7
46 https://doi.org/10.1016/s0955-0674(97)80061-0
47 https://doi.org/10.1053/j.gastro.2005.06.003
48 https://doi.org/10.1074/jbc.271.49.31612
49 https://doi.org/10.1074/jbc.273.29.18165
50 https://doi.org/10.1074/jbc.274.36.25701
51 https://doi.org/10.1074/jbc.c000684200
52 https://doi.org/10.1074/jbc.m006132200
53 https://doi.org/10.1074/jbc.m108677200
54 https://doi.org/10.1074/jbc.m202866200
55 https://doi.org/10.1074/jbc.m407403200
56 https://doi.org/10.1080/10408699891274200
57 https://doi.org/10.1096/fasebj.9.9.7601337
58 https://doi.org/10.1111/j.1349-7006.1998.tb00647.x
59 https://doi.org/10.1111/j.1600-0463.2004.apm11204-0502.x
60 https://doi.org/10.1126/science.270.5235.467
61 https://doi.org/10.1126/science.8052857
62 https://doi.org/10.1152/ajpgi.00453.2003
63 schema:datePublished 2006-12
64 schema:datePublishedReg 2006-12-01
65 schema:description BACKGROUND: Constitutive activation of MEK1 (caMEK) can induce the oncogenic transformation of normal intestinal epithelial cells. To define the genetic changes that occur during this process, we used oligonucleotide microarrays to determine which genes are regulated following the constitutive activation of MEK in normal intestinal epithelial cells. RESULTS: Microarray analysis was performed using Affymetrix GeneChip and total RNA from doxycycline inducible RIEtiCAMEK cells in the presence or absence of doxycycline. MEK-activation induced at least a three-fold difference in 115 gene transcripts (75 transcripts were up-regulated, and 40 transcripts were down-regulated). To verify whether these mRNAs are indeed regulated by the constitutive activation of MEK, RT-PCR analysis was performed using the samples from caMEK expressing RIE cells (RIEcCAMEK cells) as well as RIEtiCAMEK cells. The altered expression level of 69 gene transcripts was confirmed. Sixty-one of the differentially expressed genes have previously been implicated in cellular transformation or tumorogenesis. For the remaining 8 genes (or their human homolog), RT-PCR analysis was performed on RNA from human colon cancer cell lines and matched normal and tumor colon cancer tissues from human patients, revealing three novel targets (rat brain serine protease2, AMP deaminase 3, and cartilage link protein 1). CONCLUSION: Following MEK-activation, many tumor-associated genes were found to have significantly altered expression levels. However, we identified three genes that were differentially expressed in caMEK cells and human colorectal cancers, which have not been previously linked to cellular transformation or tumorogenesis.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf N8b6b18eb9b5346e9be465d1f909a3077
70 Nde369e5893854395b9fa4d4986e27dda
71 sg:journal.1031030
72 schema:name Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells
73 schema:pagination 63
74 schema:productId N89c2647be0aa4a60a4f091e4b75e66c8
75 N946c4a1f2310444db788152975ba32f1
76 N98002ee7e85641c29206d666bd05fc4b
77 Ndfb52933c7ec4856b8560383f0b35d93
78 Nff75a8bc2227410f84791f293eb83f1c
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033776610
80 https://doi.org/10.1186/1476-4598-5-63
81 schema:sdDatePublished 2019-04-10T17:32
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N96b6d33164814aedad0d586c5c29689f
84 schema:url http://link.springer.com/10.1186%2F1476-4598-5-63
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N0bc80dfdad084959b58d31a390873791 rdf:first sg:person.01132045232.27
89 rdf:rest Nbd16ccc2facd47b68a463abeca62a9ba
90 N0eec1260fd51450593cae824eca1c428 rdf:first sg:person.0705556226.09
91 rdf:rest N78fe125ddc144c5a831ff1ccca0f63a5
92 N18635fe7eec145599d91841559e78f07 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Signal Transduction
94 rdf:type schema:DefinedTerm
95 N25ac8093f28840068077e01ebb9df506 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Cell Transformation, Neoplastic
97 rdf:type schema:DefinedTerm
98 N386b55c022484d5590a3f0189e6719e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Colonic Neoplasms
100 rdf:type schema:DefinedTerm
101 N4f17307db46846b5a7a11bc5b220375f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Time Factors
103 rdf:type schema:DefinedTerm
104 N54e58c9ee2bf409181378f3acdc9f243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Intestines
106 rdf:type schema:DefinedTerm
107 N62ebcd7d6fb64c3588925d90dd0c4ca9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Gene Expression Profiling
109 rdf:type schema:DefinedTerm
110 N64d6f0841cdb48d8b03f162f8b84c4fc rdf:first sg:person.01217757103.81
111 rdf:rest N0bc80dfdad084959b58d31a390873791
112 N78fe125ddc144c5a831ff1ccca0f63a5 rdf:first sg:person.013741710522.15
113 rdf:rest Nec0567b8dfb9484ea9720874993f791a
114 N7dd289c958e844cba6ffe203f67150e2 rdf:first sg:person.01334024263.69
115 rdf:rest N0eec1260fd51450593cae824eca1c428
116 N89c2647be0aa4a60a4f091e4b75e66c8 schema:name nlm_unique_id
117 schema:value 101147698
118 rdf:type schema:PropertyValue
119 N8b6b18eb9b5346e9be465d1f909a3077 schema:volumeNumber 5
120 rdf:type schema:PublicationVolume
121 N946c4a1f2310444db788152975ba32f1 schema:name dimensions_id
122 schema:value pub.1033776610
123 rdf:type schema:PropertyValue
124 N96b6d33164814aedad0d586c5c29689f schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N98002ee7e85641c29206d666bd05fc4b schema:name readcube_id
127 schema:value a0e64fb6566748f0b13a70f8683bf760c943d415bcdc1c5d52b4d7181ba5a1b7
128 rdf:type schema:PropertyValue
129 N9eb104524e48447a8652b6f8dd17182d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Polymerase Chain Reaction
131 rdf:type schema:DefinedTerm
132 Na2ca5e90547d4f24b24b2b56ebae7510 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Epithelial Cells
134 rdf:type schema:DefinedTerm
135 Na3e9eb9b2eb4468fba70ba6c43b7fbe3 rdf:first sg:person.01246273632.72
136 rdf:rest N64d6f0841cdb48d8b03f162f8b84c4fc
137 Naa4d066d3adc4c679f79c6b76567a047 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Rats
139 rdf:type schema:DefinedTerm
140 Nb4fb8755b8a94af780168da4338353df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Animals
142 rdf:type schema:DefinedTerm
143 Nb976dd55a48c4d0583f5c092071eb634 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name MAP Kinase Kinase 1
145 rdf:type schema:DefinedTerm
146 Nbd16ccc2facd47b68a463abeca62a9ba rdf:first sg:person.0613614240.07
147 rdf:rest N7dd289c958e844cba6ffe203f67150e2
148 Ncb4dde90e10943d5ae6f666f66c69030 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Gene Expression Regulation
150 rdf:type schema:DefinedTerm
151 Ncb4fab36e01048a3ac6c33a11abaf8f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Cell Line
153 rdf:type schema:DefinedTerm
154 Nde369e5893854395b9fa4d4986e27dda schema:issueNumber 1
155 rdf:type schema:PublicationIssue
156 Ndfb52933c7ec4856b8560383f0b35d93 schema:name doi
157 schema:value 10.1186/1476-4598-5-63
158 rdf:type schema:PropertyValue
159 Ne85e6b628d4e4d649ffedd276d50c843 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Oligonucleotide Array Sequence Analysis
161 rdf:type schema:DefinedTerm
162 Nebf3fee3aa1e4607ab10cf9d1868cad9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Humans
164 rdf:type schema:DefinedTerm
165 Nec0567b8dfb9484ea9720874993f791a rdf:first sg:person.0626301614.27
166 rdf:rest rdf:nil
167 Nf5e6ca31c2bc48d89bcdae4120d3b77a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Enzyme Activation
169 rdf:type schema:DefinedTerm
170 Nff75a8bc2227410f84791f293eb83f1c schema:name pubmed_id
171 schema:value 17112382
172 rdf:type schema:PropertyValue
173 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
174 schema:name Biological Sciences
175 rdf:type schema:DefinedTerm
176 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
177 schema:name Biochemistry and Cell Biology
178 rdf:type schema:DefinedTerm
179 sg:grant.2435709 http://pending.schema.org/fundedItem sg:pub.10.1186/1476-4598-5-63
180 rdf:type schema:MonetaryGrant
181 sg:grant.2438863 http://pending.schema.org/fundedItem sg:pub.10.1186/1476-4598-5-63
182 rdf:type schema:MonetaryGrant
183 sg:grant.2495079 http://pending.schema.org/fundedItem sg:pub.10.1186/1476-4598-5-63
184 rdf:type schema:MonetaryGrant
185 sg:grant.2497652 http://pending.schema.org/fundedItem sg:pub.10.1186/1476-4598-5-63
186 rdf:type schema:MonetaryGrant
187 sg:grant.2634812 http://pending.schema.org/fundedItem sg:pub.10.1186/1476-4598-5-63
188 rdf:type schema:MonetaryGrant
189 sg:journal.1031030 schema:issn 1476-4598
190 schema:name Molecular Cancer
191 rdf:type schema:Periodical
192 sg:person.01132045232.27 schema:affiliation https://www.grid.ac/institutes/grid.251924.9
193 schema:familyName Otaka
194 schema:givenName Michiro
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132045232.27
196 rdf:type schema:Person
197 sg:person.01217757103.81 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
198 schema:familyName Buchanan
199 schema:givenName F Gregory
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217757103.81
201 rdf:type schema:Person
202 sg:person.01246273632.72 schema:affiliation https://www.grid.ac/institutes/grid.251924.9
203 schema:familyName Komatsu
204 schema:givenName Koga
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246273632.72
206 rdf:type schema:Person
207 sg:person.01334024263.69 schema:affiliation https://www.grid.ac/institutes/grid.251924.9
208 schema:familyName Odashima
209 schema:givenName Masaru
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334024263.69
211 rdf:type schema:Person
212 sg:person.013741710522.15 schema:affiliation https://www.grid.ac/institutes/grid.251924.9
213 schema:familyName Watanabe
214 schema:givenName Sumio
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013741710522.15
216 rdf:type schema:Person
217 sg:person.0613614240.07 schema:affiliation https://www.grid.ac/institutes/grid.251924.9
218 schema:familyName Jin
219 schema:givenName Mario
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613614240.07
221 rdf:type schema:Person
222 sg:person.0626301614.27 schema:affiliation https://www.grid.ac/institutes/grid.412807.8
223 schema:familyName DuBois
224 schema:givenName Raymond N
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626301614.27
226 rdf:type schema:Person
227 sg:person.0705556226.09 schema:affiliation https://www.grid.ac/institutes/grid.251924.9
228 schema:familyName Horikawa
229 schema:givenName Yohei
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705556226.09
231 rdf:type schema:Person
232 sg:pub.10.1007/s10585-004-2873-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011908235
233 https://doi.org/10.1007/s10585-004-2873-4
234 rdf:type schema:CreativeWork
235 sg:pub.10.1023/a:1018894227169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018262363
236 https://doi.org/10.1023/a:1018894227169
237 rdf:type schema:CreativeWork
238 sg:pub.10.1023/a:1023003616848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044978636
239 https://doi.org/10.1023/a:1023003616848
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/35094017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002632915
242 https://doi.org/10.1038/35094017
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/nature00766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023536940
245 https://doi.org/10.1038/nature00766
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/nbt0790-662 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001073995
248 https://doi.org/10.1038/nbt0790-662
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nbt1296-1675 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005458398
251 https://doi.org/10.1038/nbt1296-1675
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/ng892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050818541
254 https://doi.org/10.1038/ng892
255 rdf:type schema:CreativeWork
256 sg:pub.10.1038/sj.onc.1202367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035710963
257 https://doi.org/10.1038/sj.onc.1202367
258 rdf:type schema:CreativeWork
259 sg:pub.10.1038/sj.onc.1208517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048855788
260 https://doi.org/10.1038/sj.onc.1208517
261 rdf:type schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1074472579 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1074801158 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1075108947 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1078311007 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1079010052 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1083198113 schema:CreativeWork
268 https://doi.org/10.1002/1097-0290(2000)71:3<184::aid-bit1008>3.0.co;2-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1026412747
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1002/1097-4644(20001201)79:3<355::aid-jcb20>3.0.co;2-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007245033
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/0092-8674(94)90133-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004251712
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/j.crvi.2003.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051380530
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/j.gastro.2005.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054735486
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0002-9440(10)64863-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039071960
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0006-291x(03)00670-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039492208
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1016/s0009-9120(83)94432-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044740376
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1016/s0090-6980(02)00030-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048488434
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1016/s0165-3806(03)00011-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048195926
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/s0955-0674(97)80061-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026339231
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1053/j.gastro.2005.06.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026242666
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1074/jbc.271.49.31612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050605794
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1074/jbc.273.29.18165 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025233137
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1074/jbc.274.36.25701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031496902
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1074/jbc.c000684200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041849685
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1074/jbc.m006132200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052409248
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1074/jbc.m108677200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012308549
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1074/jbc.m202866200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043155979
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1074/jbc.m407403200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028831950
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1080/10408699891274200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033352610
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1096/fasebj.9.9.7601337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082430408
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1111/j.1349-7006.1998.tb00647.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1000803562
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1111/j.1600-0463.2004.apm11204-0502.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031558251
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1126/science.270.5235.467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062551475
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1126/science.8052857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652101
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1152/ajpgi.00453.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018951402
321 rdf:type schema:CreativeWork
322 https://www.grid.ac/institutes/grid.251924.9 schema:alternateName Akita University
323 schema:name Department of Gastroenterology, Honjo Daiichi General Hospital, Yurihonjo, Japan
324 Department of Gastroenterology/Internal Medicine, Akita University School of Medicine, Akita, Japan
325 rdf:type schema:Organization
326 https://www.grid.ac/institutes/grid.412807.8 schema:alternateName Vanderbilt University Medical Center
327 schema:name Departments of Medicine and Cancer Biology, Vanderbilt-Ingram Cancer Center, Nashville, USA
328 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...